Search

This paper examines the economic impact potential of a major innovative effort by the US Government to systematically coordinate, implement, and manage a technical infrastructure to support innovation and subsequent market penetration of advanced material technologies. Called the Materials Genome Initiative (MGI), this high-tech infrastructure consists of a range of policy instruments that can be used to leverage the efficiency of both research and development and production. To determine and rank the potential economic impacts of various MGI infrastructure targets and thereby provide policy input for portfolio management, surveys were conducted to obtain industry estimates of materials infrastructure needs. From these surveys, the economic benefits of implementing the MGI were calculated. The analysis projects potential economic benefits from an improved materials innovation infrastructure of between $123 billion and $270 billion per year. [ABSTRACT FROM AUTHOR]

A basic mission of NASA is to use the United States' segment of the International Space Station (ISS), designated a national laboratory, to facilitate the growth of a commercial marketplace in low Earth orbit for scientific research, technology development, observation and communications. Protein crystallization research has long been promoted as a promising commercial application of the ISS for drug development. In this paper we examine the case for microgravity protein crystallization under different private and public investment scenarios. The analysis suggests that sustaining investment is unlikely to come from individual companies alone. Public and private investment must be combined and managed to overcome a number of challenges including the need to integrate microgravity crystallization into the complex system of technologies involved in structure-based drug design. Multiple risks related to transportation costs/frequency, risk for cargo and research crew, and uncertainty about the longevity of the ISS complicate the calculus. [ABSTRACT FROM AUTHOR]

This paper shows that the probability of small business firms obtaining outside financing to support their research and development projects is greater given more complex commercial opportunities – defined as a greater number of different potential applications for a project’s anticipated results – for their innovations. The effects on the probability of outside finance found for other factors are consistent with the earlier findings in the literature about innovative entrepreneurial firms. [ABSTRACT FROM AUTHOR]

When a principal's monitoring information is private (nonverifiable), the agent should be concerned that the principal could misrepresent the information to reduce the agent's wage or collect a monetary penalty. Restoring credibility may lead to an extreme waste of resources-the so-called burning of money. A more realistic and efficient outcome is feasible when the private information arrives in time to rescale the agent's effort. Rescaling is more effective than pure monetary penalties because effort has different values to different parties whereas money is equally valuable to all parties. Furthermore, when rescaling is feasible, private monitoring is more efficient than public monitoring subject to collusion because nonmonetary penalties are ineffective to deter collusion. [ABSTRACT FROM AUTHOR]

This paper examines how strategic alliances to create and use standards affect economic growth and development. The explanation of the link from standards to economic growth and development is through the effects of standards on the incentives to perform industrial research and development (R&D). We examine product standards, metrology traceable to national and international standards, and regulatory standards to address negative externalities. The paper develops a theoretical explanation for the link from standards to growth, survey/interview-guides to gather information from industrial R&D experts about the explanation, and case-study evidence about the explanation. We discuss the standard-setting process and explain that it entails strategic alliances among firms and with government involvement. Case studies of R&D projects in firms and in a national laboratory support the belief that standards implemented via strategic alliances leverage economic growth and development. [ABSTRACT FROM PUBLISHER]

The development of disease-modifying treatments for Alzheimer's disease (AD) faces a number of barriers. Among these are the lack of surrogate biomarkers, the exceptional size and duration of clinical trials, difficulties in identifying appropriate populations for clinical trials, and the limitations of monotherapies in addressing such a complex multifactorial disease. This study sets out to first estimate the consequent impact on the expected cost of developing disease-modifying treatments for AD and then to estimate the potential benefits of bringing together industry, academic, and government stakeholders to co-invest in, for example, developing better biomarkers and cognitive assessment tools, building out advanced registries and clinical trial-readiness cohorts, and establishing clinical trial platforms to investigate combinations of candidate drugs and biomarkers from the portfolios ofmultiple companies. Estimates based on interviews with experts on AD research and development suggest that the cost of one new drug is now $5.7 billion (95% confidence interval (CI) $3.7-9.5 billion) and could be reduced to $2.0 billion (95% CI $1.5-2.9 billion). The associated acceleration in the arrival of disease-modifying treatments could reduce the number of case years of dementia by 7.0 million (95% CI 4.4-9.4 million) in the United States from 2025 through 2040. [ABSTRACT FROM AUTHOR]

The development of disease-modifying treatments for Alzheimer's disease (AD) faces a number of barriers. Among these are the lack of surrogate biomarkers, the exceptional size and duration of clinical trials, difficulties in identifying appropriate populations for clinical trials, and the limitations of monotherapies in addressing such a complex multifactorial disease. This study sets out to first estimate the consequent impact on the expected cost of developing disease-modifying treatments for AD and then to estimate the potential benefits of bringing together industry, academic, and government stakeholders to co-invest in, for example, developing better biomarkers and cognitive assessment tools, building out advanced registries and clinical trial-readiness cohorts, and establishing clinical trial platforms to investigate combinations of candidate drugs and biomarkers from the portfolios of multiple companies. Estimates based on interviews with experts on AD research and development suggest that the cost of one new drug is now $5.7 billion (95% confidence interval (CI) $3.7-9.5 billion) and could be reduced to $2.0 billion (95% CI $1.5-2.9 billion). The associated acceleration in the arrival of disease-modifying treatments could reduce the number of case years of dementia by 7.0 million (95% CI 4.4-9.4 million) in the United States from 2025 through 2040. [ABSTRACT FROM AUTHOR]

Studies evaluating the relationship between microbes and human health at non-point source beaches are necessary for establishing criteria which would protect public health while minimizing economic burdens. The objective of this study was to evaluate water quality and daily cumulative health effects (gastrointestinal, skin, and respiratory illnesses) for bathers at a non-point source subtropical marine recreational beach in order to better understand the inter-relationships between these factors and hence improve monitoring and pollution prevention techniques. Daily composite samples were collected, during the Oceans and Human Health Beach Exposure Assessment and Characterization Health Epidemiologic Study conducted in Miami (Florida, USA)at a non-point source beach, and analyzed for several pathogens, microbial source tracking markers, indicator microbes, and environmental parameters. Analysis demonstrated that rainfall and tide were more influential, when compared to other environmental factors and source tracking markers, in determining the presence of both indicator microbes and pathogens. Antecedent rainfall and F+ coliphage detection in water should be further assessed to confirm their possible association with skin and gastrointestinal (GI) illness outcomes, respectively. The results of this research illustrate the potential complexity of beach systems characterized by non-point sources, and how more novel and comprehensive approaches are needed to assess beach water quality for the purpose of protecting bather health. [ABSTRACT FROM AUTHOR]

The efficacy levels of different physical and chemical washing treatments in the reduction of viral and bacterial pathogens from inoculated strawberries were evaluated. Escherichia coli O157:H7, Salmonella Montevideo, poliovims 1, and the bacteriophages PRD1, φX174, and MS2 were used as model and surrogate organisms. Chemicals readily available to producers and/or consumers were evaluated as antimicrobial additives for the production of washes. The gentle agitation of contaminated strawberries in water for 2 min led to reductions in microbial populations ranging from 41 to 79% and from 62 to 90% at water temperatures of 22 and 43°C, respectively. Significant reductions (>98%) in numbers of bacteria and viruses were obtained with sodium hypochlorite (50 to 300 ppm of free chlorine), Oxine or Carnebon (200 ppm of product generating "stabilized chlorine dioxide"), Tsunami (100 ppm of peroxyacetic acid), and Alcide (100 or 200 ppm of acidified sodium chlorite) washes. Overall, 200 ppm of acidified sodium chlorite produced the greatest reductions of microorganisms. Hydrogen peroxide (0.5%) was slightly less effective than free chlorine in a strawberry wash and caused slight fruit discoloration. Cetylpyridinium chloride (0.1%) was effective in the reduction of bacterial species, while trisodium phosphate (1%) was effective against viruses. The consumer-oriented produce wash Fit was very effective (>99%) in reducing the numbers of bacteria but not in reducing the numbers of viruses. Another wash, Healthy Harvest, was significantly less effective than Fit in reducing bacterial pathogens but more effective for viruses. The performance of automatic dishwashing detergent was similar to that of Healthy Harvest and significantly better than that of liquid dishwashing detergent. Solutions containing table salt (2% NaCl) or vinegar (10%) reduced the numbers of bacteria by about 90%, whereas only the vinegar wash reduced the numbers of viruses significantly (ca. 95%). [ABSTRACT FROM AUTHOR]

Current virus-recovery procedures using negatively charged microporous filters provide an inexpensive, reliable method for the recovery and detection of enteroviruses from water and wastewater; however, adjustment of the test samples to pH 3.5 to promote enterovirus adsorption results in significant inactivation of bacteriophage and an inability to simultaneously recover them from large volumes of water using this procedure. Procedures specifically designed for the detection of bacteriophage are currently in use but generally are only effective for small volumes of water. Positively charged filters can be used to recover both enteroviruses and bacteriophage from large volumes of water at neutral pH; however, the filters are expensive. The addition of manganese chloride to test solutions at pH 3.5 prior to filtration through negatively charged Filterite[sup ®] filters allowed for sampling of larger volumes of water by reducing the inactivation of bacteriophage and increasing the recovery of PRD1, MS2, and naturally isolated bacteriophage by a factor of four or five when compared with recoveries from solutions without MnCl[sub 2] . This method provides an inexpensive, reliable alternative to large-volume bacteriophage recovery procedures that use positively charged filters at neutral pH.Key words: bacteriophage, water, recovery, microporous filters.Les méthodes courantes d'isolement des virus utilisant des filtres microporeux à charge négative demeurent une façon peu coûteuse et fiable pour détecter et isoler les entérovirus dans l'eau et dans les eaux usées. Par contre, pour augmenter l'adsorption des entérovirus, il faut ajuster à 3,5 le pH de l'échantillon à tester, ce qui entraîne une inactivation significative des bactériophages et il devient impossible d'isoler simultanément ces deux groupes de virus dans des gros volumes d'eau en utilisant cette méthode. Il existe actuellement des méthodes spécifiquement adaptées pour la détection des bactériophages mais règle générale, elles sont efficaces seulement avec des faibles volumes d'eau. Il est possible d'utiliser des filtres chargés positivement pour isoler simultanément les entérovirus et les bactériophages à partir de gros volumes d'eau à pH neutre mais, par contre, les filtres sont dispendieux. L'addition de chlorure de manganèse dans les échantillons ajustés à pH 3,5 avant la filtration avec des filtres Filterite[sup ®] chargés négativement a permis de traiter adéquatement des plus gros volumes d'eau en diminuant l'inactivation des bactériophages et en augmentant l'isolement de PRD1, MS2 et des bactériophages isolés naturellement par un facteur de 4 à 5 comparativement à la récupération de ces virus dans les échantillons ne contenant pas de MnCl[sub 2] . Cette méthode représente une alternative peu coûteuse et fiable comparativement aux méthodes suggérées utilisant des filtres à charge positive à pH neutre pour isoler des phages dans des gros volumes d'eau.Mots clés : bactériophage, l'eau, récupération, filtres microporeux.[Traduit par la Rédaction] [ABSTRACT FROM AUTHOR]