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An experimental evaluation is presented of a two-equation model for the low frequency (< 25 kHz), large amplitude (> --> 100 % of mean) discharge oscillations exhibited by a 9-kW class magnetically shielded Hall thruster. The model is based on a theoretical treatment of the "breathing mode" oscillations in Hall thrusters (Barral and Peradzyński, "A new breath for the breathing mode," IEPC-2009-070) and includes governing equations for fluctuations in the discharge current and the spatially averaged neutral density in the thruster channel. The derivation of the governing equations is reviewed, and the key simplifying assumptions are formulated in terms of comparisons between the magnitudes of relative fluctuations in spatially averaged plasma properties. Experimental measurements are performed of these plasma properties at an operating condition of 300 V discharge voltage and 10 A discharge current. It is found that all quantities of interest such as drift speed, electric field, and temperature fluctuate on the timescale of the low frequency oscillations. However, the relative phasing of these properties combine in such that the key assumptions of the model are satisfied—all but the neutral density and discharge fluctuations can be neglected in the equations for neutral density and current oscillations. A physical interpretation of the validity of the assumptions is presented, and the model is discussed in the context of its extensibility to other operating conditions. The validated model forms the basis for a parametric study presented in Part II of mode transitions and the criterion for these transitions in a magnetically shielded Hall thruster. [ABSTRACT FROM AUTHOR]

A stability criterion is derived for mode transitions in the discharge current oscillations of a magnetically shielded Hall thruster. The two-equation model evaluated in Paper I for these large-amplitude (> --> 100 % background), low-frequency (< 25 kHz) current oscillations is generalized and then validated with measurements from a 9 kW class test article. It is shown that the model can re-create quantitatively trends in both oscillation amplitude and frequency with discharge voltage and current. The validated model is non-dimensionalized and applied to derive an analytical stability criterion for the onset of large-amplitude oscillations. The resulting expression depends on several properties, including discharge current, discharge voltage, neutral transit time in the channel, length of the acceleration zone, magnetic field strength, and channel area. The criterion is leveraged to inform two mitigation strategies—changing magnetic field strength and controlling anode temperature— for adjusting the stability margin of the thruster. The criterion is also employed to motivate a physical explanation for why mode transitions occur and, in turn, why the stability margin differs between shielded and unshielded thrusters. [ABSTRACT FROM AUTHOR]

Using proprietary data from AngelList Talent, we study how startup job seekers' search and application behavior changed during the COVID-19 downturn. We find that workers shifted their searches and applications away from less-established startups and toward more-established ones, even within the same individual over time. At the firm level, this shift was not offset by an influx of new job seekers. Less-established startups experienced a relative decline in the quantity and quality of applications, ultimately affecting their hiring. Our findings uncover a flight-to-safety channel in the labor market that may amplify the procyclical nature of entrepreneurial activities. [ABSTRACT FROM AUTHOR]

Gait asymmetry is a predictor of fall risk and may contribute to increased falls during pregnancy. Previous work indicates that pregnant women experience asymmetric joint laxity and pelvic tilt during standing and asymmetric joint moments and angles during walking. How these changes translate to other measures of gait asymmetry remains unclear. Thus, the purpose of this case study was to determine the relationships between pregnancy progression, subsequent pregnancies, and gait asymmetry. Walking data were collected from an individual during 2 consecutive pregnancies during the second and third trimesters and 6 months postpartum of her first pregnancy and the first, second, and third trimesters and 6 months postpartum of her second pregnancy. Existing asymmetries in step length, anterior–posterior (AP) impulses, AP peak ground reaction forces, lateral impulses, and joint work systematically increased as her pregnancy progressed. These changes in asymmetry may be attributed to pelvic asymmetry, leading to asymmetric hip flexor and extensor length, or due to asymmetric plantar flexor strength, as suggested by her ankle work asymmetry. Relative to her first pregnancy, she had greater asymmetry in step length, step width, braking AP impulse, propulsive AP impulse, and peak braking AP ground reaction force during her second pregnancy, which may have resulted from increased joint laxity. [ABSTRACT FROM AUTHOR]

The fluorinated alcohols, (CF3)3COH (RF9OH) and (CF3)2MeCOH (RF6OH), react with W(NR)2Cy2 (Cy=Cyclohexyl; R=2,6‐diisopropylphenyl or 1‐adamantyl) in C6D6 at 55 °C to give cyclohexylidene complexes. Traditional routes to terminal alkylidene complexes (neopentylidene or neophylidene) have used either triflic acid or HCl (rarely), but relatively weak fluorinated acids are sufficient and active bisalkoxide catalysts are therefore prepared directly. An α hydrogen abstraction reaction to give a cyclohexylidene complex from a biscyclohexyl complex appears to be as facile as α hydrogen abstraction to give a neopentylidene or neophylidene ligand, but isomerization of a cyclohexene formed through β hydrogen abstraction is also a possibility. The ORF9 ligands can be replaced readily with dimethylpyrrolide (Me2Pyr) or other more basic alkoxides. Single crystal X‐ray studies were carried out on W(NAr)2Cy2, W(NAr)(ORF9)2(C6H10)(ArNH2), W(NAr)(ORF6)2(C6H10)(ArNH2), W(NAd)(ORF9)2(C6H10)(AdNH2), W(NAr)(O‐i‐PrF6)3Cy, and W(NAd)(η1‐Me2Pyr)2(C6H10) (C6H10=cyclohexylidene). [ABSTRACT FROM AUTHOR]

The fluorinated alcohols, (CF3)3COH (RF9OH) and (CF3)2MeCOH (RF6OH), react with W(NR)2Cy2 (Cy=Cyclohexyl; R=2,6‐diisopropylphenyl or 1‐adamantyl) in C6D6 at 55 °C to give cyclohexylidene complexes. Traditional routes to terminal alkylidene complexes (neopentylidene or neophylidene) have used either triflic acid or HCl (rarely), but relatively weak fluorinated acids are sufficient and active bisalkoxide catalysts are therefore prepared directly. An α hydrogen abstraction reaction to give a cyclohexylidene complex from a biscyclohexyl complex appears to be as facile as α hydrogen abstraction to give a neopentylidene or neophylidene ligand, but isomerization of a cyclohexene formed through β hydrogen abstraction is also a possibility. The ORF9 ligands can be replaced readily with dimethylpyrrolide (Me2Pyr) or other more basic alkoxides. Single crystal X‐ray studies were carried out on W(NAr)2Cy2, W(NAr)(ORF9)2(C6H10)(ArNH2), W(NAr)(ORF6)2(C6H10)(ArNH2), W(NAd)(ORF9)2(C6H10)(AdNH2), W(NAr)(O‐i‐PrF6)3Cy, and W(NAd)(η1‐Me2Pyr)2(C6H10) (C6H10=cyclohexylidene). [ABSTRACT FROM AUTHOR]

Background/Objectives: Host cell protein (HCP) content is a major attribute for biological and vaccine products that must be extensively characterized prior to product licensure. Enzyme Linked Immunosorbent Assay (ELISA) and Mass Spectrometry (MS) are conventional methods for quantitative host cell protein analysis in biologic and vaccine products. Both techniques are usually very tedious, labor-intensive, and challenging to transfer to other laboratories. In addition, the ELISA methodology requires 2D SDS PAGE and 2D western blot antibody reagent validation to establish reagent coverage. This reagent coverage provides a rather weak link that is currently accepted, as the western blot is run under denaturing conditions and the ELISA is run under native conditions. Simple Western™ is a relatively new, automated, capillary western blot-based technology that allows for the separation, blotting, and detection of proteins. But, unlike traditional western blots, Simple Western™ is quantitative, allowing for the quantification of HCP content in biologic and vaccine samples. Antibody reagent validation is much more straightforward, as the reagent coverage can be directly linked between the 2D methodology and Simple Western™, as they are both run under denatured and reduced conditions. Methods: Herein we describe the development of a capillary western blot method to quantify the HCP content in samples generated using a Vero cell line for the production of an investigational live virus vaccine candidate (V590) for Coronavirus Disease-2019 (COVID-19). The HCP content in COVID-19 vaccine samples was evaluated using three methods: the new capillary western, the gold standard ELISA, and SDS-PAGE. Results/Conclusions: Strong agreement was observed in the HCP content data between the capillary western and SDS PAGE methods, whereas the ELISA HCP data were outliers, suggesting that the capillary western is generating HCP concentrations closer to the true concentration. This is the first report of using capillary western technology in analyzing HCP in vaccine samples. [ABSTRACT FROM AUTHOR]

Background: The period after psychiatric hospital discharge is one of elevated risk for suicide‐related behaviors (SRBs). Post‐discharge clinical outreach, although potentially effective in preventing SRBs, would be more cost‐effective if targeted at high‐risk patients. To this end, a machine learning model was developed to predict post‐discharge suicides among Veterans Health Administration (VHA) psychiatric inpatients and target a high‐risk preventive intervention. Methods: The Veterans Coordinated Community Care (3C) Study is a multicenter randomized controlled trial using this model to identify high‐risk VHA psychiatric inpatients (n = 850) randomized with equal allocation to either the Coping Long Term with Active Suicide Program (CLASP) post‐discharge clinical outreach intervention or treatment‐as‐usual (TAU). The primary outcome is SRBs over a 6‐month follow‐up. We will estimate average treatment effects adjusted for loss to follow‐up and investigate the possibility of heterogeneity of treatment effects. Results: Recruitment is underway and will end September 2024. Six‐month follow‐up will end and analysis will begin in Summer 2025. Conclusion: Results will provide information about the effectiveness of CLASP versus TAU in reducing post‐discharge SRBs and provide guidance to VHA clinicians and policymakers about the implications of targeted use of CLASP among high‐risk psychiatric inpatients in the months after hospital discharge. Clinical trials registration: ClinicalTrials.Gov identifier: NCT05272176 (https://www.clinicaltrials.gov/ct2/show/NCT05272176). [ABSTRACT FROM AUTHOR]

Soil salinity adversely affects plant growth and development, reducing the yield of most crops, including wheat. The highly salt-tolerant wheat germplasm lines W4909 and W4910 were derived from a cross between two moderately salt-tolerant lines, the Chinese Spring (CS)/Thinopyrum junceum disomic addition line AJDAj5 (AJ) and the Ph-inhibitor line (Ph-I) derived from CS/Aegilops speltoides. Molecular markers for gene introgressions in W4909 and W4910 were not reported. Four sequence-tagged site (STS) molecular markers of Ph-I were developed and tested in the above-mentioned lines and the F2 progenies of the two crosses, Anza (AZ) × 4740 (sib of W4910) and Yecora Rojo (YR) × 4728 (sib of W4909). Additionally, homogeneity was assessed in several derivatives of W4909, 4728, W4910, and 4740 using the four markers. The four STS markers are not associated with salt tolerance, but they provide an indication of the transfer of chromatin in 3B chromosome of Ae. speltoides via Ph-I. Moreover, salt tolerance and leaf sodium concentration were determined in CS, AJ, Ph-I, 7151 (progeny of W4909), 7157 (progeny of W4910), AZ, and YR under salt treatment and control. Surprisingly, AJ had the lowest leaf sodium concentration under the control and salt treatment, indicating greater sodium exclusion than that in CS, AZ, and YR. This low level of leaf sodium concentration was heritable from 4740 to its hybrid progenies. On the other hand, the higher leaf sodium concentration, indicative of the tissue tolerance to salinity in Ph-I, had been inherited by both W4909 and W4910 and then transmitted to their hybrid progenies. One offspring line each in both W4909 and W4910 (7762 and 7159, respectively) were homozygous for the three molecular markers and lacked the marker psr1205 of Su1-Ph1 gene, making them better materials than the original lines for future research on, for example, whole-genome sequencing and gene mining. The implications of these findings for the utilization of W4909 and W4910 in breeding salt-tolerant wheat cultivars are discussed. [ABSTRACT FROM AUTHOR]

The recent demand for more efficient gas turbine engines has led to a growing need for new high performance materials and engineered surfaces. Consequently, there has been recent development of thermally sprayed coatings capable of withstanding harsh environments to advance these engines. For instance, oxide-based coatings exhibit high temperature stability, making them potential coating candidates for applications at elevated temperatures, thereby further improving gas turbine engines' efficiency. In particular, cobalt- and chromium- based oxides have previously been shown to be beneficial in terms of reducing friction and wear in high temperature environments. However, limited work has been performed on the deposition of such coatings by means of thermal spray processes. Therefore, the main purpose of this study is to develop and critically evaluate thermally sprayed cobalt- and chromium-based coatings for extreme environments. More specifically, the coatings were deposited by means of suspension plasma spray (SPS) and characterized before and after ball-on-flat tests at different temperatures. The coatings developed in this study have demonstrated high resistance to wear when tested against IN718. In all cases, most of the wear was observed on the counterballs. The CoO coating exhibited the lowest combined wear when compared to the other coatings. Ex-situ Raman analysis revealed the formation of Co3O4 for the worn cobalt oxide-based coatings tested at 450 °C, which correlates well with the lower wear rates. [ABSTRACT FROM AUTHOR]

Site‐directed spin labeling electron paramagnetic resonance (SDSL‐EPR) using nitroxide spin labels is a well‐established technology for mapping site‐specific secondary and tertiary structure and for monitoring conformational changes in proteins of any degree of complexity, including membrane proteins, with high sensitivity. SDSL‐EPR also provides information on protein dynamics in the timescale of ps–μs using continuous wave lineshape analysis and spin lattice relaxation time methods. However, the functionally important time domain of μs–ms, corresponding to large‐scale protein motions, is inaccessible to those methods. To extend SDSL‐EPR to the longer time domain, the perturbation method of pressure‐jump relaxation is implemented. Here, we describe a complete high‐pressure EPR system at Q‐band for both static pressure and ms‐timescale pressure‐jump measurements on spin‐labeled proteins. The instrument enables pressure jumps both up and down from any holding pressure, ranging from atmospheric pressure to the maximum pressure capacity of the system components (~3500 bar). To demonstrate the utility of the system, we characterize a local folding–unfolding equilibrium of T4 lysozyme. The results illustrate the ability of the system to measure thermodynamic and kinetic parameters of protein conformational exchange on the ms timescale. [ABSTRACT FROM AUTHOR]

Our study analyzes the factors associated with the faculty influence. We explore Google Scholar citation counts of 226 faculty at the top 20 doctoral programs in criminology and criminal justice. Our multivariate models show that some of the publication-related factors matter; the number of journal articles, proportion of articles published in prestigious journals, and proportion of books published with prestigious publishers are all positively related to citation counts, while the proportion of solo-authored articles and the number of textbooks published are both negatively related to the citation counts. Among demographic factors, faculty rank, length of years since the Ph.D., and race are related to citation counts, while gender is not. Finally, institutional prestige is positively related to citation counts, while the field of specialization is not. [ABSTRACT FROM AUTHOR]

Aim: Seasonality governs species composition at a given place and time. However, the effects of climate and land‐use change can vary by season, altering species composition. These changes can lead to a loss of distinct seasonal community composition, representing a novel form of biotic homogenisation. We ask if breeding and winter bird communities are becoming more similar over time. If so, is homogenisation occurring more rapidly in winter than in the breeding season, and has the presence of individual species changed between seasons? Location: Northeastern United States. Time Period: 1989–2019. Major Taxa Studied: Two hundred thirty‐eight bird species. Methods: We use data from The National Audubon Society's Christmas Bird Count and the North American Breeding Bird Survey to test if winter and breeding bird communities have become more similar (homogenised). We evaluate this change using the Sørensen dissimilarity index, and its components of turnover (species replacement) and nestedness (a subset of a more species rich community) and describe the mechanism in which the seasonal winter and breeding bird communities are changing. Results: We found that winter and breeding bird communities are homogenising, driven by significant decrease in turnover and a marginal decrease nestedness. When viewing breeding and wintering communities separately, we observe different trends. Breeding communities are becoming more unique with decreasing turnover and nestedness. Winter communities are becoming more similar to each other, with decreasing turnover and nestedness. More breeding species are declining and species that are typically found in the winter and year‐round residents are the main contributors to the homogenisation between seasons. Main Conclusions: We show for the first time homogenisation between winter and breeding bird communities over time across the northeastern United States. This insight into how individual species are faring between seasons, and how they impact community structure, can be used when implementing conservation measures for maintaining ecological functioning and integrity. [ABSTRACT FROM AUTHOR]

Wave runup, the excess water level above mean sea level, has been measured using different techniques with varying degrees of precision and associated practical limitations. This critical parameter, typically included in coastal assessment studies, varies temporally and spatially and depends on variables that include beach characteristics and nearshore hydrodynamics. Access to continuous datasets, using efficient mechanisms can assist resource-limited regions, such as Caribbean small-island developing states (SIDS), in overcoming coastal resilience obstacles. Experiments were conducted at University College London (UCL) and the University of the West Indies (UWI), which were designed to explore the temporal behaviour of the water surface within the bed during runup events. The experiments encompassed linear waves impacting a static porous bed (UCL) and a moveable granular beach (UWI), with pressure sensors buried at the base of each beach. The analyses showed that the averaged values of the time-varying water elevations within the bed, when spatially presented, produced a quadratic or cubic polynomial fit, where the curves' stationary points were accurate indicators of the location of the maximum runup position at the surface of the bed. In this way, an arrangement of buried pressure sensors can be used as an efficient means to accurately produce a continuous time series of maximum runup positions. This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'. [ABSTRACT FROM AUTHOR]

After Ukraine, the need for robust mechanisms to rebuild trust and ensure transparency among states would become more pressing than ever. Renowned for its transparency and trust-building capabilities, the Open Skies Treaty (OST) could serve as a cornerstone for post-conflict security arrangements. This article examines the potential for revisiting the Open Skies framework to adapt to innovative surveillance technologies, assist with verification of arms control agreements, and enhance diplomatic efforts to foster a collaborative deterrence between former enemies and include agreeable neighboring states. Utilizing a qualitative methodology involving the analysis of public statements, policy documents, and related scholarship, the study underscores the OST's critical role in establishing a transparent military environment. This recognized framework can foster trust among former adversaries, supporting broader goals of international peace and stability. [ABSTRACT FROM AUTHOR]

Artificial intelligence (AI) uses sophisticated algorithms to "learn" from large volumes of data. This could be used to optimise recruitment of blood donors through predictive modelling of future blood supply, based on previous donation and transfusion demand. We sought to assess utilisation of predictive modelling and AI blood establishments (BE) and conducted predictive modelling to illustrate its use. A BE survey of data modelling and AI was disseminated to the International Society of Blood transfusion members. Additional anonymzed data were obtained from Italy, Singapore and the United States (US) to build predictive models for each region, using January 2018 through August 2019 data to determine likelihood of donation within a prescribed number of months. Donations were from March 2020 to June 2021. Ninety ISBT members responded to the survey. Predictive modelling was used by 33 (36.7%) respondents and 12 (13.3%) reported AI use. Forty‐four (48.9%) indicated their institutions do not utilise predictive modelling nor AI to predict transfusion demand or optimise donor recruitment. In the predictive modelling case study involving three sites, the most important variable for predicting donor return was number of previous donations for Italy and the US, and donation frequency for Singapore. Donation rates declined in each region during COVID‐19. Throughout the observation period the predictive model was able to consistently identify those individuals who were most likely to return to donate blood. The majority of BE do not use predictive modelling and AI. The effectiveness of predictive model in determining likelihood of donor return was validated; implementation of this method could prove useful for BE operations. [ABSTRACT FROM AUTHOR]

Atrophic kidney-like lesion (AKLL) is a rare kidney lesion, which was recently suggested by the Genitourinary Pathology Society as a provisional entity. As of now, 16 examples of AKLL have been described in the literature. Here we report a new tumor which shows similar clinicopathologic characteristics with those previously reported in AKLL. Immunohistochemical (IHC) studies in the current lesion identified a biphasic staining pattern consisting of a mixture of WT1+/KRT7-/PAX8- large dilated cysts and WT-/KRT7+/PAX8+ small atrophic cysts. Histomorphologic features of AKLL overlap with several neoplastic and non-neoplastic entities which can lead to mischaracterization. Awareness of the differentiating features is likely important when evaluating these lesions. [ABSTRACT FROM AUTHOR]

Background/Objectives: There is evidence of overtreatment in patients with subclinical hypothyroidism (SCH). We aimed to identify the proportion of patients treated for SCH and the determinants of thyroid hormone therapy initiation. Methods: We included a random sample of adult Veterans diagnosed with SCH from 1 January 2016 to 31 December 2018 and conducted univariate and multivariable logistic regression to identify factors associated with levothyroxine initiation. Results: Out of 229 Veterans with SCH [90.0% male, 87.2% White, 99.1% non-Hispanic, median age (interquartile range; IQR) 68 (17) years], 27.5% were treated with levothyroxine. The treated group had a higher proportion of White patients (95.2% vs. 84.2%, p = 0.039), a higher thyrotropin level [median (IQR), 6.98 (2.06) mIU/L vs. 6.14 (1.10) mIU/L, p = 0.0002], a higher proportion of patients with thyrotropin level ≥ 10 mIU/L (11.1% vs. 3.0%, p = 0.021), a lower frequency of confirmatory thyroid testing before initiating levothyroxine (49.2% vs. 97.0%, p < 0.0001), and a similar frequency of thyroid autoimmunity testing (3.2% vs. 0.6%, p = 0.18) compared to the untreated group. In a multivariable logistic regression analysis, White race (OR = 4.50, 95% CI 1.19 to 17.08, p = 0.026) and index thyrotropin level [OR = 1.71, 95% CI 1.24 to 2.35, p = 0.001; for every SD increase (1.6 mIU/L)] were associated with higher odds of treatment. Conclusions: Three in 10 Veterans with SCH received levothyroxine, often based on a single abnormal thyroid test without autoimmunity assessment. White race and higher thyrotropin level were linked to increased odds of starting treatment, indicating potential disparities and the influence of SCH severity on decision-making. [ABSTRACT FROM AUTHOR]

Background: Most people with a stoma worry about leakage, and a quarter experience leakage of stomal effluent outside the baseplate on a monthly basis. Leakage has additional physical and psychosocial consequences, for instance, peristomal skin complications, feeling unable to cope, and self-isolation. Method: An interventional, single-arm, multi-centre study was undertaken in the United Kingdom to evaluate a novel digital leakage notification system for ostomy care, including a support service (=test product) for 12 weeks in patients with a recent stoma formation (≤9 months). Patients completed questionnaires at baseline and after 4, 6, 8, 10, and 12 weeks, evaluating leakage episodes, Ostomy Leak Impact (tool containing three domains), and patient self-management (by PAM-13). Additionally, mental well-being (by WHO-5) and health-related quality of life (QoL) (by EQ-5D-5L) were assessed. Outcomes between baseline and final evaluation were compared by generalised linear and linear mixed models. Results: 92 patients (ITT population) with a mean age of 49.4 years (range 18–81 years) were recruited. Of these, 80% had an ileostomy, and 53% were female. After 12 weeks of using the test product, a significant decrease in mean episodes of leakage outside the baseplate (1.57 versus 0.93, p < 0.046) was observed. Ostomy Leak Impact scores improved across all three domains (p < 0.001), indicating less embarrassment, increased engagement in social activities, and increased control. Patient self-management also improved significantly (PAM-13 score: ∆6.6, p < 0.001), as did the WHO-5 well-being index (∆8.0, p < 0.001). Lastly, EQ-5D-5L profile scores tended to improve (p = 0.075). Conclusions: A new digital leakage notification system demonstrated strong improvements to patients' stoma self-care, mental well-being, and QoL. Registration number on ClinicalTrials.gov: NCT05135754. [ABSTRACT FROM AUTHOR]

Metastatic cutaneous melanoma is a fatal skin cancer. Resistance to targeted and immune therapies limits the benefits of current treatments. Identifying and adding anti‐resistance agents to current treatment protocols can potentially improve clinical responses. Myocardin‐related transcription factor (MRTF) is a transcriptional coactivator whose activity is indirectly regulated by actin and the Rho family of GTPases. We previously demonstrated that development of BRAF inhibitor (BRAFi) resistance frequently activates the Rho/MRTF pathway in human and mouse BRAFV600E melanomas. In clinical trials, pretreatment with BRAFi reduces the benefit of immune therapies. We aimed to test the efficacy of concurrent treatment with our MRTF pathway inhibitor CCG‐257081 and anti‐PD1 in vivo and to examine its effects on the melanoma immune microenvironment. Because MRTF pathway activation upregulates the expression of immune checkpoint inhibitor genes/proteins, we asked whether CCG‐257081 can improve the response to immune checkpoint blockade. CCG‐257081 reduced the expression of PDL1 in BRAFi‐resistant melanoma cells and decreased surface PDL1 levels on both BRAFi‐sensitive and ‐resistant melanoma cells. Using our recently described murine vemurafenib‐resistant melanoma model, we found that CCG‐257081, in combination with anti‐PD1 immune therapy, reduced tumor growth and increased survival. Moreover, anti‐PD1/CCG‐257081 co‐treatment increased infiltration of CD8+ T cells and B cells into the tumor microenvironment and reduced tumor‐associated macrophages. Here, we propose CCG‐257081 as an anti‐resistance and immune therapy‐enhancing anti‐melanoma agent. [ABSTRACT FROM AUTHOR]

Pharmacogenomic (PGx) biomarkers integrated using machine learning can be embedded within the electronic health record (EHR) to provide clinicians with individualized predictions of drug treatment outcomes. Currently, however, drug alerts in the EHR are largely generic (not patient‐specific) and contribute to increased clinician stress and burnout. Improving the usability of PGx alerts is an urgent need. Therefore, this work aimed to identify principles for optimal PGx alert design through a health‐system‐wide, mixed‐methods study. Clinicians representing multiple practices and care settings (N = 1062) in urban, rural, and underserved regions were invited to complete an electronic survey comparing the usability of three drug alerts for citalopram, as a case study. Alert 1 contained a generic warning of pharmacogenomic effects on citalopram metabolism. Alerts 2 and 3 provided patient‐specific predictions of citalopram efficacy with varying depth of information. Primary outcomes included the System's Usability Scale score (0–100 points) of each alert, the perceived impact of each alert on stress and decision‐making, and clinicians' suggestions for alert improvement. Secondary outcomes included the assessment of alert preference by clinician age, practice type, and geographic setting. Qualitative information was captured to provide context to quantitative information. The final cohort comprised 305 geographically and clinically diverse clinicians. A simplified, individualized alert (Alert 2) was perceived as beneficial for decision‐making and stress compared with a more detailed version (Alert 3) and the generic alert (Alert 1) regardless of age, practice type, or geographic setting. Findings emphasize the need for clinician‐guided design of PGx alerts in the era of digital medicine. [ABSTRACT FROM AUTHOR]

This article describes the development and validation of accurate whole body sweat rate prediction equations for individuals performing indoor cycle ergometer and treadmill exercise, where power output can be measured or derived from simple inputs. For cycle ergometry, 112 trials (67 participants) were used for model development and another 56 trials (42 participants) for model validation. For treadmill exercise, 171 trials (67 participants) were used for model development and another 95 trials (63 participants) for model validation. Trials were conducted over a range of dry-bulb temperature (20°C to 40°C), relative humidity (14% to 60%), and exercise intensity (∼40% to 85% of peak aerobic power) conditions, which were matched between model development and model validation. Whole body sweat rates were measured, and proprietary prediction models were developed (accounting for all relevant biophysical factors) and then validated. For model validation, mean absolute error for predicted sweating rate was 0.01 and 0.02 L·h−1 for cycle and treadmill trials, respectively. The 95% confidence intervals were modest for cycle ergometer (+0.25 and −0.22 L·h−1) and treadmill exercise (+0.33 and −0.29 L·h−1). The accounted for variance between predicted and measured values was 92% and 78% for cycle and treadmill exercise, respectively. Bland–Altman analysis indicated that zero and one predicted value exceeded the a priori acceptable level of agreement (equivalent to ±2% of total body mass in 3 h) for cycle and treadmill exercise, respectively. There were fewer trials with female subjects, but their values did not differ from those expected for males. This is the foremost study to develop and validate whole body sweat rate prediction equations for indoor treadmill and cycle ergometer exercise of moderate to high intensity. These prediction equations are publicly available for use (https://sweatratecalculator.com). NEW & NOTEWORTHY: This study presents the development of new proprietary whole body sweat rate prediction models for people exercising indoors on a cycle ergometer or treadmill using simple input parameters and delivered through a publicly available online calculator: https://sweatratecalculator.com. In an independent validation group, the predictive models for both indoor cycling and treadmill exercise were accurate across moderate to high exercise intensities in temperate to hot conditions. These equations will enable individualized hydration management during physical training and exercise physiology experiments. [ABSTRACT FROM AUTHOR]

Longitudinal dispersal of migratory fish species can be interrupted by factors that fragment rivers, such as dams and reservoirs with incompatible habitats, and indirect alterations to variables, such as water temperature or turbidity. The endangered pallid sturgeon (Scaphirhynchus albus) population in the Upper Missouri River Basin in North Dakota and Montana is an example of such fragmentation and alteration due to the construction of dams. We applied a high-resolution, 2+-dimensional modelling framework composed of hydrodynamic and Lagrangian particle tracking components to simulate pallid sturgeon larval drift and dispersal along a 33-km section of the Upper Missouri River to evaluate three main issues: a comparison between multidimensional models and traditional 1-dimensional models, the sensitivity of hydrodynamics to channel morphology, and the implications of channel morphology on retention and transport-time metrics for larval fish. The results indicate that multidimensional models better represent breakthrough curves of transporting larvae compared to 1-dimensional models, especially for the long tail of slow drifters in the population. Results also indicate that channel morphology and hydraulic complexity play significant roles in larval dispersal with certain flow conditions and channel features increasing larval retention and providing potential management options to increase survival rates by adjusting flow conditions during spawning events. For example, modelling indicates increased retention times at discharges 23–38% daily flow exceedance, coincident with emergence of mid-channel sandbars. Findings additionally emphasize the need for improved understanding of biological factors that affect larval drift and dispersal. [ABSTRACT FROM AUTHOR]

We investigate how the stellar rotational support changes as a function of spatially resolved stellar population age (⁠|$D_n4000$|⁠) and relative central stellar surface density (⁠|$\Delta \Sigma _1$|⁠) for MaNGA isolated/central disc galaxies. We find that the galaxy rotational support indicator |$\lambda _{R_\mathrm{e}}$| varies smoothly as a function of |$\Delta \Sigma _1$| and |$D_n4000$|⁠. |$D_n4000$| versus |$\Delta \Sigma _1$| follows a 'J-shape', with |$\lambda _{R_\mathrm{e}}$| contributing to the scatters. In this 'J-shaped' pattern rotational support increases with central |$D_n4000$| when |$\Delta \Sigma _1$| is low but decreases with |$\Delta \Sigma _1$| when |$\Delta \Sigma _1$| is high. Restricting attention to low- |$\Delta \Sigma _1$| (i.e. large-radius) galaxies, we suggest that the trend of increasing rotational support with |$D_n4000$| for these objects is produced by a mix of two different processes, a primary trend characterized by growth in |$\lambda _{R_\mathrm{e}}$| along with mass through gas accretion, on top of which disturbance episodes are overlaid, which reduce rotational support and trigger increased star formation. An additional finding is that star-forming galaxies with low |$\Delta \Sigma _1$| have relatively larger radii than galaxies with higher |$\Delta \Sigma _1$| at fixed stellar mass. Assuming that these relative radii rankings are preserved while galaxies are star forming then implies clear evolutionary paths in central |$D_n4000$| versus |$\Delta \Sigma _1$|⁠. The paper closes with comments on the implications that these paths have for the evolution of pseudo-bulges versus classical bulges. The utility of using |$\rm D_n4000$| – |$\Delta \Sigma _1$| to study |$\lambda _{R_\mathrm{e}}$| reinforces the notion that galaxy kinematics correlate both with structure and with stellar-population state, and indicates the importance of a multidimensional description for understanding bulge and galaxy evolution. [ABSTRACT FROM AUTHOR]

Urbanization is defining global change, and megacities are fast becoming a hallmark of the Anthropocene. Humanity's pursuit toward sustainability is reliant on the successful management of these massive urban centers and their progression into sustainable and resilient settlements. Indicators and indices are applied assessment and surveillance tools used to measure, monitor, and gauge the sustainable development and urban resilience of megacities. Unknown is how indicator-based evaluations of sustainable development and urban resilience of the world's largest 43 cities compare. In response, this review paper used the PRISMA reporting protocol, governed by 33 established and 10 emerging megacities, to compare and contrast evaluations of sustainable development and urban resilience. Results reveal that applied assessments of sustainable development of megacities appeared earlier in time and were more abundant than those of urban resilience. Geographically, China dominated other nations in affiliations to scientific research for both sustainable development and urban resilience of megacities. Among the 100 most recurrent terms, three distinct key term clusters formed for sustainable development; seven budding key term clusters formed for urban resilience suggesting breadth in contrast to sustainable development depth. The most cited assessments of sustainable development emphasize topics of energy, methodological approaches, and statistical modeling. The most cited assessments of urban resilience emphasize topics of flooding, transit networks, and disaster risk resilience. Megacities research is dominated by few countries, suggesting a need for inclusion and international partnerships. Lastly, as the world's people become increasingly urbanized, sustainable development and urban resilience of megacities will serve as a key barometer for humanity's progress toward sustainability. [ABSTRACT FROM AUTHOR]

To date, we have access to enormous inventories of stellar spectra that allow the extraction of atmospheric parameters and chemical abundances essential in stellar studies. However, characterizing such a large amount of data is complex and requires a good understanding of the studied object to ensure reliable and homogeneous results. In this study, we present a methodology to measure homogenously the basic atmospheric parameters and detailed chemical abundances of over 1600 thin disc main-sequence stars in the 100 pc solar neighbourhood, using APOGEE-2 infrared spectra. We employed the code tonalli to determine the atmospheric parameters using a prior on |$\log {g}$|⁠. The |$\log {g}$| prior in tonalli implies an understanding of the treated population and helps to find physically coherent answers. Our atmospheric parameters agree within the typical uncertainties (100 K in |$\mathrm{T_{eff}}$|⁠ , 0.15 dex in |$\log {g}$| and [M/H]) with previous estimations of ASPCAP and Gaia DR3. We use our temperatures to determine a new infrared colour–temperature sequence, in good agreement with previous works, that can be used for any main-sequence star. Additionally, we used the bacchus code to determine the abundances of Mg, Al, Si, Ca, and Fe in our sample. The five elements (Mg, Al, Si, Ca, Fe) studied have an abundance distribution centred around slightly subsolar values in agreement with previous results for the solar neighbourhood. The over 1600 main-sequence stars' atmospheric parameters and chemical abundances presented here are useful in follow-up studies of the solar neighbourhood or as a training set for data-driven methods. [ABSTRACT FROM AUTHOR]

A 48-year-old female presented to the emergency department with severe fatigue. Admission laboratory test results were hemoglobin 6.6 g/dL, platelet count 287,000/μL, and white blood cell count 25,200/μL. Lactate dehydrogenase was elevated at 898 U/L, haptoglobin was markedly decreased (< 31 mg/dL), indirect bilirubin was elevated (5.3 mg/dL), and the absolute reticulocyte count was low at 0.0050/μL. A sample was sent to the immunohematology reference laboratory. The direct antiglobulin test immunoglobulin G was negative; C3 was 1+. All cells were reactive at immediate spin phase, indirect antiglobulin testing (IAT) with polyethylene glycol, with low ionic strength saline, neat, prewarm, and in the solid phase. All cells were nonreactive at IAT-ficin. Additional testing included a cold antibody titer that was 1:4096 and thermal amplitude studies demonstrating reactivity of 2+ at 37°C. These results were consistent with a clinically significant anti-Pr and cold agglutinin disease (CAD). Although rituximab is effective in autoimmune hemolytic anemia, this may take weeks. The patient was treated with pegcetacoplan, a pegylated peptide that targets C3 inhibiting hemolysis. The patient was discharged on day 29 with a hemoglobin of 8 g/dL. This is a report of one of the first patients successfully treated with pegcetacoplan for CAD. [ABSTRACT FROM AUTHOR]

Background/Objectives: Multi-gene, multi-cancer, hereditary cancer risk screenings may be useful in cancer prevention and treatment, not only for cancer patients but also for patients' family members. If genetic cancer screening is to have the widest possible benefit, it must be extended into diverse cancer care settings that serve diverse patient communities, providing cancer patients and their relatives with individualized cancer risk evaluations. Little research, to date, has examined the impact of extending multigenic cancer screening into diverse settings. Without empirical data characterizing the support needs of cancer patients and their family members, we may not adequately satisfy the needs of all patients and risk exacerbating existing disparities in cancer care and outcomes. Methods: We examined patient perspectives on the sharing of genetic results with at-risk family members by surveying a racially diverse sample of cancer patients receiving a multi-gene, multi-cancer risk screen in a community hospital setting. Results: In a survey of 230 cancer patients, we found that intent to share results with family members was high but varied across family member types. More respondents planned to disclose results to at least one sister (82.5%) compared to at least one brother (73.1%). Over one-fourth of participants (27.4%) were either uncertain about sharing or intended to withhold their genomic screening results from at least one at-risk family member eligible for cascade testing. Participants were more likely to withhold their results from a sibling than from a child. Furthermore, intent to share across all family member types was lower if probands failed to identify at least one benefit to sharing. Conclusions: Understanding factors associated with decisions to share results with at-risk relatives in diverse patient populations can help clinicians support cascade genetic cancer screenings in diverse communities and settings. [ABSTRACT FROM AUTHOR]

In response to COVID-19, many states revised, developed, or attempted to develop plans to allocate scarce critical care resources in the event that crisis standards of care were triggered. To our knowledge, no prior analysis has assessed this plan development process, including whether plans were successfully adopted. How did states develop or revise scarce resource allocation plans during the COVID-19 pandemic, and what were the barriers and facilitators to their development and adoption at the state level? Plan authors and state leaders completed a semistructured interview February to September 2022. Interview transcripts were qualitatively analyzed for themes related to plan development and adoption according to the principles of grounded theory. Thirty-six participants from 34 states completed an interview, from states distributed across all US regions. Among participants' states with plans that existed prior to 2020 (n = 24), 17 were revised and adopted in response to COVID-19. Six states wrote a plan de novo , with the remaining states failing to develop or adopt a plan. Thirteen states continued to revise their plans in response to disability or aging bias complaints or to respond to evolving needs. Many participants expressed that urgency in the early days of the pandemic prevented an ideal development process. Facilitators of successful plan development and adoption include: coordination or support from the state department of health and existing relationships with key community partners, including aging and disability rights groups and minoritized communities. Barriers include: lack of perceived political will to adopt a plan and development during a public health emergency. To avoid repeating mistakes from the early days of the COVID-19 response, states should develop or revise plans with community engagement and consider maintaining a standing committee with diverse membership and content expertise to periodically review plans and advise state officials on pandemic preparedness. [ABSTRACT FROM AUTHOR]

Unlike prior studies that have examined the research productivity to develop various rank-order metrics of particular scholars or institutions, we seek to determine ways in which criminology and criminal justice faculty at the top 21 doctoral programs publish their research. To account for a potential diversity in faculty publication productivity, our study considers various outlets for faculty publications—journal articles, books, and book chapters—and develops composite profiles of publication productivity. Our intention is not to rank faculty and determine academic stars, but to distinguish groups of faculty similar in their patterns of faculty productivity. We analyze the publications of over 90% of all tenured and tenure-track faculty employed by the top 21 U.S. doctoral programs in criminology and criminal justice. Our latent profile analysis yielded five distinct profiles of productivity among the faculty in the top doctoral programs. Our study reaffirms the need for the use of multidimensional measures of publication productivity. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Agricultural Economics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

(Hetero)biaryls are fundamental building blocks in the pharmaceutical industry and rapid access to these scaffolds is imperative for the success of numerous medicinal chemistry campaigns. Herein, a highly general, mild, and chemoselective reductive cross‐electrophile coupling between (hetero)aryl iodides and heteroaryl bromides is reported. By employing more reactive (hetero)aryl halides, a broad range of successful substrates (45 examples) were identified. The reaction was also found to be chemoselective for C(sp2)‐C(sp2) bond formation between (hetero)aryl iodides and bromides over (hetero)aryl chlorides, which were generally inert under the described reaction conditions. The efficiency of the procedure is also further demonstrated in parallel synthesis library format, on gram scale, as well as in the formal synthesis of Ruxolitinib, a potent JAK inhibitor. As such, we anticipate this method will find widespread utility in the assembly of (hetero)biaryls for medicinal chemistry efforts. [ABSTRACT FROM AUTHOR]

Higher breast cancer mortality rates continue to disproportionally affect black women (BW) compared to white women (WW). This disparity is largely due to differences in tumor aggressiveness that can be related to distinct ancestry-associated breast tumor microenvironments (TMEs). Yet, characterization of the normal microenvironment (NME) in breast tissue and how they associate with breast cancer risk factors remains unknown. N-glycans, a glucose metabolism-linked post-translational modification, has not been characterized in normal breast tissue. We hypothesized that normal female breast tissue with distinct Breast Imaging and Reporting Data Systems (BI-RADS) categories have unique microenvironments based on N-glycan signatures that varies with genetic ancestries. Profiles of N-glycans were characterized in normal breast tissue from BW (n  = 20) and WW (n  = 20) at risk for breast cancer using matrix assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI). A total of 176 N-glycans (32 core-fucosylated and 144 noncore-fucosylated) were identified in the NME. We found that certain core-fucosylated, outer-arm fucosylated and high-mannose N-glycan structures had specific intensity patterns and histological distributions in the breast NME dependent on BI-RADS densities and ancestry. Normal breast tissue from BW, and not WW, with heterogeneously dense breast densities followed high-mannose patterns as seen in invasive ductal and lobular carcinomas. Lastly, lifestyles factors (e.g. age, menopausal status, Gail score, BMI, BI-RADS) differentially associated with fucosylated and high-mannose N-glycans based on ancestry. This study aims to decipher the molecular signatures in the breast NME from distinct ancestries towards improving the overall disparities in breast cancer burden. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the sulfur hexafluoride (SF6) tracer technique for estimating methane (CH4) emissions in dual-flow continuous culture systems (DFCCS). In experiment 1 (Exp1), fermenters were filled with water, and known CH4 concentrations (0, 1.35, 2.93, or 4.43 g/d) were injected using permeation tubes with SF6 release rates (3.30 or 9.65 mg/d). Headspace gas was collected using canisters, and the SF6 technique estimated CH4 recovery. Experiment 2 (Exp2) involved a DFCCS fermentation trial with ruminal fluid from three Holstein cows, testing diets with soybean meal or its partial replacement (50%) by Chlorella or Spirulina. Headspace gas was collected at intervals post-feeding. Standard curves for SF6 and CH4 quantification were inadequate for DFCCS samples, with the CH4:SF6 ratio differing from standards, indicating the data needs further SF6 release rate evaluation. In Exp1, a high correlation (r = 0.97) was found between infused and calculated CH4, indicating good repeatability. Low and high SF6 rates performed similarly at low CH4 infusion, but high SF6 overestimated CH4 at high infusion. Exp2 showed CH4 emissions irrespective of SF6 rate and indicated reduced CH4 emissions and increased NDF degradation with algae-containing diets. Further evaluation of the SF6 tracer technique is warranted for DFCCS. [ABSTRACT FROM AUTHOR]

Background and Objectives: A plasma transfusion dose should be weight‐based (10–20 mL/kg), which equates to three to four units in an average‐sized adult; therefore, the transfusion of single units under most circumstances is sub‐therapeutic. Materials and Methods: This retrospective observational study examined the prevalence of single‐unit plasma transfusion in adults within a 12‐hospital system from 1 January 2018, to 31 December 2019. Results: During the study period, 5791 patients received plasma transfusions. The overall prevalence of single‐unit plasma was 17.1% for 988 patients. The majority, 3047 (52.6%), occurred at one hospital, 2132 (36.9%) among five hospitals and 612 (10.7%) at the remaining six hospitals. Cardiac and gastrointestinal (GI)/transplant transfused 2707 (46.8%), combined respiratory, neurological, orthopaedic and congenital/dermatology/other comprised 2133 (36.9%) of the six hospitals that transfused less than 200 patients, four (66.7%) transfused single units above the overall prevalence. Conclusion: In this hospital system, more than one in six patients received a transfusion of a single plasma unit. Six of the 12 hospitals had 89.5% of the patients who were transfused plasma. Six service lines transfused 83.7% of all patients receiving plasma. Hospitals that infrequently transfused plasma were more likely to under‐dose. [ABSTRACT FROM AUTHOR]

Rett syndrome is a severe neurodevelopmental disorder in girls, underpinned by mutations in the X-linked gene MECP2. In their recent work (Frasca et al, 2024), Frasca and colleagues identified a novel pathway involving interferon-gamma (IFNγ) that could pave the way to potential therapies. R. Meehan and S. Pennings discuss the recent work from Frasca et al, in this issue of EMBO Mol Med, that shows that neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. [ABSTRACT FROM AUTHOR]

Skipping has been proposed as a viable cross-training exercise to running due to its lower knee contact forces and higher whole-body energy expenditure. However, how individual muscle forces, energy expenditure, and joint loading are affected by differences in running and skipping mechanics remains unclear. The purpose of this study was to compare individual muscle forces, energy expenditure, and lower extremity joint contact forces between running and skipping using musculoskeletal modeling and simulations of young adults (n = 5) performing running and skipping at 2.5 m·s−1 on an instrumented treadmill. In agreement with previous work, running had greater knee and patella contact forces than skipping which was accompanied by greater knee extensor energetic demand. Conversely, skipping had greater ankle contact forces and required greater energetic demand from the uniarticular ankle plantarflexors. There were no differences in hip contact forces between gaits. These findings further support skipping as a viable alternative to running if the primary goal is to reduce joint loading at the commonly injured patellofemoral joint. However, for those with ankle injuries, skipping may not be a viable alternative due to the increased ankle loads. These findings may help clinicians prescribe activities most appropriate for a patient's individual training or rehabilitation goals. [ABSTRACT FROM AUTHOR]

Copyright of Journal of the Botanical Research Institute of Texas is the property of Journal of the Botanical Research Institute of Texas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Rapid and cost‐effective techniques for soil analysis are essential to guide sustainable land management and production agriculture. This study aimed at evaluating the performance and consistency of portable handheld Fourier‐transform near‐infrared spectrometers and the NeoSpectra scanners in estimating 12 common soil physical and chemical properties including pH; organic carbon (OC); inorganic carbon (IC); total nitrogen (TN); cation exchange capacity (CEC); clay, silt, and sand fractions; and exchangeable potassium (K), phosphorus (P), calcium (Ca), and magnesium (Mg). A diverse set of samples (n = 600) were retrieved from a national‐scale soil archive of the Kellogg Soil Survey Laboratory of USDA‐NRCS and scanned with five NeoSpectra scanners. Predictive models for the soil properties were developed using partial least squares regression (PLSR), Cubist, and memory‐based learning (MBL). Cubist outperformed PLSR and MBL, with the best prediction performance for clay, OC, and CEC (R2 > 0.7), followed by IC, sand, silt, and Mg (R2 > 0.6), and then pH, TN, and Ca (R2 > 0.5). K and P were predicted somewhat poorly with R2 of 0.48 and 0.22. All five NeoSpectra yielded comparable near‐infrared (NIR) spectral data and the PLSR models for the soil properties (in terms of model regression coefficients). However, the consistency assessment showed that the model performance was significantly decreased when the training and testing spectra were from different NeoSpectra scanners. It is concluded that NeoSpectra scanners could be rapid and cost effective for estimating certain soil properties, and calibration transfer should be considered for applications where multiple devices are involved and high estimation accuracy from NIR data is required. Core Ideas: Soil samples (n = 600) were retrieved from Kellogg Soil Survey Laboratory and analyzed with 5 NeoSpectra scanners.Partial least squares regression (PLSR), Cubist, and memory‐based learning (MBL) were employed to estimate 12 soil properties from NIR data.Cubist outperformed PLSR and MBL, with 10 of 12 properties having R2 > 0.5.The five NeoSpectra scanners yielded comparable NIR spectral data and PLSR models.Cross‐device assessment suggested that calibration transfer is needed to maintain higher accuracy of NIR models. [ABSTRACT FROM AUTHOR]

With increasing interest in the role of emotions in politics across the discipline, we review theoretical and methodological approaches utilized by political psychologists. Although theorists have been highlighting the role of emotions in politics for thousands of years, modern political psychologists primarily employ Marcus, Neuman, and MacKuen's (2000) affective intelligence theory to grapple with the consequences of emotions for political attitudes and behavior. We present results from a formal meta‐analytic assessment exploring the strength of the empirical evidence for the relationship between emotions and political information search and decision strategies. Overall, we find weak but statistically reliable evidence linking anger, anxiety, and enthusiasm to information search when search is self‐reported, but when information search is objectively measured, we find no link between it and anxiety or enthusiasm. Surprisingly, we also find little reliable evidence linking emotions to differential reliance on heuristics or more evidence‐based criteria in voter decision‐making. [ABSTRACT FROM AUTHOR]

Purpose: Morning glory disc anomaly (MGDA) is a rare congenital ophthalmologic disorder. Historically it has been diagnosed fundoscopically, with little in the literature regarding its imaging findings. The purpose of this study is to further characterize the orbital and associated intracranial magnetic resonance imaging (MRI) findings of MGDA in our tertiary pediatric center. Methods: A retrospective review was performed of fundoscopically-diagnosed cases of MGDA, that had been referred for MRI. All MRI studies were scrutinized for orbital and other intracranial abnormalities known to occur in association with MGDA. Results: 18 of 19 cases of MGDA showed three characteristic MRI findings: funnel-shaped morphology of the posterior optic disc, abnormal soft tissue associated with the retrobulbar optic nerve, and effacement of adjacent subarachnoid spaces. The ipsilateral (intraorbital) optic nerve was larger in one patient and smaller in six. The ipsilateral optic chiasm was larger in two patients and smaller in one. Conclusion: This study represents a comprehensive radiological-led investigation into MGDA. It describes the most frequently-encountered MRI findings in MGDA and emphasizes the importance of MRI in this cohort, i.e., in distinguishing MGDA from other posterior globe abnormalities, in assessing the visual pathway, and in screening for associated intracranial abnormalities – skull base/cerebral, vascular, and facial. It hypothesizes neurocristopathy as an underlying cause of MGDA and its associations. Caliber abnormalities of the ipsilateral optic nerve and chiasm are a frequent finding in MGDA. Optic pathway enlargement should not be labeled "glioma". (239/250). [ABSTRACT FROM AUTHOR]