1. Clinical and magnetic resonance imaging predictors of disease progression in multiple sclerosis: a nine-year follow-up study.
- Author
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Lavorgna, L, Bonavita, S, Ippolito, D, Lanzillo, R, Salemi, G, Patti, F, Valentino, P, Coniglio, G, Buccafusca, M, Paolicelli, D, d’Ambrosio, A, Bresciamorra, V, Savettieri, G, Zappia, M, Alfano, B, Gallo, A, Simone, IL, and Tedeschi, G more...
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MAGNETIC resonance imaging ,MULTIPLE sclerosis research ,MYELIN sheath diseases ,DEMYELINATION ,ATROPHY ,CEREBRAL atrophy - Abstract
Objective: The objective of this paper is to identify clinical or magnetic resonance imaging (MRI) predictors of longtermclinical progression in a large cohort of multiple sclerosis (MS) patients.Methods: A total of 241 relapsing–remitting (RR) MS patients were included in a nine-year follow-up (FU) study. Thereference MRIs were acquired at baseline (BL) as part of a multicenter, cross-sectional, clinical-MRI study. VolumetricMRI metrics were measured by a fully automated, operator-independent, multi-parametric segmentation method. Clinicalprogression was evaluated as defined by: conversion from RR to secondary progressive (SP) disease course; progressionof Expanded Disability Status Scale (EDSS); achievement and time to reach EDSS 4.Results: We concluded that conversion from RR to SP (OR 0.79; CI 0.7–0.9), progression of EDSS (OR 0.85; CI 0.77–0.93), achievement of EDSS 4 (OR 0.8; CI 0.7–0.9), and time to reach EDSS 4 (HR 0.88; CI 0.82–0.94) were all predictedby BL gray matter (GM) volume and, except for progression of EDSS, by BL EDSS (respectively: (OR 2.88; CI 1.9–4.36),(OR 2.7; CI 1.7–4.2), (HR 3.86; CI 1.94–7.70)).Conclusions: BL GM volume and EDSS are the best long-term predictors of disease progression in RRMS patients witha relatively long and mild disease. [ABSTRACT FROM AUTHOR] more...
- Published
- 2014
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