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A variety of novel 3-propyl-2-substitutedamino-quinazolin-4(3 H)-ones were synthesized by reacting the amino group of 2-hydrazino-3-propyl quinazolin-4(3 H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-propyl quinazolin-4(3 H)-one was synthesized from propylamine. The title compounds were investigated for analgesic and anti-inflammatory activities. The compound 2-(1-ethylpropylidene-hydrazino)-3-propyl-quinazolin-4(3 H)-one ( SR2) emerged as the most active compound of the series, and it is more potent in its analgesic and anti-inflammatory activities when compared with the reference standard diclofenac sodium. [ABSTRACT FROM AUTHOR]

Effects of topical administration of ethanolic extract of Malvastrum Tricuspidatum ointment was studied respectively on two types of wound models in wistar rats, (i) the incision and (ii) the dead space wound model. The ointment of the ethanolic extract of Malvastrum Tricuspidatum produced significant response in both of the wound types tested. In the incision model the extract treated wounds were found to epithelialise faster and the rate of wound contraction was higher, as compared to control wounds. The extract facilitates the healing process as evidenced by increase in the tensile strength in the incision model. [ABSTRACT FROM AUTHOR]

Telmisartan is a Anti-hypertensive drugs which is insoluble in water, hence the drug may be slowly or incompletely dissolves in the gastro-intestinal tract. So the rate of dissolution and therefore its bioavailability is less (bioavailability 42%). In the present study an attempt has been made to prepare Fast Dissolving tablets of Telmisartan by using Superdisintegrants- Cross carmellose sodium, Microcrystalline cellulose and sodium starch glycolate, level of addition to increase the rate of drug release from dosage form to increase the dissolution rate and hence its bioavailability. The tablets were prepared by Direct Compression methods and the prepared blend and tablets were evaluated for their physicochemical properties and In-Vitro dissolution study. The evaluation studies were performed such as Weight Variation, Thickness, Hardness, Disintegrating Time, Wetting Time, and In-Vitro Drug Release. The Disintegration time of Fast Dissolving tablets were increased by the addition of concentration of Superdisintegrants [ABSTRACT FROM AUTHOR]

A new series of 3-(3-ethylphenyl)-2-substituted hydrazino-3 H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-ethylphenyl)-3 H-quinazolin-4-one with a variety of aldehydes and ketones. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index behavior. The compound 2-(N′-3-pentylidene-hydrazino)-3-(3-ethylphenyl)-3H-quinazolin-4-one ( AS2) emerged as the most active compound in exhibiting analgesic activity and the compound 2-(N′-2-pentylidene-hydrazino)-3-(3-ethylphenyl)-3 H-quinazolin-4-one ( AS3) emerged as the most active compound in exhibiting anti-inflammatory activity; and these compounds are moderately potent when compared with the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared with aspirin. [ABSTRACT FROM AUTHOR]

A variety of novel 3-(benzyl)-2-substituted amino-quinazolin-4(3 H)-ones were synthesized by reacting the amino group of 3-benzyl-2-hydrazino quinazolin-4(3 H)-one with a variety of aldehydes and ketones. The starting material, 3-benzyl-2-hydrazino quinazolin-4(3 H)-one, was synthesized from benzyl amine. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic index activities. The compound 3-benzyl-2-[ N’-(1-ethyl-propylidene)-hydrazino]-3 H-quinazolin-4-one ( AS2) emerged as the most active compound of the series and is moderately more potent in its analgesic and anti-inflammatory activities when compared to the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic potential when compared to aspirin. [ABSTRACT FROM AUTHOR]