3,257 results on '"Sequeira, A"'
Search Results
2. Randomized Controlled Trial to Evaluate the Efficacy of Positive Mental Health Program for Adults: Study Protocol.
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Teixeira, Sónia Manuela Almeida, Ferré‐Grau, Carme, da Cruz Sequeira, Carlos Alberto, Santos, José Manuel, Guerra, Maria Manuela, and Lluch, Maria Teresa
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COMMUNITY health services ,MENTAL health ,EVALUATION of human services programs ,RANDOMIZED controlled trials ,WELL-being - Abstract
Aim: To evaluate the effectiveness of a positive mental health program for adults (PMHP) in the community. Background: Positive mental health (PMH) can be seen as a construct represented by six factors (personal satisfaction, prosocial attitude, self‐control, autonomy, problem resolution, and self‐actualization, and interpersonal relationship skills) according to the Multifactorial Model for PMH. Although there are several interventions in promoting mental health, research on effective promotion of PMH for adults in the community with structured and validated programs of PMH is scarce. Methods: This study protocol describes a randomized controlled trial (RCT) following a wait‐list control design, aimed at evaluating the effectiveness of a PMHP in the community. This study was approved in June 2019 by the Ethics Committee. Participants will be recruited from the school community of teachers. Participants aged ≥ 18 years. The participants will be randomized 1:1 to either (a) an intervention group, which will integrate the PMHP, or (b) the standby control group. Three assessment moments for both groups will take place initial, after the intervention, and a follow‐up of 3–6 months. The evaluation instruments will include a sociodemographic questionnaire, a PMH questionnaire, and a psychological vulnerability scale. Conclusion: The current study provides an innovative approach to PMH. Further, the study may demonstrate new interventions in PMH in the community, based on a program with systematized guidelines and sessions structured according to individual needs. It is expected that at the end of the program, the experimental group will increase the level of PMH. Relevance to clinical practice: To allow future official implementation of the PMH program and the replication of the study in other professional groups as a promotion tool. No patient or public contribution: There was no funding to remunerate a participant for this study. Trial Registration: ClinicalTrials.gov identifier: NCT04600401. Registered on May 15, 2020 [ABSTRACT FROM AUTHOR]
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- 2025
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3. External Validation of SHA2PE Score: A Score to Predict Low‐Risk Lower Gastrointestinal Bleeding in the Emergency Department.
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Ahmad, Akram I., El Sabagh, Ahmed, Zhang, Jennie, Caplan, Claire, Al-Dwairy, Ahmad, Bakain, Tarek, Buchanan, Faith, Fisher, Lea, Wilbur, Andrew, Marshall, Samantha, Buechner, Garrett, Hamzeh, Malaak, Dhanjal, Rachna, Boos, Alexander, Sequeira, Lynette, and Toyokawa, Tatsuya
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Introduction: Lower gastrointestinal bleeding (LGIB) frequently leads to emergency department (ED) visits and hospitalizations, encompassing a spectrum of outcomes from spontaneous resolution to intrahospital mortality. Aim: The purpose of this study was to validate a scoring system designed to identify cases of low‐risk LGIB, allowing for safe discharge from the ED. Methods: A retrospective analysis of all gastrointestinal bleeding cases presented at three EDs in 2020 was conducted, focusing specifically on patients with LGIB. The SHA2PE score incorporates factors such as systolic blood pressure, hemoglobin levels, use of antiplatelet or anticoagulant medications, pulse rate, and episodes of bright blood per rectum. Results: Out of 1112 patients presenting with LGIB to the ED, 55 were hospitalized, 20 required blood transfusions, 15 underwent colonoscopies, one underwent interventional radiology procedures, and two patients died. Employing a SHA2PE score with a cutoff value of 1 yielded a specificity of 78.5% (95% CI (confidence interval) [75.8–81.0]), sensitivity of 76.8% (95% CI [63.6–87.0]), positive predictive value (PPV) of 17.0% (95% CI [12.6–22.2]), and negative predictive value (NPV) of 98.3% (95% CI [97.2–99.1]) for predicting the need for hospitalization and intrahospital intervention. When considering return visits to the ED within 7 days with the same presentation, the score demonstrated a specificity of 78.8% (95% CI [76.0–81.3]), sensitivity of 68.6% (95% CI [56.4–79.1]), PPV of 19% (95% CI [14.3–24.4]), and NPV of 97.2% (95% CI [95.8–98.2]). Conclusions: The SHA2PE score demonstrates potential in predicting cases of low‐risk LGIB, offering a high NPV for hospitalization, the need for intrahospital intervention, and return visits to the ED. However, these findings should be interpreted cautiously given the low prevalence of interventions and limitations in the study's population and design. [ABSTRACT FROM AUTHOR]
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- 2025
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4. Applicability of the Scottish screen-detected polyp cancer study (SSPoCS) algorithm in a multicentric cohort in the management of malignant colorectal polyps.
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Gonçalves, André Ruge, Azevedo Silva, Maria, Sequeira, Cristiana, Mascarenhas, André, Costa, Mara, Pinto Pais, Teresa, Barreiro, Pedro, Almeida, Nuno, Rama, Nuno, Fernandes, Alexandra, Eliseu, Liliana, Dinis-Ribeiro, Mário, and Vasconcelos, Helena
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RECEIVER operating characteristic curves ,COLON polyps ,ENDOSCOPIC surgery ,SURGICAL margin ,DECISION making - Abstract
Background/Objectives: Robust evidence regarding the management after endoscopic resection of malignant colorectal polyps (MCP) is lacking. Inconsistencies in reporting on potential prognostic factors hinder the decision process. To address these issues, the Scottish Screen-detected Polyp Cancer Study (SSPoCS) introduced an algorithm based in two easily obtainable variables: resection margin and lymphovascular invasion. This study aims to assess the applicability of the SSPoCS algorithm in a Portuguese multicentric cohort. Methods: Endoscopically resected MCP in five centers were included. The main outcome was residual/recurrent malignancy (RRM), defined as any of the following: (1) residual intramural or lymph node malignancy in the surgical specimen after completion surgery; (2) local or systemic recurrent disease in conservatively managed patients. Results: Two-hundred and eleven patients were included (mean age: 68.6 ± 10.4 years; male participants: 65.4%); 121 underwent completion surgery while 90 remained in surveillance. Thirty-two patients (15.2%) experienced RRM: 27 displayed residual malignancy in the surgical specimen and five developed recurrent disease. According to the SSPoCS algorithm: 120 patients were classified as having low-risk of residual disease, six of whom displayed RRM (5.0%); 10 as medium-risk, with one having RRM (10.0%); and 81 as high-risk, 25 of whom experienced RRM (30.9%). Lesions classified as low risk showed a negative predictive value (NPV) of 95.0% to exclude RRM. The algorithm demonstrated good accuracy in predicting RRM in a Receiver Operating Characteristic curve analysis (AUC: 0.74; 95% CI: 0.65–0.83; p < 0.001). Conclusions: The SSPoCS algorithm revealed good accuracy in predicting residual/recurrent malignancy with a NPV of 95.0% to exclude RRM in low-risk lesions. [ABSTRACT FROM AUTHOR]
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- 2025
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5. Ecophysiological variables retrieval and early stress detection: insights from a synthetic spatial scaling exercise.
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Pacheco-Labrador, Javier, Cendrero-Mateo, M.Pilar, Van Wittenberghe, Shari, Hernandez-Sequeira, Itza, Koren, Gerbrand, Prikaziuk, Egor, Fóti, Szilvia, Tomelleri, Enrico, Maseyk, Kadmiel, Čereković, Nataša, Gonzalez-Cascon, Rosario, Malenovský, Zbyněk, Albert-Saiz, Mar, Antala, Michal, Balogh, János, Buddenbaum, Henning, Dehghan-Shoar, Mohammad Hossain, Fennell, Joseph T., Féret, Jean-Baptiste, and Balde, Hamadou
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LEAF area index ,REMOTE sensing ,CHLOROPHYLL spectra ,PLANT physiology ,SURFACE temperature - Abstract
The ability to access physiologically driven signals, such as surface temperature, photochemical reflectance index (PRI), and sun-induced chlorophyll fluorescence (SIF), through remote sensing (RS) are exciting developments for vegetation studies. Accessing this ecophysiological information requires considering processes operating at scales from the top-of-the-canopy to the photosystems, adding complexity compared to reflectance index-based approaches. To investigate the maturity and knowledge of the growing RS community in this area, COST Action CA17134 SENSECO organized a Spatial Scaling Challenge (SSC). Challenge participants were asked to retrieve four key ecophysiological variables for a field each of maize and wheat from a simulated field campaign: leaf area index (LAI), leaf chlorophyll content (C
ab ), maximum carboxylation rate (Vcmax,25 ), and non-photochemical quenching (NPQ). The simulated campaign data included hyperspectral optical, thermal and SIF imagery, together with ground sampling of the four variables. Non-parametric methods that combined multiple spectral domains and field measurements were used most often, thereby indirectly performing the top-of-the-canopy to photosystem scaling. LAI and Cab were reliably retrieved in most cases, whereas Vcmax,25 and NPQ were less accurately estimated and demanded information ancillary to RS imagery. The factors considered least by participants were the biophysical and physiological canopy vertical profiles, the spatial mismatch between RS sensors, the temporal mismatch between field sampling and RS acquisition, and measurement uncertainty. Furthermore, few participants developed NPQ maps into stress maps or provided a deeper analysis of their parameter retrievals. The SSC shows that, despite advances in statistical and physically based models, the vegetation RS community should improve how field and RS data are integrated and scaled in space and time. We expect this work will guide newcomers and support robust advances in this research field. [ABSTRACT FROM AUTHOR]- Published
- 2025
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6. Relationship of high‐density lipoprotein subfractions and apolipoprotein A‐I with fat in the pancreas.
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Liu, Yutong, Shamaitijiang, Xiatiguli, Skudder‐Hill, Loren, Kimita, Wandia, Sequeira‐Bisson, Ivana R., and Petrov, Maxim S.
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MAGNETIC resonance imaging ,HDL cholesterol ,INSULIN resistance ,BODY composition ,PANCREAS ,CHOLESTERYL ester transfer protein - Abstract
Aim: To investigate the associations of high‐density lipoprotein (HDL) subfractions and apolipoprotein A‐I (apo A‐I) with fat in the pancreas. Methods: A total of 170 individuals were studied. All participants underwent magnetic resonance imaging on a single 3.0‐Tesla scanner to determine the presence/absence of fatty pancreas. HDL subfractions were measured using a commercially available lipoprotein subfractions testing system and classed as large, intermediate and small HDL. Both unadjusted and adjusted (accounting for demographics, anthropometrics, insulin resistance and other covariates) logistic regression models were built. Results: Individuals with fatty pancreas had significantly lower circulating levels of the large HDL class and apo A‐I. Every unit decrease in the large HDL class was associated with a 93% increase in the likelihood of fatty pancreas in the most adjusted model (P <.001). Every unit decrease in apo A‐I was associated with a 45% increase in the likelihood of fatty pancreas in the most adjusted model (P =.012). The intermediate and small HDL classes were not significantly associated with fatty pancreas. Conclusions: Fat in the pancreas is inversely associated with the circulating levels of large HDL particles and apo A‐I. Purposely designed studies are warranted to investigate the potential of fatty pancreas as an indicator of the risk of cardiovascular diseases. [ABSTRACT FROM AUTHOR]
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- 2025
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7. The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms.
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Xuankun Li, Marvaldi, Adriana E., Oberprieler, Rolf G., Clarke, Dave, Farrell, Brian D., Sequeira, Andrea, Silvia Ferrer, M., O'Brien, Charles, Salzman, Shayla, Seunggwan Shin, Tang, William, and McKenna, Duane D.
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- 2024
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8. Industry4Redispatch – Demonstration der Integration industrieller Anlagen in den Prozess des Engpassmanagements und der TSO‑DSO‑Koordination.
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Hembach, Felix, Sequeira Taxer, Veronica, Hemm, Regina, and Fanta, Sarah
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Copyright of e & i Elektrotechnik und Informationstechnik is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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9. Colonisation by multidrug-resistant organisms in health workers in primary care: narrow spectrum oral antimicrobials are a risk factor.
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de Oliveira, Vítor Falcão, de Britto-Costa, Letícia Fernandes, de Aragão, Gabrielly Lacerda, Scaccia, Nazareno, Mamana, Ana Carolina, Côrtes, Marina Farrel, de Oliveira, Maura Salaroli, de Melo Tavares, Bruno, Manuli, Erika Regina, Leal, Fábio Eudes, de Oliveira Xavier, Gabriela Tonon, Grespan, Regina Maura Zetone, Sequeira, Cibele Cristine Remondes, Nunes, Fatima L. S., Dropa, Milena, Martone-Rocha, Solange, Razzolini, Maria Tereza Pepe, Sabino, Ester Cerdeira, Padoveze, Maria Clara, and Holmes, Alison
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COMMUNITY health workers ,STENOTROPHOMONAS maltophilia ,MULTIDRUG resistance ,METHICILLIN-resistant staphylococcus aureus ,BACTERIAL colonies - Abstract
Background: Limited information exists on carriage of multidrug-resistant organisms (MDRO) by health workers (HWs) in primary care settings. This study aims to determine the prevalence of MDRO carriage among HWs in primary care and to identify associated risk factors. Methods: A cross-sectional study was conducted across all 12 primary care units in São Caetano do Sul-SP, Brazil, from October to December 2023. Self-collected samples (nasal, oropharyngeal, and inguinal) were obtained. Environment cultures (potable water, sewage and stream water) were evaluated. Stenotrophomonas maltophilia isolates (human and environmental) were typed. Results: The study included 265/288 (92%) of HWs in primary care teams, mostly women with a median age of 47 years (IQR 38—57); 78% had no comorbidities. MDRO colonisation was found in 8.7% (23 HWs). The following bacteria were found: S. maltophilia (n = 9; 3.4%) in inguinal swabs; methicillin-resistant Staphylococcus aureus (n = 8; 3%) from all sites; extended-spectrum ß-lactamase-producing bacteria (n = 5; 2%) in inguinal swabs; and vancomycin-resistant enterococci in an inguinal swab (n = 1; 0.4%). Previous antibiotic use was significantly associated with MDRO colonisation (OR 2.91, 95% CI 1.19–7.09, p = 0.018), mainly narrow spectrum oral beta-lactams and macrolides. S. malthophilia was polyclonal and human and environmental isolates differed. Conclusion: Colonisation by MRSA, VRE, and ESBL-producing bacteria was low; however, 4% were surprisingly colonized by polyclonal S. maltophilia. This pathogen may also suggest using narrow-spectrum rather than the expected broad-spectrum antimicrobials. Antibiotic use was the only risk factor found, mainly with oral narrow-spectrum drugs. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Point-Cloud Instance Segmentation for Spinning Laser Sensors.
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Casado-Coscolla, Alvaro, Sanchez-Belenguer, Carlos, Wolfart, Erik, and Sequeira, Vitor
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POINT cloud ,DEEP learning ,DATA mining ,DETECTORS ,LIDAR - Abstract
In this paper, we face the point-cloud segmentation problem for spinning laser sensors from a deep-learning (DL) perspective. Since the sensors natively provide their measurements in a 2D grid, we directly use state-of-the-art models designed for visual information for the segmentation task and then exploit the range information to ensure 3D accuracy. This allows us to effectively address the main challenges of applying DL techniques to point clouds, i.e., lack of structure and increased dimensionality. To the best of our knowledge, this is the first work that faces the 3D segmentation problem from a 2D perspective without explicitly re-projecting 3D point clouds. Moreover, our approach exploits multiple channels available in modern sensors, i.e., range, reflectivity, and ambient illumination. We also introduce a novel data-mining pipeline that enables the annotation of 3D scans without human intervention. Together with this paper, we present a new public dataset with all the data collected for training and evaluating our approach, where point clouds preserve their native sensor structure and where every single measurement contains range, reflectivity, and ambient information, together with its associated 3D point. As experimental results show, our approach achieves state-of-the-art results both in terms of performance and inference time. Additionally, we provide a novel ablation test that analyses the individual and combined contributions of the different channels provided by modern laser sensors. [ABSTRACT FROM AUTHOR]
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- 2024
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11. The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat.
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Skudder‐Hill, Loren, Sequeira‐Bisson, Ivana R., Ko, Juyeon, Poppitt, Sally D., and Petrov, Maxim S.
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MAGNETIC resonance imaging ,GLYCOSYLATED hemoglobin ,FAT ,COHORT analysis ,CHOLESTEROL - Abstract
Objective: Previous studies have investigated the association between hepatic fat and intrapancreatic fat deposition (IPFD); however, results have been inconclusive. The presence of cardiometabolic factors in certain subpopulations could explain this discrepancy. The aim of the present study was to use moderation analyses to determine the conditions under which hepatic fat is associated with IPFD. Methods: All participants underwent 3T abdominal magnetic resonance imaging (MRI) and spectroscopy. Hepatic fat and IPFD were manually quantified by independent raters. Moderation analyses were performed with adjustment for sex and ethnicity. Results: There were 367 participants included. Adjusted analyses of the overall cohort revealed that age, glycated hemoglobin (HbA1c), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and triglycerides were significant moderators (p < 0.05) of the association between hepatic fat and IPFD. Ranges of significance included age < 61 years, HbA1c < 45 mmol/mol, LDL‐C < 157 mg/dL, HDL‐C > 36 mg/dL, and triglycerides < 203 mg/dL. Conclusions: The association between hepatic fat and IPFD is generally present in young and middle‐aged adults with good cardiometabolic health, whereas the link between the two fat depots becomes uncoupled in older adults or individuals with cardiometabolic risk factors. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Electrocoagulation vs. coagulation–flocculation applied to real wastewater and set up to pilot/full scale.
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Girón-Navarro, Rocío, Linares-Hernández, Ivonne, Castillo-Suárez, Luis Antonio, Martínez-Miranda, Verónica, and Teutli-Sequeira, Elia Alejandra
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WASTEWATER treatment ,FACTORIES ,AQUEOUS solutions ,PILOT plants ,FLOCCULATION - Abstract
Electrocoagulation (EC) and coagulation – flocculation (CF), have been employed for the treatment of different organic contaminants present in aqueous solutions owing to their efficiency. This review article reports the results obtained by different authors in the last 5 years, where EC, CF, and their coupling with other processes, are employed at the laboratory, pilot plant, and industrial scales. The evaluation of operating conditions, efficiencies, applications, limitations, and opportunities that arise in scaling both processes are presented. In this way, the present paper is novel because it presents evidence on the advantages and disadvantages of EC and CF technologies implemented at pilot/full scale to treat real wastewater, which has not been collected and synthesised in previous studies. The average elimination percentages (%COD) were evaluated at a pilot/industrial plant scale, where EC (%COD = 70%) presents higher efficiencies compared to CF (%COD = 60%). In CF, the %COD increases when using longer times, contrary to EC (%COD = 75% at t = 10 h in CF and %COD = 80% at t = 0.33 h in EC). Achieving neutral conditions in treated wastewater promotes high efficiencies and low energy consumption, causing costs to be reduced. The origin and composition of the wastewater also influence the pH and efficiencies. EC is the most studied method at laboratory scale, however, its development at an industrial level is minimal, unlike CF, where more studies are reported on a pilot and industrial scale. In both processes, the use of oxidising agents and ultraviolet energy favours the formation of metal radicals and the transformation of contaminants, increasing removal efficiencies. [ABSTRACT FROM AUTHOR]
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- 2024
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13. A Starting Point on Recycling Land and Sea Snail Shell Wastes to Manufacture Quicklime, Milk of Lime, and Hydrated Lime.
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Ferraz, Eduardo, Terroso, Denise, Sequeira, Maria Cristina, Azevedo, Maria Celeste, Coroado, João, Monteiro, Carlos, Rocha, Fernando, and Gamelas, José A. F.
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The valorization of gastropod shell wastes in the production of lime is the topic of this study. First, shells from land snail and sea snail were characterized for their mineralogical, chemical, and thermal properties. Then, the shells were calcined at 1000 °C, and the obtained quicklimes were characterized for their specific surface area, pore diameter, and particle morphology, followed by evaluation of their reactivity in wet slaking tests. Comparisons were made with lime from limestone. It was found that both gastropod shell wastes were composed of aragonite as the dominant crystalline phase. The quicklime from land snail belonged to the most reactive class (R5) of the wet slaking reactivity, reaching 60 °C in about 5 min, whereas the quicklime from the sea snail belonged to the R4 class, reaching 60 °C in about 14 min. However, both were much less reactive than the lime from limestone (60 °C in 25 s). The lower reactivity of quicklime from sea snail shells compared to quicklime from land snail shells could be related to its higher sulfur content (as contaminant), lower pore diameter, and the presence of particles with rounder surfaces. The reference quicklime from limestone was more reactive, mainly due to the much higher specific surface area and lower particle size. It was concluded that the gastropod shell wastes can be used in lime manufacturing. [ABSTRACT FROM AUTHOR]
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- 2024
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14. µ-NMR Technology for Biomedical Applications: A Review.
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Sequeira-Antunes, Beatriz and Ferreira, Hugo Alexandre
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NUCLEAR magnetic resonance ,INDIVIDUALIZED medicine ,MICROFLUIDICS ,METABOLOMICS ,POINT-of-care testing - Abstract
Nuclear magnetic resonance (NMR) is a versatile method that non-invasively provides detailed insights into the atomic and molecular information of samples containing non-zero spin nuclei, facilitating observations of their structure, dynamics, and interactions. By miniaturizing NMR systems, micro-NMR (µ-NMR) devices overcome the limitations of traditional bulky NMR instruments, making them more portable, cost-effective, and suitable for a wide range of applications. As such, this review aims to provide a comprehensive overview of the recent advancements and potential applications of µ-NMR in the field of biomedicine. Beginning with an overview of the principles underlying NMR, this paper explains the fundamental concepts essential for understanding µ-NMR technology. It then delves into miniaturization techniques, detailing advancements in microcoils and probes and the development and integration with microfluidics, which have enhanced the sensitivity, portability, and versatility of µ-NMR devices. Ultimately, this review discusses the current biomedical applications of µ-NMR, including molecular imaging, metabolomics, biomarker detection, and point-of-care diagnosis, and highlights the potential of this technology to revolutionize precision medicine and healthcare. Despite the promising applications, challenges such as sensitivity, spectral resolution, and integration with other technologies are discussed, along with recent advances and innovations aimed at addressing these limitations. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Primary Care and Transgender Youth: Care Experiences and the Need for more Comprehensive Care Provision.
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Sethness, Janis and Sequeira, Gina M.
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- 2024
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16. Regional Variations in Nasal Parameters in South India: A Descriptive Study.
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Devika, J. and Sequeira, Joyce P.
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Background: This paper aims to evaluate and standardize measurements of 11 nasal parameters specific to the South Indian population. This is significant because different ethnicities exhibit varying nasal proportions. The findings of this study will serve as a foundation for rhinoplasty procedures performed on the South Indian population as currently there is a lack of literature in this area of study. Methodology: A total of 136 young individuals of age group 18–30 were taken as a sample; 34 from each state that is Kerala, Karnataka, Tamil Nadu, and Andhra Pradesh were taken up for the study. Standardized photographs of the nose were taken. Eleven nasal parameters were measured using Digimiser software and analyzed. Results: Eight out of eleven parameters have statistically significant differences among the population of all four South Indian states, while three parameters did not have much of a statistically significant difference. Conclusion: When compared to the standard values of nasal parameters of the Indian population, only radix height and nasolabial angle were similar. The nasal index of all four South Indian ethnicities was platyrrhine. The nasal parameters did not differ among males and females in all the four South Indian populations. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Adherence to Pulmonary Tuberculosis Medication and Associated Factors Among Adults: A Cross-Sectional Study in the Metinaro and Becora Sub-Districts, Dili, Timor-Leste.
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Fernandes, Amentinho, Laohaprapanon, Sawanya, Nam, Truong Thanh, Sequeira, Ercia Maria Da Conceicao, and Le, Cua Ngoc
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- 2024
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18. In defence of the entity of Macaronesia as a biogeographical region.
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Fernández‐Palacios, José María, Otto, Rüdiger, Capelo, Jorge, Caujapé‐Castells, Juli, de Nascimento, Lea, Duarte, Maria Cristina, Elias, Rui B., García‐Verdugo, Carlos, Menezes de Sequeira, Miguel, Médail, Frédéric, Naranjo‐Cigala, Agustín, Patiño, Jairo, Price, Jonathan, Romeiras, Maria M., Sánchez‐Pinto, Lázaro, and Whittaker, Robert J.
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ARCHIPELAGOES ,CANARIES ,PHYTOGEOGRAPHY ,ENDEMIC species ,COINAGE - Abstract
Since its coinage ca. 1850 AD by Philip Barker Webb, the biogeographical region of Macaronesia, consisting of the North Atlantic volcanic archipelagos of the Azores, Madeira with the tiny Selvagens, the Canaries and Cabo Verde, and for some authors different continental coastal strips, has been under dispute. Herein, after a brief introduction on the terminology and purpose of regionalism, we recover the origins of the Macaronesia name, concept and geographical adscription, as well as its biogeographical implications and how different authors have positioned themselves, using distinct terrestrial or marine floristic and/or faunistic taxa distributions and relationships for accepting or rejecting the existence of this biogeographical region. Four main issues related to Macaronesia are thoroughly discussed: (i) its independence from the Mediterranean phytogeographical region; (ii) discrepancies according to different taxa analysed; (iii) its geographical limits and the role of the continental enclave(s), and, (iv) the validity of the phytogeographical region level. We conclude that Macaronesia has its own identity and a sound phytogeographical foundation, and that this is mainly based on three different floristic components that are shared by the Macaronesian core (Madeira and the Canaries) and the outermost archipelagos (Azores and Cabo Verde). These floristic components are: (i) the Palaeotropical‐Tethyan Geoflora, formerly much more widely distributed in Europe and North Africa and currently restricted to the three northern archipelagos (the Azores, Madeira and the Canaries); (ii) the African Rand Flora, still extant in the coastal margins of Africa and Arabia, and present in the southern archipelagos (Madeira, the Canaries and Cabo Verde), and (iii) the Macaronesian neoendemic floristic component, represented in all the archipelagos, a result of allopatric diversification promoted by isolation of Mediterranean ancestors that manage to colonize Central Macaronesia and, from there, the outer archipelagos. Finally, a differentiating floristic component recently colonized the different archipelagos from the nearest continental coast, providing them with different biogeographic flavours. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Robots at work: New evidence with recent data.
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Almeida, Derick and Sequeira, Tiago Neves
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QUANTILE regression ,EMPLOYMENT policy ,REGRESSION analysis ,WORKING hours ,LABOR productivity ,DATA analysis - Abstract
We reassess the relationship between robotization and the growth in labor productivity with more recent data. We discover that the effect of robot density in the growth productivity substantially decreased in the post‐2008 period. In this period, the lower positive effect of robot density in the growth of labor productivity is less dependent on the increase in value added. The data analysis dismisses any positive effect of robotization on hours worked. Results are confirmed by several robustness checks, cross‐sectional (and panel‐data) Instrumental Variable and quantile regression analysis. By means of the quantile regression analysis, we learn that the effect of robots on labor productivity is stronger for low productivity sectors and that in the most recent period, the effect of robotization felt significantly throughout the distribution. This highlights one of the possible sources of stagnation in the era of robotization and have implication both for labor market and R&D policies. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Latent class analysis of actigraphy within the depression early warning (DEW) longitudinal clinical youth cohort.
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Sequeira, Lydia, Fadaiefard, Pantea, Seat, Jovana, Aitken, Madison, Strauss, John, Wang, Wei, Szatmari, Peter, and Battaglia, Marco
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MENTAL depression risk factors ,RISK assessment ,STATISTICAL correlation ,ACADEMIC medical centers ,RESEARCH funding ,QUESTIONNAIRES ,ACCELEROMETRY ,ACTIGRAPHY ,WEARABLE technology ,STRUCTURAL equation modeling ,DESCRIPTIVE statistics ,LONGITUDINAL method ,SLEEP duration ,TECHNOLOGY ,RESEARCH ,DISEASE relapse ,DATA analysis software ,SLEEP quality ,PSYCHOLOGICAL tests ,PHENOTYPES ,SLEEP disorders ,DISEASE risk factors ,ADOLESCENCE - Abstract
Background: Wearable-generated data yield objective information on physical activity and sleep variables, which, are in turn, related to the phenomenology of depression. There is a dearth of wearable-generated data regarding physical activity and sleep variables among youth with clinical depression. Methods: Longitudinal (up to 24 months) quarterly collections of wearable-generated variables among adolescents diagnosed with current/past major depression. Latent class analysis was employed to classify participants on the basis of wearable-generated: Activity, Sleep Duration, and Sleep efficiency. The Patient Health Questionnaire adapted for adolescents (PHQ-9-A), and the Ruminative Response Scale (RRS) at study intake were employed to predict class membership. Results: Seventy-two adolescents (72.5% girls) were recruited over 31 months. Activity, Sleep Duration, and Sleep efficiency were reciprocally correlated, and wearable-generated data were reducible into a finite number (3 to 4) of classes of individuals. A PHQ-A score in the clinical range (14 and above) at study intake predicted a class of low physical activity (Acceleration) and a class of shorter Sleep Duration. Limitations: Limited power related to the sample size and the interim nature of this study. Conclusions: This study of wearable-generated variables among adolescents diagnosed with clinical depression shows that a large amount of longitudinal data is amenable to reduction into a finite number of classes of individuals. Interfacing wearable-generated data with clinical measures can yield insights on the relationships between objective psychobiological measures and symptoms of adolescent depression, and may improve clinical management of depression. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Definitional Challenges in Understanding Hypertrophic Cardiomyopathy.
- Author
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Federspiel, Jan M., Pfeifer, Jochen, Ramsthaler, Frank, Reil, Jan-Christian, Schmidt, Peter H., and Sequeira, Vasco
- Subjects
HYPERTROPHIC cardiomyopathy ,SEARCH algorithms ,GENETIC disorders ,RESEARCH personnel ,DATABASE searching - Abstract
Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy. It is often caused by mutations of genes encoding for sarcomeric or sarcomere-associated proteins. Despite its clinical importance, divergent definitions are published by major cardiology societies. Some regard HCM as a specific genetic disease, whereas others define it as a broad 'spectrum of the thick heart'. The present narrative review aimed to assess both definitions from a pathoanatomical perspective. As a conjoint interdisciplinary and translational approach is needed to further increase knowledge and improve the understanding of HCM, the PubMed database was searched using several advanced search algorithms to explore the perspectives of the (forensic) pathologist, clinician, and basic researcher regarding the difference between the definitions of HCM. This discrepancy between definitions can impact critical data, such as prevalence and mortality rate, and complicate the understanding of the disease. For example, due to the different definitions, research findings regarding molecular changes from studies applying the narrow definition cannot be simply extended to the 'spectrum' of HCM. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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22. A gestão urbana a partir do institucionalismo técnico.
- Author
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Maior de Oliveira, Tatiana Souto, Slugek da Silveira, Rafael, Quintana Sequeira, Donald Francisco, da Rocha, Leonel, Derosso Chu, Geane, Vitor Torquato, João, and Alcides Rezende, Denis
- Abstract
Copyright of GeSec: Revista de Gestao e Secretariado is the property of Sindicato das Secretarias e Secretarios do Estado de Sao Paulo (SINSESP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
23. Existing and Evolving Therapies for Arteriovenous Fistula and Graft Dysfunction.
- Author
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Vachharajani, Tushar J, Bhargava, Vinant, Sequeira, Adrian, and Meena, Priti
- Abstract
A functional vascular access (VA) is of paramount importance to patients on hemodialysis therapy. While arteriovenous fistula (AVF) remains the preferred VA, their long-term patency is unpredictable. A dysfunctional VA contributes to a high morbidity rate, an increased susceptibility to major adverse cardiovascular events, recurrent hospitalization, and a poor quality of life. The recent innovations in devices and technologies have significantly expanded our options to create and prolong VA patency. Endovascular devices such as WavelinQ and Ellipsys are recent additions to creating a VA. The endovascular creation of AVF helps reduce the wait time and potentially avoids or reduces the duration of catheter use. The bioengineered graft and immediate access arteriovenous graft offer reasonable alternatives in a select group of patients. There is growing evidence that covered stents and drug-coated balloons offer options to prolong the VA patency. Finally, the role of stem cell therapy in VA is currently being explored. This article presents a comprehensive review of the conventional and current developments in the management of a dysfunctional VA. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
24. Genotypic spectrum of albinism in Mali.
- Author
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Diallo, Modibo, Sylla, Ousmane, Sidibé, Mohamed Kole, Plaisant, Claudio, Mercier, Elina, Sequeira, Angèle, Javerzat, Sophie, Hadid, Abdelaziz, Lasseaux, Eulalie, Michaud, Vincent, and Arveiler, Benoit
- Subjects
MOLECULAR genetics ,ALBINISM ,VISUAL acuity ,GENOTYPES ,WESTERN countries - Abstract
Albinism is a phenotypically and genetically heterogeneous condition characterized by a variable degree of hypopigmentation and by ocular features leading to reduced visual acuity. Whereas numerous genotypic studies have been conducted throughout the world, very little is known about the genotypic spectrum of albinism in Africa and especially in sub‐Saharan Western Africa. Here we report the analysis of all known albinism genes in a series a 23 patients originating from Mali. Four were diagnosed with OCA 1 (oculocutaneous albinism type 1), 17 with OCA 2, and two with OCA 4. OCA2 variant NM_000275.3:c.819_822delinsGGTC was most frequently encountered. Four novel variants were identified (two in TYR, two in OCA2). A deep intronic variant was found to alter splicing of the OCA2 RNA by inclusion of a pseudo exon. Of note, the OCA2 exon 7 deletion commonly found in eastern, central, and southern Africa was absent from this series. African patients with OCA 1 and OCA 4 had only been reported twice and once, respectively, in previous publications. This study constitutes the first report of the genotypic spectrum of albinism in a western sub‐Saharan country. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
25. Nanophysics Is Boosting Nanotechnology for Clean Renewable Energy.
- Author
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Lobo, Rui F. M. and Sequeira, César A. C.
- Subjects
GREEN fuels ,GREENHOUSE gases ,CLEAN energy ,RENEWABLE energy sources ,LASER plasmas - Abstract
As nanophysics constitutes the scientific core of nanotechnology, it has a decisive potential for advancing clean renewable energy applications. Starting with a brief foray into the realms of nanophysics' potential, this review manuscript is expected to contribute to understanding why and how this science's eruption is leading to nanotechnological innovations impacting the clean renewable energy economy. Many environmentally friendly energy sources are considered clean since they produce minimal pollution and greenhouse gas emissions; however, not all are renewable. This manuscript focuses on experimental achievements where nanophysics helps reduce the operating costs of clean renewable energy by improving efficiency indicators, thereby ensuring energy sustainability. Improving material properties at the nanoscale, increasing the active surface areas of reactants, achieving precise control of the physical properties of nano-objects, and using advanced nanoscale characterization techniques are the subject of this in-depth analysis. This will allow the reader to understand how nanomaterials can be engineered with specific applications in clean energy technologies. A special emphasis is placed on the role of such signs of progress in hydrogen production and clean storage methods, as green hydrogen technologies are unavoidable in the current panorama of energy sustainability. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
26. Hepatocellular Adenoma: A Life-Threatening Presentation of a Rare Liver Tumor – Case Report and Literature Review.
- Author
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Ramos Lopes, Sara, Santos, Inês Costa, Teixeira, Madalena, Sequeira, Cristiana, Carvalho, Ana Maria, and Gamito, Élia
- Published
- 2024
- Full Text
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27. An Advanced Knee Simulator Model Can Reproducibly Be Used for Ligament Balancing Training during Total Knee Arthroplasty.
- Author
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Logan, Scott, Sequeira, Sean B., Jerabek, Seth A., Malkani, Arthur L., Mahoney, Ormond M., Crutcher, James P., Mont, Michael A., and Faizan, Ahmad
- Published
- 2024
- Full Text
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28. The Electrooxidation of Synthetic Bipyridyl Herbicide Wastewaters with Boron-Doped Diamond Electrodes: A Technical and Economic Study to Boost Their Application for Pollution Prevention in the Agricultural Sector.
- Author
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Teutli-Sequeira, Elia Alejandra, Vasquez-Medrano, Ruben, Prato-Garcia, Dorian, and Ibanez, Jorge G.
- Subjects
AGRICULTURAL pollution ,ELECTRIC batteries ,ELECTRIC power distribution grids ,CARBON emissions ,RENEWABLE natural resources - Abstract
Boron-doped diamond electrodes (BDDEs) offer a highly efficient pathway to mineralize recalcitrant compounds due to their reduced energy requirements, fewer chemical inputs, and mechanical stability. In this work, the electrochemical degradation of paraquat (PQ) and diquat (DQ) was studied using an undivided cell (Condiacell
® -type) at circumneutral pH, and under galvanostatic control. The roles of applied current density, volumetric flow rate, and herbicide concentration were systematically studied through a central composite design (CCD) using a closed-flow reaction setup. Under the best operating conditions (i.e., for PQ: 1.6 mA/cm2 , 80 mL/min, and 70 mL/min, and 70 mg/L; and for DQ: 1.5 mA/cm2 , 80 mL/min, and 73 mg/L), a spectrophotometric analysis evidenced that the herbicides were satisfactorily removed (ca. 100%) while mineralization degrees were above 90%. Furthermore, the produced effluents yielded significant increases in seed germination and root length, which suggest a reduction in toxicity. Energy consumptions of 0.13 and 0.18 kWh/g of TOC are reported with the electrochemical cells for the PQ and DQ treatments, respectively. The PQ and DQ treatments by electrooxidation are estimated to emit nearly 2.7 and 38.9 kg CO2 /m3 of water treated, with a cost around USD 250/m3 . Carbon emissions could be greatly decreased for PQ (0.28 kg CO2 /m3 ) and DQ (0.40 kg CO2 /m3 ) if electricity were generated from renewable resources. Although this study suggests that the use of BDDE can be considered as a green alternative for agrochemical removal due to lower carbon emissions, the environmental profile of the process is determined by the degree of renewability of the electrical grid of each country or region. [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
29. Leaflet morphometric variation of Elatostema integrifolium, an Anoa forage plant, in Abdul Latief Forest Park, South Sulawesi, Indonesia.
- Author
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AZIZ, ISNA RASDIANAH, MUSPA, ADE, MUTHIADIN, CUT, HAJRAH, ARMITA, DEVI, MASRIANY, ZULKARNAIN, AMRULLAH, SYARIF HIDAYAT, RUSTAM, ASWAR, DIRHAMZAH, MUSTAMI, MUHAMMAD KHALIFAH, SUPARDAN, DADAN, and SEGURA-SEQUEIRA, DAVID
- Published
- 2024
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30. Quantification of Sarcoplasmic Reticulum Ca2+ Release in Primary Ventricular Cardiomyocytes.
- Author
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Afsar, Md Nure Alam, Akter, Mahmuda, Ko, Christopher Y., Sequeira, Vasco, Olgar, Yusuf, and Johnson, Christopher N.
- Published
- 2024
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31. QUALITY OF LIFE AND AGING IN PLACE IN RURAL AREAS: WHAT COMMUNITY SOCIAL SUPPORT SYSTEMS?
- Author
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Gonçalves, Hermínia and Sequeira, Teresa
- Subjects
OLDER people ,SOCIAL networks ,SYMBOLIC interactionism ,QUALITY of life ,SOCIAL services - Abstract
Copyright of Environmental & Social Management Journal / Revista de Gestão Social e Ambiental is the property of Environmental & Social Management Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
32. WELL-BEING AND GOVERNANCE: PERSPECTIVES AND CHALLENGES.
- Author
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Pereira, Cristina, Gonçalves, Herminia, and Sequeira, Teresa
- Subjects
COMMUNITY involvement ,WELL-being ,CITIZENS ,GOVERNMENT policy ,TRUST - Abstract
Copyright of Environmental & Social Management Journal / Revista de Gestão Social e Ambiental is the property of Environmental & Social Management Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
33. The Use of Vegetation Fire in Portugal: Historical Legislative and Normative Analysis.
- Author
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DE OLIVEIRA, E., SEQUEIRA, A.C., FERNANDES, P.M., and COLAÇO, M.C.
- Subjects
OPEN access publishing ,LAND tenure ,TWENTY-first century ,LAND use ,DEFORESTATION - Abstract
Fire has been a widely used tool in habitat and landscape management, mainly associated with land use dynamics of deforestation, pasture renewal, hunting and reclaiming new agriculture and rangeland areas. Ancient societies followed norms and rules regarding the used of fire. However, as these societies developed and land ownership changed, the conflicts generated by using fire triggered the need to regulate this practice by establishing the first laws. Such laws became of a broader type and narrower application over time until the twenty-first century. This research hypothesises that imposing constraints and regulations on using agro-silvopastoral fire through legislation in Portugal did not discourage its traditional use by communities. Through the historical legislative reconstruction of fire uses from before Portugal's Foundation until 2021, it was possible to confirm the hypothesis and conclude that a paradigm change is needed by means of setting up an adequate legal framework for the different uses of fire in the land. This article was published open access under a CC BY licence: . [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
34. Learn to be happy—an experimental study in clinical context with depressive patients in Germany.
- Author
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Sequeira-Nazaré, Elena Renée and Schmitz, Bernhard
- Subjects
POSITIVE psychology ,LIFE satisfaction ,PSYCHOTHERAPY ,DEPRESSED persons ,MENTAL depression ,LIFE skills - Abstract
The increase in the number of people with mental disorders and the relapse rate of depressive patients give reason to constantly question and further develop psychotherapeutic interventions in order to stabilize therapy effects. Studies show that the art of living, described as the ability to lead a conscious and reflective life, can be learned and trained. The question arises as to what role the development of “art of living skills” have played in the treatment of depressed patients to date, and to what extent the targeted promotion of art of living within the framework of the therapy of depressed patients has an effect on the well-being and the level of depression that goes beyond this. The study is based on a mixed design. Study participants in the first experimental group (EG1, n = 53) each received one session of 50 min psychotherapy per week for 4 weeks. The second experimental group (EG2, n = 54) received psychotherapy equivalent to EG1 with additional life-skills reflection questions, which were to be answered every day and recorded in a diary. The control group (n = 53) received neither therapy nor reflection questions. The art of living, degree of depression, and satisfaction with life were assessed before and after the 4-week therapy and in the follow-up after 3 months, and the effects were compared. There was a significant decrease in the depression score over the 4 weeks in both therapy groups. EG2 showed a greater decrease in depression over the 4 weeks. However, the difference did not persist over the 3 months. Furthermore, in EG2 there was a significant increase in the Art of Living, Satisfaction with life, and Flourishing Scale over the 4 weeks, while in EG1 there was no change. However, the comparison in the follow-up after 3 months also shows that these effects could not stabilize. Overall, the results provide promising indications for integrating the art of living as a concept more strongly into the therapy of depressive patients. The question arises as to what long-term effects result from additional life skills stimulation and how the therapy effects gained can be stabilized over a longer period of time. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. The Passing-on Problem in Damages and Restitution under EU Law.
- Author
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Sequeira, Benedita
- Subjects
LAW enforcement ,DAMAGES (Law) ,LAW reviews ,EUROPEAN law ,ANTITRUST law ,CIVIL restitution - Abstract
The article "The Passing-on Problem in Damages and Restitution under EU Law" published in the Market & Competition Law Review discusses the passing-on phenomenon in EU law, where harm or loss incurred by a commercial undertaking is passed on to customers in the supply chain. The article explores legal issues related to locus standi, causal links, and estimating damages in passing-on situations. It provides a comprehensive roadmap to address legal hurdles and offers insights into actions against the EU, Member States, and private entities for breaches of EU law. The article is structured into five parts, each discussing passing-on problems in different contexts, such as actions against the EU, Member States, and private entities for competition law infringements. The article concludes with perspectives and suggestions for consistent approaches to the passing-on problem in the EU, making it a valuable resource for practitioners, legislators, and policymakers in the field of competition law enforcement. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
36. Buprenorphine/naloxone micro-induction in a tertiary care hospital: a retrospective cohort analysis.
- Author
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Nunn, Robert, Sylvestre, Anne, Sequeira, Kelly, and Tanzini, Rosa Maria
- Subjects
SUBSTANCE abuse ,COMBINATION drug therapy ,PATIENT compliance ,TERTIARY care ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,LONGITUDINAL method ,OPIOID analgesics ,MEDICAL records ,ACQUISITION of data ,NALOXONE ,DRUGS ,BUPRENORPHINE ,PATIENTS' attitudes - Abstract
Objectives: To describe the use of buprenorphine/naloxone micro-inductions in hospitalized patients and characterize the success rate of these inductions. Methods: We conducted a retrospective chart review of hospitalized patients receiving a buprenorphine/naloxone micro-induction for opioid use disorder in a tertiary care hospital from Jan 2020–Dec 2020. The primary outcome was a description of the micro-induction prescribing patterns used. The secondary outcomes were a description of the demographic characteristics of patients, the estimated frequency of withdrawal symptoms experienced by patients undergoing a micro-induction, and the overall success rate of the micro-inductions defined as retention on buprenorphine/naloxone therapy with no precipitated withdrawal experienced. Results: Thirty-three patients were included in the analysis. Three main micro-induction regimens were identified, including rapid micro-inductions (8 patients), 0.5 mg SL BID initiations (6 patients), and 0.5 mg SL daily initiations (19 patients). Twenty-four patients (73%) met the criteria for a successful micro-induction, defined as being retained in buprenorphine/naloxone therapy with no precipitated withdrawal experienced. The most common reason for micro-induction failure was patient request to discontinue buprenorphine/naloxone therapy due to perceived adverse effects or personal preference. Conclusion: Buprenorphine/naloxone micro-induction in hospitalized patients resulted in a majority of patients being successfully initiated on buprenorphine/naloxone therapy without requiring opioid abstinence prior to induction. Dosing regimens were variable, and the ideal regimen remains unclear. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. Clinical pharmacology in adolescent transgender medicine.
- Author
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Cirrincione, Lauren R., Huang, Kai J., and Sequeira, Gina M.
- Subjects
TRANSGENDER youth ,TRANSGENDER people ,BODY composition ,TRANS men ,DRUG absorption ,PUBERTY - Abstract
Adolescent transgender medicine is a growing clinical field. Gender‐affirming medications for transgender youth may include gonadotropin‐releasing hormone (GnRH) agonists, gender‐affirming hormones or both. To evaluate the potential effects of GnRH agonists (puberty suppression) on pharmacokinetic processes for transgender youth, we searched PubMed from inception to May 2024 for publications on the effects of GnRH agonists on drug absorption, distribution, metabolism or excretion for transgender adolescents or effects on hormones (including gonadotropins, adrenal androgens, sex steroids) that are associated with changes in drug metabolism during puberty in the general adolescent population. No publications discussed the effects of GnRH agonist treatment on pharmacokinetic processes for adolescent transgender people. Sixteen publications observed marked decreases in gonadotropins and sex steroids for both adolescent transgender men and adolescent transgender women and slight effects on adrenal androgens. During GnRH agonist treatment, changes in body composition and body shape were greater for adolescent transgender people than for cisgender adolescent people. Further research is needed to better understand the effects of GnRH agonists on drug metabolism and other pharmacokinetic processes for transgender adolescents receiving GnRH agonists and other gender‐affirming medications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
38. Myonuclear position and blood vessel organization during skeletal muscle postnatal development.
- Author
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Sequeira, Catarina, Martha Wackerbarth, Lou, Pena, Andreia, Sá-Pereira, Mafalda, Franco, Cláudio A., and Gomes, Edgar R.
- Subjects
MUSCLE growth ,BLOOD vessels ,PUERPERIUM ,MICE ,ADULTS - Abstract
Skeletal muscle development is a complex process involving myoblast fusion to generate multinucleated fibers. Myonuclei first align in the center of the myotubes before migrating to the periphery of the myofiber. Blood vessels (BVs) are important contributors to the correct development of skeletal muscle, and myonuclei are found next to BVs in adult muscle. Here, we show that most myonuclear migration to the periphery occurs between embryonic day 17.5 and postnatal day 1 in mouse. Furthermore, myonuclear accretion after postnatal day 7 does not result in centrally nucleated myofibers as observed in the embryo. Instead, myonuclei remain at the periphery of the myofiber without moving to the center. Finally, we show that hypovascularization of skeletal muscle alters the interaction between myonuclei and BVs, suggesting that BVs may contribute to myonuclear positioning during skeletal muscle postnatal development. Overall, this work provides a comprehensive analysis of skeletal muscle development during the highly dynamic postnatal period, bringing new insights about myonuclear positioning and its interaction with BVs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. NÓTULA A RESPEITO DO DIREITO APLICÁVEL AO CONTRATO DE SUPRIMENTO.
- Author
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Sequeira Dinis, David and Bertolo Rosa, Luís
- Subjects
LEGAL opinions ,CONFLICT of laws ,INTERNATIONAL law ,JUDGE-made law ,STOCKHOLDERS - Abstract
Copyright of Actualidad Jurídica (1578-956X) is the property of Dykinson SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
40. Effective doses of scout projections in maxillofacial cone beam computed tomography.
- Author
-
Barros-Costa, Matheus, Britten, Jack, Jones, Colin, Ramage, Amanda, Cascante-Sequeira, Deivi, Blackburn, Megan, Swanson, Christine, Santaella, Gustavo Machado, Scarfe, William, and Oliveira-Santos, Christiano
- Abstract
Objectives: To assess the effective and organ/tissue equivalent radiation doses of different scout projection protocols in four CBCT units. Methods: Optically stimulated luminescence dosimeters (OSLD) were placed in reference anatomical locations in the head and neck segments of an anthropomorphic phantom representing an average adult male. Ten repeated exposures were obtained from each of the twelve scout projections studied, acquired from four maxillofacial cone beam computed tomography (CBCT) units (Midmark EIOS, 3D Accuitomo F170, Veraviewepocs 3D R100, and Veraview X800). The effective and organ/tissue equivalent doses were calculated for each protocol. Results: Effective doses ranged from 0.7 µSv (Accuitomo F170 60 × 60 mm—anterior maxilla) to 6.9 µSv (Midmark 50 × 50 mm—anterior maxilla). The highest organ/tissue equivalent doses were recorded for the oral mucosa and salivary glands; however, the thyroid was the highest contributor to the effective dose, followed by the salivary glands. Conclusions: Despite some variability among CBCT machines and protocols, the acquisition of scout projections is a low-dose procedure. The use of scout projections to ensure an adequate position of the region of interest within the field of view is highly desirable as they contribute minimally to overall CBCT patient dose. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Clasificación avanzada de la artrosis de rodilla utilizando tecnologías de Inteligencia Artificial.
- Author
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Segura, Facundo, Segura, Florencio P., Lucero Zudaire, María Paz, Segura, Florencio V., Mendía, Rocío, Ribotta Falco, Lucía, Zalazar, Paula S., and Sequeira, Daniel E.
- Published
- 2024
- Full Text
- View/download PDF
42. The Dilemmas and Opportunities of Co‐Creating Health Interventions to Fit Local Contexts: An Ethnographic Study on the Adaptation of Clinical Guidelines in Tanzania.
- Author
-
Osaki, Haika, Skovdal, Morten, Sørensen, Jane Brandt, Maaløe, Nanna, Housseine, Natasha, Dmello, Brenda Sequeira, and Mbekenga, Columba
- Subjects
MEDICAL protocols ,MATERNAL health services ,ETHNOLOGY research ,CONSUMER attitudes ,INTERVIEWING ,ETHNOLOGY ,JUDGMENT sampling ,DESCRIPTIVE statistics ,INTRAPARTUM care ,THEMATIC analysis ,PROFESSIONS ,ACTION research ,CONCEPTUAL structures ,ADULT education workshops ,STAKEHOLDER analysis ,PATIENTS' attitudes - Abstract
Introduction: Healthcare providers' role in co‐creating health interventions and implementation strategies has evolved significantly, and yet, there is little documentation of this from low‐resource settings. This study aims to share the dilemmas of engaging healthcare providers in co‐creating locally adapted clinical guidelines for maternity facilities in Dar es Salaam, Tanzania, and strategies used to address them. Methods: An ethnographic study explored the co‐creation of locally adapted clinical guidelines for childbirth care within five maternity facilities in Dar es Salaam. Participant observations were conducted during 11 co‐creation workshops. Six in‐depth interviews explored participant experiences. Data were analyzed using Attride‐Stirling's thematic network analysis framework. Results: The analysis revealed four themes representing dilemmas in the co‐creation process and strategies to improve co‐creation: (i) navigating diverse contexts: adapting a single set of guidelines to various, diverse facilities was challenging; this was addressed through engaging in dialogue and flexibility while adjusting care practices. (ii) Competing knowledge systems and sources: differing knowledge sources between researchers and healthcare providers challenged discussions on recommended practices. However, validating scientific recommendations with practical care experience in this context helped bridge this gap. (iii) Fostering meaningful participation: participation was time‐consuming for some. However, early stakeholder engagement and facility‐led participant selection facilitated the meaningful involvement of healthcare providers. (iv) Power imbalances: power dynamics influenced the co‐creation process; involving stakeholders in planning and co‐facilitating workshops helped mitigate these imbalances and encourage more equal participation. Conclusion: Navigating contextual variation, differences in knowledge systems, meaningful participation and power dynamics were key challenges in the co‐creation process. However, reflexivity, open and honest dialogue with stakeholders and early engagement enhanced the co‐creation process. Co‐creating locally adapted clinical guidelines with frontline healthcare workers and scientific experts is essential for feasibility and safety. Further research is needed to explore context specificity, decision‐making and the efficacy of co‐creation in low‐resource settings. Patient or Public Contribution: Healthcare providers and health managers from five maternity facilities who participated in the co‐creation process were actively involved in this study by providing their consent to be interviewed about their experiences of participation. Clinical Trial Registration: This study is a substudy within the PartoMa project. PartoMa is a registered clinical trial with the trial registration number NCT04685668. PartoMa's date of initial trial registration is 28 December 2020. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
43. Can local organizations act as middle actors in energy support? Exploring their functions, motivations, challenges, and needs.
- Author
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Sequeira, Miguel Macias, Gouveia, João Pedro, and Joanaz de Melo, João
- Abstract
Energy efficiency is vital for energy transitions, and energy-poor, vulnerable, and hard-to-reach groups are at risk of being left behind. In this context, local middle actors have been suggested as partners in deploying targeted energy support. Nevertheless, scarce research has engaged with them to assess if they are willing and capable of contributing, if they can reach households, and if they have unmet needs. In this research, we draw on the mapping of 198 local organizations and 34 semi-structured interviews conducted after deploying a pilot energy support service in Setúbal, Portugal. Interviews characterized the organizations and target audiences, assessed energy literacy, explored potential collaborative roles, and recognized drivers, barriers, and solutions. Results show that most organizations are willing to disseminate activities, forward citizens, facilitate contacts, co-organize events, and participate in training. Half can identify vulnerable families for proactive support. Drivers include environmental concerns, community participation, and social support. However, few seem able to conduct energy support, hire/redirect staff, or participate in coordination. Scarce human resources, lack of time, other priorities, and financing concerns severely constrain local organizations. This case study finds some potential for local organizations to act as intermediaries in energy support, building on their communication channels and trusted relationships to fulfill specific roles. However, they are often hard-to-reach themselves and burdened with demanding activities. Thus, we suggest that fostering collaborations with local organizations is challenging but possible. It requires dedicated funding, time, and resources to empower, capacitate, and reward middle actors for their contributions in delivering energy support. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
44. MOSCA 2.0: A bioinformatics framework for metagenomics, metatranscriptomics and metaproteomics data analysis and visualization.
- Author
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Sequeira, João C., Pereira, Vítor, Alves, M. Madalena, Pereira, M. Alcina, Rocha, Miguel, and Salvador, Andreia F.
- Subjects
DATA visualization ,PROTEIN expression ,MASS spectrometry ,MICROBIAL communities ,FUNCTIONAL analysis - Abstract
The analysis of meta‐omics data requires the utilization of several bioinformatics tools and proficiency in informatics. The integration of multiple meta‐omics data is even more challenging, and the outputs of existing bioinformatics solutions are not always easy to interpret. Here, we present a meta‐omics bioinformatics pipeline, Meta‐Omics Software for Community Analysis (MOSCA), which aims to overcome these limitations. MOSCA was initially developed for analysing metagenomics (MG) and metatranscriptomics (MT) data. Now, it also performs MG and metaproteomics (MP) integrated analysis, and MG/MT analysis was upgraded with an additional iterative binning step, metabolic pathways mapping, and several improvements regarding functional annotation and data visualization. MOSCA handles raw sequencing data and mass spectra and performs pre‐processing, assembly, annotation, binning and differential gene/protein expression analysis. MOSCA shows taxonomic and functional analysis in large tables, performs metabolic pathways mapping, generates Krona plots and shows gene/protein expression results in heatmaps, improving omics data visualization. MOSCA is easily run from a single command while also providing a web interface (MOSGUITO). Relevant features include an extensive set of customization options, allowing tailored analyses to suit specific research objectives, and the ability to restart the pipeline from intermediary checkpoints using alternative configurations. Two case studies showcased MOSCA results, giving a complete view of the anaerobic microbial communities from anaerobic digesters and insights on the role of specific microorganisms. MOSCA represents a pivotal advancement in meta‐omics research, offering an intuitive, comprehensive, and versatile solution for researchers seeking to unravel the intricate tapestry of microbial communities. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
45. HPV and Lung Cancer: A Systematic Review.
- Author
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Sequeira, Telma, Pinto, Rui, Cardoso, Carlos, Almeida, Catarina, Aragão, Rita, Almodovar, Teresa, Bicho, Manuel, Bicho, Maria Clara, and Bárbara, Cristina
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PAPILLOMAVIRUS disease diagnosis ,PAPILLOMAVIRUS diseases ,SQUAMOUS cell carcinoma ,MEDICAL information storage & retrieval systems ,ADENOCARCINOMA ,RESEARCH funding ,SYSTEMATIC reviews ,MEDLINE ,LUNG tumors ,ONLINE information services ,COMPARATIVE studies ,LUNG cancer - Abstract
Simple Summary: Lung cancer remains a significant global health challenge with high incidence and mortality rates worldwide. In recent years, there has been a growing recognition of the role of Human Papillomavirus (HPV) in lung cancer development. This systematic review aims to explore the diagnostic criteria, epidemiology, etiology, and prognosis of HPV infection in lung cancer. A total of 97 studies encompassing 9098 patients worldwide, revealing varied HPV infection rates in lung cancer, ranging from 0% to 69%, were analyzed. While HPV16/18 was predominant in some regions, its association with lung cancer remained inconclusive due to conflicting findings. Some studies suggested a limited role of HPV in lung carcinogenesis, particularly in non-smokers. Despite inconclusive evidence, intriguing associations between HPV and lung adenocarcinoma and squamous cell carcinoma have emerged. Further research with standardized methodologies and larger cohorts is needed for clarity. This systematic review aims to explore the diagnostic criteria, epidemiology, etiology, and prognosis of Human Papillomavirus (HPV) infection in lung cancer. This PRISMA-guided review searched the PubMed
® and EmbaseTM databases for "lung cancer AND HPV" on 10 June 2023, filtering human subject papers. A total of 97 studies encompassing 9098 patients worldwide, revealing varied HPV infection rates in lung cancer, ranging from 0% to 69%, were analyzed. While HPV16/18 was predominant in some regions, its association with lung cancer remained inconclusive due to conflicting findings. Studies from Asia reported lower HPV infection rates compared to Western populations. Some studies suggested a limited role of HPV in lung carcinogenesis, particularly in non-smokers. However, intriguing associations were noted, including HPV's potential role in lung adenocarcinoma and squamous cell carcinoma. Discrepancies in HPV detection methods and sample sources highlight the need for further research with standardized methodologies to elucidate HPV's role in lung carcinogenesis and its clinical implications. Overall, this systematic review offers insights into HPV's role in lung cancer epidemiology and clinical characteristics. Despite inconclusive evidence, intriguing associations between HPV and lung adenocarcinoma and squamous cell carcinoma have emerged. Further research with standardized methodologies and larger cohorts is needed for clarity. [ABSTRACT FROM AUTHOR]- Published
- 2024
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46. Effects of low dose computed tomography (LDCT) on lung cancer screening on incidence and mortality in regions with high tuberculosis prevalence: A systematic review.
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Pires, Debora Castanheira, Arueira Chaves, Luisa, Dantas Cardoso, Carlos Henrique, Faria, Lara Vinhal, Rodrigues Campos, Silvio, Sobreira da Silva, Mario Jorge, Sequeira Valerio, Tayna, Rodrigues Campos, Mônica, and Emmerick, Isabel Cristina Martins
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DATA libraries ,COMPUTED tomography ,LUNG cancer ,EARLY detection of cancer ,TUBERCULOSIS - Abstract
Background: Lung cancer screening (LCS) using low-dose computed tomography (LDCT) is a strategy for early-stage diagnosis. The implementation of LDCT screening in countries with a high prevalence/incidence of tuberculosis (TB) is controversial. This systematic review and meta-analysis aim to identify whether LCS using LDCT increases early-stage diagnosis and decreases mortality, as well as the false-positive rate, in regions with a high prevalence of TB. Methods/Design: Studies were identified by searching BVS, PUBMED, EMBASE, and SCOPUS. RCT and cohort studies (CS) that show the effects of LDCT in LC screening on mortality and secondary outcomes were eligible. Two independent reviewers evaluated eligibility and a third judged disagreements. We used the Systematic Review Data Repository (SRDR+) to extract the metadata and record decisions. The analyses were stratified by study design and incidence of TB. We used the Cochrane "Risk of bias" assessment tool. Results: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) were used. Thirty-seven papers were included, referring to 22 studies (10 RCTs and 12 cohorts). Few studies were from regions with a high incidence of TB (One RCT and four cohorts). Nonetheless, the evidence is compatible with European and USA studies. RCTs and CS also had consistent results. There is an increase in early-stage (I-II) diagnoses and reduced LC mortality in the LCDT arm compared to the control. Although false-positive rates varied, they stayed within the 20 to 30% range. Discussion: This is the first meta-analysis of LDCT for LCS focused on its benefits in regions with an increased incidence/prevalence of TB. Although the specificity of Lung-RADS was higher in participants without TB sequelae than in those with TB sequelae, our findings point out that the difference does not invalidate implementing LDCT LCS in these regions. Trial registration: Systematic review registration Systematic review registration PROSPERO CRD42022309581. [ABSTRACT FROM AUTHOR]
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- 2024
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47. Struggling with fish age, a comparison of otolith preparation techniques to unravel age and growth of boarfish, Capros aper (Linnaeus, 1758).
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Silva, Maria Inês, Martins, Rui, Sequeira, Vera, Silva, Dina, Farias, Inês, Assis, Carlos A., Gordo, Leonel Serrano, and Vieira, Ana Rita
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OTOLITHS ,SIZE of fishes ,FISH growth ,ESTIMATION theory ,AGE ,LIFE history theory - Abstract
Fish age and growth data are crucial for understanding vital species' traits and their populations. Boarfish is a pelagic species widely distributed in the Northeast Atlantic that is one of the most discarded non-commercial species on the Portuguese coast. Due to its potential valorisation as a new fishery in the Northeast Atlantic, boarfish has become object of interest in several published studies. However, since no age standard protocol has been implemented for boarfish, studies have used a variety of different otolith preparation techniques to estimate age, leading to contradicting and discrepant results. This research aims to consolidate biological insights into boarfish age and growth, lay the foundation for a standardized ageing protocol and serve as a benchmark study for the Portuguese west coast before commercial exploitation. Through the comparison of two otolith ageing methodologies, this study recommends using whole otoliths as the best method, revealing a maximum age of 15 years. The growth pattern estimated, indicated a biphasic growth pattern, with a faster initial growth rate that slows down at 2.4 years, the moment of change, when energy is allocated for sexual maturation. This finding was corroborated by a maturity ogive and analysis of fish size and otolith length relationship. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Unsuspected consequences of synonymous and missense variants in OCA2 can be detected in blood cell RNA samples of patients with albinism.
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Michaud, Vincent, Sequeira, Angèle, Mercier, Elina, Lasseaux, Eulalie, Plaisant, Claudio, Hadj‐Rabia, Smail, Whalen, Sandra, Bonneau, Dominique, Dieux‐Coeslier, Anne, Morice‐Picard, Fanny, Coursimault, Juliette, Arveiler, Benoît, and Javerzat, Sophie
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RNA analysis ,MISSENSE mutation ,GENETIC counseling ,CELL analysis ,GENETIC transcription - Abstract
Oculocutaneous albinism type 2 (OCA2) is the second most frequent form of albinism and represents about 30% of OCA worldwide. As with all types of OCA, patients present with hypopigmentation of hair and skin, as well as severe visual abnormalities. We focused on a subgroup of 29 patients for whom genetic diagnosis was pending because at least one of their identified variants in or around exon 10 of OCA2 is of uncertain significance (VUS). By minigene assay, we investigated the effect of these VUS on exon 10 skipping and showed that not only intronic but also some synonymous variants can result in enhanced exon skipping. We further found that excessive skipping of exon 10 could be detected directly on blood samples of patients and of their one parent with the causal variant, avoiding invasive skin biopsies. Moreover, we show that variants, which result in lack of detectable OCA2 mRNA can be identified from blood samples as well, as shown for the most common OCA2 pathogenic missense variant c.1327G>A/p.(Val443Ile). In conclusion, blood cell RNA analysis allows testing the potential effect of any OCA2 VUS on transcription products. This should help to elucidate yet unsolved OCA2 patients and improve genetic counseling. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Text Message-Based Cessation Intervention for People Who Smoked or Used Smokeless Tobacco in India: A Feasibility Randomized Controlled Trial.
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Nadkarni, Abhijit, Gaikwad, Leena, Sequeira, Miriam, D'souza, Joseline, Lopes, Megan, Haldankar, Rajanish, Murthy, Pratima, Velleman, Richard, Bhatia, Urvita, and Naughton, Felix
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SMOKELESS tobacco ,SMOKING ,MEDICAL personnel ,RESOURCE-limited settings ,INFORMED consent (Medical law) ,NICOTINE replacement therapy - Abstract
Introduction Despite the high burden of tobacco use in India, users do not have access to adequate help. This pilot trial aimed to evaluate the feasibility and acceptability of a text messaging intervention for tobacco cessation, generate preliminary estimates of its impact, and fine-tune procedures for a definitive trial. Aims and Methods Parallel two-arm single blind individually randomized controlled pilot trial with nested qualitative study. Participants included adult current tobacco users (smoked and smokeless). Eligible and consenting participants were randomized to receive either (1) text messaging intervention (ToQuit) which covered specific content areas such as psychoeducation about consequences of tobacco use and benefits of quitting and tobacco avoidance strategies or (2) information about tobacco cessation helplines such as the helpline number and the languages in which tobacco cessation support was available (control). Feasibility data included screening and consent rates, treatment dropouts, and outcome ascertainment. The primary abstinence outcome was self-reported abstinence from tobacco in the past seven days at 3 months post-randomization. In-depth interviews were conducted with a subsample of participants primarily to collect acceptability data. The primary abstinence analysis used a chi-squared test and logistic regression (complete case), and qualitative data was analyzed using thematic analysis. Results Ninety-eight participants were randomized into the two trial arms; 77 (79%) completed outcome evaluation. No between-arm differences in abstinence were found though findings favored the intervention (7-day abstinence: ToQuit 23%, control 19%; adjusted odds ratio 1.23, 95% confidence interval 0.38, 3.97). Participants appreciated the language, comprehensibility, and relevance of the messages; and reported overall satisfaction with and positive impact from the intervention on their lives. Conclusions The findings indicate the acceptability and feasibility of ToQuit and if found effective, it could be a potentially scalable first-line response to tobacco use in low-resource settings. Implications Our pilot randomized control trial provides sufficient findings supporting the acceptability and feasibility of an intervention for tobacco cessation which is suitable for a context which has a shortage of healthcare workers and for individuals who use smoked or smokeless tobacco. This is critical on a background of limited contextually relevant interventions for a problem with a high burden in low- and middle-income countries such as India. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Epidemiology of infectious diseases in migrant populations from endemic or high‐endemic countries: A multicentric primary care‐based study in Spain.
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Cruz, Angeline, Sequeira‐Aymar, Ethel, Gonçalves, Alessandra Queiroga, Camps‐Vila, Laura, Monclús‐González, Marta M., Revuelta‐Muñoz, Elisa M., Busquet‐Solé, Núria, Sarriegui‐Domínguez, Susana, Casellas, Aina, Cuxart‐Graell, Alba, Rosa Dalmau Llorca, M., Aguilar‐Martín, Carina, and Requena‐Méndez, Ana
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MEDICAL personnel ,CHAGAS' disease ,HIV ,COMMUNICABLE diseases ,HEPATITIS B virus - Abstract
Objectives: We aimed to evaluate the epidemiology of seven infections (Chagas disease, strongyloidiasis, schistosomiasis, human immunodeficiency virus, hepatitis B and C virus, and active tuberculosis) in migrant populations attended at primary care facilities in Catalonia, Spain. Methods: This is a cross sectional study conducted from March to December 2018 at eight primary care centres in Catalonia, Spain where health professionals were recommended to systematically screen multiple infections in migrants considering the endemicity of the pathogens in their country of birth. Routine health data were retrospectively extracted from electronic health records of the primary care centres. The proportion of cases among individuals tested for each infection was estimated with its 95% confident interval (CI). Mixed‐effects logistics regression models were conducted to assess any possible association between the exposure variables and the primary outcome. Results: Out of the 15,780 migrants that attended primary care centres, 2410 individuals were tested for at least one infection. Of the 508 (21.1%) migrants diagnosed with at least one condition, a higher proportion originated from Sub‐Saharan Africa (207, 40.7%), followed by South‐East Europe (117, 23.0%) and Latin‐America (88, 17.3%; p value <0.001). The proportion of migrants diagnosed with Chagas disease was 5/122 (4.1%, 95%CI 0.5–7.7), for strongyloidiasis 56/409 (13.7%, 95%CI 10.3–17.0) and for schistosomiasis 2/101 (2.0%, 95%CI 0.0–4.7) with very few cases tested. The estimated proportion for human immunodeficiency virus was 67/1176 (5.7%, 95%CI 4.4–7.0); 377/1478 (25.5%, 95%CI 23.3–27.7) for hepatitis B virus, with 108/1478 (7.3%, 95%CI 6.0–8.6) of them presenting an active infection, while 31/1433 (2.2%, 95%CI 1.4–2.9) were diagnosed with hepatitis C virus. One case of active tuberculosis was diagnosed after testing 172 migrant patients (0.6%, 95%CI 0.0–1.7). Conclusions: We estimated a high proportion of the studied infections in migrants from endemic areas. Country‐specific estimations of the burden of infections in migrants are fundamental for the implementation of preventive interventions. [ABSTRACT FROM AUTHOR]
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- 2024
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