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2. Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain.

Author

Rae-Hyung Kim, Jia-Qi Chu, Jeong-Nam Park, Seo-Yong Lee, Yeo-Joo Lee, Mi-Kyeong Ko, Ji-Hyeon Hwang, Kwang-Nyeong Lee, Su-Mi Kim, Dongseob Tark, Young-Joon Ko, Hyang-Sim Lee, Min-Goo Seo, Min-Eun Park, Byounghan Kim, and Jong-Hyeon Park

Subjects
FOOT & mouth disease vaccines, MOLECULAR cloning, VACCINES, SEROTYPES, ANTISENSE DNA
Abstract

We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype. [ABSTRACT FROM AUTHOR]

Published
2015
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