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The esterification reaction of n‐butanol and acetic acid has been performed in batch reactor in the presence of different homogeneous acid catalyst, namely sulfuric acid, nitric acid, and para toluene sulfonic acid (p‐TSA). The objective of present research work is to investigate kinetic behavior of esterification reaction over the temperature range of 60°C–80°C. The effect of reaction parameter such as catalyst loading varied from 1% to 5% v/v and acid to alcohol molar ratio of 1:1, 1:3, and 1:5 has been observed. A pseudo homogeneous kinetic model has been applied. Kinetic parameters such as equilibrium constant, reaction rate constant, enthalpy, activation energy, and entropy were calculated by the experimental data for different acid catalyst system. It was observed that sulfuric acid gives higher conversion 73% than p‐TSA 68.5% and nitric acid 66.25% at temperature of 80°C, 1:1 molar ratio and 3% catalyst concentration. The activation energy was estimated 36448.49, 23324.31 and 19060.156 J/mol K for three different catalyst sulfuric acid, nitric acid and p‐TSA respectively. The enthalpy and entropy of the esterification reaction of acetic acid with n‐butanol over three different catalysts has been calculated (Enthalpy: 25.788 KJ/mol, 12.256 KJ/mol, 28.320 KJ/mol, Entropy: 88.1 J/mol K, 45.298 J/mol K, 91.44 J/mol K) and found enthalpy is having positive value that shows reaction is endothermic. [ABSTRACT FROM AUTHOR]

The main aim of this research paper is to formulate and evaluate Orodispersible tablets of OndasetronHCl by direct compression method. The oral route of drug administration is that the most vital method for administering drugs for systemic effects. For rapid dissolution of dosage, water must rapidly penetrate into the tablet matrix to cause quick disintegration and instantaneous dissolution may be a fundamental to formulate ODT. Oro-dispersible tablets of ondansetron hydrochloride are prepared by direct compression method. The formulation 75% of super disintegrate (i.e) Starch Glycolate and Cross Povidone, Ac Di Sol & Microcrystalline Cellulose pH102 has shown best release with 99.46% at the top of 30 minutes the bubbling mixture further assists in taste masking of Ondansetron hydrochloride. Consistent with IR studies there's no incompatibility shown. The formulation found stable at 40°C±2°C and 75%RH±5%RH. [ABSTRACT FROM AUTHOR]

The main aim of this research paper is to formulate and evaluate Oro-dispersible tablets of Ondasetron HCl by direct compression method. The oral route of drug administration is that the most vital method for administering drugs for systemic effects. For rapid dissolution of dosage, water must rapidly penetrate into the tablet matrix to cause quick disintegration and instantaneous dissolution may be a fundamental to formulate ODT. Oro-dispersible tablets of ondansetron hydrochloride are prepared by direct compression method. The formulation 10% of super disintegrate (i.e) Croscarmellose sodium has shown best release with 99.46% at the top of 30 min. the bubbling mixture further assists in taste masking of Ondansetron hydrochloride. Consistent with IR studies there's no incompatibility shown. The formulation found stable at 40°C±2ºC and 75%RH±5%RH. [ABSTRACT FROM AUTHOR]

The main aim of this research paper is to formulate and evaluate Oro-dispersible tablets of Ondasetron HCl by direct compression method. The oral route of drug administration is that the most vital method for administering drugs for systemic effects. For rapid dissolution of dosage, water must rapidly penetrate into the tablet matrix to cause quick disintegration and instantaneous dissolution may be a fundamental to formulate ODT. Oro-dispersible tablets of ondansetron hydrochloride are prepared by direct compression method. The formulation 10% of super disintegrate (i.e) Croscarmellose sodium has shown best release with 99.46% at the top of 30 min. the bubbling mixture further assists in taste masking of Ondansetron hydrochloride. Consistent with IR studies there's no incompatibility shown. The formulation found stable at 40°C±2°C and 75%RH±5%RH. [ABSTRACT FROM AUTHOR]