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An efficient sequential one pot three component reaction involving anilines, DEAD/DMAD and glyoxal in aqueous media is reported. The protocol is environmentally benign and provides a new synthetic route to access polyfunctionalised pyrrole derivatives in high yield. The reaction proceeded via supramolecular catalysis. [ABSTRACT FROM AUTHOR]

An efficient triphenylphosphine-catalyzed synthesis ofβ-acetamido carbonyls via multicomponent reaction of aromatic aldehydes, enolizable ketones orβ-keto esters, acid chlorides and acetonitrile at room temperature is described. The process is remarkably simple, environmentally benign, and uses Lewis base for the first time in such type of reaction. [ABSTRACT FROM AUTHOR]

Novel spiro-oxindole derivatives were synthesised by one-pot multicomponent reaction using isatins, urea and 1,3-dicarbonyls. β-Cyclodextrin, an oligosaccharide, catalysed the reaction and can be reused for further reaction after recovery. This developed synthetic route is environmentally benign in which water is used as solvent to produce excellent yields of products. The synthesised compounds were evaluated for their antimicrobial activities against two bacteria and two fungi. All the synthesised spiro-oxindoles exhibit significant antimicrobial activity. [ABSTRACT FROM PUBLISHER]

An efficient and general method has been described for the synthesis of imidazo[2,1-b]-1,3,4-thiadiazole by the reaction of 2-aminothiadiazoles with phenacyl bromides in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO). The method is suitable for the synthesis of functionalized imidazothiadiazoles. [ABSTRACT FROM AUTHOR]

Oxa-aza-phenanthrene and anthracene derivatives which contain a bridgehead nitrogen are synthesized in an aqueous micellar system. The synthetic route is easy and yield is excellent. In this proposed method, solvent, base and surfactant are optimized and the best result was obtained by DBU in water with surfactant CTAB. All synthesized molecules are new. This method is an efficient, viable and sequential one pot synthetic route for the construction of desired product. [ABSTRACT FROM AUTHOR]