32 results on '"Shuai, Lan"'
Search Results
2. Sociocognitive Processes and Item Response Models: A Didactic Example.
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Gong, Tao, Shuai, Lan, and Mislevy, Robert J.
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ITEM response theory - Abstract
The usual interpretation of the person and task variables in between‐persons measurement models such as item response theory (IRT) is as attributes of persons and tasks, respectively. They can be viewed instead as ensemble descriptors of patterns of interactions among persons and situations that arise from sociocognitive complex adaptive system (CASs). This view offers insights for interpreting and using between‐persons measurement models and connecting with sociocognitive research. In this article, we use data generated from an agent‐based model to illustrate relations between "social" and "cognitive" features of a simple underlying CAS and the variables of an IRT model fit to resulting data. We note how the ideas connect to explanatory item response modeling and briefly comment on implications for score interpretations and uses in practice. [ABSTRACT FROM AUTHOR]
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- 2024
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3. A systematic review and meta-analysis of Comaneci/Cascade temporary neck bridging devices for the treatment of intracranial aneurysms.
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Bowen Sun, Shuai Lan, Harshal Sawant, Yuchen Li, Yeping Ling, Bohan Zhang, Pei Wu, Chunlei Wang, Huaizhang Shi, and Shancai Xu
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INTRACRANIAL aneurysms ,RUPTURED aneurysms ,ENDOVASCULAR surgery ,INTRACRANIAL aneurysm ruptures ,ANGIOGRAPHY - Abstract
Background: The temporary neck bridging devices represented by Comaneci and Cascade are a type of promising endovascular device for the treatment of intracranial bifurcation or wide-necked aneurysms. This systematic review and meta-analysis aim to assess the efficacy and safety of Comaneci/Cascade devices for the treatment of intracranial aneurysms. Methods: We performed a systematic literature search on articles in PubMed, Embase, and Web of Science that evaluated the efficacy and safety of Comaneci/Cascade devices for endovascular treatment of intracranial aneurysms, based on the Preferred Reporting Items for Systematic Reviews and Meta Analytics (PRISMA) guideline. We extracted the characteristics and treatment related information of patients included in the study, recorded the rate of technical success, procedural related complications, and angiographic outcomes. The angiographic outcome was evaluated based on Raymond Roy classification, and adequate occlusion was defined as Raymond Ray I + II. Results: Nine studies comprising 253 patients with 255 aneurysms were included. Among them, eight studies were conducted in Europe, one study was conducted in the USA. All these studies were retrospective. 206 aneurysms (80.78%) were ruptured. The vast majority of patients with ruptured aneurysms did not receive antiplatelet therapy. The rate of technical success was 97.1% (95% CI, 94.9 to 99.3%, I2 = 0%). The rate of periprocedural clinical complications was 10.9% (95% CI, 5.4 to 22.1%, I2 = 54%). The rate of complete occlusion (RR1) and adequate occlusion (RR1 + RR2) on immediate angiography after the procedure were 77.7% (95% CI, 72.7 to 83.2%, I2 = 35%) and 98% (95% CI, 95.9 to 100%, I2 = 0%) respectively. The rate of complete occlusion (RR1) and adequate occlusion (RR1 + RR2) on the last follow-up angiography were 81.2% (95% CI, 69.2 to 95.2%, I2 = 81%) and 93.7% (95% CI, 85.6 to 100%, I2 = 69%) respectively, with follow-up range from 3 to 18 months. 22/187 (11.76%) cases of aneurysms progressed during the follow-up period. 39/187 (20.86%) cases of aneurysms received additional treatment during the follow-up period. No fatal complications occurred during the treatment. Conclusion: The Comaneci/Cascade device can be used as an auxiliary treatment for intracranial aneurysms, with a good occlusion effect, but the incidence of complications still needs to be monitored. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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4. Executive Function Training for Preschool Children With ADHD: A Randomized Controlled Trial.
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Shuai, Lan, Wang, Yuanyuan, Li, Wei, Wilson, Amanda, Wang, Shanshan, Chen, Runsen, and Zhang, Jinsong
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PRESCHOOL children ,EXECUTIVE function ,ATTENTION-deficit hyperactivity disorder ,RANDOMIZED controlled trials ,NEUROPSYCHOLOGICAL tests ,TREATMENT of attention-deficit hyperactivity disorder ,RESEARCH ,RESEARCH methodology ,EVALUATION research ,COMPARATIVE studies ,PARENTS - Abstract
Objective: This randomized controlled study explored the efficacy, feasibility, and acceptability of executive function training (EFT) for preschool children with ADHD.Method: The current study design was an 8 week randomized parallel groups, single-blinded trial, using EFT-P. A total of 96 children with an ADHD diagnosis at age 4 to 5 years old were randomized into the intervention group and waitlist group. In the intervention group, 46 out of 50 participants completed the 8-week program, compared with 39 out of 46 in the waiting group. The level of ADHD symptoms and the executive function (EF) were evaluated by both neuropsychological tests from NEPSY Second Edition (NEPSY-II) and Behavior Rating Inventory of Executive Function Preschool version (BRIEF-P).Results: The EFT is feasible to administer and is acceptable for preschool children, with a 93% retention rate. Results showed that following the intervention, the visual-motor precision (p = .024), ADHD diagnostic state (p = .01), and oppositional defiant symptoms (p = .023) improved significantly in preschool children. However, the symptoms of ADHD and other EF evaluations were found to be insignificant.Conclusion: The EFT is feasible, acceptable, and potentially effective to reduce symptoms and improve EF for preschool children with ADHD. The next step is to extend the program time and provide more frequent practice of activities between the children and the therapist and/or parent, to improve the effectiveness. [ABSTRACT FROM AUTHOR]- Published
- 2021
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5. Callous-unemotional traits in Chinese preschool children with attention-deficit/hyperactivity disorder.
- Author
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Zhang, Jinsong, Li, Wei, Zhang, Huifeng, Wilson, Amanda, Shuai, Lan, Xia, Weiping, Wang, Zhouye, Qiu, Meihui, and Wang, Yuanyuan
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PRESCHOOL children ,OPPOSITIONAL defiant disorder in children ,ATTENTION-deficit hyperactivity disorder ,MULTIPLE regression analysis ,PROSOCIAL behavior ,MEDICAL personnel - Abstract
Background: Children with early onset of Callous-Unemotional (CU) traits are at a higher risk for long-term, persistent psychosocial problems. The current study aimed to explore the characteristics of CU in preschool children with Attention Deficit Hyperactivity Disorder (ADHD) and the diagnostic significance of CU traits in ADHD. Methods: A total of 176 preschool children (89 with ADHD and 87 Typically Developing Children [TDC]) aged 4–5 years old were recruited to the study. The participants were assessed for CU traits, emotional and behavioral problems, and how their executive functioning was associated with ADHD using multiple assessment scales. Multiple linear regression analysis was performed to assess the incremental validity of the Inventory of Callous-Unemotional Traits (ICU), adjusting for possible covariates by child's sex, conduct problems, and oppositional defiant symptoms. Results: The results showed that there was a significant difference of ICU scores between the ADHD and TDC groups (F = 30.12, P < 0.001). In terms of callousness, ADHD + Oppositional Defiant Disorder (ODD) group showed a significant high score, and the ADHD only group scored significantly higher than the TDC group (F = 20.42, P < 0.001). The ICU was negatively associated with the prosocial behaviour subscale (γ = − 0.57, P < 0.01) and showed low to moderate positive correlations with emotional and behavioural problems, as well as executive function (γ = 0.24–0.67, P < 0.05). The ICU scores explained 6% of the incremental validity in ADHD symptoms. The diagnostic value of the ICU for ADHD was medium and acceptable. Conclusions: The current study indicated that early identification of CU traits may help clinicians better understand symptoms and behavioural problems in children with ADHD. CU traits therefore could be considered as a useful assessment tool for ADHD. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Influences of digital media use on children and adolescents with ADHD during COVID-19 pandemic.
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Shuai, Lan, He, Shan, Zheng, Hong, Wang, Zhouye, Qiu, Meihui, Xia, Weiping, Cao, Xuan, Lu, Lu, and Zhang, Jinsong
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COVID-19 pandemic ,OPPOSITIONAL defiant disorder in children ,COVID-19 ,ATTENTION-deficit hyperactivity disorder ,DIGITAL media ,BEHAVIORAL assessment ,CHILD psychiatry - Abstract
Objective: To explore the influences of digital media use on the core symptoms, emotional state, life events, learning motivation, executive function (EF) and family environment of children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD) during the novel coronavirus disease 2019 (COVID-19) pandemic.Method: A total of 192 participants aged 8-16 years who met the diagnostic criteria for ADHD were included in the study. Children scoring higher than predetermined cut-off point in self-rating questionnaires for problematic mobile phone use (SQPMPU) or Young's internet addiction test (IAT), were defined as ADHD with problematic digital media use (PDMU), otherwise were defined as ADHD without PDMU. The differences between the two groups in ADHD symptoms, EF, anxiety and depression, stress from life events, learning motivation and family environment were compared respectively.Results: When compared with ADHD group without PDMU, the group with PDMU showed significant worse symptoms of inattention, oppositional defiant, behavior and emotional problems by Swanson, Nolan, and Pelham Rating Scale (SNAP), more self-reported anxiety by screening child anxiety-related emotional disorders (SCARED) and depression by depression self-rating scale for children (DSRSC), more severe EF deficits by behavior rating scale of executive function (BRIEF), more stress from life events by adolescent self-rating life events checklist (ASLEC), lower learning motivation by students learning motivation scale (SLMS), and more impairment on cohesion by Chinese version of family environment scale (FES-CV). The ADHD with PDMU group spent significantly more time on both video game and social media with significantly less time spend on physical exercise as compared to the ADHD without PDMU group.Conclusion: The ADHD children with PDMU suffered from more severe core symptoms, negative emotions, EF deficits, damage on family environment, pressure from life events, and a lower motivation to learn. Supervision of digital media usage, especially video game and social media, along with increased physical exercise, is essential to the management of core symptoms and associated problems encountered with ADHD. [ABSTRACT FROM AUTHOR]- Published
- 2021
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7. Functional connectivity in the developing language network in 4‐year‐old children predicts future reading ability.
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Jasińska, Kaja K., Shuai, Lan, Lau, Airey N. L., Frost, Stephen, Landi, Nicole, and Pugh, Kenneth R.
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NEUROLINGUISTICS ,FUNCTIONAL connectivity ,NEAR infrared spectroscopy ,PSYCHOPHYSIOLOGY ,CHILDREN'S language ,LANGUAGE ability - Abstract
Understanding how pre‐literate children's language abilities and neural function relate to future reading ability is important for identifying children who may be at‐risk for reading problems. Pre‐literate children are already proficient users of spoken language and their developing brain networks for language become highly overlapping with brain networks that emerge during literacy acquisition. In the present longitudinal study, we examined language abilities, and neural activation and connectivity within the language network in pre‐literate children (mean age = 4.2 years). We tested how language abilities, brain activation, and connectivity predict children's reading abilities 1 year later (mean age = 5.2 years). At Time 1, children (n = 37) participated in a functional near infrared spectroscopy (fNIRS) experiment of speech processing (listening to words and pseudowords) and completed a standardized battery of language and cognitive assessments. At Time 2, children (n = 28) completed standardized reading assessments. Using psychophysiological interaction (PPI) analyses, we observed significant connectivity between the left IFG and right STG in pre‐literate children, which was modulated by task (i.e., listening to words). Neural activation in left IFG and STG and increased task‐modulated connectivity between the left IFG and right STG was predictive of multiple reading outcomes. Increased connectivity was associated later with increased reading ability. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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8. No Morphological Markers, No Problem: ERP Study Reveals Semantic Contribution to Distinct Neural Substrates Between Noun and Verb Processing in Online Sentence Comprehension.
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Feng, Jun, Gong, Tao, Shuai, Lan, and Wu, Yicheng
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VERBS ,COMPREHENSION ,AMBIGUITY ,NATIVE language ,NOUN phrases (Grammar) ,CRIMINAL sentencing - Abstract
Neural mechanisms behind noun and verb processing during the course of language comprehension are ubiquitously separate, yet it remains highly controversial as to which factor, syntax or semantics, should be responsible for this separation. This paper conducted an event-related potential (ERP), sentence comprehension experiment as an attempt to resolve this issue. The experiment used Chinese sentences in the configuration of noun phrase + ("not/no") + noun/verb/noun-verb-ambiguous-word, which excluded grammatical or syntactic factors that could hint at the lexical categories of sentence-final target words. Results showed significantly distinct ERP components of P200, N400, and P600 between noun and verb processing in native speakers, indicating that semantic factors are essential for the differentiated neural mechanisms behind noun and verb processing. Distinct P200, N400, and P600 also manifested between noun and noun-verb-ambiguous-word processing, but not between verb and noun-verb-ambiguous-word processing. This suggests that lacking clues on lexical category renders the dynamic properties of the ambiguous words more salient than the static properties, thus causing interpretation of such words more likely as verbs. This further elaborates the crucial role of semantic factors in noun and verb processing. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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9. The acceptability judgment of Chinese pseudo-modifiers with and without a sentential context.
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Gong, Tao, Shuai, Lan, and Wu, Yicheng
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NATIVE language ,JUDGMENT (Psychology) ,LINGUISTIC analysis ,TERMS & phrases ,MANDARIN dialects ,JUDGMENT sampling ,SEMANTICS - Abstract
This paper investigates a particular type of non-canonical construction in Mandarin Chinese displaying an apparent semantics-syntax mismatch. We conducted an acceptability judgment experiment on native Mandarin speakers to evaluate whether such sequences could stand out of context as acceptable fragments. Analyses on experimental results revealed that: both semantic and syntactic acceptability of these sequences were significantly lower than those of canonical nominal classifier phrases; whereas if contextualized, the syntactic acceptability of those sequences became similar to that of canonical nominal phrases. This suggests that the non-canonical sequences are grammatically not on the same footing as canonical expressions; and it is the sentential context that makes these sequences appear structurally well-formed. These findings contribute to general discussions on relationship between constituency and grammaticality by demonstrating the gradient nature of grammaticality, and advocate a dynamic perspective in linguistic analysis that looks at a sequence of words in interaction with other elements in a sentence. [ABSTRACT FROM AUTHOR]
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- 2019
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10. Uncovering the Fine Structure of Intrinsic Fluorescent Emission from Amine-containing Small Molecules.
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Rui Qi, Dongni Wang, Hongyang Wang, Dandan Jia, Shuai Lan, and Dongjun Wang
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- 2020
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11. Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents.
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Tong Wu, Ting Li, Ya-Nan Kang, Li Liu, Xi-Man Wang, Jin-Shuai Lan, Yue Ding, and Tong Zhang
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ANTINEOPLASTIC agents ,SUBSTITUTION reactions ,CHEMICAL reactions ,CHEMICAL synthesis ,BREAST cancer - Abstract
A series of novel alkyl amine-substituted icariside II (ICA II) derivatives were synthesized by Mannich reactions at the 6-C position (compounds 4a-d) and changing the carbon chain length at the 7-OH position (compounds 7a-h), and their in vitro antitumor activity towards human breast cancer lines (MCF-7 and MDA-MB-231) and human hepatoma cell lines (HepG2 and HCCLM3-LUC) were evaluated by the MTT assay. Compared with ICA II, most of the twelve derivatives showed good micromole level activity and a preliminary structure-activity relationship (SAR) for the anticancer activity was obtained. Compound 7g showed the most potent inhibitory activity for the four cancer cell lines (13.28 µM for HCCLM3-LUC, 3.96 µM for HepG2, 2.44 µM for MCF-7 and 4.21 µM for MDA-MB-231), which was 2.94, 5.54, 12.56 and 7.72-fold stronger than that of ICA II. The preliminary SAR showed that the introduction of a alkyl amine substituent at 6-C was not favorable for the anticancer activity, while most of the 7-O-alkylamino derivatives exhibited good antitumor activity and the anticancer activity 7-O-alkylamino derivatives were influenced by the alkyl chain length and the different terminal amine substituents. Furthermore, the effects of compound 7g on apoptosis and cell cycle of MCF-7 cells were further investigated, which showed that compound 7g triggered apoptosis and arrested the cell cycle at the G0/G1 phase in MCF-7 cells. Our findings indicate that compound 7g may be a promising anticancer drug candidate lead. [ABSTRACT FROM AUTHOR]
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- 2018
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12. Cortical Responses to Chinese Phonemes in Preschoolers Predict Their Literacy Skills at School Age.
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Hong, Tian, Shuai, Lan, Frost, Stephen J, Landi, Nicole, Pugh, Kenneth R, and Shu, Hua
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PRESCHOOL children ,PHONOLOGICAL awareness ,SPEECH perception ,LANGUAGE acquisition ,READING ability testing - Abstract
We investigated whether preschoolers with poor phonological awareness (PA) skills had impaired cortical basis for detecting speech feature, and whether speech perception influences future literacy outcomes in preschoolers. We recorded ERP responses to speech in 52 Chinese preschoolers. The results showed that the poor PA group processed speech changes differentially compared to control group in mismatch negativity (MMN) and late discriminative negativity (LDN). Furthermore, speech perception in kindergarten could predict literacy outcomes after literacy acquisition. These suggest that impairment in detecting speech features occurs before formal reading instruction, and that speech perception plays an important role in reading development. [ABSTRACT FROM AUTHOR]
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- 2018
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13. Simulating the Effects of Cross-Generational Cultural Transmission on Language Change.
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Gong, Tao and Shuai, Lan
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- 2016
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14. A Fluorescent Coumarin-Based Probe for the Fast Detection of Cysteine with Live Cell Application.
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Rui-Feng Zeng, Jin-Shuai Lan, Xiao-Die Li, Hui-Fen Liang, Yan Liao, Ying-Jie Lu, Tong Zhang, and Yue Ding
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COUMARINS ,CYSTEINE ,BENZOPYRANS ,SULFUR amino acids ,GLUTATHIONE ,AMINO acids - Abstract
A new coumarin-based fluorescent probe, containing an allylic esters group, has been designed and synthesized for sensing cysteine in physiological pH. In this fluorescent probe, the coumarin was applied as the fluorophore and an allylic esters group was combined as both a fluorescence quencher and a recognition unit. The probe can selectively and sensitively detect cysteine (Cys) over homocysteine, glutathione, and other amino acids, and has a rapid response time of 30 min and a low detection limit of 47.7 nM. In addition, the probe could be applied for cell imaging with low cytotoxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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15. Predictability of Urinary CD80 in the Relapse of Primary Nephrotic Syndrome.
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Liao, Juan, Wu, Xiao-Chuan, Cheng, Qia, Li, Can-Lin, Yi, Zhu-Wen, Cao, Yan, and Shuai, Lan-Jun
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DISEASE relapse ,NEPHROTIC syndrome ,ANTIGENS ,BIOTRANSFORMATION (Metabolism) ,STATISTICAL correlation ,CREATININE ,ENZYME-linked immunosorbent assay ,PREDICTIVE validity ,CONTROL groups ,CHILDREN ,PROGNOSIS - Abstract
Purpose. The current study is aimed at investigating whether urinary CD80 is reliable to predict the recurrence of pediatric PNS. Materials and Methods. A total of 128 children, 105 males and 23 females, were enrolled in this study. Urinary samples were collected from SSNS and SRNS patients and 25 healthy children as controls. Urinary CD80 was measured by ELISA and adjusted for urinary creatinine excretion. Results. Urinary CD80 in relapse stage of SSNS was significantly higher, and the urinary CD80 of paired relapse and remission stages of each SSNS patient were also significantly different. No significant difference was found between the urinary CD80 in SRNS relapse group, SRNS remission group, and the control group. Similarly, there was no significant difference between frequent SSNS and not frequent SSNS in remission group, as well as the relapse group. There is no correlation between urinary CD80 and 24-hour urinary protein. Conclusion. The increase of urinary CD80 was closely associated with the relapse of SSNS but was not related to the frequency of relapse. The urinary CD80 changes of concentration were reliable to predict the recurrence of SSNS. However, it cannot be used to predicate the frequent recurrence of PNS. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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16. Adapting an attention-deficit hyperactivity disorder parent training intervention to different cultural contexts: The experience of implementing the New Forest Parenting Programme in China, Denmark, Hong Kong, Japan, and the United Kingdom.
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Thompson, Margaret J. J., Au, Alma, Laver‐Bradbury, Cathy, Lange, Anne‐Mette, Tripp, Gail, Shimabukuro, Shizuka, Zhang, Jin S., Shuai, Lan, Thompson, Catherine E., Daley, David, and Sonuga‐Barke, Edmund J.
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ATTENTION-deficit hyperactivity disorder ,PARENTING education ,CULTURAL adaptation ,CHILD psychology ,MENTAL health ,CLINICAL trials - Abstract
The New Forest Parenting Programme (NFPP) is a parenting program developed for parents who have a child with attention-deficit hyperactivity disorder (ADHD). It is a manualized program that is delivered in a parent's home over 8 weeks, or in a group format, or through a self-help manual. Three randomized controlled trials have been carried out in the United Kingdom. The NFPP group has adapted the program according to feedback from parents and therapists, and for use with different populations, both within the United Kingdom and internationally. The first international trial took place in New York, United States. Trials in Denmark, Hong Kong, and Japan followed. More recently, a trial of the self-help manual has been carried out in mainland China. This paper will outline the adaptions that were needed in order to be able to deliver the program in different countries with their own expectations of parenting, culture, and language. Training had to be differently focused; manuals and handouts had to be revised, translated and back-translated; and supervision had to be delivered at a distance to maintain the fidelity of the program. The international group will outline their experience of running trials in their own countries with the NFPP in a face-to-face format (Denmark), a group format (Hong Kong and Japan), and a self-help format (mainland China). [ABSTRACT FROM AUTHOR]
- Published
- 2017
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17. Encoding lexical tones in jTRACE: a simulation of monosyllabic spoken word recognition in Mandarin Chinese.
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Shuai, Lan and Malins, Jeffrey
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DECODERS & decoding ,MANDARIN dialects -- Study & teaching ,CHINESE dialects ,CODING theory ,SEQUENTIAL decoding - Abstract
Despite its prevalence as one of the most highly influential models of spoken word recognition, the TRACE model has yet to be extended to consider tonal languages such as Mandarin Chinese. A key reason for this is that the model in its current state does not encode lexical tone. In this report, we present a modified version of the jTRACE model in which we borrowed on its existing architecture to code for Mandarin phonemes and tones. Units are coded in a way that is meant to capture the similarity in timing of access to vowel and tone information that has been observed in previous studies of Mandarin spoken word recognition. We validated the model by first simulating a recent experiment that had used the visual world paradigm to investigate how native Mandarin speakers process monosyllabic Mandarin words (Malins & Joanisse, 2010). We then subsequently simulated two psycholinguistic phenomena: (1) differences in the timing of resolution of tonal contrast pairs, and (2) the interaction between syllable frequency and tonal probability. In all cases, the model gave rise to results comparable to those of published data with human subjects, suggesting that it is a viable working model of spoken word recognition in Mandarin. It is our hope that this tool will be of use to practitioners studying the psycholinguistics of Mandarin Chinese and will help inspire similar models for other tonal languages, such as Cantonese and Thai. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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18. Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.
- Author
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Fan Li, Zhi-Min Wang, Jia-Jia Wu, Jin Wang, Sai-Sai Xie, Jin-Shuai Lan, Wei Xu, Ling-Yi Kong, and Xiao-Bing Wang
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DONEPEZIL ,ALZHEIMER'S disease treatment ,PHARMACOLOGY ,CHOLINESTERASE inhibitors ,MONOAMINE oxidase inhibitors ,DRUG synthesis ,THERAPEUTICS - Abstract
In a continuing effort to develop multitargeted compounds as potential treatment agents against Alzheimer's disease (AD), a series of donepezil-like compounds were designed, synthesized and evaluated. In vitro studies showed that most of the designed compounds displayed potent inhibitory activities toward AChE, BuChE, MAO-B and MAO-A. Among them, w18 was a promising agent with balanced activities, which exhibited a moderate cholinesterase inhibition (IC
50 , 0.220 μM for eeAChE; 1.23 μM for eqBuChE; 0.454 mM for hAChE) and an acceptable inhibitory activity against monoamine oxidases (IC50 , 3.14 μM for MAO-B; 13.4 μM for MAO-A). Moreover, w18 could also be a metal-chelator, and able to cross the blood-brain barrier with low cell toxicity on PC12 cells. Taken together, these results suggested that w18 might be a promising multitargeted compound for AD treatment. [ABSTRACT FROM AUTHOR]- Published
- 2016
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19. Simulating the coevolution of language and long-term memory.
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Shuai, Lan, Wang, Zhen, and Gong, Tao
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- 2014
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20. Modeling Coevolution between Language and Memory Capacity during Language Origin.
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Gong, Tao and Shuai, Lan
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COEVOLUTION ,LANGUAGE acquisition ,MEMORY ,ORIGIN of languages ,NATURAL selection - Abstract
Memory is essential to many cognitive tasks including language. Apart from empirical studies of memory effects on language acquisition and use, there lack sufficient evolutionary explorations on whether a high level of memory capacity is prerequisite for language and whether language origin could influence memory capacity. In line with evolutionary theories that natural selection refined language-related cognitive abilities, we advocated a coevolution scenario between language and memory capacity, which incorporated the genetic transmission of individual memory capacity, cultural transmission of idiolects, and natural and cultural selections on individual reproduction and language teaching. To illustrate the coevolution dynamics, we adopted a multi-agent computational model simulating the emergence of lexical items and simple syntax through iterated communications. Simulations showed that: along with the origin of a communal language, an initially-low memory capacity for acquired linguistic knowledge was boosted; and such coherent increase in linguistic understandability and memory capacities reflected a language-memory coevolution; and such coevolution stopped till memory capacities became sufficient for language communications. Statistical analyses revealed that the coevolution was realized mainly by natural selection based on individual communicative success in cultural transmissions. This work elaborated the biology-culture parallelism of language evolution, demonstrated the driving force of culturally-constituted factors for natural selection of individual cognitive abilities, and suggested that the degree difference in language-related cognitive abilities between humans and nonhuman animals could result from a coevolution with language. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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21. The Presence of Ferrihydrite Promotes Abiotic Formation of Manganese (Oxyhydr)oxides.
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Xiaoming wang, Shuai Lan, Mengqiang Zhu, Ginder-Vogel, Matthew, Hui Yin, Fan Liu, Wenfeng Tan, and Xionghan Feng
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MANGANESE oxides ,OXIDATION ,MANGANITE ,OXIDES ,SEDIMENTS - Abstract
Iron (Fe) and manganese (Mn) occur in various geological settings and are often associated with each other. In the present study, we examined the impacts of ferrihydrite surfaces on the oxidation of dissolved Mn(II) and concurrent formation of Mn(III/IV) (oxyhydr)oxides under various conditions. In the absence of ferrihydrite, the oxidation products of 24 mM Mn(II) by atmospheric O
2 are manganite (γ-MnOOH) at pH 7.5 and 8.5, feitknechtite (β-MnOOH), groutite (α-MnOOH) and manganite at pH 8, and hausmannite (Mn3 O4 ) only at pH 9. In contrast, in the presence of ferrihydrite, manganite is formed at pH 6.5 to 8, manganite and hausmannite at pH 8.5, hausmannite and birnessite (α-MnO2 ) at pH 9. When 24 mM Mn(II) is oxidized by pure O2 (i.e., at higher dissolved O2 level) at pH 9 in the absence of ferrihydrite, the products are mainly hausmannite and birnessite with a small amount of feitknechtite, while only birnessite is obtained in the presence of ferrihydrite. These results suggest that the presence of ferrihydrite promotes the formation of manganite, birnessite, and hausmannite, disfavoring the formation of feitknechtite and groutite. The three favored phases in the presence of ferrihydrite are the commonly observed Mn (oxyhydr)oxides in the environment, suggesting the important role of mineral surfaces in their formation. The resulting solids are intimate mixtures of Fe and Mn oxides, which could contribute to the formation of Fe/Mn complex mineral assemblage in soils and sediments. [ABSTRACT FROM AUTHOR]- Published
- 2015
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22. Segmental and suprasegmental features in speech perception in Cantonese-speaking second graders: An ERP study.
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Tong, Xiuhong, McBride, Catherine, Lee, Chia‐Ying, Zhang, Juan, Shuai, Lan, Maurer, Urs, and Chung, Kevin K. H.
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SPEECH perception in children ,CANTONESE dialects ,CONSONANTS ,TONE (Phonetics) ,SYLLABLE onset ,AUTOSEGMENTAL theory (Linguistics) ,SCHOOL children ,DISCRIMINATION in education - Abstract
Using a multiple-deviant oddball paradigm, this study examined second graders' brain responses to Cantonese speech. We aimed to address the question of whether a change in a consonant or lexical tone could be automatically detected by children. We measured auditory mismatch responses to place of articulation and voice onset time ( VOT), reflecting segmental perception, as well as Cantonese lexical tones including level tone and contour tone, reflecting suprasegmental perception. The data showed that robust mismatch negativities ( MMNs) were elicited by all deviants in the time window of 300-500 ms in second graders. Moreover, relative to the standard stimuli, the VOT deviant elicited a robust positive mismatch response, and the level tone deviant elicited a significant MMN in the time window of 150-300 ms. The findings suggest that Hong Kong second graders were sensitive to neural discriminations of speech sounds both at the segmental and suprasegmental levels. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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23. Exploring the Effect of Power Law Social Popularity on Language Evolution.
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Gong, Tao and Shuai, Lan
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SOCIOLINGUISTICS ,LEXICAL access ,SOCIALIZATION ,SOCIAL acceptance ,SOCIAL interaction - Abstract
We evaluate the effect of a power-law-distributed social popularity on the origin and change of language, based on three artificial life models meticulously tracing the evolution of linguistic conventions including lexical items, categories, and simple syntax. A cross-model analysis reveals an optimal social popularity, in which the λ value of the power law distribution is around 1.0. Under this scaling, linguistic conventions can efficiently emerge and widely diffuse among individuals, thus maintaining a useful level of mutual understandability even in a big population. From an evolutionary perspective, we regard this social optimality as a tradeoff among social scaling, mutual understandability, and population growth. Empirical evidence confirms that such optimal power laws exist in many large-scale social systems that are constructed primarily via language-related interactions. This study contributes to the empirical explorations and theoretical discussions of the evolutionary relations between ubiquitous power laws in social systems and relevant individual behaviors. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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- View/download PDF
24. Task-dependent neural representations of salient events in dynamic auditory scenes.
- Author
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Shuai, Lan and Elhilali, Mounya
- Subjects
VOCAL tract ,MEMORY ,PSYCHOLOGY ,CONTINUUM mechanics ,PSYCHOACOUSTICS - Abstract
Selecting pertinent events in the cacophony of sounds that impinge on our ears every day is regulated by the acoustic salience of sounds in the scene as well as their behavioral relevance as dictated by top-down task-dependent demands. The current study aims to explore the neural signature of both facets of attention, as well as their possible interactions in the context of auditory scenes. Using a paradigm with dynamic auditory streams with occasional salient events, we recorded neurophysiological responses of human listeners using EEG while manipulating the subjects' attentional state as well as the presence or absence of a competing auditory stream. Our results showed that salient events caused an increase in the auditory steady-state response (ASSR) irrespective of attentional state or complexity of the scene. Such increase supplemented ASSR increases due to task-driven attention. Salient events also evoked a strong N1 peak in the ERP response when listeners were attending to the target sound stream, accompanied by an MMN-like component in some cases and changes in the P1 and P300 components under all listening conditions. Overall, bottom-up attention induced by a salient change in the auditory stream appears to mostly modulate the amplitude of the steady-state response and certain event-related potentials to salient sound events; though this modulation is affected by top-down attentional processes and the prominence of these events in the auditory scene as well. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
25. Executive function in children and adolescents with posttraumatic stress disorder 4 and 12 months after the Sichuan earthquake in China.
- Author
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Yang, Rui, Xiang, Yu‐Tao, Shuai, Lan, Qian, Ying, Lai, Kelly Y.C., Ungvari, Gabor S., Chiu, Helen F.K., and Wang, Yu‐Feng
- Subjects
NATURAL disasters ,ANALYSIS of variance ,CHI-squared test ,COGNITION ,INTELLIGENCE tests ,INTERVIEWING ,NEUROPSYCHOLOGICAL tests ,U-statistics ,POST-traumatic stress disorder in adolescence ,REPEATED measures design ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Background While several studies have found executive function deficits in adults and maltreated children with posttraumatic stress disorder ( PTSD), there are few data on executive function in children and adolescents with PTSD related to natural disasters. The objective of this study was to test executive function changes over time in children and adolescents with PTSD after a magnitude 8.0 earthquake in Sichuan, China. Method A sample of 34 children and adolescents with diagnosed PTSD following the Sichuan earthquake and 66 matched controls exposed to the same earthquake but without PTSD participated in the study. Executive function was assessed using a battery of interviewer-rated neuropsychological tests and the guardian-rated Behavior Rating Scale of Executive Function ( BRIEF) at 4- and 12-month after the earthquake. Results Children and adolescents with PTSD performed similar to controls in executive function at 4-months after the earthquake. Both groups improved significantly in similar domains of cognition during the following 8 months. The PTSD group exhibited daily deficits in emotional control compared with the controls at the 4-month assessment, but the differences disappeared during the following 8 months. Conclusions Children and adolescents with PTSD related to a natural disaster have deficits only in the emotional control domain of executive function compared with controls exposed to the same disaster, but even these deficits did not persist. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
26. Who Is Who? Interpretation of Multiple Occurrences of the Chinese Reflexive: Evidence from Real-Time Sentence Processing.
- Author
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Shuai, Lan, Gong, Tao, and Wu, Yicheng
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HERMENEUTICS ,SENTENCES (Grammar) ,LINGUISTS ,THEORY of self-knowledge ,CHINESE language ,GOVERNMENT-binding theory (Linguistics) ,PARADIGM (Linguistics) - Abstract
Theoretical linguists claim that the notorious reflexive ziji ‘self’ in Mandarin Chinese, if occurring more than once in a single sentence, can take distinct antecedents. This study tackles possibly the most interesting puzzle in the linguistic literature, investigating how two occurrences of ziji in a single sentence are interpreted and whether or not there are mixed readings, i.e., these zijis are interpretively bound by distinct antecedents. Using 15 Chinese sentences each having two zijis, we conducted two sentence reading experiments based on a modified self-paced reading paradigm. The general interpretation patterns observed showed that the majority of participants associated both zijis with the same local antecedent, which was consistent with Principle A of the Standard Binding Theory and previous experimental findings involving a single ziji. In addition, mixed readings also occurred, but did not pattern as claimed in the theoretical linguistic literature (i.e., one ziji is bound by a long-distance antecedent and the other by a local antecedent). Based on these results, we argue that: (i) mixed readings were due to manifold, interlocking and conflicting perspectives taken by the participants; and (ii) cases of multiple occurrences of ziji taking distinct antecedents are illicit in Chinese syntax, since the speaker, when expressing a sentence, can select only one P(erspective)-Center that referentially denotes the psychological perspective in which the sentence is situated. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
27. Review of the 9th International Conference on the Evolution of Language (Evolang9).
- Author
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Coupé, Christophe, Shuai, Lan, and Gong, Tao
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HISTORICAL linguistics ,COMPARATIVE linguistics ,BIOLINGUISTICS ,LANGUAGE & languages ,LANGUAGE & history - Abstract
The article provides an overview of a variety of reports that was discussed during the Conference on the Evolution of Language (Evolang). It summarizes the primary arguments on evolutionary linguistics and biolinguistics during the conference. It highlights the significant evolutions of the field in terms of methods and content.
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- 2013
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- View/download PDF
28. Modelling the coevolution of joint attention and language.
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Gong, Tao and Shuai, Lan
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JOINT attention ,COEVOLUTION ,COGNITIVE ability ,HUMAN beings ,SIMULATION methods & models ,QUANTITATIVE research - Abstract
Joint attention (JA) is important to many social, communicative activities, including language, and humans exhibit a considerably high level of JA compared with non-human primates. We propose a co-evolutionary hypothesis to explain this degree-difference in JA: once JA started to aid linguistic comprehension, along with language evolution, communicative success (CS) during cultural transmission could enhance the levels of JA among language users. We illustrate this hypothesis via a multi-agent computational model, where JA boils down to a genetically transmitted ability to obtain non-linguistic cues aiding comprehension. The simulation results and statistical analysis show that: (i) the level of JA is correlated with the understandability of the emergent language; and (ii) CS can boost an initially low level of JA and 'ratchet' it up to a stable high level. This coevolutionary perspective helps explain the degree-difference in many language-related competences between humans and non-human primates, and reflects the importance of biological evolution, individual learning and cultural transmission to language evolution. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
29. Studying Language Change Using Price Equation and Pólya-urn Dynamics.
- Author
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Gong, Tao, Shuai, Lan, Tamariz, Mó nica, and Jäger, Gerhard
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LINGUISTIC change ,BIOLOGICAL evolution ,COMPUTER simulation ,SOCIAL structure ,SOCIOCULTURAL factors ,LINGUISTICS - Abstract
Language change takes place primarily via diffusion of linguistic variants in a population of individuals. Identifying selective pressures on this process is important not only to construe and predict changes, but also to inform theories of evolutionary dynamics of socio-cultural factors. In this paper, we advocate the Price equation from evolutionary biology and the Pó lyaurn dynamics from contagion studies as efficient ways to discover selective pressures. Using the Price equation to process the simulation results of a computer model that follows the Pó lya-urn dynamics, we analyze theoretically a variety of factors that could affect language change, including variant prestige, transmission error, individual influence and preference, and social structure. Among these factors, variant prestige is identified as the sole selective pressure, whereas others help modulate the degree of diffusion only if variant prestige is involved. This multidisciplinary study discerns the primary and complementary roles of linguistic, individual learning, and socio-cultural factors in language change, and offers insight into empirical studies of language change. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
30. Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial.
- Author
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Yang, Li, Cao, Qingjiu, Shuai, Lan, Li, Haimei, Chan, Raymond C. K., and Wang, Yufeng
- Subjects
ATOMOXETINE ,ATTENTION-deficit hyperactivity disorder ,RANDOMIZED controlled trials ,COMPARATIVE studies ,OSMOSIS ,SHORT-term memory - Abstract
This study aimed to compare the effects of osmotic release oral system-methylphenidate (OROS-MPH) and atomoxetine (ATX) on executive function in children and adolescents with attention deficit hyperactivity disorder (ADHD) by a randomized controlled trial. Subjects who met DSM-IV ADHD criteria were randomized to receive either OROS-MPH or ATX treatment. The doses were titrated to achieve optimal response and then maintained for 4–6 wk. A battery of executive function tests and the Behavior Rating Inventory of Executive Function (BRIEF) were administered to subjects who completed the dose titration (OROS-MPH, n=85; ATX, n=57) at the pre- and post-treatment periods. Forty-six children without ADHD were recruited as controls. Both OROS-MPH and ATX significantly improved scores in the Rey Complex Figure Test (RCFT), digit span, and Stroop color-word task. The scores in RCFT and the reverse digit span were not significantly different from the control group at post-treatment assessment (OROS-MPH=ATX=control, p>0.05), whereas the word interference time of the Stroop test was still more than that of the control group (OROS-MPH=ATX>control, p>0.05). OROS-MPH also significantly improved the total correct response in the verbal fluency test to normal level, and the shifting time in the trail-making test to subnormal level. The current findings suggest both OROS-MPH and ATX improved executive function generally in children and adolescents with ADHD, and could return working memory back to normative performance level. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
31. Executive Function Profile of Chinese Boys with Attention-Deficit Hyperactivity Disorder: Different Subtypes and Comorbidity.
- Author
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Shuai, Lan, Chan, Raymond C.K., and Wang, Yufeng
- Subjects
CHINESE people ,OPPOSITIONAL defiant disorder in children ,CONDUCT disorders in children ,ATTENTION-deficit hyperactivity disorder ,EXECUTIVE function ,COMORBIDITY ,INTELLIGENCE levels - Abstract
This study examined the executive function (EF) profile of Chinese boys with attention-deficit hyperactivity disorder (ADHD) using a large sample. Executive function performance within the ADHD subtypes and the effects of comorbidity were also investigated. Five hundred Chinese boys (375 with ADHD and 125 controls) aged 6–15 completed a battery of EF tests. Boys with all types of ADHD performed worse in all of the EF tests than age- and intelligence quotient-matched healthy controls. The boys with the inattention ADHD subtype and the combined subtype showed similar impairments across different EF tasks, whereas the boys with the hyperactive-impulsive ADHD subtype primarily displayed deficits in theory of mind and visual memory. Comorbid oppositional defiant disorder/conduct disorder had no additional influence on the EF characteristics of the boys with ADHD only, whereas comorbid learning disorder increased the severity of inhibition and shifting impairments. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
- Full Text
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32. Language as an emergent group-level trait.
- Author
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Shuai, Lan and Gong, Tao
- Subjects
LANGUAGE & languages ,SOCIAL groups ,SOCIAL structure ,SOCIAL psychology ,SOCIAL interaction ,GROUP theory - Abstract
Following Smaldino's definition, we claim that language is also an emergent group-level trait, and propose two facets (human groups tend to organize in a way to efficiently trigger language and linguistic interactions can render formation of certain social organization) to verify this statement, both of which also provide a general framework to address the future work about group-level traits. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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