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Seeded emulsion polymerization is a powerful universal method to produce ultrasmall multifunctional magnetic nanohybrids. In a two-step procedure, iron oxide nanocrystals were initially encapsulated in a polystyrene (PS) shell and subsequently used as beads for a controlled assembly of elongated quantum dots/quantum rods (QDQRs). The synthesis of a continuous PS shell allows the whole construct to be fixed and the composition of the nanohybrid to be tuned. The fluorescence of the QDQRs and magnetism of iron oxide were perfectly preserved, as confirmed by single-particle investigation, fluorescence decay measurements, and relaxometry. Bio-functionalization of the hybrids was straightforward, involving copolymerization of appropriate affinity ligands as shown by immunoblot analysis. Additionally, the universality of this method was shown by the embedment of a broad scale of NPs. [ABSTRACT FROM AUTHOR]

A series of novel, highly symmetrical phthalocyanines bearing eight peptide residues has been prepared by microwaveassisted Cu(I)-catalyzed 1,3-dipolar cycloaddition ('click' reaction). Water-soluble conjugates were obtained after straightforward deprotection of the amine and amide functionalities. The phthalocyanine conjugates were found to be nontoxic along the whole concentration range, which makes them promising photosensitizers for therapeutic use. [ABSTRACT FROM AUTHOR]

A variety of 2,3-disubstituted 5,6,7,8-tetrahydronaphthyl analogues have been synthesized via vinylation of cyclic ketones, subsequent lactonisation and thermally induced, inverse electron demand hetero Diels-Alder reaction. The diversity of the obtained products derives from the multiplicity of cyclic ketones and from the variety of dienophiles of the Diels-Alder reaction. [ABSTRACT FROM AUTHOR]