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Background: Recent Latino immigrants (RLIs) to the U.S. have shown high smoking rates during their first year since arrival, raising concern about future escalation of tobacco use.Objective: To examine trajectories of cigarette and Electronic nicotine delivery systems (ENDS) use among RLIs from pre-immigration (T0) through their first (T1) and second (T2) year in the U.S.Methods: Data originated from a longitudinal study of 540 (50% females) RLIs aged 18-34. Inclusion criteria was residing in Miami/Dade County (MDC), and having immigrated from a Latin American country within the past year. Trajectories were identified by using the Proc Traj procedure (SAS©, v 9.4).Results: Rates of cigarette use per month declined from 11.8 days/month in T0 to 4.9 d/m in T2. Rates for ENDS use however, increased from T0 (1.1 d/m) to T1 (1.8 d/m) and then lowered back to 0.9 d/m in T2. Four separate cigarette and e-cigarette use trajectories were identified. Only one of them showed increase in cigarette (10.6% of RLIs), and ENDS use (4.5% of RLIs). Being male, and not completing high school were significant factors in explaining smoking trajectories. Being younger than 30 years old was largely associated with ENDS use. No evidence of a substitution effect between cigarette and ENDS use was found.Discussion/Conclusions: Interventions to discourage tobacco use among Latino immigrants should begin early in the immigration process, aimed to preserve initial reductions and dissuade those at risk of increased tobacco use overtime. [ABSTRACT FROM AUTHOR]

Biorefineries are novel biotechnological routes designed to generate sustainable processes from renewable raw materials. The valorization of orange peel waste (OPW) provides high-value products based on their composition. The economic optimization of biorefineries through conceptual design and generation of superstructures based on the analysis of processing units is a topic of great interest. This work aimed to obtain the most profitable biorefinery through economic optimization strategies based on high-value-added products from OPW. Two stages were considered: The first stage consisted of the conceptual design of multiple OPW processing units (production of essential oil, mucic acid, phenolic compounds, biogas, among others). An OPW flow rate of 140 kg/h was selected as the base case. From the stand-alone units, a biorefinery superstructure (second stage) was designed. Finally, the units with the best mass and energy results were selected in order to maximize the net present value (NPV) and obtain an optimal biorefinery configuration. The results evidenced that the production of essential oil and biogas presented the best yields (2.61 mL and 0.028 m3 per kg OPW, respectively). This biorefinery configuration obtained an NPV of −7.7 mUSD from the base case. Through the evaluation of the different superstructure configurations, the combined production of essential oil, biogas, and mucic acid and a scale-up of over 22 times the base case generated the minimum processing scale. Under a Colombian context, the implementation of the biorefineries analyzed are promising since the minimum processing scale contemplated only 8.8% of the OPW production. Efforts to increase yields and decrease capital and operating expenses while keeping environmental impacts low should be pursued. [ABSTRACT FROM AUTHOR]

In today's changing environment, faculty are searching for ways to improve student learning outcomes in both face-to-face and virtual environments. Transparency in learning and teaching requires a course design that focuses not only on the how but also on the why. When combined with the concepts of backward course design, transparency in learning and teaching provides students with a solid framework for success. Often, students are searching for real-world connections to help them understand the value of their course activities. The authors of this current study will discuss how the “principles of backward design and transparency in learning and teaching” have been used in the introductory business course to enhance student learning and satisfaction. The authors of this study will also focus on applying these theories to the assignment delivery of group projects in a fully online Principles of Management course. [ABSTRACT FROM AUTHOR]

Satisfaction with an intervention influences the uptake of behavior changes and the long-term efficacy of the intervention. Therefore, it is crucial to assess satisfaction by participant profile when creating and adapting behavior interventions for minoritized populations. Qualitative and quantitative data on participant trauma symptom severity and intervention satisfaction were collected through self-report surveys from 54 women. The sample was 59.3% Hispanic, with an average age of 33.21 (SD = 10.42), who were in residential treatment for substance use disorders (SUDs) and participated in a 12-session mindfulnessbased intervention. Qualitative responses were coded using thematic analysis, and an integrative mixed-methods approach was used to compare qualitative theme frequency between high-trauma (N = 28) and low-trauma (N = 26) groups at session 2 and session 11. High- and low-trauma groups were determined by interquartile ranges (bottom 25% = low; top 75% = high). In session 2, the lowtrauma group reported significantly higher satisfaction (M = 4.20, SD = 0.55) than the high-trauma group (M = 3.77, SD = 0.89); t(43) = 1.90, p = 0.03. In session 11, there was no significant difference between groups. The mixed-methods analysis revealed that "trouble focusing" appeared more frequently in the hightrauma group than in the low-trauma group during session 2, but the theme was not present in either group at session 11, suggesting that this might pose an initial barrier for individuals with high trauma but subsides as the intervention progresses. This speaks to the importance of retention strategies tailored for participants with SUDs and high trauma while they adjust to the intervention. Assessing initial challenges with satisfaction may help facilitators intervene to increase participant satisfaction. [ABSTRACT FROM AUTHOR]

Few valorization pathways have been implemented as alternatives to reduce the orange peel waste (OPW) disposal in landfills. OPW can be a source of income or economic savings in juice production factories since this waste is a potential source of value-added products (e.g., bioactive compounds) and energy vectors (e.g., biogas). Valorization alternatives should be based on (i) orange peel chemical composition, (ii) market analysis, and (iii) availability. Nevertheless, few literature papers have highlighted the chemical composition change caused by the different juice production schemes as a potential opportunity to obtain different value-added products and biorefinery schemes. Thus, the aims of this review paper are related to (i) reviewing different orange fruit processing pathways, (ii) analyzing several OPW chemical compositions reported in the open literature, (iii) providing a summary of OPW extraction pathways for bioactive compounds production, and (iv) evaluating the effect of applying different extraction methods on bioactive compound extraction performance. This review includes a description of the OPW matrix, market insights, packaging, physicochemical characterization, processing technologies, and suggested biorefinery approaches. Finally, different extraction methods for obtaining bioactive compounds from OPW are compared. As a result, the supercritical fluid extraction process has the highest extraction performance and selectivity since this method extracted a high amount of hesperidin (8.18 g/kg OPW db.). In conclusion, OPW is a source of bioactive compounds and valuable products that can be introduced in juice-producing factories to increase product portfolio or economic savings by changing the energy matrix. [ABSTRACT FROM AUTHOR]

Tropical forests provide a development opportunity for communities that subsist on small crop value chains. Annatto and açai are exotic fruits used as a source of natural dyes and high-calorie beverages, respectively. However, the processing of these fruits generates considerable residues that have a negative environmental impact and can be used for biofuel production. This work elucidates valorization schemes of annatto and açai in integrated raw material systems to improve the value chains of tropical forest fruits. The economic and environmental pre-feasibility for producing annatto dye, açai powder, and biogas was evaluated through experimental and simulation data. As the main results, it was obtained that the extraction of dye by abrasion shows to be a methodology with high carotenoid content. Additionally, freeze-drying improves the antioxidant activity and the content of polyphenols and anthocyanins on açai pulps. The processing residues of both fruits were used as the substrate for anaerobic digestion purposes and as a low-cost valorization alternative, showing the best biogas yields for the exhausted annatto seed. The experimental results were fed to the simulation of small-scale processing schemes based on exotic fruits. The main results demonstrated that working in batch six-monthly schemes allows for obtaining economic feasibility based on fruit production lower than the national scale. Although freeze-drying is an expensive process, the production of açai fruit powder is the most cost-effective scenario. From an environmental perspective, the disposal of digestate as waste drastically affects the environmental analysis. However, for the five environmental indices analyzed, producing açai powder, biogas, and digestate valorization as fertilizer is the scenario with the lowest environmental impact. Finally, the results were analyzed regarding the impact on the Sustainable Development Goals (SDGs) of the region. This work demonstrated that small-scale schemes based on the processing of tropical forest fruits improve the regional agribusiness performance by strengthening the value chain considering economic, environmental, and social issues. [ABSTRACT FROM AUTHOR]

BACKGROUND: Polymerization conditions affect the physical-mechanical properties of acrylic resins used for craniofacial prostheses. OBJECTIVE: The aim of this study was to evaluate the effect of microwave polymerization on the thermomechanical properties and surface morphology of ocular prostheses fabricated with polymethyl methacrylate (PMMA). METHODS: PMMA discs were polymerized with microwave energy and with conventional heat polymerization (CHP) method. Ocular prostheses were fabricated to determine whether there were changes according to the polymerization method. The surface morphology and roughness were observed under SEM and AFM. The Vickers Hardness number (VHN) and flexural strength were measured. Thermal properties were evaluated with TGA/DSC, and chemical composition with FTIR. RESULTS: The PMMA acrylic resin polymerized with microwave energy showed a smooth surface with some relief areas. In the internal surface of the ocular prosthesis with microwave energy the PMMA is more compact. The mean roughness values were higher and statistically significant with CHP (P < 0.05), while the surface hardness and flexural strength were higher with microwave energy (P < 0.05). CONCLUSION: There were no changes in the calorimetry with either method, TGA showed an exothermic peak around 120 °C with CHP method. PMMA polymerized with microwave energy improved the mechanical and surface properties of the ocular prostheses. [ABSTRACT FROM AUTHOR]

Their initial years in the U.S. can be stressful for recent Latino/a immigrants (RLIs). This study examines the association between perceived stress and depressive symptoms and the moderating effect of emotion regulation and dispositional mindfulness. Cross-sectional data from an ongoing longitudinal study of RLIs was used. Hierarchical multiple regression analyses were performed to examine simple main effects of the predictor variables on depressive symptoms. The study also tested the moderating effects of emotion regulation and dispositional mindfulness on the association between perceived stress and depressive symptoms. Greater perceived stress and cognitive reappraisal were associated with greater depressive symptoms. Lower levels of appraisal and higher levels of non-reactivity mindfulness strengthened the association between perceived stress and depressive symptoms. Findings can inform the development of culturally tailored interventions that account for distinct aspects of emotion regulation and dispositional mindfulness associated with managing stress and decreasing depressive symptoms among RLIs. [ABSTRACT FROM AUTHOR]

The sustainability of food value chains is affected by the large amounts of waste produced with a high environmental impact. Food waste valorization applying the biorefinery concept has emerged as an alternative to reduce the generation of greenhouse gases and to promote the socio-economic development of value chains at local, regional, and national levels. This paper analyzes the sustainability of food waste biorefineries designed for boosting rural economic development in Colombia. These biorefineries were designed following a strategy based on a portfolio of bioprocesses involving fractions based on the composition of the raw materials. The valorization of six food residues produced in three representative rural areas of Colombia (i.e., Chocó, Caldas, and Sucre) was analyzed. Acai, annatto, sugarcane bagasse, rejected plantain and avocado, and organic kitchen food waste (OKFW) were selected as food wastes for upgrading. The biorefinery design strategy comprised five steps for filtering the most promising bioprocesses to be implemented. The OKFW was analyzed in detail, applying the design strategy to provide a step-by-step guide involving a portfolio of bioproducts, the technological maturity index, and the socio-economic context. This strategy implementation for OKFW valorization resulted in a scenario where biorefineries with levulinic acid production were the most feasible and sustainable, with high techno-economic performances and low environmental impacts. For the valorization of the other food residues, the processes with the greatest feasibility of being implemented in rural areas were bioactive compounds, oil, flour, and biogas production. [ABSTRACT FROM AUTHOR]

Objective: This study examined associations of family cohesion and acculturation gap conflicts with depressive symptoms, as well as the moderation effect of family cohesion on the association between acculturation gap conflicts and depressive symptoms among Latinx emerging adults. Background: In addition to normative developmental stressors (e.g., making long‐term career decisions), many Latinx emerging adults face additional sociocultural stressors (acculturative stress, ethnic discrimination) that put them at risk of experiencing adverse psychological outcomes. However, acculturation gap conflicts have not been examined much in this population. Method: Data from a cross‐sectional survey were collected from 200 participants from Arizona (n = 99) and Florida (n = 101). Hierarchical multiple regression and moderation analyses were conducted to examine the association between acculturation gap conflicts and depressive symptoms and the moderating effects of family cohesion of that respective association. Results: Higher family cohesion was associated with lower depressive symptoms. Conversely, higher acculturation gap conflicts were associated with higher depressive symptoms. Moderation analyses indicated that family cohesion moderated the association between acculturation gap conflicts and depressive symptoms. Conclusion: This study adds to the limited literature on acculturation gap conflicts among Latinx emerging adults and advances our understanding of the role of family cohesion as a modifiable moderator. Implications: It is critical to identify culturally relevant and modifiable determinants that can have beneficial or adverse associations with the mental health of Latinx emerging adults. Findings from this study have the potential to inform intervention for mental health targeting Latinx emerging adults. [ABSTRACT FROM AUTHOR]

Previous studies have found Latinx cultural values to be positively associated with healthy behaviors. This study aims to examine socioeconomic and cultural correlates of alcohol use among Latinx adult men living in Miami-Dade County, Florida. The study sample included 122 Latinx adult men (mean age = 44, SD = 10), predominantly of South and Central American origin. Data was collected using REDCap. Interviews included the Timeline Follow-Back scale for alcohol use. Results indicate that Caribbean participants were significantly less likely to report drinking in the past 90 days (aOR = 0.08, p = 0.042) compared to their Venezuelan counterparts. Higher machismo scores were associated with low drinking frequency (aRR = 0.67, p = 0.043), while no significant associations were found between machismo and other drinking outcomes. Drinking quantity and frequency are significantly associated with higher income and authorized immigration status in the US among Latinx men in South Florida. Higher machismo scores were associated with low drinking frequency. [ABSTRACT FROM AUTHOR]

Biorefineries have been profiled as potential alternatives to increase biomass use at the industrial level. However, more efforts are required to improve the sustainability of these facilities through process improvement and product portfolio increase. The catalytic conversion of biomass to chemicals and energy vectors is one of the most studied research lines today. The open literature has described catalytic pathways for producing biofuels and platform molecules using this renewable resource. Nevertheless, few literature reviews have aimed to analyze the role of the catalytic conversion of biomass in biorefineries while considering the following items: (i) biocatalysis, (ii) carbon dioxide conversion, (iii) design based on catalytic biomass upgrading, and (iv) sustainability metrics. This paper reviews several processes where catalysis has been applied to improve yields and conversion to elucidate the potential of this research field to boost biomass implementation in different productive sectors. This paper provides an overview of the catalytic conversion of biomass into a series of biofuels and high-value-added products, involving key topics related to catalyst performance, use, applications, and recent trends. In addition, several research gaps and ideas are highlighted based on previous studies. In conclusion, the catalytic conversion of biomass has the potential to increase biorefineries' sustainability. Nevertheless, more studies focused on (i) the production of new catalysts using renewable resources, (ii) the techno-economic and environmental assessment of processes involving catalysis, and (iii) the influence of involving biomass valorization via heterogeneous catalysis in existing facilities are required to obtain a real understanding of catalytic upgrades' benefits. [ABSTRACT FROM AUTHOR]

Most research on cultural stressors and alcohol has focused on intercultural stressors. Continuing to exclude intracultural stressors (e.g., intragroup marginalization) from alcohol research will yield a biased understanding of the experiences of Hispanics living in a bicultural society. As we amass more studies on intracultural stressors, research will be needed to identify mutable sociocultural factors that may mitigate the association between intracultural stressors and alcohol. To address these limitations, we examined the association between intragroup marginalization and alcohol use severity and the extent to which gender and bicultural self-efficacy may moderate this association. A convenience sample of 200 Hispanic emerging adults ages 18-25 (men = 101, women = 99) from Arizona (n = 99) and Florida (n = 101) completed a cross-sectional survey. Data were analyzed using hierarchical multiple regression and moderation analyses. Higher intragroup marginalization was associated with higher alcohol use severity. Gender functioned as a moderator whereby intragroup marginalization was associated with higher alcohol use severity among men, but not women. Also, higher social groundedness functioned as a moderator that weakened the association between intragroup marginalization and alcohol use severity. Role repertoire did not function as a moderator. Our findings are significant because they enhance the reliability of the association between intragroup marginalization and alcohol use severity, and the moderating effect of gender in this respective association. This emerging line of research suggests that alcohol interventions targeting Hispanics may have a significant limitation by not accounting for intracultural stressors. [ABSTRACT FROM AUTHOR]

Having a family history of alcohol (FH+) use is a well-documented risk factor for alcohol use and alcohol related problems. However, there are limited studies examining the impact of FH + on current alcohol use among Latino immigrants. This study aimed to determine the influence of having a FH + on current alcohol use among Latino immigrants and the influence of alcohol outcome expectancies (AOEs) and acculturation on this relationship. This is a longitudinal secondary data analysis of data from the Recent Latino Immigrant Study (RLIS), the first community-based cohort study to examine pre- to post-immigration alcohol use trajectories of young adult Latino immigrants. Linear mixed models were performed to assess the association between various pre- and post-immigration factors and alcohol use among Latino immigrants. There were 518 young adult Latino immigrants with 18.7% reporting a FH + with those with a FH + having higher mean AUDIT score compared to those without (4.74 vs. 3.81; p = 0.028). Positive AOEs were associated with increase AUDIT scores. FH + individuals with greater positive AOEs experienced higher AUDIT scores compared to FH- individuals. Family cohesion was protective against alcohol use while endorsement of Americansism was associated with increased alcohol use. Theses results provide the framework for more in-depth exploration regarding the influences of FH+, AOEs, and acculturation have on the alcohol use among Latino immigrants. Future longitudinal research studies should account for whether traditional cultural values mediate or moderate the relationship between a FH+, AOE, and alcohol use of Latino immigrants. [ABSTRACT FROM AUTHOR]

Food losses (FL) and waste (FW) occur throughout the food supply chain. These residues are disposed of on landfills producing environmental issues due to pollutants released into the air, water, and soil. Several research efforts have focused on upgrading FL and FW in a portfolio of added-value products and energy vectors. Among the most relevant research advances, biotechnological upgrading of these residues via fermentation has been demonstrated to be a potential valorization alternative. Despite the multiple investigations performed on the conversion of FL and FW, a lack of comprehensive and systematic literature reviews evaluating the potential of fermentative processes to upgrade different food residues has been identified. Therefore, this article reviews the use of FL and FW in fermentative processes considering the composition, operating conditions, platforms, fermentation product application, and restrictions. This review provides the framework of food residue fermentation based on reported applications, experimental, and theoretical data. Moreover, this review provides future research ideas based on the analyzed information. Thus, potential applications and restrictions of the FL and FW used for fermentative processes are highlighted. In the end, food residues fermentation must be considered a mandatory step toward waste minimization, a circular economy, and the development of more sustainable production and consumption patterns. [ABSTRACT FROM AUTHOR]

Background: Previous research conducted among Latino/a immigrants has shown the underlying effect that exposure to stress after immigrating to the U.S. (i.e. health access, racial/ethnic discrimination, and language barriers) has on alcohol use patterns. However, given the demographic shifts in recent immigrants, understanding the influence of stress before (i.e. poverty, healthcare, and educational opportunities) and after immigration on their alcohol use (i.e. alcohol consumption and drinking behaviors in the past 12 months) in the context of migration and traditional gender roles is warranted. Objectives: To examine the (a) cumulative effects of pre- to post-immigration stress, (b) respective moderating effects of traditional gender roles, and (c) forced migration on alcohol use for men and women. Methods: Hierarchical multiple regression and moderation analyses were conducted on a cross-sectional sample of 529 (N = 268 men, N = 261 women) adult (18–34 years) from recent Latino/a immigrants in South Florida. Results: Gender had a statistically significant difference on alcohol use, (F 527) = 18.68, p <.001, with men (p = 4.36 ± SE =.22) reporting higher alcohol use than women (p = 3.08 ± SE =.20). Post-immigration stress (β =.12, p =.03) but not pre-migration stress had a statistically significant association with alcohol use. There is no interaction effect by traditional gender roles and forced migration on the associations between pre- to post-immigration stress and alcohol use. Conclusion: Results suggest that post-immigration stress may be a reasonable intervention target to mitigate alcohol use among recent Latino/a immigrants, particularly among men. [ABSTRACT FROM AUTHOR]

This study examines the cumulative effects of negative context of reception (NCR), traditional Latino gender norms, and acculturation on depressive symptoms among adult Latino immigrant men, and if levels of acculturation and traditional Latino gender norms moderated associations between NCR and depressive symptoms in the study sample. Hierarchical Multiple Regression (HMR) and moderation analyses were conducted on a cross-sectional sample of 280 Latino men. Predictor variables were entered into the HMR model: (1) demographic variables, (2) perceived stress, (3) acculturation and gender norms, and (4) NCR. Subsequently, moderation analysis was conducted using PROCESS v3.2 model 1. 19% of the variance of depressive symptoms was explained by all predictor variables entered in the HMR model. Moderation analyses revealed significant interaction effects with machismo (exacerbating) and Hispanicism (attenuating) the association between NCR and depressive symptoms. Study findings have implications for culturally appropriate interventions that target gender norms among Latino immigrant men. [ABSTRACT FROM AUTHOR]

The objective of this study is to compare the environmental and social performance of two small-scale avocado biorefineries implanted in a rural zone in the North of Colombia. Two small-scale biorefineries were proposed. Small-B1 addressed to produce avocado oil and animal feed, and Small-B2 focused on the guacamole production. The environmental analysis was done by applying the life cycle assessment methodology. Then, agronomic information and process simulation were required to complete the analysis. Moreover, the water footprint of the avocado crops was estimated. Both biorefineries were compared with the direct avocados production and commercialization. The social assessment was achieved by the estimation of quantitative indicators related to wages, jobs, and working hours. The agricultural carbon and water footprints of the creole avocado crop were 0.59 kg CO2-eq/kg and 2.13 m3/kg. In the same way, Small-B1 and Small-B2 obtained a carbon and water footprints of 8.99 kg CO2-eq/kg and 6.63 m3/kg and 0.72 kg CO2-eq/kg and 1.38 m3/kg, respectively. The hotspots of the creole avocado crop are related to the use of fertilizers and fungicides. Then, new strategies should be implemented to reduce the farmer's dependency. The social analysis exhibit a high resilience of the Small-B1 biorefinery since a salary increase to worker about 50% can be proposed. In addition, the installation of this biorefinery can create more than ten jobs. A disjunction was found between the economic, environmental, and social analyses. Thus, the need to establish a multidimensional strategy to design sustainable biorefineries is presented. [ABSTRACT FROM AUTHOR]

Objective: Strong evidence links exposure to traumatic life events with subsequent substance use disorders (SUD). Compared to men, women in SUD treatment are more likely to have a history of trauma, characterized in part by emotion dysregulation known to negatively influence treatment outcomes. Existing research has been conducted with predominantly male and non-Hispanic White samples, with an emphasis on adverse childhood experiences. Little is known about how exposure to cumulative traumatic events across the lifespan affects emotion dysregulation and how this may influence craving, particularly among racial and ethnic minoritized women with SUD. Mindfulness disposition may serve as a protective factor that could buffer the impact of trauma exposure and emotion dysregulation on substance use craving among underrepresented minoritized women with SUD. This study examined the association between cumulative exposure to traumatic events, emotion dysregulation, and mindfulness disposition on substance use craving in a sample of predominantly Hispanic and non-Hispanic Black women in residential treatment for SUD. Method: Cross-sectional data were analyzed for a baseline sample of 241 women (56.96% Hispanic, 20.7% non-Hispanic White, 20.7% non-Hispanic Black; age: M = 32.11) entering a SUD residential treatment facility who agreed to participate in a parent randomized controlled trial. Results: Findings indicated that greater cumulative exposure to traumatic events and emotion dysregulation were associated with higher levels of craving. Cumulative traumatic event exposure was indirectly associated with higher craving via lower levels in the mindfulness dimension of acting with awareness. Interaction effects also revealed greater exposure to traumatic events was associated with higher levels of craving among women with low and average (but not high) levels of mindfulness disposition. Conclusion: These findings provide insight into the potential benefits of targeting emotion regulation and mindfulness-building strategies such as acting with awareness in interventions among racial-ethnically diverse women with SUD. These strategies may be particularly beneficial among those that have experienced extensive histories of trauma exposure. Overall, knowledge gained from the present study can be particularly valuable towards informing treatment models in minoritized groups that currently experience disparities in treatment utilization and outcomes. [ABSTRACT FROM AUTHOR]

This paper presents a detailed economic assessment of the polylactic acid (PLA) production line in an existing petrochemical facility in Colombia. The detailed economic assessment was done by applying an integrated methodology for the economic assessment to reduce the existing gap between the capital expenditures estimated from conceptual design and detailed engineering. The integrated economic assessment approach was developed involving conceptual and detailed design aspects. For this purpose, the PLA production process was evaluated using the glucose platform from sugarcane bagasse, coffee cut stems, and plantain peels as raw materials. The yield of glucose, operating and investment costs were considered from the open literature. The mass and energy balances for the process were obtained using Aspen Plus V.9.0. software. The capital cost estimation (CapEx) was made using the Aspen Capital Cost Estimator. CapEx and operational expenditures (OpEx) estimates were adjusted using industry guidelines. Finally, financial analysis methods and key ratios were used to measure the investment profitability and prefeasibility of the process at various PLA gross incomes. Regarding the methodology proposed, a comparison between the traditional economic assessment and the proposed integrated strategy showed a deviation of 256%. The results are more similar than those reported by the engineering, procurement, and construction (EPC) companies. Finally, the CapEx for the PLA process with an annual production rate of 2000 MT reached up to USD 10.35 million with a gross income of USD 1400/MT and 9.5 years payback period from containing economic prefeasibility. [ABSTRACT FROM AUTHOR]

Pre-migration trauma is associated with adverse mental health outcomes among Latinx immigrants. Pre-migration assets like family cohesion and social support may promote positive mental health outcomes in this population. The current study aims to identify the cumulative and interaction effects of pre-migration trauma, social support, and family cohesion on acculturative stress among recent Latinx immigrants (RLIs). The current study utilizes baseline data from an on-going longitudinal study following 540 RLIs during their initial 3 years in the U.S. Simple main effects of the predictor variables on acculturative stress were estimated using hierarchical multiple regression (HMR). Predictor variables were entered into the HMR model as follows: (1) demographic variables were entered in the first block, (2) family cohesion and social support in the second block and (3) pre-migration trauma in the third block. Interaction effects between family cohesion and social support on the association between pre-migration trauma and acculturative stress were examined. Results showed that 20.6% of the variance of acculturative stress was explained by the predictor variables entered into the HMR model. The first predictor block included demographic variables and explained 13.5% of the variability in acculturative stress, R2 = 13.5, F(6, 521) = 13.55, p <.001. The second block added family cohesion and social support to the HMR model and showed an ΔR2 of 4.5%, R2 = 18.0, F(8, 519) = 14.22, p <.001. The third block added pre- migration trauma to the HMR model and showed an ΔR2 change of 2.6%, R2 = 20.6, F(9, 518) = 14.93, p <.001. Significant interaction effects were found for family cohesion among documented RLIs. Social support was not a significant moderator. Study findings suggest pre-migration resources such as family cohesion and social support may ameliorate post-immigration acculturative stress among RLI, while pre-migration trauma, may exacerbate acculturative stress. [ABSTRACT FROM AUTHOR]

Background: History of exposure to traumatic events (ETE) is common among women in substance use disorder (SUD) treatment and is related to craving. We examined whether ETE (i.e., emotional, physical, sexual abuse) in childhood, adulthood, or both is related to craving via trauma symptoms and how trait mindfulness might attenuate this association. Methods: Baseline data from a larger randomized clinical trial of a mindfulness-based intervention for women (N = 245) in SUD treatment were used. Inclusion criteria were: 18–65 years of age, SUD diagnosis, English fluency, no cognitive impairment, and willingness to be audio recorded and provide consent. Demographics and validated measures of ETE, posttraumatic stress symptoms, trait mindfulness, and substance use craving were collected via in-person interviews. Descriptive statistics, correlational analysis, and relative direct, indirect, and conditional indirect effects models were run. Results: Most participants identified as Hispanic (58.5%), had at least a high school education (52.2%), with a mean age of 32.2. Women reported ETE in childhood only (20.4%), adulthood only (17.5%), both childhood and adulthood (50.0%), and never (11.4%). Compared to women with ETE in both childhood and adulthood, those with exposure in adulthood only (β = -.10, 95% CI = -.20, -.02) or no exposure (β = -.11, 95% CI = -.23, -.03; [∆R2=.347, F(8, 245) = 15.7, p <.001) had lower craving via lower trauma symptomatology but no difference when compared to those with ETE only in childhood. Acting with awareness moderated this indirect effect (∆R2 =.04, F(3, 245) = 4.66, p =.004. At low levels of awareness, women with ETE during both childhood and adulthood reported higher craving via trauma symptomatology than women with no exposure or only adulthood exposure. Conclusions: Low levels of acting with awareness may worsen trauma symptoms after ETE, which in turn may lead to more craving for women in substance use treatment. Despite a small moderating effect size, acting with awareness may have clinical significance due to the prevalence of trauma symptoms among women in SUD treatment. [ABSTRACT FROM AUTHOR]

US female Latina seasonal farm workers (LSW) are a medically underserved community experiencing severe health disparities. We explored the relationship between alcohol and prescription medication, and LSW social networks using a qualitative approach. In 2015, this study used convenience sampling to recruit 28 LSWs in South Florida for three focus group discussions in Spanish. Focus groups were translated to English for analysis, which employed a general inductive approach. Themes included prescription medication distribution within networks, spirituality/religion practice with friends and family, and alcohol use with friends. Substance abuse prevention and treatment interventions should account for the unique needs of LSW. [ABSTRACT FROM AUTHOR]

Introduction: Shifts in the sociopolitical context of Latin America have led to steep increases in recent Latinx immigrants (RLI) arriving in the US within the context of forced migration. Yet, little is known about how adverse experiences of RLIs before and after immigration may impact their health including drug use. The purpose of this study was to examine prescription drug and cannabis use before and just after immigration among RLIs and how this drug use is influenced by pre-and post-immigration factors. Methods: This study utilized baseline data from a study examining pre- to post-immigration drinking and driving trajectories among RLI in the United States (US). Baseline criteria included: self-identifying as a Latinx immigrant, 18 − 34 years old, who recently immigrated from a Latin American country. Multivariate logistic regression was conducted to determine predictors of drug use both prior to and after immigrating. Results: There were 540 RLI, 50.2% male and 47.8% subjected to forced migration. Prescription and illicit drug use decreased post-immigration with sedatives being the most common. Higher levels of education was associated with increased odds of pre-immigration prescription drug use and cannabis use. Those experiencing forced migration were more likely to engage in prescription drug use before and after immigration, while no associations were found for cannabis use. Conclusion: Findings suggest a need for increased substance use and mental health services among RLIs arriving within the context of forced migration. More research is needed to understand the trajectories of drug use among RLI as their time in the US increases. [ABSTRACT FROM AUTHOR]

Background: Evidence indicates escalating rates of cigarette use among foreign-born Latinx as their time in the U.S increases. As such, it's important to understand shifts in pre- to post-immigration smoking patterns early in the immigration process and its associated factors. Objectives: To examine 1) cigarette use among recent Latinx immigrants (RLIs) during their initial year in the U.S.; 2) whether cigarette use after immigration is influenced by smoking patterns in immigrant's country of origin; and 3) associations between pre/post immigration sociocultural factors and changes in cigarette use after immigration. Methods: Baseline data were utilized from an on-going longitudinal study of 540 young adult (50% females) RLIs. Inclusion criteria was being between ages 18 and 34, residing in Miami-Dade County, Florida, and having immigrated from a Latin American country within the past year Results: Approximately 31% of participants reported being smokers in their country of origin while 26% were current smokers (while residing in the U.S). Post-immigration cigarette use was substantially influenced by country of origin cigarette use (V =.68); 84% of pre-immigration smokers reported no change in smoking frequency, while 11% lowered and 6% increased their cigarette use post-immigration. Reduction in smoking after immigration was more likely among participants with higher pre-immigration social support (aOR = 1.87) and less likely among those residing in high-crime neighborhoods (aOR =.84). Conclusion: Interventions aimed to discourage cigarette use should begin early in the immigration process and account for RLIs' pre-immigration smoking patterns. Interpersonal supports and neighborhood contextual factors should be considered when developing smoking cessation programs with this population. [ABSTRACT FROM AUTHOR]

Latina immigrant farmworkers are a vulnerable and understudied population that face a host of socio-cultural and structural barriers that place them at risk for HIV infection. Cultural factors, including traditional gender roles (egalitarian and marianismo) that frequently inhibit communication between partners and promote rigid roles, may particularly affect self-efficacy for HIV prevention among this population. Objective: This study examines the impact of women's gender norms on HIV knowledge and safe sex negotiation skills, along with the moderating influence of HIV self-efficacy among Latina immigrants in a farmworker community. Design: The current cross-sectional analysis study examines data from a sample (N = 157) of mostly undocumented Latina immigrant farmworkers in South Miami-Dade County, Florida. Analysis was performed on secondary data obtained from baseline collected on an intervention pilot study. Measures of traditional American (egalitarian) and Latina (marianismo) gender norms, HIV self-efficacy, and HIV knowledge, as well as key demographic variables were collected. Results: Findings revealed higher American (egalitarian) gender norms directly and indirectly predict higher HIV prevention factors. Additionally, HIV self-efficacy did not mediate effects of marianismo on HIV risk. Conclusion: Findings conclude that HIV prevention can be especially challenging due to socio-cultural and traditional gender norms faced by Latinas in farm working communities and that such norms should be taken into account when developing and adapting culturally appropriate interventions to reduce HIV related risk behaviors for Latinas residing in urban or farm working communities. [ABSTRACT FROM AUTHOR]

The present study investigated neighborhood effects on substance use, mental and medical health, and health-care access. We used data collected from a sample of adult Latinas of Caribbean and South and Central American descent in 2011. The findings indicate that for adult Latinas, concentrated disadvantage in neighborhoods is associated with increased risk of alcohol misuse and inability to obtain prescription drugs due to lack of money, while Hispanic/immigrant concentration in neighborhoods is associated with fewer mental disorder symptoms. Individual age, criminal justice involvement, religious involvement, intimate partner violence, and employment are also associated with one or more health-related outcomes. We provided practice implications for macro and micro social work practice. Future research is needed to examine the mechanism underlying the negative association between neighborhood Hispanic/immigrant concentration and mental disorder symptoms. [ABSTRACT FROM AUTHOR]

Background/Purpose: Emerging adulthood is an important time where substance use often peaks. Neighborhood Latinx ethnic density could be protective against negative health behaviors. Most studies on neighborhood ethnic density have focused on census-level aggregate measures, however perception of the neighborhood ethnic density could differ from objectively measured neighborhood density. This study investigated the effects of neighborhood ethnic density, both perceived ethnic and objectively measured ethnic density, on hazardous alcohol use among Latinx emerging adults in Maricopa County Arizona and Miami-Dade County Florida by gender. Methods: 200 Latinx emerging adults residing in Arizona and Florida completed a cross-sectional survey. Inclusion criteria were being age 18-25, self-identify as Latinx, and currently living in Maricopa County or Miami-Dade County. Data were analyzed using multivariate logistic regression and moderation analyses. Results: There was a statistically significant difference between perceived and objective ethnic density (Kappa = 0.353, p < 0.001). When ethnic density was measured objectively, alcohol use severity was statistically significantly lower for individuals living in highly ethnically dense neighborhoods (OR: 0.34, 95% CI: 0.12, 0.92). However, this association was only found for women in moderation analyses. There was no statistically significant association between perceived ethnic density and alcohol use severity. Conclusion: The present study found a statistically significant decrease in alcohol use severity among Latinx emerging adults who live in highly ethnically dense neighborhoods after adjusting for covariates. Future research should investigate the potential mechanisms in which these neighborhoods protect against alcohol use severity among Latinx emerging adults. [ABSTRACT FROM AUTHOR]

Sexual trauma is a national public health concern due to the alarming rates at which it occurs and decades of research supporting its long-term deleterious effects on health outcomes. We assessed the impact of gender norms and sexual trauma on power within sexual relationships among Latina immigrant farmworkers. At baseline, participants (N  = 175) completed a survey examining demographic information, sexual trauma history, and gender norms; a follow-up was administered 6 months later. Past sexual trauma was associated with less power in sexual relationships, r  = -.25, p < .001, as was endorsement of traditional Latina gender norms (i.e., marianismo): sexual relationship control, r  = -.38, p < .001; sexual decision-making dominance, r  = -.21, p  = .005. In contrast, egalitarian gender norm endorsement was associated with higher levels of sexual relationship control, r  = .37, p < .001, and sexual decision-making dominance, r  = .17, p  = .023. Gender norms moderated the association between sexual trauma and sexual relationship power. Specifically, women who subscribed more to marianismo and reported sexual trauma had less decision-making dominance in sexual relationships, whereas those with lower ratings of marianismo reported higher levels of decision-making dominance despite sexual trauma, R2   = .03, p  = .022. Sexual trauma history coupled with higher ratings of egalitarian gender norms was associated with higher levels of sexual relationship control, DR2   = .02, p  = .023. These results highlight the importance of culturally informed research to increase the sexual and overall health of vulnerable populations (e.g., Latina immigrant farmworkers). [ABSTRACT FROM AUTHOR]

Since 2015, more than four million Venezuelans have fled their once prosperous nation, prompting an ever-intensifying refugee crisis. Recent research with Venezuelan parents suggests that many are exposed to elevated migration-related stress, experience behavioral health problems, and express profound concern for their children's post-migration wellbeing. We examine the relationships between stress, family functioning, and substance use risk with a cultural stress theoretical lens. Methods: Survey data were collected between November 2018 and June 2019 from 402 recently-arrived Venezuelan immigrant youth ages 10–17. Outcomes include perceived discrimination, negative context of reception, family support/communication, and substance use intentions and normative beliefs. Structural equation modeling was used to examine the relationships between variables. Results: Structural equation modeling results indicated that negative context of reception was associated with permissive substance use norms (via family communication; B = 0.070, p <.01) and intentions to use (via family support; B = 0.051, p <.01). Discrimination was not mediated by family functioning, rather it exerted a direct effect on substance use norms (β = 0.20, p <.01) and intentions (β = 0.33, p <.001). Discussion: We see clear evidence that negative context of reception and discrimination are related to substance use risk, both directly (in the case of discrimination) and indirectly (in the case of negative context of reception). Given the manifold stressors faced by Venezuelan immigrants both prior to migration and in the process of resettling in the US, it is critical that practitioners and policymakers support this rapidly-growing population. [ABSTRACT FROM AUTHOR]

Childhood abuse has been linked to problematic drinking in adulthood. It is also documented that people living with HIV have higher rates of alcohol use than the general population. In Haiti, a total of 25% of women living with HIV have experienced childhood sexual abuse (CSA), which puts them at an increased risk for alcohol abuse. CSA has also been associated with anxiety disorders in adulthood. Therefore, it is critical to understand the relationship between CSA, anxiety, and alcohol use among women living with HIV. A total of 244 women living with HIV participated in this study, with 35% reporting CSA. Alcohol abuse was measured with the AUDIT, anxiety with the State-Trait Anxiety Inventory test, and sexual abuse with the Childhood Trauma Questionnaire. Compared to participants who did not experience childhood sexual abuse, participants who experienced childhood sexual abuse reported greater levels of alcohol use [(17.0, SD = 9.1) (11.9, SD = 8.6) p =.001] and anxiety [(55.8, SD = 9.8) (48.9 SD = 8.3) p =.001] respectively. The indirect effect of anxiety on the association between CSA and alcohol use was significant [(ß =.19 p =.05) 95% bootstrap CI.019 –.13] Thus, women who reported being sexually abused as children reported anxiety, which in turn, was associated with an increased risk for alcohol abuse. Results demonstrate that alcohol may be used as a negative coping mechanism to alleviate anxiety symptoms triggered by CSA. These findings elucidate the need for further research examining the impact that sexual trauma has on mental health. [ABSTRACT FROM AUTHOR]

By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare. [ABSTRACT FROM AUTHOR]

Bioeconomies need sustainable technologies and strategies for biomass processing. One of the best ways to do that is to consider biorefineries as a practical way to achieve real developments in the industry for integral production of energy, food, feed and chemicals under an ideal dream of replacing today's crude-oil and basically using the accessible biomass in the world as much as possible. Additionally, the existent biofuel facilities are constantly adding new processing lines without integral design strategies, and possibly repeating the past design and implementation errors in refineries based on crude-oil. In recent years, more as a fashion or tendency, these processing lines from biofuels industry have been integrated in a system called "biorefinery" and many sectors have supported this idea through policies to incentivize the development of the bio-based economies adopting this concept. The design of biorefineries is presented as a relevant topic due to the multiple processing paths that could be available to obtain a set of desirable products. However, after many scientific efforts in design through well validated methodologies the biorefineries currently are not working properly or are more close to a conventional standalone biomass processing. Some big facilities already implemented today as biorefineries are closed or working just as standalone process (biofuels plant), but not through a promising multiproduct biorefinery configuration for which the resulting design was developed. In this work, 13 biorefineries were analysed including 4 industrial cases that were implemented after specific design and different industrial plants that use different raw materials of renewable origin. To achieve this, different strategic cases were considered: raw materials with inherent logistics restrictions, technical, economic, environmental assessments together with social considerations and finally market restrictions. As a result, and based on different case studies (where these process engineering strategies where applied through conceptual design using Aspen Plus and Potential Environmental Impacts) the positive and negative lessons are discussed in detail. The main result is an overall learning from different cases of study for future design, analysis and implementation of new biorefineries with a real sustainability and avoiding a repetition of the same evolution that risky and controversial crude-oil refineries had. [ABSTRACT FROM AUTHOR]

Parental engagement is critical to adolescent substance use prevention. However, our understanding of the degree to which parents are actually talking to their children about tobacco, alcohol, and drugs remains limited. The present study provides new evidence on the prevalence and trends of parental substance use communication (PSC) in the United States between 2002 and 2016. Trend analyses were conducted using 15 years of cross-sectional survey data from non-Hispanic White (n = 153,087), Black/African American (n = 35,216), and Hispanic (n = 45,780) adolescents aged 12-17 from the National Survey on Drug Use and Health. Since the early-to-mid 2000s, the rate of past-year PSC declined significantly, even when accounting for sociodemographic factors. We observed particularly noteworthy declines among adolescents residing in households earning less than $20,000 per year, declining by 19% (in relative terms) from a high of 58% PSC in 2003 and 2008 to a low of 47% in 2016. Teens reporting PSC reported higher levels of perceived parental warmth/engagement and consistent discipline/limit setting. Findings underscore the importance of engaging parents, particularly those less likely to talk to their children about substance use, and providing caregivers instruction and encouragement to talk to teens about the very real dangers of substance use. [ABSTRACT FROM AUTHOR]

Religious institutions can be a source of support for recent Latino immigrants struggling to adjust to a new culture. For undocumented immigrants, who are often marginalized from other formal institutions, they may symbolize a place of refuge and hope through supportive social networks that mitigate common challenges such as social isolation and other forms of immigration stress. This cross-sectional study examined the impact of religious social capital and social support on immigration stress among documented and undocumented recent Latino immigrants (N = 408). Religious social capital was associated with higher levels of social support, while social support was protective against immigration stress. Social support mediated associations between religious social capital and immigration stress, but only among undocumented immigrants. Findings suggest religious social capital may be a particularly useful resource for undocumented immigrants, aiding in the provision of social support and in decreasing levels of immigration stress. Future research directions and implications for culturally tailored service delivery are presented. [ABSTRACT FROM AUTHOR]

The preservation of mould-ripened salami was investigated during 48 days at 19-20 °C under different packaging conditions: (i) high barrier film filled with air, 100 % N2 or under vacuum, (ii) biaxially oriented polypropylene film, (iii) microperforated polyethylene film and (iv) unpackaged. Sensory, texture profile, physicochemical and microbiological analyses were performed. Fungal quantification revealed two data groups. In group 1 (consisting of salami in microperforated polyethylene film, biaxially oriented polypropylene film and unpackaged) the conidium viability was relatively constant. In group 2 (salami preserved in high barrier film filled with air, 100 % N2 or under vacuum) the conidium viability decreased due to the absence of oxygen and the high carbon dioxide volume fraction. SEM micrographs showed micromorphological changes in fungal structure; microperforated polyethylene film, biaxially oriented polypropylene film and unpackaged conditions preserved the conidial morphology, while high barrier film filled with air, 100 % N2 or vacuum conditions collapsed the hyphae and most of the conidia. Salami packed in microperforated polyethylene film and biaxially oriented polypropylene film showed the most acceptable organoleptic characteristics and lower hardness and chewiness values after packaging. [ABSTRACT FROM AUTHOR]

Purpose: We put forward a theoretical and dynamical approach for the semi-quantitative analysis of CD4+ T cell differentiation, the process by which cells with different functions are derived from activated CD4+ T naïve lymphocytes in the presence of particular cytokine microenvironments. We explore the system-level mechanisms that underlie CD4+ T plasticity-the conversion of polarized cells to phenotypes different from those originally induced. Methods: In this paper, we extend a previous study based on a Boolean network to a continuous framework. The network includes transcription factors, signaling pathways, as well as autocrine and exogenous cytokines, with interaction rules derived using fuzzy logic. Results: This approach allows us to assess the effect of relative differences in the concentrations and combinations of exogenous and endogenous cytokines, as well as of the expression levels of diverse transcription factors. We found either abrupt or gradual differentiation patterns between observed phenotypes depending on critical concentrations of single or multiple environmental cytokines. Plastic changes induced by environmental cytokines were observed in conditions of partial phenotype polarization in the T helper 1 to T helper 2 transition. On the other hand, the T helper 17 to induced regulatory T-cells transition was highly dependent on cytokine concentrations, with TGFβ playing a prime role. Conclusion: The present approach is useful to further understand the system-level mechanisms underlying observed patterns of CD4+ T differentiation and response to changing immunological challenges. [ABSTRACT FROM AUTHOR]

We examined the perception of adolescent children’s marijuana use and its consequences in the Hispanic seasonal farmworking community of South Florida via three focus groups with Hispanic adult female seasonal workers (n = 29). The women described how adolescents’ marijuana use increased over the past five years. Social networks for marijuana use were reported near schools and bus stations. Although participants expressed concern over adolescent marijuana use and involvement in selling marijuana, they reported that their job demands preclude their ability to supervise their children. Participants do not report unlawful marijuana use due to fear of deportation. [ABSTRACT FROM AUTHOR]

Few studies have examined the socio-cultural determinants of alcohol and drug misuse trajectories among adult Latinas. To assess the associations between socio-cultural determinants and alcohol and drug misuse, we used a longitudinal design to follow a sample of adult Latina mother-daughter-dyads (N = 267) for ten years, and collected four waves of data. They were adult Latinas of Caribbean, South and Central American descent. Specifically, this study investigated the effects of the following factors: (1) Individual Determinants (e.g., socioeconomic conditions, mental health, and medical status); (2) Cultural Determinants (e.g., acculturation to US culture); (3) Interpersonal Determinants (e.g., interpersonal support, relationship stress, mother-daughter attachment, intimate partner violence); (4) Community Determinants (e.g., neighborhood related stress); and (5) Institutional Determinants (e.g., religious involvement, involvement with the criminal justice system). Using hierarchical modeling, we found that taking prescribed medication on a regular basis for a physical problem, religious involvement, and mother-daughter attachment were negatively associated with drug misuse, while involvement in criminal activity was positively associated with drug misuse. Regarding alcohol misuse, results showed that age at arrival in the United States, number of years in the United States, and religious involvement were negatively associated with alcohol misuse, while involvement in criminal activity was positively associated with alcohol misuse. Based on our findings, explicit implications are provided for culturally relevant interventions. [ABSTRACT FROM AUTHOR]

Prompt HIV diagnosis decreases the risk of HIV transmission and improves health outcomes. The study objective was to examine rates of delayed HIV diagnosis among non-Latino Black Caribbean immigrants in Florida. The sample included 39,008 Black HIV-positive individuals, aged 13 or older from the Caribbean and the mainland U.S. Delayed HIV diagnosis was defined as AIDS diagnosis within three months of HIV diagnosis. After adjusting for demographic factors, year of HIV diagnosis, transmission mode, neighborhood level socioeconomic status, and rural- urban residence, a disparity persisted for Caribbean-born Blacks in the Bahamas and Haiti compared with U.S.-born Blacks. Male Jamaican-Bahamian-Haitian-born Blacks were more likely to have delayed diagnosis (aOR 2.17, 95% confidence interval [CI] 1.53-3.03; aOR 1.88, 95% CI 1.01-3.44; aOR 1.58, 95%CI 1.58). Findings suggest the need for targeted, culturally relevant interventions to reduce delayed diagnosis incidence among specific Caribbean- born Blacks. [ABSTRACT FROM AUTHOR]

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Background: Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-level mechanisms that alter CD4+ T cell differentiation and plasticity are not well understood. Results: We model how hyperinsulinemia alters the dynamics of the CD4+ T regulatory network, and this, in turn, modulates cell differentiation and plasticity. Different polarizing microenvironments are simulated under basal and high levels of insulin to assess impacts on cell-fate attainment and robustness in response to transient perturbations. In the presence of high levels of insulin Th1 and Th17 become more stable to transient perturbations, and their basin sizes are augmented, Tr1 cells become less stable or disappear, while TGFβ producing cells remain unaltered. Hence, the model provides a dynamic system-level framework and explanation to further understand the documented and apparently paradoxical role of TGFβ in both inflammation and regulation of immune responses, as well as the emergence of the adipose Treg phenotype. Furthermore, our simulations provide new predictions on the impact of the microenvironment in the coexistence of the different cell types, suggesting that in pro-Th1, pro-Th2 and pro-Th17 environments effector and regulatory cells can coexist, but that high levels of insulin severely diminish regulatory cells, especially in a pro-Th17 environment. Conclusions: This work provides a first step towards a system-level formal and dynamic framework to integrate further experimental data in the study of complex inflammatory diseases. [ABSTRACT FROM AUTHOR]