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The present study is aimed at assessing the chronic toxic effects of arsenic trioxide on liver and intestine of the zebrafish. For this purpose, histopathological changes in the liver and intestine tissues of adult zebrafish exposed to waterborne arsenic trioxide concentrations (50ppb and 500ppb respectively) for 90 days evaluated. Activation of 8- hydroxy-2'-deoxyguanosine (8-OHdG) was also assessed by immunofluorescence assay. We observed severe histopathological alterations, including cellular degeneration, vacuolization of hepatocytes, and an increase in the hepatic plate in the liver. Histopathological changes in the intestine includes vacuolization of the enterocytes, hyperplasia of goblet cells, displacement of the lamina propria, and disruption of the apical cytoplasm of epithelial cells that cover the intestinal villi were observed. Strong signs of immunofluorescence reaction for 8-OHdG in the exposed liver and intestine tissues in a dose-dependent manner has also been detected. Results of the study indicate that toxicity of arsenic trioxide lead to crucial histopathological alteration and induce oxidative DNA damage in both liver and intestine of zebrafish. [ABSTRACT FROM AUTHOR]

The article describes the case of a full-term male infant who was noted to be very jittery in the delivery room with oscillatory tremor of upper and lower extremities. Highlights include consistency of gestational age examination with full-term status, the infant's initial point-of-care glucose testing, and hyperthyroidism in the neonate.

The article describes the case of a 24-year-old G2P1001 African American female at 38.2 weeks of gestation who was induced for labor for a fetus with prenatally diagnosed intrauterine growth restriction. Case highlights include maternal and familial history of the female, fetal growth chart obtained at time of birth, and implication of asymmetric growth restriction.

Surface of nylon membrane was modified by the graft copolymerization of glycidyl methacrylate (GMA) using persulfate and thiosulfate as redox initiator system. Effect of various reaction parameters such as initiator concentration, monomer concentration, polymerization time, and temperature on degree of grafting was also studied. Maximum grafting of 100% was achieved by using equimolar concentration (0.008M) of redox initiator and 0.5Mof GMA monomer at 70°C in 60 min. Grafted nylon membranes with various graft levels of GMA were characterized by various techniques such as fourier transform infrared spectroscopy, thermo gravimetric analysis, and scanning electron microscopy. The GMA grafted nylon (NyM‐g‐GMA) membranes with different graft levels were evaluated as a support for immobilization of rabbit anti goat antibody (RAG IgG). Antibody (Ab) immobilized NyM‐g‐GMA membranes were evaluated using ELISA and Bradford protein estimation method. Nylon membrane with 60% graft level showed optimum immobilization of Ab at RAG IgG conc. of 0.625 μg/mL with low nonspecific binding. Maximum immobilization efficiency (I.E.%) of 56% was observed for membrane with 60% graft level at 50 μg/mL of RAG IgG in PBS (pH 7.4). Ab immobilized NyM‐g‐GMA discs were found to be stable up to 6 weeks at 4°C and 2 days at 37°C. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 [ABSTRACT FROM AUTHOR]