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Climate change poses various challenges for agriculture and water management practices in Central Asia (CA). Central to these challenges are cryosphere dynamics, fragile mountain ecosystems, and ongoing natural hazards that highlight the need for robust projections of regional climate change. For the first time, dynamic downscaling was conducted in Central Asia at a spatial resolution of 5 km. This produced a regional dataset that incorporated periods between 1980 and 2000 and 2076 to 2096. Results show that dynamic downscaling significantly improves the simulation of temperature and precipitation across CA compared to General Circulation Models (GCMs) and other Regional Climate Models (RCMs) due to better representation of topography and related meteorological fields. Our analysis shows that there will be a significant warming trend in Central Asia with a projected increase of 6°C under the Shared Socioeconomic Pathway (SSP) scenario SSP5-8.5 from 2076 to 2096. Pronounced warming is detected over mountainous areas of CA from autumn to spring, which can be explained by the snow-albedo feedback. Precipitation increases are projected from winter to spring and decreases are projected from summer to autumn. [ABSTRACT FROM AUTHOR]

Background: Spinal metastasis is considered to have a worse prognosis in lung cancer than in other cancers, but recent clinical studies report improved overall survival of lung cancer. We compared the postoperative prognoses of vertebral metastatic tumors from lung with other types of cancer.Methods: From 2011 to 2015, 31 Japanese patients (mean age 73 years, range 55-88 years; 19 males, 12 females) underwent surgery for spinal metastasis at our center. We observed patients retrospectively in March 2016, dividing them into groups by cancer type: lung (LK group, n = 10); prostate, breast, or thyroid (PB group, n = 12); and other (OT group, n = 9). We compared survival and revised Tokuhashi score, which provides a basis for choosing a treatment course. Neurologic status was graded before and after surgery using the Frankel system.Results: Mean follow-up was 16.5 months (range 1-62 months). Only seven of 31 patients (22.6%) were alive at final follow-up. Frankel grade significantly improved postoperatively only in the LK (P = 0.01) and PB (P = 0.048) groups. Revised Tokuhashi score differed across groups (P < 0.0001), and was significantly lower in the LK group than in the PB group (P = 0.00) and OT group (P = 0.02). Postoperative survival was significantly shorter in the LK group than in the PB group (P = 0.01) but did not differ between the LK and OT groups.Conclusions: The revised Tokuhashi score may underestimate the survival of lung cancer patients, who may derive the same benefit from surgical intervention as those with vertebral metastasis from other cancer types. [ABSTRACT FROM AUTHOR]

Theory and empirical evidence suggest that plant-soil feedback (PSF) determines the structure of a plant community and nutrient cycling in terrestrial ecosystems. The plant community alters the nutrient pool size in soil by affecting litter decomposition processes, which in turn shapes the plant community, forming a PSF system. However, the role of microbial decomposers in PSF function is often overlooked, and it remains unclear whether decomposers reinforce or weaken litter- mediated plant control over nutrient cycling. Here, we present a theoretical model incorporating the functional diversity of both plants and microbial decomposers. Two fundamental microbial processes are included that control nutrient mineralization from plant litter: (I) assimilation of mineralized nutrient into the microbial biomass (microbial immobilization), and (ii) release of the microbial nutrients into the inorganic nutrient pool (net mineralization). With this model, we show that microbial diversity may act as a buffer that weakens plant control over the soil nutrient pool, reversing the sign of PSF from positive to negative and facilitating plant coexistence. This is explained by the decoupling of litter decomposability and nutrient pool size arising from a flexible change in the microbial community composition and decomposition processes in response to variations in plant litter decomposability. Our results suggest that the microbial community plays a central role in PSF function and the plant community structure. Furthermore, the results strongly imply that the plant-centered view of nutrient cycling should be changed to a plant-microbe-soil feedback system, by incorporating the community ecology of microbial decomposers and their functional diversity. [ABSTRACT FROM AUTHOR]