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Patient‐Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient‐derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear. Herein, the transcriptomic and chromatin accessibility landscapes of matched colorectal cancer (CRC) PDO, PDX, PDO‐derived PDX (PDOX), and original patient tumors (PT) are compared. Two major remodeling axes are discovered. The first axis delineates PDMC from PT, and the second axis distinguishes PDX and PDO. PDOX are more similar to PDX than PDO, indicating the growth environment is a driving force for chromatin adaptation. Transcription factors (TF) that differentially bind to open chromatins between matched PDO and PDOX are identified. Among them, KLF14 and EGR2 footprints are enriched in PDOX relative to matched PDO, and silencing of KLF14 or EGR2 promoted tumor growth. Furthermore, EPHA4, a shared downstream target gene of KLF14 and EGR2, altered tumor sensitivity to MEK inhibitor treatment. Altogether, patient‐derived CRC cells undergo both common and distinct chromatin remodeling in PDO and PDX/PDOX, driven largely by their respective microenvironments, which results in differences in growth and drug sensitivity and needs to be taken into consideration when interpreting their ability to predict clinical outcome. [ABSTRACT FROM AUTHOR]

This chapter describes two case studies that highlight how courses can be taught simultaneously in classrooms across partnering university campuses using the effective, evidence‐based team‐based learning (TBL) method. The objective is to assist faculty in effectively using TBL in a synchronous virtual collaborative space. [ABSTRACT FROM AUTHOR]

Discusses the elements and issues that have developed around emotional intelligence. Definition of emotional intelligence; Components of an individual's success at work; Leadership competencies; Information on how to introduce the concept of emotional intelligence in an organization.

Details how a human resource (HR) profiling process was utilized to evaluate National Basketball Association (NBA) and Women's NBA player draft choices, coaches and front-office staff. Description of the tools used during the assessment and evaluation part of the project; Development of an HR information system which measures the efforts of all key HR processes; Significance of organizational culture to the success of the teams.