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1. Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity, as shown by kinetic analyses and surface plasmon resonance detection.

Author

Flatmark, Torgeir, Almås, BjΦrg, Knappskog, Per M., Berge, Sissel V., Svebak, Randi M., Chehin, Rosana, Muga, Arturo, and Martínez, Aurora

Subjects
TYROSINE, CATECHOLAMINES
Abstract

Examines the kinetic properties of tetrameric recombinant human tyrosine hydroxylase (TH) isoform. Physiological regulation of catecholamine biosynthesis in neuroendocrine cells; Activation of doxygen and hydroxalate; Crystal structure of the catalytic domain in rat TH.

Published
1999
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