11 results on '"Reddy, Niranjan"'
Search Results
2. Association of HbE Haemoglobinopathy in Patients with Systemic Lupus Erythematosus: A Cross-sectional Study.
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KAMANNA, ANURADHA, NAOREM, SANTA, TAURO, SHERAL RAINA, SAHA, SUPRATIM, AKULI, SOUMYA PRATIM, REDDY, NIRANJAN N., KARTHIK, Y. R., and KRISHNAPPA, NIHARIKA
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SYSTEMIC lupus erythematosus ,ERYTHROCYTES ,CROSS-sectional method ,MEDICAL sciences - Abstract
Introduction: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease of autoimmune origin that affects multiple systems, with the haematologic system being commonly involved. However, the co-existence of haemoglobinopathies and connective tissue disorders has rarely been investigated, and the available data on this matter are primarily anecdotal. Aim: To determine the prevalence of Haemoglobin E (HbE) haemoglobinopathy in adult SLE patients and to assess the association of HbE haemoglobinopathy and SLE with disease activity. Materials and Methods: A hospital-based cross-sectional study was conducted at the Department of General Medicine, Regional Institute of Medical Sciences (RIMS) Hospital, Imphal, Manipur, India, from April 2021 to July 2022. The study included SLE patients diagnosed during the study period who attended the rheumatology Outpatient Department (OPD). The independent variables were age, gender, occupation, religion, and family history, while HbE haemoglobinopathy, Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Red Blood Cell (RBC) count, and Systemic Lupus Activity Measure Revised Index (SLAM-R index) score were the dependent variables. Data were analysed using Statistical Package for Social Sciences (SPSS) version 21.0, with proportions analysed using the Chi-square test and Fisher's-exact test, and means compared using Analysis of Variance (ANOVA) and independent t-test. A p-value of <0.05 was considered significant. Results: Of the 105 SLE patients included in the study, 93% were females. The majority of participants (36.2%) were in the age group of 21-30 years. Twenty-five patients (23.8%) had HbE haemoglobinopathy. Anaemia and MCV were significantly associated with HbE patients. Among the 25 HbE patients, 24 (96%) had active SLE disease. Among the HbE negative patients, 55 (68.7%) had active disease, while 25 (31.3%) did not have any active disease. Active SLE disease was significantly associated with HbE haemoglobinopathy (p-value=0.002). Conclusion: The overall prevalence of HbE haemoglobinopathy in SLE patients was found to be 24%. Hb levels and MCV levels were significantly lower in HbE patients. There was a significant association between active SLE disease and HbE haemoglobinopathy. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Prognostic value of heart rate variability in acute coronary syndrome.
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Pernaje Seetharam, Smitha, Shankar MS, Vinutha, Udupa, Kaviraja, A., Raveesha, and Reddy, Niranjan
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SUDDEN death ,PERCUTANEOUS coronary intervention ,PREDICTIVE tests ,ACUTE coronary syndrome ,MYOCARDIAL infarction ,HEART beat ,ELECTROCARDIOGRAPHY ,SENSITIVITY & specificity (Statistics) ,RECEIVER operating characteristic curves - Abstract
To assess the predictive value of pre-discharge heart rate variability (HRV) parameters in patients with acute coronary syndrome (ACS) treated by percutaneous coronary intervention (PCI). 145 consecutive male patients with ACS (aged 57.12 ± 10.81 years) were included in this study. Fifteen minutes electrocardiogram recording was done to measure time-domain [standard deviation of N–N intervals (SDNN), root-mean square differences of successive R–R intervals (rMSSD)] and frequency-domain [low-frequency (LF) power, high-frequency (HF) power and total power (TP)] HRV parameters before and after PCI. The primary end point was the occurrence of major clinical events (MCE) defined as death, sudden death or re-acute myocardial infarction at the end of 3 months follow-up. At a follow-up of 3 months, MCE occurred in 06 patients (4.14%) (Cardiac death was 3.01%, while that of sudden death was 1.13%). Out of six-MCE, four deaths and two re-AMIs occurred. Pre-discharge HRV values (SDNN, rMSSD, TP, LF and HF) were significantly lower in patients with ACS without MCE. Only total power HRV index (AUC=0.748; p=0.040) showed greater prognostic accuracy. In conclusion, study showed an increase in SDNN, rMSSD, LF, HF and TP after successful revascularization with PCI in patients who had MCE. The resultant sensitivity, specificity of HRV is still limited in the present study. Particularly, its sensitivity is higher (33–83%) with a modest specificity (61–72%). [ABSTRACT FROM AUTHOR]
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- 2023
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4. Evaluation of Systolic Time Intervals in Patients of Ischemic Heart Disease with Clinical Heart Failure.
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Seetharam, Smitha Pernaje, Shankar, M. S. Vinutha, and Reddy, Niranjan
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CARDIAC contraction ,HEART disease diagnosis ,HEART failure ,ECHOCARDIOGRAPHY ,CLINICAL trials - Abstract
Introduction: Left ventricular (LV) systolic function evaluation is based on ejection fraction assessment. Due to the great sensitivity of the examination and the ease of measurement, systolic time intervals (STIs) are ideally appropriate for studying the effects of pharmacologic agents upon the heart. In this context, the present study aimed to estimate and compare STI in patients with ischemic heart disease (IHD) with clinical heart failure and among control subjects without clinically established LV dysfunction based on their LV ejection fraction (LVEF). Materials and Methods: This case-control study included 33 IHD patients as cases and 32 healthy subjects as controls. All subjects underwent pulsed-Doppler echocardiogram to estimate STIs: total electromechanical systole (QS2), preejection period (PEP), and LV ejection time (LVET). Results: A significant difference between PEP (145.23 ± 23.20 vs. 82.99 ± 8.63, P < 0.00001), LVET (231.34 ± 40.89 vs. 265.39 ± 31.98, P = 0.000947), and PEP/LVET ratio (0.63 ± 0.15 vs. 0.31 ± 0.08, P < 0.00001) between cases and controls was found. On subgroup analysis, a weak correlation was found in patients with LVEF =40% and PEP/LVET (r = -0.3677, P = 0.1958). In addition, a relatively strong correlation between LVET and heart rate (r = -0.432, P = 0.012) was found among the cases. Conclusion: The current study results showed that the differences in the values of STI among cases than in controls could be an indicator of LV systolic dysfunction. In addition, this method may have impending applications in the management of IHD. [ABSTRACT FROM AUTHOR]
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- 2022
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5. A Narrative Review of Clinical Applications of Systolic Time Intervals.
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Seetharam, Smitha Pernaje, Shankar, M. S. Vinutha, and Reddy, Niranjan
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CARDIAC contraction ,CARDIOVASCULAR diseases ,ECHOCARDIOGRAPHY ,HEART failure ,ATRIAL fibrillation - Abstract
Systolic time interval (STI) estimation is an established noninvasive method for the quantifiable assessment of left ventricular (LV) performance in well-being and disease states; it stays valuable for clinical application and forms no burden to the subjects. This manuscript reviews the potential clinical applications and prognostic value of STI for the assessment of LV systolic function in cardiovascular disease (CVD). STIs could be obtained by several noninvasive imaging modalities such as transthoracic echocardiography, tissue Doppler imaging M-mode echocardiography, conventional echocardiography, and so on. In view of that, a literature review for studies reporting the clinical applications of STI in assessing LV systolic function among CVD patients was carried out using PubMed search. Accordingly, the current review describes how STI can be measured; reliability of cardiac time interval measurement in patients with CVD and its role in a clinical setting. With the advent of modern techniques, STI could be easily measured in a clinical setting. Likewise, STI parameter, particularly preejection period and LV ejection time ratio (PEP/LVET), has got the highest degree of correlation with LV ejection fraction (LVEF) in assessing LV performance. Furthermore, reproducibility of systolic ejection time (SET) achieved by the TDI M-mode method is outstanding and better when compared with the reproducibility of SET obtained by the conventional pulsed Doppler method. Furthermore, prolonged SET is independently related with enhanced outcomes among heart failure with reduced EF (HFrEF, i.e., EF =40%) but not HF with preserved EF (HFpEF, i.e., EF >40%) patients, indicating that stabilizing SET would be helpful in the case of systolic dysfunction. Clinically, tissue Doppler-derived time intervals could be beneficial to analyze abnormal cases in comparison with other invasive and noninvasive methods of ventricular function examination. Furthermore, phonoelectrocardiography-derived STI parameters, particularly electromechanical activation time-to-LVET ratio, may have a significant role in the diagnostic approach of heart failure (HF) in patients with undifferentiated dyspnea. In addition, in HF patients, PEP/LVET of >0.43 helps to detect LVEF <35% by pulsed Doppler echocardiography. Moreover, LVET continues to be an independent predictor of incident HF and provides incremental prognostic value on the future HF risk and death but not myocardial infarction. In conclusion, STI measurement could be useful, particularly in identifying LVEF <35% in the case of refractory HF patients. This could be beneficial in the selection of patients requiring cardiac resynchronization, specifically when accurate LVEF evaluation by echocardiography proves challenging in atrial fibrillation or if the evaluation is done by a trainee echocardiographer. Furthermore, the cardiac time intervals including SET can be acquired irrespective of rhythm. Good image quality is required for the assessment of LVEF. In contrast, evaluation of SET could be useful in the case of echocardiograms with poor quality images. As a final point, the present review suggests using an echocardiographic parameter like STIs to procure additional information regarding the risk of mortality in patients with HFrEF along with LVEF measurement. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Integrated modeling of steel refining, casting and rolling operations to obtain design set points for quality steel sheet production.
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Gupta, Akash, Kumar, Prabhash, Anapagaddi, Ravikiran, Reddy, Niranjan, Goyal, Sharad, Singh, A. K., and Padmanabhan, K. A.
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SHEET-steel ,METAL refining ,ROLLING (Metalwork) ,CASTING (Manufacturing process) ,SYSTEMS design ,MECHANICAL properties of metals ,CRYSTAL structure - Abstract
Non-metallic inclusions are defects present in steel which disrupt the homogeneity of structure and adversely affects the mechanical properties. To some extent silo approach based mathematical models have been successfully used to modify and control inclusions in steel making but very few attempts have been made to deal with these processes in integrated framework. With computational advancement and high promising potential of ICME (Integrated Computational Materials Engineering), physics based models can be integrated which will lead to overall increase of process understanding, control and eventually to better properties and performance of material. The objectives of the present work are: (a) using CFD based models understand the influence of various design and process parameters on inclusion removal during secondary steel making, (b) using FEM model study the effects of type and characteristics of inclusions during solid state forming operations, and finally (c) integrate these models in order to develop an integrated modeling framework. This integrated framework will determine the extent up to which inclusions can be tolerated in downstream processes without affecting the quality and properties of final steel sheet significantly and suggest modifications in upstream processes if inclusions are above acceptable limit. [ABSTRACT FROM AUTHOR]
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- 2013
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7. Experimental determination of comfort benefits from cool-roof application to an un-conditioned building in India.
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Arumugam, Rathish, Garg, Vishal, Mathur, Jyothirmay, Reddy, Niranjan, Gandhi, Jalpa, and Fischer, Marc L.
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Increasing roof reflectance helps in savings in air-conditioning energy consumption, increase in indoor comfort at the building level and mitigates Urban Heat Island effect, reduces net solar radiation absorbed by the earth, lowers local air temperature and pollutant formation, and reducing global warming at the macro level. Previous studies have demonstrated energy savings in buildings using cool roofs. However, not many have evaluated the indoor comfort benefits of cool roofs for unconditioned interior spaces, especially in India. Here, we describe a study of an un-conditioned, institutional building in a composite climate in India. Monitoring was performed for a period of six months (January to June 2012) on two adjacent sections of continuous concrete roof surface, one of which had been previously coated with a white paint coating. The measured shortwave band-averaged (0.3–3 µm) solar reflectance was 0.28 and 0.57, for the uncoated and coated surfaces, respectively. The increased reflectivity reduced the seasonal average indoor air temperature and heat flux by 1.07°C, and 14.4 W m−2, respectively, with peak reductions of 1.38°C and 18.3 Wm−2in April 2012. This increased the number of adaptive comfort hours by 80 h (about 8% increase compared to dark roof), providing a significant improvement in human comfort. [ABSTRACT FROM PUBLISHER]
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- 2014
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8. Spermatogonial Stem Cells (SSCs) in Buffalo (Bubalus bubalis) Testis.
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Mahla, Ranjeet Singh, Reddy, Niranjan, and Goel, Sandeep
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STEM cells ,WATER buffalo ,MICE ,TRANSCRIPTION factors ,FIRE assay - Abstract
Background: Water buffalo is an economically important livestock species and about half of its total world population exists in India. Development of stem cell technology in buffalo can find application in targeted genetic modification of this species. Testis has emerged as a source of pluripotent stem cells in mice and human; however, not much information is available in buffalo. Objectives and Methods: Pou5f1 (Oct 3/4) is a transcription factor expressed by pluripotent stem cells. Therefore, in the present study, expression of POU5F1 transcript and protein was examined in testes of both young and adult buffaloes by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemical analysis. Further, using the testis transplantation assay, a functional assay for spermatogonial stem cells (SSCs), stem cell potential of gonocytes/spermatogonia isolated from prepubertal buffalo testis was also determined. Results: Expression of POU5F1transcript and protein was detected in prepubertal and adult buffalo testes. Western blot analysis revealed that the POU5F1 protein in the buffalo testis exists in two isoforms; large (∼47 kDa) and small (∼21 kDa). Immunohistochemical analysis revealed that POU5F1 expression in prepubertal buffalo testis was present in gonocytes/ spermatogonia and absent from somatic cells. In the adult testis, POU5F1 expression was present primarily in post-meiotic germ cells such as round spermatids, weakly in spermatogonia and spermatocytes, and absent from elongated spermatids. POU5F1 protein expression was seen both in cytoplasm and nuclei of the stained germ cells. Stem cell potential of prepubertal buffalo gonocytes/spermatogonia was confirmed by the presence of colonized DBA-stained cells in the basal membrane of seminiferous tubules of xenotransplanted mice testis. Conclusion/Significance: These findings strongly indicate that gonocytes/spermatogonia, isolated for prepubertal buffalo testis can be a potential target for establishing a germ stem cell line that would enable genetic modification of buffaloes. [ABSTRACT FROM AUTHOR]
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- 2012
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9. Gonadal status of male recipient mice influences germ cell development in immature buffalo testis tissue xenograft.
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Reddy, Niranjan, Mahla, Ranjeet Singh, Thathi, Revanth, Suman, Sanjay Kumar, Jose, Jedy, and Goel, Sandeep
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XENOGRAFTS ,GONAD physiology ,XENOTRANSPLANTATION ,WATER buffalo ,MICE ,GERM cells ,SPERMATOGENESIS in animals - Abstract
Growth and development of immature testis xenograft from various domestic mammals has been shown in mouse recipients; however, buffalo testis xenografts have not been reported to date. In this study, small fragments of testis tissue from 8-week-old buffalo calves were implanted subcutaneously onto the back of immunodeficient male mouse recipients, which were either castrated or left intact (non-castrated). The xenografts were retrieved and analyzed 12 and 24 weeks later. The grafted tissue survived and grew in both types of recipient with a significant increase in weight and seminiferous tubule diameter. Recovery of grafts from intact recipients 24 weeks post-grafting was significantly lower than that from the castrated recipients. Seminal vesicle indices and serum testosterone levels were lower in castrated recipients at both collection time points in comparison to the intact recipients and non-grafted intact mouse controls. Pachytene spermatocytes were the most advanced germ cells observed in grafts recovered from castrated recipients 24 weeks post-grafting. Complete spermatogenesis, as indicated by the presence of elongated spermatids, was present only in grafts from intact recipients collected 24 weeks post-grafting. However, significant number of germ cells with DNA damage was also detected in these grafts as indicated by TUNEL assay. The complete germ cell differentiation in xenografts from intact recipients may be attributed to efficient Sertoli cell maturation. These results suggest that germ cell differentiation in buffalo testis xenograft can be completed by altering the recipient gonadal status. [ABSTRACT FROM AUTHOR]
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- 2012
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10. UCHL-1 protein expression specifically marks spermatogonia in wild bovid testis.
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Goel, Sandeep, Mahla, Ranjeet Singh, Suman, Sanjay Kumar, Reddy, Niranjan, and Imai, Hiroshi
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GERM cells ,SPERMATOGENESIS ,MAMMALS ,TESTICULAR diseases ,ENDANGERED species ,BOVIDAE - Abstract
Spermatogonia are germ cells that initiate spermatogenesis in mammalian testis and they are the only cells in adult body capable of dividing both mitotically and meiotically. Therefore, isolation and preservation of spermatogonia can provide an alternative method for preservation of genetic pool of endangered animals. To achieve this objective, it is essential to identify markers that can specifically distinguish spermatogonia from other cells in the testis. In the present study, anti-ubiquitin C-terminal hydroxylase-1 (UCHL-1/PGP 9.5) antibody specifically recognized spermatogonia in the testis of wild and domestic bovid. The size of the UCHL-1 protein in various species of bovid testes was identical, and similar to that in mice. Furthermore, UCHL-1 staining could be utilized for the identification of spermatogonia in isolated testicular cells from wild bovids suggesting that UCHL-1 protein expression could be used as a specific marker for spermatogonia in bovid family. [ABSTRACT FROM AUTHOR]
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- 2011
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11. Long-term Mortality of Patients Admitted to the Intensive Care Unit for Gastrointestinal Bleeding.
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Gopalswamy, Narasimh, Malhotra, Vikas, Reddy, Niranjan, Singh, Brij M., Markert, Ronald J., Sangal, Satya, and Jordan, Roy
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- 2004
- Full Text
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