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This article discusses the identification of a novel frameshift mutation in the cathepsin C gene in a patient with coexisting Papillon-Lefevre syndrome (PLS) and rheumatoid arthritis (RA). PLS is a rare autosomal recessive disorder characterized by palmoplantar keratoderma and severe periodontitis, while RA is an inflammatory joint disease. The patient, a Taiwanese individual, exhibited dental and cutaneous features consistent with PLS and was later diagnosed with RA. Genetic testing revealed a homozygous frameshift mutation in the cathepsin C gene. The coexistence of PLS and RA in this patient is unique and suggests a complex relationship between the two conditions. Further research is needed to understand the pathogenic link between PLS and RA. [Extracted from the article]

The article presents a case study of a 31-year-old woman presented with painful generalized blistering and erosions since birth. Topics include plectin has a linker-protein that has expressed ubiquitously in tissues, including skin, muscle and nervous system; and mutations in the plectin gene has underlie both autosomal dominant and autosomal recessive subtypes of the inherited blistering disease.

A conference paper that explores the behavioral and interleukin-2 effects of dioscorea or will yam, a Chinese medicine or postmenopausal anxiety and depression is presented. Results reveal that the ovariectomy-induced anxiety and the changes of neuroimmunological function in the cortex are reversed by dioscorea. Individual differences should be considered when psychoneuroimmunological issues are measured.