1. N-Pyrrylarylsulfones with High Therapeutic Potential.
- Author
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Valeria Famiglini, Sabrina Castellano, and Romano Silvestri
- Subjects
SULFONAMIDES ,STRUCTURE-activity relationship in pharmacology ,HETEROCYCLIC compounds ,POLYCYCLIC compounds ,DRUG design - Abstract
This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure-activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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