145 results on '"Sinha, Aditi"'
Search Results
2. Abbreviated protocol of plasma exchanges for patients with anti-factor H associated hemolytic uremic syndrome.
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Thangaraju, Sharan, Khandelwal, Priyanka, Mishra, Kirtisudha, Kumar, Manish, Puraswani, Mamta, Saini, Rahul, Hari, Pankaj, Coshic, Poonam, Sinha, Aditi, and Bagga, Arvind
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HEMOLYTIC-uremic syndrome treatment ,MEDICAL protocols ,RESEARCH funding ,AUTOANTIBODIES ,HEMOLYTIC-uremic syndrome ,DESCRIPTIVE statistics ,TREATMENT effectiveness ,DISEASE remission ,LONGITUDINAL method ,PLASMA exchange (Therapeutics) ,IMMUNOSUPPRESSION ,DISEASE risk factors - Abstract
Background: Plasma exchanges (PEX) and immunosuppression are the cornerstone of management of anti-factor H (FH) antibody-associated atypical hemolytic uremic syndrome (aHUS), particularly if access to eculizumab is limited. The duration of therapy with PEX for anti-FH aHUS is empirical. Methods: We compared the efficacy of abbreviated PEX protocol (10–12 sessions) in a prospective cohort of patients diagnosed with anti-FH aHUS (2020–2022), to standard PEX protocol (20–22 sessions) in a historical cohort (2016–2019; n = 65). Efficacy was defined as 70% decline in anti-FH titers or fall to ≤ 1300 AU/ml at 4 weeks. Patients in both cohorts received similar immunosuppression with oral prednisolone, IV cyclophosphamide (5 doses) and mycophenolate mofetil. Outcomes included efficacy, rates of hematological remission and adverse kidney outcomes at 1, 3 and 6 months. Results: Of 23 patients, 8.2 ± 2.1 years old enrolled prospectively, two were excluded for significant protocol deviation. PEX was abbreviated in 18/21 (86%) patients to 11.5 ± 3.3 sessions. Abbreviation failed for lack of hematological remission by day 14 (n = 2) and persistent neurological manifestations (n = 1). All patients in whom PEX was abbreviated achieved > 70% reduction in anti-FH titers at day 28. The percentage fall in anti-FH titers was similar for the abbreviated vs. standard PEX protocols at 1, 3 and 6 months. At last follow-up, at median 50 months and 25 months for standard and abbreviated cohorts, the estimated GFR was similar at 104.8 ± 29.1 vs. 93.7 ± 53.4, respectively (P = 0.42). Conclusion: Abbreviation of the duration of PEX is feasible and efficacious in reducing anti-FH titers. Short-term outcomes were comparable in patients managed by abbreviated and standard PEX protocols. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Anti-factor B antibodies in atypical hemolytic uremic syndrome.
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Khandelwal, Priyanka, Nambiar, Shreesha, Saini, Rahul, Saini, Savita, Coshic, Poonam, Sinha, Aditi, Hari, Pankaj, Palanichamy, Jayanth Kumar, and Bagga, Arvind
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AUTOANTIBODY analysis ,IMMUNOGLOBULIN analysis ,RISK assessment ,RESEARCH funding ,ENZYME-linked immunosorbent assay ,HEMOGLOBINS ,HEMOLYTIC-uremic syndrome ,COMPLEMENT (Immunology) ,SEVERITY of illness index ,DESCRIPTIVE statistics ,GLOMERULONEPHRITIS ,GENETIC variation ,VOLUMETRIC analysis ,BLOOD platelets ,WESTERN immunoblotting ,CONFIDENCE intervals ,DISEASE relapse ,GENETICS - Abstract
Background: The etiology of atypical hemolytic uremic syndrome (aHUS) is unknown in 30–40% of patients. Anti-factor B (FB) antibodies are reported in C3 glomerulopathy (C3G) and immune-complex membranoproliferative glomerulonephritis (IC-MPGN), though not in aHUS. Methods: We screened patients < 18-year-old from cohorts of aHUS and C3G/idiopathic IC-MPGN. Anti-FB IgG antibodies were measured by ELISA and confirmed by Western blot. Normative levels were based on antibody levels in 103 healthy blood donors. Results: Prevalence of anti-FB antibodies was 9.7% (95% CI 6.1–14.5%; n = 21) in 216 patients with aHUS, including 11.5% (95% CI 6.4–18.5%; n = 14) in anti-FH associated aHUS and 11.8% (95% CI 4.4–23.9%; n = 6) in patients without a definitive genetic or autoimmune etiology. Patients with significant genetic variants did not show anti-FB antibodies. In patients with concomitant anti-FB and anti-FH antibodies, median anti-FH titers were higher (11,312 AU/mL vs. 4920 AU/mL; P = 0.04). Anti-FB antibody titer correlated with disease severity (hemoglobin and platelets; P < 0.05), declined following plasma exchange and increased during relapse. While 4/64 patients with C3G (6.3%) and 1/17 with IC-MPGN showed anti-FB antibodies, titers were higher in aHUS (544.8 AU/mL vs. 1028.8 AU/mL; P = 0.003). Conclusion: Anti-FB antibodies are present in 6–10% of patients with aHUS and C3G/IC-MPGN, with higher titers in the former. The diagnostic and therapeutic implication of anti-FB antibodies in aHUS needs confirmation and further studies. The study shows propensity for autoantibody generation and co-existence of multiple risk factors for aHUS in Indian children. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.
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Hari, Pankaj, Meena, Jitendra, Kumar, Manish, Sinha, Aditi, Thergaonkar, Ranjeet W., Iyengar, Arpana, Khandelwal, Priyanka, Ekambaram, Sudha, Pais, Priya, Sharma, Jyoti, Kanitkar, Madhuri, Bagga, Arvind, Agarwal, Indira, Bajpai, Minu, Banerjee, Sushmita, Jana, Manisha, Kalra, Suprita, Kumar, Rakesh, Krishan, Anurag, and Krishnamurthy, Nisha
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URINARY tract infection treatment ,ANTIBIOTICS ,URINARY tract infection prevention ,MEDICAL protocols ,DIAGNOSTIC imaging ,DISEASE management ,VESICO-ureteral reflux ,BACTERIURIA ,PEDIATRICS ,URINALYSIS ,PYELONEPHRITIS ,EVIDENCE-based medicine ,MEDICAL screening - Abstract
We present updated, evidence-based clinical practice guidelines from the Indian Society of Pediatric Nephrology (ISPN) for the management of urinary tract infection (UTI) and primary vesicoureteric reflux (VUR) in children. These guidelines conform to international standards; Institute of Medicine and AGREE checklists were used to ensure transparency, rigor, and thoroughness in the guideline development. In view of the robust methodology, these guidelines are applicable globally for the management of UTI and VUR. Seventeen recommendations and 18 clinical practice points have been formulated. Some of the key recommendations and practice points are as follows. Urine culture with > 10
4 colony forming units/mL is considered significant for the diagnosis of UTI in an infant if the clinical suspicion is strong. Urine leukocyte esterase and nitrite can be used as an alternative screening test to urine microscopy in a child with suspected UTI. Acute pyelonephritis can be treated with oral antibiotics in a non-toxic infant for 7–10 days. An acute-phase DMSA scan is not recommended in the evaluation of UTI. Micturating cystourethrography (MCU) is indicated in children with recurrent UTI, abnormal kidney ultrasound, and in patients below 2 years of age with non-E. coli UTI. Dimercaptosuccinic acid scan (DMSA scan) is indicated only in children with recurrent UTI and high-grade (3–5) VUR. Antibiotic prophylaxis is not indicated in children with a normal urinary tract after UTI. Prophylaxis is recommended to prevent UTI in children with bladder bowel dysfunction (BBD) and those with high-grade VUR. In children with VUR, prophylaxis should be stopped if the child is toilet trained, free of BBD, and has not had a UTI in the last 1 year. Surgical intervention in high-grade VUR can be considered for parental preference over antibiotic prophylaxis or in children developing recurrent breakthrough febrile UTIs on antibiotic prophylaxis. [ABSTRACT FROM AUTHOR]- Published
- 2024
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5. The Indian Academy of Pediatrics and Directorate General of Health Services, Government of India White Paper on Transition of Care for Youth with Special Health Care Needs.
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Chandra, Jagdish, Manglani, Mamta, Aneja, Satinder, Vinayan, K. P., Sinha, Aditi, Mandal, Piali, Mishra, Devendra, Seth, Rajeev, and Kinjawadekar, Upendra
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MEDICAL needs assessment ,GOVERNMENT publications ,MEDICAL care ,YOUTH health ,STANDARD operating procedure - Abstract
Over the years, survival of children with chronic diseases has significantly improved and a large proportion of them now are entering into adulthood. Transition of Care (ToC) of such patients with having childhood onset of chronic diseases to the adult health care system is well organized in developed countries, although it is an emerging concept in India. In situations where the systems for ToC are not in place, such cases are fraught with unsatisfactory health outcomes. With proper ToC in place, these patients are likely to receive uninterrupted care by the adult care physicians and hence reach their full potential. This document highlights the need, rationale and way forward for ToC of youth with special health care needs (YSHCN) across the country. It also describes the standard operating procedures to develop the ToC at a hospital level for clinicians and administrators. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Emulgels: a promising topical drug delivery system for arthritis management and care.
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Sinha, Aditi, Garg, Unnati, Nagaich, Upendra, Chaudhary, Amit, Pandey, Manisha, and Jain, Neha
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DRUG delivery systems ,JOINT pain ,TARGETED drug delivery ,ARTHRITIS ,ANTIRHEUMATIC agents ,THERAPEUTICS - Abstract
Emulgels, hybrid formulations of emulsions and gels, offer distinct benefits viz. extended release, enhanced bioavailability, and targeted drug delivery to inflamed joints, thereby minimizing systemic side effects, and maximizing therapeutic efficacy in targeting the diseases. Oral medications and topical creams have limitations viz. limited permeation, efficacy, and side effects. Arthritis is a prevalent chronic inflammatory disorder affecting a substantial global population of about 350 million necessitating the exploration of innovative and effective treatment approaches. Inflammation of one or more joints in the body is referred to generally as arthritis, associated with joint discomfort, edema, stiffness, and decreased motion in the joints. Emulgels further improve drug solubility and penetration into the affected tissues, augmenting the potential for disease-modifying effects. This review article comprehensively examines recent research for the potential of emulgels (micro- and nanoemulgels) as a potential therapeutic approach for arthritis management, thus showcasing their promising potential in precise treatment regimens. Despite the considerable progress in emulgel-based arthritis therapies, the review emphasizes the need for additional research and translation to clinical trials, thus ascertaining their long-term safety, efficacy, and cost-effectiveness compared to conventional treatments. With ongoing advancements in drug delivery, emulgels present an exciting frontier in arthritis-associated conditions, with the potential to revolutionize arthritis treatment and significantly enhance patient life's quality. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Best way to clean your slate: corporate insolvency resolution process vis-à-vis sale as a going concern in liquidation.
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H., Jayesh, Nenwani, Palak, and Sinha, Aditi
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CORPORATE bankruptcy ,CORPORATE resolutions ,LIQUIDATION ,CORPORATE reorganizations ,BANKRUPTCY ,DEBTOR & creditor - Abstract
This article explores the option of restructuring a corporate debtor through sale as a going concern in liquidation, as opposed to the corporate insolvency resolution process. Although the existing insolvency law in India treats liquidation as a matter of last resort, this article argues that if sale as a going concern in liquidation entails a higher realisation for the creditors, it should be viewed as an equally viable and beneficial option for restructuring. However, this would necessitate overhauling the existing insolvency regime to allow the stakeholders to assess and select the best option for themselves and the corporate debtor. [ABSTRACT FROM AUTHOR]
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- 2023
8. Clinical features and outcomes of patients with diacylglycerol kinase epsilon nephropathy: a nationwide experience.
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Khandelwal, Priyanka, Thangaraju, Sharan, Krishnamurthy, Sriram, Ohri, Alpana, Pais, Priya, Mathew, Georgie, Sharma, Jyoti, Sharma, Aditi, Hari, Pankaj, Sinha, Aditi, Singh, Geetika, and Bagga, Arvind
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HYPERTENSION risk factors ,KIDNEY disease treatments ,ESCHERICHIA coli ,PATIENT aftercare ,CHRONIC kidney failure ,GENETICS ,GENETIC mutation ,SEQUENCE analysis ,DIARRHEA ,HEMOLYSIS & hemolysins ,HEALTH outcome assessment ,KIDNEY diseases ,DISEASE relapse ,TRANSFERASES ,MEDICAL records ,PROTEINURIA ,RESEARCH funding ,THROMBOCYTOPENIA ,HEMATURIA ,HISTOLOGY ,DISEASE risk factors ,SYMPTOMS - Abstract
Background: Thrombotic microangiopathy (TMA) is usually caused due to dysregulation of the alternative complement pathway. Rarely, thrombotic microangiopathy is caused by non-complement mediated mutations in diacylglycerol kinase epsilon (DGKE); information about therapy and outcome of these patients is limited. Methods: Medical records of patients, younger than 18 years, diagnosed with TMA and variants in DGKE were reviewed to include 12 patients from seven centers. Genetic studies included targeted exome sequencing and multiplex-ligation dependent probe amplification of CFH-CFHR5. Results: Patients presented at a median age of 11 (7.5, 12.3) months; all were younger than 2 years. All patients had an infectious prodrome; enteroinvasive, enteropathogenic, and enterotoxigenic Escherichia coli were detected in two patients with diarrhea. Chief features included those of microangiopathic hemolysis (n = 11), microscopic hematuria (n = 10), nephrotic range proteinuria (n = 10), hypoalbuminemia (n = 6), elevated total cholesterol (n = 6), and hypocomplementemia (n = 4). Histopathology showed thrombotic microangiopathy (n = 4), overlapping with membranoproliferative pattern of injury (n = 1). At median 3.3 years of follow-up, significant hypertension and/or proteinuria (40%), relapses (66.7%), and death or progression to CKD (60%) were common. Genetic sequencing showed 13 homozygous and compound heterozygous variants (7 pathogenic, 3 likely pathogenic) located throughout DGKE; 11 variants were novel. Conclusions: This case series highlights the need to suspect DGKE nephropathy in young patients with TMA, especially those with severe proteinuria. Medium-term outcomes are unsatisfactory with risk of relapses, progressive kidney failure, and death. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Short-term safety and efficacy of escalating doses of atorvastatin for dyslipidemia in children with predialysis chronic kidney disease stage 2–5.
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Ramesh, Punitha Lakxmi, Khandelwal, Priyanka, Lakshmy, R., Sinha, Aditi, Bagga, Arvind, and Hari, Pankaj
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TREATMENT of chronic kidney failure ,DRUG therapy for hyperlipidemia ,DRUG efficacy ,CONFIDENCE intervals ,ATORVASTATIN ,LOW density lipoproteins ,SEVERITY of illness index ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,HEMODIALYSIS ,HIGH density lipoproteins ,ODDS ratio ,PATIENT safety ,LIPIDS ,CHILDREN - Abstract
Background: Dyslipidemia is a potentially modifiable risk factor in patients with chronic kidney disease (CKD). Information on the safety and efficacy of statins in pediatric CKD is limited. Methods: Patients with CKD stage 2–5 and aged 5–18 years with low-density lipoprotein cholesterol (LDL-C) > 130 mg/dL and/or non-high-density lipoprotein cholesterol (non-HDL-C) > 145 mg/dL were enrolled from September 2019 to February 2021. All patients were administered atorvastatin 10 mg/day, which was escalated to 20 mg/day if LDL-C remained > 100 mg/dL and/or non-HDL-C > 120 mg/dL at 12 weeks. Proportion of patients achieving target lipid levels (LDL-C ≤ 100 mg/dL and non-HDL-C ≤ 120 mg/dL) and adverse events were assessed at 24 weeks. Results: Of 31 patients enrolled, target lipid levels were achieved in 45.2% (95% CI 27.8–63.7%) at 24 weeks; 22 patients required dose escalation to 20 mg at 12 weeks. There was no difference in median lipid level reduction with 10 (n = 9) versus 20 mg/day (n = 22, P = 0.3). Higher baseline LDL-C (OR 1.06, 95% CI 1.00–1.11) and older age (OR 36.5, 95% CI 2.57–519.14) were independent predictors of failure to achieve target lipid levels with 10 mg/day atorvastatin. None had persistent rise in AST/ALT > 3 times upper normal limit (UNL) or CPK > 10 times UNL. No differences were noted in adverse events due to atorvastatin 10 or 20 mg/day. Conclusion: Atorvastatin (10–20 mg/day) administered for 24 weeks was safe and effectively reduced LDL-C and non-HDL-C in children with CKD stages 2–5. Patients with higher baseline LDL-C required higher doses to achieve the target. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome.
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Khandelwal, Priyanka, Joshi, Aditi, Mathur, Aradhana, Puraswani, Mamta, Gurjar, Bahadur Singh, Sinha, Aditi, Hari, Pankaj, Faruq, Mohammed, and Bagga, Arvind
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HEMOLYTIC-uremic syndrome treatment ,AUTOANTIBODIES ,GLOMERULAR filtration rate ,COMPLEMENT (Immunology) ,SEQUENCE analysis ,CONFIDENCE intervals ,BLOOD plasma ,PLASMA exchange (Therapeutics) ,KIDNEY failure ,GENETIC variation ,IMMUNOSUPPRESSION ,TREATMENT effectiveness ,RESEARCH funding ,HEMOLYTIC-uremic syndrome ,DEATH ,LONGITUDINAL method - Abstract
Background: Coexisting genetic variants in patients with anti-factor H (FH)-associated atypical hemolytic uremic syndrome (aHUS) have implications for therapy. We estimated the prevalence of complement genetic variants in children with anti-FH aHUS from a prospective nationwide cohort and determined if significant genetic variants impact long-term kidney outcomes. Methods: Of 436 patients in the database, 77 consecutive patients, 21 with a relapse and 9 with kidney failure and/or death were included. Targeted sequencing, using a 27-gene panel including CFH, CFI, CFB, C3, CD46, PLG, DGKE, and THBD and multiplex ligation-dependent probe amplification of CFH-CFHR region, was performed. The adverse outcome was eGFR < 30 ml/min/1.73 m
2 or death. Results: Patients had high anti-FH titers 5670 (2177–13,545) AU/ml, relapsing course (42.1%), and adverse outcomes (19.6%). Variants, chiefly of unknown significance, were found in 7 (6.5%; 95% CI 3.1–13.2%); a pathogenic variant was found in one patient. Homozygous deletion of CFHR1 was present in 91.6% compared to 9.8% in 184 healthy controls. Plasma exchanges and immunosuppression showed a trend of improving outcomes, independent of genetic defects (HR 0.32; P = 0.070). Meta-analysis of 18 studies (384 patients) showed that the pooled prevalence of pathogenic and likely pathogenic variants was 3% (95% CI 0–8%). Of 37 total variants in the meta-analysis, 7 (18.9%) each were pathogenic and likely pathogenic; others were variants of unknown significance. Conclusions: Significant variants in complement regulatory genes are rare in patients with anti-FH-associated aHUS. Irrespective of genetic defects, plasma exchanges and immunosuppression showed a statistical trend to improved outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2023
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11. (T-) Regulation of Immunity in Membranous Nephropathy.
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Mathew, Georgie and Sinha, Aditi
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- 2024
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12. Youngest en-bloc kidney transplant recipient in India: defying the barriers and challenges with teamwork.
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Ajmera, Jagadeep, Pol, Manjunath Maruti, Bagga, Arvind, and Sinha, Aditi
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We received a call from a transplant coordinator about the availability of a consented deceased donor. En-bloc kidneys with the aorta and IVC (inferior vena cava) were harvested from a toddler weighing 8 kg. The recipient was of early childhood weighing 14 kg who had been on haemodialysis for the last 3 years for end-stage kidney disease. He received anti-thymocyte globulin as an induction immunosuppressant. The kidneys were transplanted en bloc in the right lower quadrant retroperitoneal region; an anastomosis was performed to the recipient’s aorta and IVC, and two separate neocystoureterostomies were created. His serum creatinine reached 0.5mg/dL on the seventh postoperative day, following a few days of delayed graft function. In this study, we describe the surgical and nonsurgical challenges that we faced while performing enbloc kidney transplant to the youngest recipient and how a multidisciplinary team approach helped us overcome them. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Management of Acute Kidney Injury in Critically Ill Children.
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Krishnasamy, Sudarsan, Sinha, Aditi, and Bagga, Arvind
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Acute kidney injury (AKI) is common in critically ill patients, affecting almost one in four critically ill children and one in three neonates. Higher stages of AKI portend worse outcomes. Identifying AKI timely and instituting appropriate measures to prevent and manage severe AKI is important, since it is independently associated with mortality. Methods to predict severe AKI should be applied to all critically ill patients. Assessment of volume status to prevent the development of fluid overload is useful to prevent adverse outcomes. Patients with metabolic or clinical complications of AKI need prompt kidney replacement therapy (KRT). Various modes of KRT are available, and the choice of modality depends most on the technical competence of the center, patient size, and hemodynamic stability. Given the significant risk of chronic kidney disease, patients with AKI require long-term follow-up. It is important to focus on improving awareness about AKI, incorporate AKI prevention as a quality initiative, and improve detection, prevention, and management of AKI with the aim of reducing acute and long-term morbidity and mortality. [ABSTRACT FROM AUTHOR]
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- 2023
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14. Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome.
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Barry, Alexandra, McNulty, Michelle T., Jia, Xiaoyuan, Gupta, Yask, Debiec, Hanna, Luo, Yang, Nagano, China, Horinouchi, Tomoko, Jung, Seulgi, Colucci, Manuela, Ahram, Dina F., Mitrotti, Adele, Sinha, Aditi, Teeninga, Nynke, Jin, Gina, Shril, Shirlee, Caridi, Gianluca, Bodria, Monica, Lim, Tze Y., and Westland, Rik
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GENOME-wide association studies ,NEPHROTIC syndrome ,DISEASE risk factors ,MONOCYTES ,MONOGENIC & polygenic inheritance (Genetics) ,IMMUNOGENETICS ,KIDNEY glomerulus diseases - Abstract
Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood glomerular disease. Previous genome-wide association studies (GWAS) identified a risk locus in the HLA Class II region and three additional independent risk loci. But the genetic architecture of pSSNS, and its genetically driven pathobiology, is largely unknown. Here, we conduct a multi-population GWAS meta-analysis in 38,463 participants (2440 cases). We then conduct conditional analyses and population specific GWAS. We discover twelve significant associations—eight from the multi-population meta-analysis (four novel), two from the multi-population conditional analysis (one novel), and two additional novel loci from the European meta-analysis. Fine-mapping implicates specific amino acid haplotypes in HLA-DQA1 and HLA-DQB1 driving the HLA Class II risk locus. Non-HLA loci colocalize with eQTLs of monocytes and numerous T-cell subsets in independent datasets. Colocalization with kidney eQTLs is lacking but overlap with kidney cell open chromatin suggests an uncharacterized disease mechanism in kidney cells. A polygenic risk score (PRS) associates with earlier disease onset. Altogether, these discoveries expand our knowledge of pSSNS genetic architecture across populations and provide cell-specific insights into its molecular drivers. Evaluating these associations in additional cohorts will refine our understanding of population specificity, heterogeneity, and clinical and molecular associations. Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Sequential rituximab therapy sustains remission of nephrotic syndrome but carries high risk of adverse effects.
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Sinha, Aditi, Mathew, Georgie, Arushi, Arushi, Govindarajan, Srinivasavaradan, Ghanapriya, Kshetrimayum, Grewal, Neetu, Rai, Khushboo, Brijwal, Megha, Kalluru, Sree Laya, Tewari, Prachi, Misra, Angeli, Khandelwal, Priyanka, Hari, Pankaj, and Bagga, Arvind
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NEPHROTIC syndrome ,BK virus ,HEPATITIS B vaccines ,RITUXIMAB ,DISEASE remission ,HEPATITIS B - Abstract
Background Sequential rituximab (RTX) administration has emerged as an important strategy to sustain remission of disease in patients with difficult-to-treat nephrotic syndrome. Methods We report the efficacy and safety of sequential therapy with two or more courses of intravenous RTX in 250 patients with difficult-to-treat steroid dependence (n = 127) and calcineurin inhibitor (CNI)-dependent or CNI-refractory steroid resistance (n = 123) managed at one center during 2015–2021. Subsets of patients were cross-sectionally tested for hypogammaglobulinemia, seroprotection against and hyporesponsiveness to vaccines for hepatitis B and tetanus, BK/JC viruria and human antichimeric antibodies (HACAs). Results Sequential RTX therapy, initiated at a median of 10 years [interquartile range (IQR) 7.3–14.4], was administered for 1.8 courses/person-year [95% confidence interval (CI) 1.7–2.0] over 2.0 years (95% CI 1.2–3.0). Therapy was associated with postponement of relapses by a median of 3 years in patients with steroid-sensitive disease and 2 years in those with steroid resistance. Relapses were reduced by a mean of 2.0 relapses/person-year (95% CI 1.8–2.2), enabling a reduction in prednisolone dose to 0.04 mg/kg/day (95% CI 0.01–0.11) and withdrawal of additional immunosuppression in 154 (62%) patients. RTX-associated adverse events, occurring at 0.20 events/person-year (95% CI 0.17–0.23), were chiefly comprised of infusion reactions (n = 108) and infections (n = 46); serious adverse events were observed in 10.8% patients, at 0.03 events/person-year (95% CI 0.02–0.05). Hypogammaglobulinemia was observed in 35% of 177 patients and was moderate to severe in 8.5% of cases. Rates of seroprotection at baseline and response following vaccination were lower for hepatitis B [1.9% and 29.4% (n = 52)] than tetanus [65.5% and 34.5% (n = 58)]. BK/JC viruria, without viremia, was observed in 7.3% of 109 cases. A total of 19 of 107 patients (17.8%) had HACAs, which were associated with B cell nondepletion and serum sickness. Age at therapy of <9–10 years was associated with a risk of early relapse, treatment failure and hypogammaglobulinemia following RTX therapy. Conclusions Sequential therapy with RTX effectively reduces relapses in patients with difficult-to-treat steroid- and/or CNI-dependent or CNI-refractory nephrotic syndrome. Therapy is associated with high rates of hypogammaglobulinemia and infusion reactions. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Feasibility and Efficacy of Sustained Low-Efficiency Dialysis in Critically Ill Children with Severe Acute Kidney Injury.
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Yadav, Menka, Tiwari, Anand N., Lodha, Rakesh, Sankar, Jhuma, Khandelwal, Priyanka, Hari, Pankaj, Sinha, Aditi, and Bagga, Arvind
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Objectives: To examine the feasibility, efficacy, and safety of sustained low-efficiency dialysis (SLED) in hemodynamically unstable, critically ill children. Methods: Critically ill patients, 1–18 y old with hemodynamic instability (≥ 1 vasoactive drugs) and severe acute kidney injury (AKI) requiring kidney replacement therapy (KRT) in a tertiary care pediatric intensive care unit were prospectively enrolled. Patients weighing ≤ 8 kg or with mean arterial pressure < 5
th percentile despite > 3 vasoactive drugs, were excluded. Patients underwent SLED until hemodynamically stable and off vasoactive drugs, or lack of need for dialysis. The primary outcome was the proportion of patients in whom the first session of SLED was initiated within 12 h of its indication and completed without premature (< 6 h) termination. Efficacy was estimated by ultrafiltration, urea reduction ratio (URR), and equilibrated Kt/V. Other outcomes included: changes in hemodynamic scores, circuit clotting, adverse events, and changes in indices on point-of-care ultrasonography and echocardiography. Results: Between November 2018 and March 2020, 18 patients with median age 8.6 y and vasopressor dependency index of 83.2, underwent 41 sessions of SLED. In 16 patients, SLED was feasible within 12 h of indication. No session was terminated prematurely. Ultrafiltration achieved was 4.0 ± 2.2 mL/kg/h, while URR was 57.7 ± 16.2% and eKt/V 1.17 ± 0.56. Hemodynamic scores did not change significantly. Asymptomatic hypokalemia was the chief adverse effect. Sessions were associated with a significant improvement in indices on ultrasound and left ventricular function. Fourteen patients died. Conclusions: SLED is feasible, safe, and effective in enabling KRT in hemodynamically unstable children with severe AKI. [ABSTRACT FROM AUTHOR]- Published
- 2023
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17. Changes in UK paediatric long-term ventilation practice over 10 years.
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Barker, Nicki, Sinha, Aditi, Jesson, Catherine, Doctor, Tahera, Narayan, Omendra, and Elphick, Heather E.
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HYPOVENTILATION ,POSITIVE pressure ventilation ,ARTIFICIAL respiration ,VENTILATION ,VOCAL cord dysfunction ,NEMALINE myopathy ,CONGENITAL myasthenic syndromes ,WOUNDS & injuries - Abstract
Objectives: To provide up-to-date information on the use of long-term ventilation (LTV) in the UK paediatric population and to compare the results with data collected 10 and 20 years previously.Design: A single timepoint census completed by LTV centres in the UK, carried out via an online survey.Setting and Patients: All patients attending paediatric LTV services in the UK.Results: Data were collected from 25 LTV centres in the UK. The total study population was 2383 children and young people, representing a 2.5-fold increase in the last 10 years. The median age was 9 years (range 0-20 years). Notable changes since 2008 were an increase in the proportion of children with central hypoventilation syndrome using mask ventilation, an increase in overall numbers of children with spinal muscular atrophy (SMA) type 1, chronic lung disease of prematurity and cerebral palsy being ventilated, and a 4.2-fold increase in children using LTV for airway obstruction. The use of 24-hour ventilation, negative pressure ventilation and tracheostomy as an interface had declined. 115 children had received a disease-modifying drug. The use of ataluren and Myozyme did not influence the decision to treat with LTV, but in 35% of the children with SMA type 1 treated with nusinersin, the clinician stated that the use of this drug had or may have influenced their decision to initiate LTV.Conclusion: The results support the need for national database for children and young people using LTV at home to inform future recommendations and assist in resource allocation planning. [ABSTRACT FROM AUTHOR]- Published
- 2023
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18. Child and caregiver perspectives on access to psychosocial and educational support in pediatric chronic kidney disease: a focus group study.
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Zhang, Yifan, Gutman, Talia, Tong, Allison, Craig, Jonathan C., Sinha, Aditi, Dart, Allison, Eddy, Allison A., Gipson, Debbie S., Bockenhauer, Detlef, Yap, Hui-Kim, Groothoff, Jaap, Zappitelli, Michael, J.A.Webb, Nicholas, Alexander, Stephen I., Furth, Susan, Samuel, Susan, Blydt-Hansen, Tom D., Dionne, Janis, Michael, Mini, and Wenderfer, Scott E.
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TREATMENT of chronic kidney failure ,PARENT attitudes ,CAREGIVER attitudes ,EDUCATION ,SOCIAL support ,HEALTH services accessibility ,FOCUS groups ,EMPATHY ,CHILDREN'S hospitals ,SELF-perception ,ATTITUDE (Psychology) ,GROUP identity ,PATIENTS' attitudes ,HEALTH ,THEMATIC analysis ,EMOTIONS ,PSYCHOLOGICAL resilience ,CHILDREN - Abstract
Background: Children with chronic kidney disease (CKD) generally have worse educational and psychosocial outcomes compared with their healthy peers. This can impair their ability to manage their treatment, which in turn can have long-term health consequences through to adulthood. We attempted to capture the experiences of children with CKD and to describe the perspectives of their parents and caregivers on access to educational and psychosocial support. Methods: Children with CKD (n = 34) and their caregivers (n = 62) were sampled via focus groups from pediatric hospitals in Australia, Canada, and the USA. Sixteen focus groups were convened and the transcripts were analyzed thematically. Results: We identified four themes: disruption to self-esteem and identity (emotional turmoil of adolescence, wrestling with the sick self, powerlessness to alleviate child's suffering, balancing normality and protection); disadvantaged by lack of empathy and acceptance (alienated by ignorance, bearing the burden alone); a hidden and inaccessible support system (excluded from formal psychological support, falling behind due to being denied special considerations); and building resilience (finding partners in the journey, moving towards acceptance of the illness, re-establishing childhood). Conclusions: Children with CKD and their caregivers encountered many barriers in accessing psychosocial and educational support and felt extremely disempowered and isolated as a consequence. Improved availability and access to psychosocial and educational interventions are needed to improve the wellbeing and educational advancement of children with CKD. A higher resolution version of the Graphical abstract is available as Supplementary information. [ABSTRACT FROM AUTHOR]
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- 2023
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19. A Study to Assess the Awareness and Practices of Helmet Use among Two-Wheeler Riders in Delhi.
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Tirwa, Milan, Joshi, Poonam, Sinha, Aditi P., Dolma, Yangchen, and Singh, Man
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HELMETS ,AWARENESS - Abstract
Objectives To assess the awareness and practice of two-wheeler riders regarding the helmet use, and to determine the association of awareness and practices with selected variables. Setting and Design This article is a descriptive survey, which was completed at All India Institute of Medical Sciences (AIIMS) premises, New Delhi, India. Materials and Methods The pretested and validated tools developed by researcher consisted of demographic sheet (8 items) along with structured awareness and practice questionnaire. Results and Conclusions Maximumparticipants were male (71.06%) with majority riding for 8 years. Asmuch as 48%of the sample population had accidentswhile driving. Only 2.9% of them reported to have sustained severe injury during these accidents. The mean awareness and practice score related to helmet use were 49.58±6.019.75±5.56. There was weak correlation between awareness and practice. Association of awareness and practices with selected variables could not be observed (p-value--0.4870). Although public awareness is present, but law needs to be more stringent. Accidents are fatal and it can happen anywhere and anytime, irrespective of long or short distance, and wearing of helmet can save a person from major injuries. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Clinical practice guidelines for nephrotic syndrome: consensus is emerging.
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Sinha, Aditi and Bagga, Arvind
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NEPHROTIC syndrome diagnosis ,NEPHROTIC syndrome treatment ,CONSENSUS (Social sciences) ,BIOPSY ,PEDIATRICS ,MEDICAL protocols ,NEPHROLOGY ,DISEASE relapse ,IMIDAZOLES ,CYCLOPHOSPHAMIDE ,PREDNISONE ,INTERNATIONAL agencies - Abstract
The article highlights clinical guidelines for the management of nephrotic syndrome. Topics mentioned include the randomized controlled trials for the use of corticosteroid therapy in the management of first episode of nephrotic syndrome, the use of prednisone for the therapy of relapses, and the importance of managing patients with frequent relapse and who are dependent with steroid to lessen the risk of morbidity and the side effects of immunosuppresive medications.
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- 2022
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21. Efficacy of rituximab versus tacrolimus in difficult-to-treat steroid-sensitive nephrotic syndrome: an open-label pilot randomized controlled trial.
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Mathew, Georgie, Sinha, Aditi, Ahmed, Aijaz, Grewal, Neetu, Khandelwal, Priyanka, Hari, Pankaj, and Bagga, Arvind
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DRUG efficacy ,RITUXIMAB ,PILOT projects ,PATIENT aftercare ,INTRAVENOUS therapy ,CONFIDENCE intervals ,NEPHROTIC syndrome ,STEROIDS ,ORAL drug administration ,TIME ,RISK assessment ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,ADVERSE health care events ,DATA analysis software ,TACROLIMUS ,DRUG toxicity ,DISEASE remission ,EVALUATION - Abstract
Background: Rituximab and tacrolimus are therapies reserved for patients with frequently relapsing or steroid-dependent nephrotic syndrome who have failed conventional steroid-sparing agents. Given their toxicities, demonstrating non-inferiority of rituximab to tacrolimus may enable choice between these medications. Methods: This investigator-initiated, single-center, open-label, pilot randomized controlled trial examined the non-inferiority of two doses of intravenous (IV) rituximab given one-week apart to oral therapy with tacrolimus (1:1 allocation), in maintaining sustained remission over 12 months follow-up, in patients with difficult-to-treat steroid-sensitive nephrotic syndrome, defined as frequently relapsing or steroid-dependent disease that had failed ≥ 2 steroid-sparing strategies. Secondary outcomes included frequency of relapses, proportion with frequent relapses, time to relapse and frequent relapses, and adverse events (CTRI/2018/11/016342). Results: Baseline characteristics were comparable for 41 patients randomized to receive rituximab (n = 21) or tacrolimus (n = 20). While 55% of patients in each limb were in sustained remission at 1 year, non-inferiority of rituximab to tacrolimus was not demonstrated (mean difference 0%; 95% CI – 30.8%, 30.8%; non-inferiority limit – 20%; P = 0.50). Frequent relapses were more common in patients administered rituximab compared to tacrolimus (risk difference 30%, 95% CI 7.0, 53.0, P = 0.023). Both groups showed similar reductions in relapse rates and prednisolone use. Common adverse events were infusion-related with rituximab and gastrointestinal symptoms with tacrolimus. Conclusions: Therapy with rituximab was not shown to be non-inferior to 12-months treatment with tacrolimus in maintaining remission in patients with difficult-to-treat steroid-sensitive nephrotic syndrome. Frequent relapses were more common with rituximab. While effective, both agents require close monitoring for adverse events. A higher resolution version of the Graphical abstract is available as Supplementary information. [ABSTRACT FROM AUTHOR]
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- 2022
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22. Metabolic and Genetic Evaluation in Children with Nephrolithiasis.
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Mandal, Anita, Khandelwal, Priyanka, Geetha, Thenral S., Murugan, Sakthivel, Meena, Jitendra, Jana, Manisha, Sinha, Aditi, Kumar, Rajeev, Seth, Amlesh, Hari, Pankaj, and Bagga, Arvind
- Abstract
Objective: To evaluate metabolic and genetic abnormalities in children with nephrolithiasis attending a referral center in North India.Methods: The patients aged 1-18 y old with nephrolithiasis underwent biochemical evaluation and whole-exome sequencing. The authors evaluated for monogenic variants in 56 genes and compared allele frequency of 39 reported polymorphisms between patients and 1739 controls from the GenomeAsia 100 K database.Results: Fifty-four patients, aged 9.1 ± 3.7 y were included. Stones were bilateral in 42.6%, familial in 33.3%, and recurrent in 25.9%. The most common metabolic abnormalities were hypercalciuria (35.2%), hyperoxaluria (24.1%), or both (11.1%), while xanthinuria (n = 3), cystinuria (n = 1), and hyperuricosuria (n = 1) were rare. Exome sequencing identified an etiology in 6 (11.1%) patients with pathogenic/likely pathogenic causative variants. Three variants in MOCOS and one in ATP7B were pathogenic; likely pathogenic variants included MOCOS (n = 2), AGXT, and SLC7A9 (n = 1, each). Causality was not attributed to two SLC34A1 likely pathogenic variants, due to lack of matching phenotype and dominant family history. Compared to controls, allele frequency of the polymorphism TRPV5 rs4252402 was significantly higher in familial stone disease (allele frequency 0.47 versus 0.53; OR 3.2, p = 0.0001).Conclusion: The chief metabolic abnormalities were hypercalciuria and hyperoxaluria. A monogenic etiology was identified in 11% with pathogenic or likely pathogenic variants using a gene panel for nephrolithiasis. Heterozygous missense variants in the sodium-phosphate cotransporter SLC34A1 were common and required evaluation for attributing pathogenicity. Rare polymorphisms in TRPV5 might increase the risk of familial stones. These findings suggest that a combination of metabolic and genetic evaluation is useful for determining the etiology of nephrolithiasis. [ABSTRACT FROM AUTHOR]- Published
- 2022
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23. Bio-Control of Citrus Canker: An Alternative to Chemical Based Treatment.
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BHOWAL, RONY, KUMARI, SONY, DEKA, PINKY, ROY, PUJA, KOCH, PRANAB JYOTI, AHMED, SHAHBAAZ, and SINHA, ADITI
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CITRUS canker ,AGRICULTURAL technology ,AGRICULTURAL productivity ,XANTHOMONAS ,BIOLOGICAL pest control agents - Abstract
The importance of the citrus crops is recognized throughout the world. Despite tremendous advancements in agricultural technology, citrus fruit production is still considered a significant challenge. Various biotic factors have trampled down the production rate of Citrus in many places. Among them, canker caused by Xanthomonas axonopodis pv. citri (Xac) and Xanthomonas citri pv. citri (Xcc) is of great importance. Infection caused by Xac leads to lesion development in leaves, fruits, and stem. Defoliation and early fruit drop can occur as a result of severe infection, resulting in a loss of fruit output. Preliminary management techniques involve quarantining and sanitizing. Chemical copper-based bactericides are frequently employed in places with large-scale production. However, the continued use of chemicals, on the other hand, has led to the evolution of resistant microorganisms and increased the rate of soil pollution. Various alternative strategies have been suggested to address this issue. This review will go over the advances in biocontrol agents that have been used to combat the disease. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Gastrostomy Tube Feeding in Indian Children with Advanced Chronic Kidney Disease.
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Sharma, Shally, Sinha, Aditi, Malik, Rohan, and Bagga, Arvind
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Guidelines recommend initiating supplemental enteral feeding through a nasogastric (NG) or gastrostomy tube (G-tube) in patients with chronic kidney disease who have inadequate oral intake despite repeated nutritional counseling. While G-tube placement is shown to improve both nutritional status and anthropometric indices of children with CKD in developed regions, information from developing countries is lacking. This retrospective report reviewed the impact of G-tube feeding on nutritional intakes and anthropometric parameters over a 1-y follow-up in 5 children with CKD-5D managed at one tertiary care center in India. Gastrostomy feeding facilitated significant increments in caloric and protein intake and was easy and safe. However, G-tube feeding led to additional expenses, and the changes in growth parameters were variable in the short term. A longer follow-up appears necessary to understand its impact on wasting, growth velocity, and stature. [ABSTRACT FROM AUTHOR]
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- 2023
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25. Anti-factor H antibody associated hemolytic uremic syndrome following SARS-CoV-2 infection.
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Khandelwal, Priyanka, Krishnasamy, Sudarsan, Govindarajan, Srinivasavaradan, Kumar, Manish, Marik, Binata, Sinha, Aditi, Hari, Pankaj, and Bagga, Arvind
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DISEASE relapse ,HEMOLYTIC-uremic syndrome treatment ,AUTOANTIBODIES ,REVERSE transcriptase polymerase chain reaction ,RESPIRATORY diseases ,GLOMERULAR filtration rate ,COVID-19 ,FEVER ,GENETIC mutation ,PREDNISOLONE ,BLOOD transfusion ,GENETIC testing ,MYCOPHENOLIC acid ,CYCLOPHOSPHAMIDE ,HEMOLYTIC-uremic syndrome ,COVID-19 testing ,DISEASE risk factors ,THERAPEUTICS - Abstract
Background: The pathogenesis of autoantibody generation in anti-factor H (FH) antibody associated atypical hemolytic uremic syndrome (aHUS) is unknown and is perhaps triggered by an infectious or environmental agent. We observed an unusual increase of patients with anti-FH antibody associated aHUS coinciding with the second pandemic wave in New Delhi and suspected that SARS-CoV-2 infection might be a potential trigger. Methods: We screened for SARS-CoV-2 infection using reverse transcriptase polymerase chain reaction (RT-PCR) and serology in 13 consecutive patients with anti-FH antibody associated aHUS during the past year in New Delhi. Results: We report 5 patients, 4–13 years old, who presented with a febrile illness without respiratory symptoms during the second pandemic wave. Of these, 3 patients presented with a relapse 25–85 months following the initial episode of aHUS. SARS-CoV-2 was detected by RT-PCR in 1 patient and by serology in 4 patients (median titer 47.1 cut-off index). Patients had high titers of anti-FH antibodies (median 2,300 AU/ml). Genetic studies, done in 3 of the 5 patients, showed homozygous CFHR1 deletion without other significant genetic abnormalities. Specific management comprised plasma exchanges and oral prednisolone, combined with either cyclophosphamide or mycophenolate mofetil. At median follow-up of 3.3 months, the estimated glomerular filtration rate in 4 patients ranged from 62 to 110 ml/min/1.73 m
2 ; one patient was dialysis-dependent. Conclusion: Increased vigilance is required during the pandemic, especially in patients with anti-FH associated aHUS, who might relapse despite quiescent disease for a prolonged period. [ABSTRACT FROM AUTHOR]- Published
- 2022
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26. Monogenic lupus with homozygous C4A deficiency presenting as bronchiectasis and immune-mediated thrombocytopenia.
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Tak, Asma S., Satapathy, Jagatshreya, Jana, Manisha, Sinha, Aditi, Jat, Kana Ram, and Bagri, Narendra K.
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JOINTS (Anatomy) ,PRIMARY immunodeficiency diseases ,THROMBOCYTOPENIA ,PULMONARY manifestations of general diseases ,WEIGHT gain ,LUPUS nephritis ,BRONCHIECTASIS - Abstract
Monogenic lupus is a subset of lupus caused by single-gene disorders, integrating the paradoxical combination of autoimmunity and immunodeficiency. Pulmonary manifestations with recurrent pneumonia and bronchiectasis have rarely been described as the predominant presentation of juvenile lupus and may suggest an alternate differential like primary immunodeficiency, especially in early childhood. We describe a case of 10-year girl who presented with a history of recurrent pneumonia, arthritis, alopecia, and poor weight gain for the past 2 years. On examination, she had respiratory distress, bilateral diffuse crackles and arthritis of the small joints of hands. Lab investigations showed pancytopenia, low complement levels and high titers of ANA and anti-dsDNA antibodies. The patient was diagnosed with juvenile lupus. Imaging studies revealed evidence of multiple lobar collapse and consolidation with bronchiectasis. She was started on steroids, HCQ and supportive measures for bronchiectasis. The child reported relief in initial symptoms of lupus on follow-up but developed recurrent thrombocytopenia requiring IVIG and escalating the doses of oral steroids. The young age and atypical presentation prompted a screening for monogenic lupus, and clinical exome sequencing revealed a novel homozygous missense variation in exon 20 of the C4Agene with clinically reduced C4 levels, consistent with the diagnosis of C4A deficiency. [ABSTRACT FROM AUTHOR]
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- 2022
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27. A Century With Craniopagus Twin Separation Surgeries: Nihilism to Optimism.
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Gupta, Deepak MCH,, Kedia, Shweta MCH, Rath, Girija Prasad DM, Pandia, Mihir Prakash, Chauhan, Sandeep, Sharma, Rajeev MCH, Raheja, Amol MCH, Darbari, Shaurya MCH, Kamra, Devasheesh MCH, Malik, Vishwas, Saxena, Anita, Hote, Milind MCH, Lodha, Rakesh, Gulati, Sheffali FRCPCH, Jauhari, Prashant, Sankar, Jhuma, Sinha, Aditi, Bagga, Arvind, Kapil, Arti, and Singhal, Maneesh MCH
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- 2022
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28. Patient and caregiver perspectives on blood pressure in children with chronic kidney disease.
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Wu, Justin Guang-Ao, Tong, Allison, Evangelidis, Nicole, Manera, Karine E, Hanson, Camilla S, Baumgart, Amanda, Amir, Noa, Sinha, Aditi, Dart, Allison, Eddy, Allison A, Guha, Chandana, Gipson, Debbie S, Bockenhauer, Detlef, Yap, Hui-Kim, Groothoff, Jaap, Zappitelli, Michael, Alexander, Stephen I, Furth, Susan L, Samuel, Susan, and Carter, Simon A
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BLOOD pressure ,PEDIATRIC nephrology ,CHRONIC kidney failure ,PATIENTS' attitudes ,PATIENT-centered care ,CARDIOVASCULAR diseases ,KIDNEY failure - Abstract
Background More than 50% of children with chronic kidney disease (CKD) have uncontrolled hypertension, increasing their long-term risk of cardiovascular disease and progression to kidney failure. Children receiving medications or dialysis may also experience acute blood pressure fluctuations accompanied by debilitating symptoms. We aimed to describe the perspectives of children with CKD and their parental caregivers on blood pressure to inform patient-centered care. Methods Secondary thematic analysis was conducted on qualitative data from the Standardized Outcomes in Nephrology—Children and Adolescents initiative, encompassing 16 focus groups, an international Delphi survey and two consensus workshops. We analyzed responses from children with CKD (ages 8–21 years) and caregivers (of children ages 0–21 years) pertaining to blood pressure. Results Overall, 120 patients and 250 caregivers from 22 countries participated. We identified five themes: invisibility and normalization (reassured by apparent normotension, absence of symptoms and expected links with CKD), confused by ambiguity (hypertension indistinguishable from cardiovascular disease, questioning the need for prophylactic intervention, frustrated by inconsistent messages and struggling with technical skills in measurement), enabling monitoring and maintaining health (gaging well-being and preventing vascular complications), debilitating and constraining daily living (provoking anxiety and agitation, helpless and powerless and limiting life activities) and burden of medications (overwhelmed by the quantity of tablets and distress from unexpected side effects). Conclusions For children with CKD and their caregivers, blood pressure was an important heath indicator, but uncertainty around its implications and treatment hampered management. Providing educational resources to track blood pressure and minimizing symptoms and treatment burden may improve outcomes in children with CKD. [ABSTRACT FROM AUTHOR]
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- 2022
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29. Severity, Risk Factors and Quality of Life of Patients associated with Chemotherapy-Induced Peripheral Neuropathy.
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Srivastava, Saumya P., Sinha, Aditi Prashant, Sharma, Kamlesh Kumari, and Malik, Prabhat Singh
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HOSPITALS ,INFERENTIAL statistics ,PERIPHERAL neuropathy ,ADULT day care ,VEGETABLES ,CANCER chemotherapy ,CROSS-sectional method ,RESEARCH methodology ,TERTIARY care ,CLINICAL medicine research ,SEVERITY of illness index ,RISK assessment ,CONCEPTUAL structures ,QUALITY of life ,HOSPITAL wards ,BODY movement ,EXERCISE ,HEALTH behavior ,FRUIT ,DESCRIPTIVE statistics ,PACLITAXEL ,STATISTICAL sampling ,DATA analysis software ,DISEASE risk factors ,EVALUATION ,SYMPTOMS - Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) refers to numbness, tingling, and burning sensation caused by chemotherapy that can cause impairment in Quality of Life (QoL) of the patients. Study assesses severity, risk factors, and quality of life of patients associated with CIPN. A cross sectional descriptive study was conducted at day care ward, tertiary care hospital India. Total of 98 patients receiving paclitaxel for ≥4 months were enrolled by convenient sampling. Data regarding demographics and clinical characteristics, CIPN severity, risk factors, and QoL were collected by structured questionnaires. Study revealed that median score of autonomic symptoms was higher than sensory and motor symptoms. Mean score of FACT/GOG-Ntx sub-domain was 99.05 ± 20.87on a scale of 0 to 152. ECOG Performance status, current exercise behavior, and fruit and vegetable intake was found to be significantly (at p <.05) associated with sensory, motor, and autonomic symptom score. Therefore, CIPN was found to have debilitating effect on QoL. [ABSTRACT FROM AUTHOR]
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- 2022
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30. Efficacy and Safety of Combination Therapy with Tolvaptan and Furosemide in Children with Nephrotic Syndrome and Refractory Edema: A Prospective Interventional Study.
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Meena, Jitendra, Hari, Pankaj, Sinha, Aditi, and Bagga, Arvind
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Objective: Severe edema in children with nephrotic syndrome is often refractory to conventional diuretics. Tolvaptan has been used satisfactorily for managing edema in patients with heart failure and cirrhosis. The safety and efficacy of combination therapy with oral tolvaptan and intravenous (IV) furosemide was assessed in patients with furosemide refractory edema. Methods: Patients, aged 5–18 y with nephrotic syndrome and severe edema, were screened for eligibility. After excluding hypovolemia, patients received IV furosemide (3–4 mg/kg/d) for 48 h. Those refractory to IV furosemide (weight loss < 3%) received tolvaptan (0.5–1 mg/kg once daily) and IV furosemide for the next 48 h. Parameters were compared between 48 h of furosemide alone and combination therapy. Results: A total of 24 patients (18 boys) with mean age of 8.0 ± 3.0 y were enrolled. Urine volume significantly increased with combination therapy as compared to furosemide therapy (mean difference: 1.2 mL/kg/h; 95% CI: 0.8–1.65 mL/kg/h) (p < 0.001). Compared to therapy with furosemide alone, combination therapy resulted in significant reduction in body weight from 26.9 ± 10.3 kg to 24.8 ± 9.7 kg (p < 0.001). Estimated glomerular filtration rate did not change (p = 0.81) but serum sodium increased from 135.7 ± 3.3 mEq/L to 140.4 ± 4.8 mEq/L (p < 0.001) with combination therapy; 2 patients showed asymptomatic hypernatremia. Conclusion: The combination of oral tolvaptan and IV furosemide is effective in augmenting diuresis and reducing weight in patients with furosemide refractory edema but requires monitoring of electrolytes and volume status. [ABSTRACT FROM AUTHOR]
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- 2022
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31. Vascular neoplasia masquerading as cellulitis and persistent hemorrhagic pericardial effusion.
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Thangaraju, Sharan, Relan, Jay, Sinha, Aditi, Arava, Sudheer, Khanna, Neena, and Raju, Sreenivasa
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BLOOD-vessel tumors ,PERICARDITIS ,PREDNISOLONE ,RAPAMYCIN ,PERICARDIAL effusion ,CELLULITIS ,DIFFERENTIAL diagnosis ,TREATMENT effectiveness ,BLOOD-vessel abnormalities ,HEMORRHAGE ,HEMANGIOMAS ,DISEASE complications ,CHILDREN - Abstract
Tufted angioma and kaposiform hemangioendothelioma are considered to represent two ends of the spectrum of benign vascular neoplasms that predominantly present during infancy or early childhood. We report a rare case of a 5-month-old infant with complicated vascular neoplasm involving the pericardial cavity and skin over cervical region, masquerading as infective pericarditis with cellulitis. The patient responded dramatically to therapy with oral prednisolone and sirolimus, with a significant reduction of size of skin lesions and complete resolution of pericardial effusion over 8 weeks. The report also highlights the importance of a multidisciplinary team in managing such complicated cases. [ABSTRACT FROM AUTHOR]
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- 2022
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32. SARS-CoV-2 infection in children with chronic kidney disease.
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Krishnasamy, Sudarsan, Mantan, Mukta, Mishra, Kirtisudha, Kapoor, Kanika, Brijwal, Megha, Kumar, Manish, Sharma, Shobha, Swarnim, Swarnim, Gaind, Rajni, Khandelwal, Priyanka, Hari, Pankaj, Sinha, Aditi, and Bagga, Arvind
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KIDNEY disease diagnosis ,THERAPEUTICS ,CONFIDENCE intervals ,NEPHROTIC syndrome ,RETROSPECTIVE studies ,RENAL replacement therapy ,TREATMENT effectiveness ,NEPHROLOGY ,SEVERITY of illness index ,DESCRIPTIVE statistics ,ODDS ratio ,COVID-19 pandemic ,ACUTE kidney failure ,CHILDREN - Abstract
Background: Information on the course of SARS-CoV-2 infection in children with chronic kidney disease (CKD) is limited. Methods: We retrospectively reviewed the presentation and outcomes of SARS-CoV-2 infection in patients with CKD followed at any of the four pediatric nephrology centers in New Delhi from April 2020 to June 2021. Outcomes, including cardiopulmonary and renal complications, were reported in relation to underlying disease category and illness severity at presentation. Results: Underlying illness in 88 patients included nephrotic syndrome (50%), other CKD stages 1–4 (18.2%), CKD 5D (17%), and CKD 5T (14.8%). Thirty-two of 61 patients with symptomatic COVID-19 and 9/27 asymptomatic patients were admitted for median 10 (interquartile range 7–15) days. Seventeen (19.3%) patients developed moderate or severe COVID-19. Systemic complications, observed in 30 (34.1%), included acute kidney injury (AKI, 34.2%), COVID-19 pneumonia (15.9%), unrelated pulmonary disease (2.3%), and shock (4.5%). Nineteen (21.6%) had severe complications (AKI stage 2–3, encephalopathy, respiratory failure, shock). Eight (11%) of twelve (16.4%) patients with severe AKI required dialysis. Three (3.4%) patients, two with steroid-resistant nephrotic syndrome in relapse and one with CKD 1–4, died due to respiratory failure. Univariate logistic regression indicated that patients presenting with nephrotic syndrome in relapse or moderate to severe COVID-19 were at risk of AKI (respective odds ratio, 95%CI: 3.62, 1.01–12.99; 4.58, 1.06–19.86) and/or severe complications (respective odds ratio, 95%CI: 5.92, 1.99–17.66; 61.2, 6.99–536.01). Conclusions: Children with CKD presenting with moderate-to-severe COVID-19 or in nephrotic syndrome relapse are at risk of severe complications, including severe AKI and mortality. A higher resolution version of the Graphical abstract is available as Supplementary information [ABSTRACT FROM AUTHOR]
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- 2022
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33. Short Course of Daily Prednisolone During Upper Respiratory Tract Infection for Children With Relapsing Steroid Sensitive Nephrotic Syndrome.
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Mathew, Joseph L., Bagga, Arvind, Sinha, Aditi, Sinha, Rajiv, and Sankar, Janani
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RESPIRATORY infections ,RESPIRATORY infections in children ,NEPHROTIC syndrome ,PREDNISOLONE ,FOCAL segmental glomerulosclerosis ,STEROIDS - Abstract
Summary: PREDNOS 2 was a double blind placebo controlled trial done to investigate the use of daily low-dose prednisolone for the treatment of upper respiratory tract infection—related relapses. It evaluated 365 children with relapsing steroid-sensitive nephrotic syndrome with and without background immunosuppressive treatment at 122 pediatric departments in the UK from February 1, 2013, to January 31, 2020. At the beginning of an upper respiratory tract infection, children received 6 days of prednisolone, 15 mg/m
2 daily, or matching placebo preparation. Those already taking alternate-day prednisolone rounded their daily dose using trial medication to the equivalent of 15 mg/m2 daily or their alternate-day dose, whichever was greater. The primary outcome was the incidence of first upper respi-ratory tract infection-related relapse. The modified intention-to-treat analysis population comprised 271 children (mean (SD) age, 7.6 (3.5) years; 64.2% male), with 134 in the prednisolone arm and 137 in the placebo arm. The number of patients experiencing an upper respiratory tract infection-related relapse was 56 (42.7%) in the predniso-lone arm and 58 (44.3%) in the placebo arm (adjusted risk difference, 0.02; 95% CI, 0.14 to 0.10; P =0.70). No evidence was found that the treatment effect differed according to background immuno-suppressive treatment. A post hoc subgroup analysis assessing the primary outcome in 54 children of South Asian ethnicity (risk ratio, 0.66; 95% CI, 0.40–1.10) vs 208 children of other ethnicity (risk ratio, 1.11; 95% CI, 0.81–1.54) found no difference in efficacy of intervention in those of South Asian ethnicity (test for interaction P=0.09). The authors concluded that, results of PREDNOS 2 suggest that administering 6 days of daily low-dose prednisolone at the time of an upper respiratory tract infection does not reduce the risk of relapse of nephrotic syndrome in children in the UK and further work is needed to study the inter-ethnic differences in the study response. [ABSTRACT FROM AUTHOR]- Published
- 2022
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34. Clinical Features and Genetic Sequencing of Children with Fanconi–Bickel Syndrome.
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Govindarajan, Srinivasavaradan, Khandelwal, Priyanka, Sharma, Shally, Agarwala, Anuja, Sinha, Aditi, Hari, Pankaj, and Bagga, Arvind
- Abstract
The present paper reports 10 patients (9 families) with Fanconi–Bickel syndrome managed during 2010–2021. Patients presented with polyuria, polydipsia, hepatomegaly, rickets, and stunting at a median of 5 (3, 7.3) mo; one had transient neonatal diabetes. Glucosuria, generalized aminoaciduria, β
2 -microglobinuria, urinary phosphate wasting, and hypercalciuria were present in all patients; 3 patients had nephrocalcinosis. Other metabolic abnormalities included hypertriglyceridemia (n = 5/6), fasting hypoglycemia (n = 5/8), and postprandial hyperglycemia (n = 3/6). Genetic analysis showed 7 homozygous or compound heterozygous variants in SLC2A2. A pathogenic variant c.952G>A, common to 4 patients (3 families), might be a potential hotspot. At a median follow-up of 43 mo, 4 patients died at a median of 25 mo; short stature persisted in all except one patient who showed catch-up growth with uncooked corn-starch diet. The present findings suggest that the Fanconi–Bickel syndrome has a severe phenotype with an unsatisfactory outcome. A high index of suspicion for diagnosis and efforts for facilitation of dietary therapy are necessary. [ABSTRACT FROM AUTHOR]- Published
- 2023
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35. Short-Term Effects of Cholecalciferol Supplementation on cFGF23 Levels in Children with Chronic Kidney Disease and Vitamin D Insufficiency.
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Sheriff, Abraar, Mathew, Georgie, Sinha, Aditi, Hari, Smriti, Gupta, Nandita, Ramakrishnan, Lakshmy, Hari, Pankaj, and Bagga, Arvind
- Subjects
TREATMENT of chronic kidney failure ,ALKALINE phosphatase ,VITAMINS ,CLINICAL trials ,GROWTH factors ,CHOLECALCIFEROL ,VITAMIN D ,PARATHYROID hormone ,DIETARY supplements ,MENTAL health surveys ,RESEARCH funding ,VITAMIN D deficiency ,CALCIUM ,PHOSPHATES ,LONGITUDINAL method - Abstract
Data on the effect of vitamin D supplementation on fibroblast growth factor 23 (FGF23), in chronic kidney disease (CKD) are scarce. In a prospective interventional study, the effect of vitamin D supplementation on cFGF23 (C-terminal FGF23) levels in children with CKD stages 2-4 was examined. Forty-one children with CKD and vitamin D insufficiency were administered 600,000 units of cholecalciferol over 3 d; 88% of patients achieved sufficiency at 8 wk. Significant increase in serum cFGF23 and phosphate levels was observed in CKD stage 2 after supplementation, but not in CKD stages 3 and 4. There was no correlation of the change in cFGF23 level with baseline or change in bone health parameters (calcium, phosphate, parathormone or alkaline phosphatase) or with change in flow-mediated dilatation (FMD) of the brachial artery. It is concluded that cholecalciferol supplementation increases serum calcium and reduces PTH, but does not adversely affect FGF23 levels in CKD. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
36. Vocal cord palsy as a sequela of paediatric cardiac surgery – a review.
- Author
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Sinha, Aditi, Geragotellis, Alexander, Singh, Guntaj Kaur, Verma, Devika, Ansari, Daniyal Matin, Tarmahomed, Abdullah, Whitehall, Emma, Lowe, Natalie, Ashry, Amer, and Harky, Amer
- Published
- 2021
- Full Text
- View/download PDF
37. Impact of Standardized Educational Intervention on Improvement in Analgesic Knowledge and Its Compliance among Patients of Advanced Cancer Patients Attending Palliative Clinic: Prospective Randomized Study.
- Author
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Aparna, S., Gopichandran, L., Garg, Rakesh, and Sinha, Aditi Prashant
- Subjects
ANALYSIS of variance ,ANALGESICS ,MANN Whitney U Test ,CANCER patients ,TUMOR classification ,RANDOMIZED controlled trials ,T-test (Statistics) ,INTELLECT ,DESCRIPTIVE statistics ,QUESTIONNAIRES ,PATIENT education ,PATIENT compliance ,DATA analysis software ,PALLIATIVE treatment ,LONGITUDINAL method - Abstract
Patient education is a low-cost intervention that can help in improving the knowledge and compliance regarding analgesics. This study aimed to assess the effectiveness of the standardized educational intervention on knowledge regarding analgesic, its compliance, and barriers to compliance among advanced cancer patients attending palliative care clinic. In this randomized control trial, 100 advanced cancer patients with pain were randomly allocated to two groups. A standardized educational intervention of 10-15 minutes on cancer pain management and analgesics was delivered at clinic visit to the patients in the intervention group at baseline and the control group received usual care. Analgesic knowledge, analgesic compliance, and barriers to compliance were measured for each patient at baseline, 2 and 4 weeks follow up visit. The data was analyzed and p < 0.05 was considered significant. Analgesic knowledge (p = 0.001) and compliance (p = 0.001) improved significantly in the experimental group at 2 weeks and 4 weeks as compared to the control group. There was also a statistically significant decrease in barriers to compliance in the experimental group as compared to the control group. A significant correlation between the knowledge and compliance score at 4 weeks in the experimental group was found with a Karl Pearson correlation coefficient, r = 0.628 (p = 0.001). The standardized educational intervention was found to be effective in improving the analgesic knowledge and analgesic compliance among cancer patients with pain at 2 and 4 weeks follow up as compared to the usual care. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
38. Consensus Guidelines on Management of Steroid Resistant Nephrotic Syndrome.
- Author
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Vasudevan, Anil, Thergaonkar, Ranjeet, Mantan, Mukta, Sharma, Jyoti, Khandelwal, Priyanka, Hari, Pankaj, Sinha, Aditi, and Bagga, Arvind
- Subjects
NEPHROTIC syndrome in children ,PEDIATRIC nephrology diagnosis ,KIDNEY disease treatments ,KIDNEY function tests ,KIDNEY disease diagnosis - Abstract
Justification: The management of steroid-resistant nephrotic syndrome (SRNS) is challenging. These guidelines update existing 2009 Indian Society of Pediatric Nephrology recommendations on its management. Objective: To frame revised guidelines on diagnosis and evaluation, treatment and follow-up, and supportive care of patients with the illness. Process: The guidelines combine evidence-based recommendations and expert opinion. Formulation of key questions was followed by systematic review of literature, evaluation of evidence by experts, and two face-to-face meetings. Recommendations: Patients with SRNS should be managed under supervision of a pediatric nephrologist. Fourteen statements provide updated advice for defining steroid resistance, and underscore the importance of estimating proteinuria and baseline kidney function and the need for kidney biopsy and genetic screening. Calcineurin inhibitors are recommended as most effective in inducing remission of proteinuria, the chief factor associated with long-term renal survival. Advice on managing allograft recurrence, congenital nephrotic syndrome, and monitoring and supportive care, including the transition of care is described. This revised practice guideline is intended to improve management and patient outcomes and provide direction for future research. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
39. Steroid Sensitive Nephrotic Syndrome: Revised Guidelines.
- Author
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Sinha, Aditi, Bagga, Arvind, Banerjee, Sushmita, Mishra, Kirtisudha, Mehta, Amarjeet, Agarwal, Indira, Uthup, Susan, Saha, Abhijeet, and Mishra, Om Prakash
- Subjects
NEPHROTIC syndrome in children ,STEROID drugs ,PEDIATRIC nephrology diagnosis ,HYPOVOLEMIA ,EDEMA - Abstract
Justification: Steroid-sensitive nephrotic syndrome (SSNS) is one of the most common chronic kidney diseases in children. These guidelines update the existing Indian Society of Pediatric Nephrology recommendations on its management. Objective: To frame revised guidelines on diagnosis, evaluation, management, and supportive care of patients with the illness. Process: The guidelines combine evidence-based recommendations and expert opinion. Formulation of key questions was followed by review of literature and evaluation of evidence by experts in two face-to-face meetings. Recommendations: The initial statements provide advice for evaluation at onset and follow-up and indications for kidney biopsy. Subsequent statements provide recommendations for the management of the first episode of illness and of disease relapses. Recommendations on the use of immunosuppressive strategies in patients with frequent relapses and steroid dependence are accompanied by suggestions for step-wise approach and plan of monitoring. Guidance is also provided regarding the management of common complications including edema, hypovolemia, and serious infections. Advice on immunization and transition of care is given. The revised guideline is intended to improve the management and outcomes of patients with SSNS and provide directions for future research. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
40. Consensus Guidelines on Management of Steroid-Resistant Nephrotic Syndrome.
- Author
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Vasudevan, Anil, Thergaonkar, Ranjeet, Mantan, Mukta, Sharma, Jyoti, Khandelwal, Priyanka, Hari, Pankaj, Sinha, Aditi, and Bagga, Arvind
- Subjects
NEPHROTIC syndrome ,RENAL biopsy ,PEDIATRIC nephrology ,EXPERT evidence ,FOCAL segmental glomerulosclerosis ,KIDNEY diseases - Abstract
Justification: The management of steroid resistant nephrotic syndrome (SRNS) is challenging. These guidelines update existing 2009 Indian Society of Pediatric Nephrology recommendations on its management. Objective: To frame revised guidelines on diagnosis and evaluation, treatment and follow up, and supportive care of patients with the illness. Process: The guidelines combine evidence-based recommendations and expert opinion. Formulation of key questions was followed by systematic review of literature, evaluation of evidence by experts and two face-to-face meetings. Recommendations: Fourteen statements provide updated advice for managing steroid resistance, and underscore the importance of estimating proteinuria and baseline kidney function, and the need for kidney biopsy and genetic screening. Calcineurin inhibitors are recommended as most effective in inducing remission of proteinuria, the chief factor associated with long-term renal survival. Advice on managing allograft recurrence, congenital nephrotic syndrome, and monitoring and supportive care, including transition of care, are described. This revised practice guideline is intended to improve management and patient outcomes, and provide direction for future research. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
41. Assessment of academic stress and its coping mechanisms among medical undergraduate students in a large Midwestern university.
- Author
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Joseph, Nitin, Nallapati, Aneesha, Machado, Mitchelle Xavier, Nair, Varsha, Matele, Shreya, Muthusamy, Navya, and Sinha, Aditi
- Subjects
OVERPRESSURE (Education) ,PSYCHOLOGICAL adaptation ,MEDICAL students ,LOGISTIC regression analysis ,UNDERGRADUATES ,PSYCHOLOGICAL distress - Abstract
Academic stress is the most common mental state that medical students experience during their training period. To assess academic stress, to find out its determinants, to assess other sources of stress and to explore the various coping styles against academic stress adopted by students. Methods: It was a cross sectional study done among medical students from first to fourth year. Standard self-administered questionnaires were used to assess academic stress and coping behaviour. Mean age of the 400 participants was 20.3 ± 1.5 years. 166(41.5%) of them were males. The academic stress was found to be of mild, moderate and severe level among 68(17%), 309(77.3%) and 23(5.7%) participants respectively. Overall coping with stress was found to be poor, average and good among 15(3.8%), 380(95%) and 5(1.2%) participants respectively. Passive emotional (p = 0.054) and passive problem (p = 0.001) coping behaviours were significantly better among males. Active problem coping behaviour (p = 0.007) was significantly better among females. Active emotional coping behaviour did not vary significantly between genders (p = 0.54). Majority of the students preferred sharing their personal problems with parents 211(52.7%) followed by friends 202(50.5%). Binary logistic regression analysis found worrying about future (p = 0.023) and poor self-esteem (p = 0.026) to be independently associated with academic stress. Academic stress although a common finding among students, the coping style to deal with it, was good only in a few. The coping behaviours were not satisfactory particularly among male participants. This along with other determinants of academic stress identified in this study need to be addressed during counselling sessions. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
42. Need for uniform definitions in childhood nephrotic syndrome.
- Author
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Schijvens, Anne M, Sinha, Aditi, Bagga, Arvind, and Schreuder, Michiel F
- Subjects
NEPHROTIC syndrome ,ACUTE kidney failure ,MEDICAL research ,CHRONIC kidney failure ,FOCAL segmental glomerulosclerosis - Published
- 2021
- Full Text
- View/download PDF
43. Effectiveness of Nurse-Driven Discharge Teaching Using Mobile Application for Home-Based Health Care Practices among Postoperative Neurosurgical Patients or Caregivers in a Tertiary Care Hospital, New Delhi: A Randomized Control Study.
- Author
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J., Metilda C., Sharma, Kamlesh K., Sinha, Aditi P., and Agrawal, Deepak
- Subjects
PATIENT compliance ,MOBILE apps ,CAREGIVERS ,MEDICAL care ,TERTIARY care ,HOME nursing ,NEUROSURGEONS ,NURSING interventions - Abstract
Introduction Considering the increased access to mobile use even in the remote areas, it may be feasible to utilize mobile application (App)-based education among neurosurgical patients and caregivers for home-based care. Objective This study was aimed to assess the effectiveness of nurse-driven discharge teaching using mobile App for home-based health care practices in terms of discharge advice compliances, revisits, and satisfaction among postoperative neurosurgical patients. Materials and Methods This randomized control trial was conducted among 100 (50 in each arm) postoperative neurosurgical patients admitted to Neurosurgery department, All India Institute of Medical Sciences (AIIMS), New Delhi. The experimental group received mobile App--based discharge teaching additional to the routine paper-based discharge teaching received by the control group. Data were collected at baseline, during first (within 30th day) and second (within 60th day) routine follow-up visits using adherence to refills and medications scale (ARMS) questionnaire (medication compliance), self-developed structured questionnaires (lifestyle practices like tracheostomy tube (TT) catheter care, exercises and diet changes, revisits, and satisfaction) and computerized log record from App. Data were analyzed using descriptive and inferential statistics. Results The demographic and clinical profiles of both groups were comparable. There was no statistically significant difference in medication compliance between the experimental group and control group (p = 0.35 and 0.53) in first and second posttests, respectively. The level of confidence to perform lifestyle practices was high among experimental group. The subgroup analysis showed that patients in experimental arm were more compliant to medications as compared with control group (p = 0.001). Both the groups were comparable in terms of revisits (p = 0.26). However, the overall satisfaction of experimental group was reported to be highly using mobile App based teaching than control group with routine paper-based discharge teaching (p = 0.001). Conclusion Nurse-driven discharge teaching using mobile App is an effective method for neurosurgical patients to adhere to home-based discharge teachings. Use of technology like mobile Apps in vernacular language can bridge the gap for improving home-based care and follow-up among patients in resource constrained settings. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
44. Steroid Sensitive Nephrotic Syndrome: Revised Guidelines.
- Author
-
Sinha, Aditi, Bagga, Arvind, Banerjee, Sushmita, Mishra, Kirtisudha, Mehta, Amarjeet, Agarwal, Indira, Uthup, Susan, Saha, Abhijeet, and Mishra, Om Prakash
- Subjects
NEPHROTIC syndrome ,PEDIATRIC nephrology ,RENAL biopsy ,CHRONIC kidney failure ,STEROIDS - Abstract
Justification: Steroid sensitive nephrotic syndrome (SSNS) is one of the most common chronic kidney diseases in children. These guidelines update the existing Indian Society of Pediatric Nephrology recommendations on its management. Objective: To frame revised guidelines on diagnosis, evaluation, management and supportive care of patients with the illness. Process: The guidelines combine evidence-based recommendations and expert opinion. Formulation of key questions was followed by review of literature and evaluation of evidence by experts in two face-to-face meetings. Recommendations: The initial statements provide advice for evaluation at onset and follow up and indications for kidney biopsy. Subsequent statements provide recommendations for management of the first episode of illness and of disease relapses. Recommendations on the use of immunosuppressive strategies in patients with frequent relapses and steroid dependence are accompanied by suggestions for step-wise approach and plan of monitoring. Guidance is also provided regarding the management of common complications including edema, hypovolemia and serious infections. Advice on immunization and transition of care is given. The revised guideline is intended to improve the management and outcomes of patients with SSNS, and provide directions for future research. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
45. Next-Generation Sequencing for Congenital Nephrotic Syndrome: A Multi-Center Cross-Sectional Study from India.
- Author
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Joshi, Aditi, Sinha, Aditi, Sharma, Aakanksha, Shamim, Uzma, Uppilli, Bharathram, Sharma, Pooja, Zahra, Sana, Parveen, Shaista, Mathur, Aradhana, Chandan, Monica, Tewari, Prachi, Khandelwal, Priyanka, Hari, Pankaj, Mukerji, Mitali, Faruq, Mohammed, and Bagga, Arvind
- Subjects
NEPHROTIC syndrome ,NUCLEOTIDE sequencing ,GENETIC variation ,CROSS-sectional method ,PHENOTYPES ,FOCAL segmental glomerulosclerosis - Abstract
Objective: Information on etiology of congenital nephrotic syndrome in non-Caucasian populations is limited. This study aimed to determine the genetic basis of congenital nephrotic syndrome in Indian patients. Methods: In this observational, cross-sectional study, whole exome sequencing was performed on samples from all children diagnosed with congenital nephrotic syndrome, presenting at centers collaborating in a nationwide registry and biorepository. Analysis was targeted to focus on reported or novel, pathogenic or likely pathogenic variants in 89 genes implicated in etiology of nephrotic syndrome. Sanger sequencing was used to confirm disease-causing variants in patients and allelic segregation of compound heterozygous variants in samples from parents. Inheritance of a shared haplotype was analyzed among ten individuals carrying the most common variant. Results: During 2017–2019, 34 patients with congenital nephrotic syndrome were screened. Consanguinity and similar illness in siblings were reported in eleven patients each. Homozygous or compound heterozygous, pathogenic or likely pathogenic variants were found in NPHS1 in 24 cases, including two novel variants. One patient each had homozygous pathogenic or likely pathogenic known or novel variant in NPHS2, PLCE1, OSGEP and LAMB2 genes. Patients with OSGEP and LAMB2 mutations had phenotype typical of Galloway Mowat and Pierson syndromes, respectively. Three variants in NPHS1 were common to 16 individuals. One reported variant in exon 19 (c.2600G>A; p.Gly867Asp) appears to share a common founder. Conclusion: A genetic cause was determined for 82.4% patients with congenital nephrotic syndrome. Variants in NPHS1 are most common in Indian patients and founder mutations might be present. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
46. Phenotypic variability in distal acidification defects associated with WDR72 mutations.
- Author
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Khandelwal, Priyanka, Mahesh V, Mathur, Vijay Prakash, Raut, Sumantra, Geetha, Thenral S., Nair, Sandhya, Hari, Pankaj, Sinha, Aditi, and Bagga, Arvind
- Subjects
FUROSEMIDE ,GENETIC mutation ,AMELOGENESIS imperfecta ,SEQUENCE analysis ,KIDNEY tubules ,FAMILIES ,GENES ,DESCRIPTIVE statistics ,BICARBONATE ions ,DENTAL caries ,DENTAL enamel ,CONSANGUINITY ,POLYURIA ,HYPOKALEMIA ,KIDNEY calcification ,URINALYSIS ,FANCONI syndrome ,PHENOTYPES ,ACIDOSIS ,HYPERCALCIUREA - Abstract
Background: Distal renal tubular acidosis (RTA) is typically caused by defects in ATP6V0A4, ATP6V1B1, and SLC4A1, accounting for 60–80% of patients. Genes recently implicated include FOXI1, ATP6V1C2, and WDR72, of which WDR72 is associated with dental enamel defects. Methods: We describe 4 patients, from three unrelated consanguineous families, with RTA and amelogenesis imperfecta. Distal tubular acidification was evaluated by furosemide-fludrocortisone test, urine-to-blood PCO2 gradient and fractional excretion of bicarbonate. Exome sequencing was performed using a panel of genes implicated in human disease. Results: Patients had polyuria, hypokalemia, hypercalciuria, and nephrocalcinosis, but metabolic acidosis varied in severity. Although all patients acidified urine to pH < 5.3 during furosemide-fludrocortisone test, urine-to-blood PCO
2 gradient was < 20 mmHg during bicarbonate loading. All patients had transient proximal tubular dysfunction with urinary losses of phosphate and beta-2-microglobulin, and generalized aminoaciduria. Homozygous pathogenic truncating variants in WDR72 was detected in all probands. Conclusion: Patients with WDR72 mutations show mild rate-dependent distal RTA with variable metabolic acidosis, and intact ability to acidify the urine on provocative testing. Concomitant proximal tubular dysfunction may be present. Mutations in WDR72 should be considered in patients with suspected distal RTA, especially if associated with dental defects. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
47. Rapid Steroid Withdrawal Unveiling Tender Nodules: A Pediatric Panniculitis Puzzle and its Management.
- Author
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Lakshmanan, Karthik, Khandpur, Sujay, Garg, Shivangi, Bagga, Arvind, and Sinha, Aditi
- Published
- 2024
- Full Text
- View/download PDF
48. Acute inhalation lung injury secondary to zinc and copper aspiration from food contact dust.
- Author
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Moss, James, Sinha, Aditi, Messahel, Shrouk, and Grime, Christopher
- Abstract
A previously healthy boy of preschool age was brought to the emergency department by ambulance with respiratory distress following the accidental inhalation of food contact dust (cake decorating powder). Prehospital oxygen saturations were 80% in room air. Initial treatment was with oxygen, nebulised salbutamol, oral dexamethasone and intravenous amoxicillin/clavulanic acid. Treatment was escalated to nasal high flow oxygen therapy and high dependency care within 8 hours. Lung fields on his initial chest X-ray were clear but the following day showed perihilar infiltrates extending into the lower zones in keeping with inflammation. He was treated with intravenous methylprednisolone, followed by a weaning dose of oral prednisolone over 14 days. He required oxygen therapy for 9 days and remained in hospital for 11 days. Outpatient follow-up, 24 days after the inhalation took place was reassuring with the child showing no signs of abnormal respiratory symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
49. Therapy and outcomes of C3 glomerulopathy and immune-complex membranoproliferative glomerulonephritis.
- Author
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Khandelwal, Priyanka, Bhardwaj, Swati, Singh, Geetika, Sinha, Aditi, Hari, Pankaj, and Bagga, Arvind
- Subjects
ELECTRON microscopy ,GLOMERULAR filtration rate ,GLOMERULONEPHRITIS ,IMMUNOHISTOCHEMISTRY ,IMMUNOSUPPRESSION ,SERUM albumin ,TREATMENT effectiveness ,DISEASE remission ,RETROSPECTIVE studies ,MYCOPHENOLIC acid ,ADVERSE health care events ,PREDNISOLONE ,LOG-rank test ,CHILDREN - Abstract
Background: Data on therapy and outcome of dense deposit disease (DDD), C3 glomerulonephritis (C3GN), and immune-complex MPGN (IC-MPGN) in children are limited. Methods: In this retrospective single-center study from 2007 to 2019, kidney biopsies were reviewed to include patients aged <18-years with C3 glomerulopathy and IC-MPGN. Initial immunosuppression comprised prednisolone, mycophenolate mofetil (n = 51), tacrolimus (n = 11), and/or IV cyclophosphamide (n = 20). Clinicopathological features, response to therapy, and adverse outcome (eGFR
cr < 15 mL/min/1.73 m2 or death) were evaluated. Results: A total of 92 patients were classified as DDD (n = 48, 52.2%), C3GN (n = 26, 28.3%), and IC-MPGN (n = 18, 19.6%) by immunohistochemistry and electron microscopy; 8 patients with DDD were misclassified as IC-MPGN on immunofluorescence. At last follow-up (median 4.3 years), complete or partial remission occurred in 28.5, 36.1, and 16.7% patients with DDD, C3GN, and IC-MPGN, respectively. Serum albumin at onset < 2.5 g/dL (HR = 0.29, P = 0.005) and persistently low serum C3 (HR = 0.34, P = 0.02) were associated with lack of remission. The 5-year kidney survival was 62.6, 85.5, and 88.5% in patients with DDD, C3GN, and IC-MPGN, respectively (log-rank, P = 0.006). Presentation as rapidly progressive GN (HR = 11.2, P < 0.001), age > 10 years at onset (HR = 4.0, P = 0.004), and DDD (HR = 4.2, P = 0.02) were independently associated with adverse outcome; achieving remission was protective (HR = 0.04; P < 0.001). Conclusion: Outcome in patients with C3 glomerulopathy and IC-MPGN was unsatisfactory, and only a small proportion of patients achieved complete or partial remission. Patients with DDD were more likely to present with rapidly progressive GN and were at higher risk of adverse outcomes, including kidney failure. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
50. Ultrasound Imaging of Renal Cysts in Children.
- Author
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Thomas, Christy Cathreen, Jana, Manisha, Sinha, Aditi, Bagga, Arvind, Ramachandran, Anupama, Sudhakaran, Dipin, and Gupta, Arun Kumar
- Subjects
CYSTIC kidney disease ,POLYCYSTIC kidney disease ,ULTRASONIC imaging ,AUTOSOMAL recessive polycystic kidney ,GENETIC disorders - Abstract
Renal cysts can be focal or diffuse and unilateral or bilateral. In childhood, most renal cysts are due to hereditary diseases rather than simple cysts or acquired cystic diseases, unlike adults. Inherited cystic diseases can be ciliopathies due to a primary ciliary defect (as in polycystic kidney diseases and nephronophthisis). Acquired causes include obstructive cystic dysplasia, dyselectrolytemia, and acquired cysts in renal replacement therapy. The final diagnosis requires a multispecialty approach, including radiology, pathology, and genetics. Imaging is a very important component in treating patients with cystic renal diseases. This article discusses the ultrasound findings of cystic renal diseases in children, along with a brief discussion of other imaging modalities and a suggested ultrasound reporting format. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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