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Your search keyword '"Stefan Wagenpfeil"' showing total 4 results
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4 results on '"Stefan Wagenpfeil"'

1. Carbamazepine for prevention of oxaliplatin-related neurotoxicity in patients with advanced colorectal cancer: Final results of a randomised, controlled, multicenter phase II study.

Author

Stefan von Delius, Florian Eckel, Stefan Wagenpfeil, Martina Mayr, Konrad Stock, Frank Kullmann, Florian Obermeier, Johannes Erdmann, Renate Schmelz, Stefan Quasthoff, Helmuth Adelsberger, Rainer Bredenkamp, Roland Schmid, and Christian Lersch

Subjects
CARBAMAZEPINE, AMIDES, ANTICONVULSANTS, NEUROTOXICOLOGY
Abstract

Summary??Background:Oxaliplatin-induced neurotoxicity is a growing, relevant clinical problem. In this study we evaluated the efficacy and safety of carbamazepine for prevention of oxaliplatin-associated neuropathy in patients with advanced colorectal cancer.
Methods:Chemotherapeutic treatment consisted of oxaliplatin 85?mg/m2given biweekly and weekly folinic acid 500?mg/m2followed by a 24-h infusion of 5-FU 2000?mg/m2(FUFOX). One cycle consisted of six consecutive weeks of treatment followed by two weeks of rest (=Treatment B). For Treatment A carbamazepine was added in a dosage for targeted plasma levels of 4?6?mg/L.
Neurotoxicity was regularly assessed using a specific scale. Moreover, an evaluation of chronic sensory symptoms and a neurologic examination including tests for vibrational sense, strength and deep tendon reflexes were added creating a peripheral neuropathy (PNP) score.
Results:The prospectively defined adequate number of patients needed to provide power for the primary outcome could not be achieved. 19 patients were assigned to Treatment A and 17 to Treatment B. At baseline, the distribution of all clinicopathologic variables was comparable between the two groups. Overall response rates were 16% and 24% and overall survival 15.1 months and 17.4 months for Treatment A and Treatment B, respectively. Between Treatment A and Treatment B there were no major differences when considering worst neurotoxicity during the study period (p=0.46). Grade 3/4 neurotoxicity occured in 4 patients with Treatment A vs. 6 patients with Treatment B. There were no major differences between both groups in each category of the PNP score.
Conclusions:Based on the small number of patients and low statistical power of our study definite conclusions regarding efficacy and safety of carbamazepine for prevention of oxaliplatin-associated neuropathy in patients with advanced colorectal cancer cannot be drawn.
[ABSTRACT FROM AUTHOR]

Published
2007
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4. Stimulus frequency influences spontaneous perceptual reversals in ambiguous apparent motion.

Author

Rüdiger Ilg, Stefan Burazanis, Afra M. Wohlschläger, Andreas Wöller, Stefan Wagenpfeil, and Mark Mühlau

Subjects
SENSES, TEMPORAL integration, STIMULUS synthesis, LANGUAGE & languages
Abstract

The temporal integration of continuous sensory information into a temporally extended percept becomes evident in spontaneous reversals of ambiguous apparent motion. To study the temporal relation of spontaneous percept reversals and temporal stimulus properties, we systematically varied presentation frequency in an ambiguous-apparent-motion paradigm. Moreover, we triggered percept reversals in a manner that was not consciously perceived by manipulating the duration of single frames. We found that the reversal rate depended on the stimulus frequency (with higher frequencies resulting in faster percept reversals) and that we could externally trigger perceptual reversals. Our findings support the idea that spontaneous reversals of ambiguous apparent motion are influenced by bottom-up effects at early processing levels. The paradigm allows for specific contrasts of spontaneous and externally triggered (but otherwise identical) perceptual reversals and, by this means, for further study of the underlying mechanisms. [ABSTRACT FROM AUTHOR]

Published
2008
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