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Corporate innovation is fundamental to the sustainable competitiveness of any economy. This paper examines whether and how local government-level macroeconomic growth pressure induced by gross domestic product (GDP) manipulation in China affects corporate innovation. Using calibrated satellite night light data to construct the GDP manipulation index, we find that GDP manipulation reduces local firms' R&D expenditure in the year ahead. The result holds up through robustness tests using different measures of GDP manipulation and corporate innovation. Additionally, we employ an instrumental variable approach to address endogeneity issues and enhance the strength of the causal inference. Furthermore, we find that the effect of GDP manipulation on local corporate innovation is stronger in regions with higher government intervention and where local governments control greater resources. Moreover, this finding is more prominent when local governors face intensified economic growth pressure or promotion incentives. This paper provides evidence that the Chinese government's incentive to boost GDP growth negatively affects corporate innovation. Our findings offer valuable insights for policymakers aiming to stimulate economic growth and enhance competitiveness within their jurisdiction. By implication, it is necessary to form a financial and administrative system that effectively promotes industrial innovation and facilitates the transformation of the economic growth model into one driven by technology and innovation to gain a reasonable competitive advantage both within China and internationally. Future research may explore the evolving dynamics of GDP manipulation's impact on other microeconomic behaviors, with particular focus on how it hinders competitiveness across industries and regions. [ABSTRACT FROM AUTHOR]

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The objective of this research is to experimentally evaluate the specific impact of a collaborative heat sink composed of gravity heat pipes (GHP) and pulsating heat pipes (PHP) on the thermal efficiency of LED light sources. The heat sink developed in this experiment is designed to improve the thermal management system, ensuring that LED operate within a safe temperature range, which is crucial as the performance of LED is directly affected by their junction temperature. An HPPHP collaborative heat sink was employed in the experiment, where PHP served as heat dissipating fins to enhance its thermal performance, while HP handles the majority of the heat transfer tasks. The results showed that under forced convection conditions, the HP-PHP collaborative heat sink can increase the maximum thermal power capacity of LED to 192 W. The HP-PHP collaborative heat sink can reduce the substrate’s temperature to below 70.5 °C in passive mode when the LED input power does not exceed 96 W. Additional experimental results show that the minimum thermal resistance of the collaborative heat sink is 0.19 K/W under natural- convection conditions, under forced convection conditions, this value drops to 0.15 K/W, which still lower than the non-collaborative heat sink. These results demonstrate that the contact thermal resistance between HP and PHP significantly enhances the thermal performance of the collaborative heat sink. Therefore, this collaborative type of heat sink is an effective method for cooling high power LED. [ABSTRACT FROM AUTHOR]

Composite lymphoma is an uncommon type of lymphoid malignancy, and those consisting of concurrent diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) in the same organ are rare. Here, we report a case of a 75-year-old male patient admitted to our emergency department with intestinal obstruction presenting with abdominal pain and vomiting. He underwent partial resection of the small intestine under general anesthesia, and subsequent histopathology confirmed the mass to be composite DLBCL and PTCL-NOS. The patient received chemotherapy with a rituximab-based regimen and achieved complete remission (CR). However, the recurrent disease presented with obstruction again ten months after treatment. He refused a second surgery, but salvage treatment was not effective. The patient survived for 20 months after diagnosis. In addition, we did a literature review to understand the clinical features, pathology, treatment, and prognosis of this type of composite lymphoma. [ABSTRACT FROM AUTHOR]

Breast plastic and reconstructive surgery are widely performed worldwide. There are various tools available to improve surgical outcomes. Among them, three-dimensional (3D) scanning is of considerable value. 3D scanning consists of hardware and software with multiple working principles. This review summarizes the recent advances in the application of 3D scanning in breast plastic and reconstructive surgery, including measuring aesthetic parameters, formulating preoperative plans, and evaluating postoperative results. The development trend of 3D scanning is to integrate with portable devices, 3D printing, deep learning, and telemedicine, opening up a wide and abundant range of application scenarios. In brief, 3D scanning plays a vital role in breast plastic and reconstructive surgery. As an auxiliary tool, it improves preoperative and postoperative satisfaction for both surgeons and patients. With the new round of medical revolution, the further development of 3D scanning will open up an efficient, digital, and intelligent field for breast plastic and reconstructive surgery. Level of evidence: Not ratable. [ABSTRACT FROM AUTHOR]

MN1 C-terminal truncation (MCTT) syndrome was first reported in 2020 and only 28 patients have been recorded to date. Since MCTT syndrome is a newly defined and rare syndrome with many clinical features, the present study reviewed the manifestations and management of oral and dental anomalies. Gene variants of MCTT syndrome and their positive phenotypes were summarised. The phenotypes of variants in two exons differed from each other mainly in the craniomaxillofacial region, including brain MRI abnormalities and palatal morphology. Pathogenic mechanisms, especially in craniofacial and oral anomalies, were discussed. Appropriate treatments in the stomatology and respiratory departments could improve the symptoms of MCTT syndrome. The different sites of MN1 gene variants may influence the clinical symptoms and there may be racial differences in MCTT syndrome. We recommend oral and pulmonary evaluations for the multidisciplinary treatment of MCTT syndrome. [ABSTRACT FROM AUTHOR]

The Central Business Districts (CBDs) are important hubs for urban economic activities. In the context of globalization, a unified CBD boundary would greatly facilitate the study of global CBD comparative analysis, urban socio-economic development, urban transport and commuting mode. However, previous studies have encountered challenges in developing a practical method for global CBD identification due to limitations in data sources and methodologies. In this study, we selected 32 global megacities as research objects and used the open-access Black Marble nighttime light (NTL) products to construct indicators with the intensity and angular effects of NTL. Clustering and decision tree were then employed to derive rules for CBD identification. Results show that combining Z-score indicators and the strategy of clustering 32 cities before decision tree classification could improve the accuracy of CBD identification, which achieved a producer accuracy of 85%. The 32 cities were clustered into three types, i.e. U.S.A.-like, the mixed type, and China-like. The rules for CBD identification became more complex in the above order, but the accuracy decreased in turn. This study provides a new CBD identification method for cities lacking reference data, allowing for the delineation of unified and comparable CBD boundaries on a large scale. [ABSTRACT FROM AUTHOR]

Background: The temporomandibular joint is often afflicted by osteoarthritis (TMJOA), causing pain and dysfunction, which is particularly prevalent in the elderly population. IL-37 is effective in avoiding excessive inflammatory damage to the organism. This article investigates the role and mechanism of intracellular IL-37 in TMJOA. Methods: Enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, Western blotting, Senescence-associated p-galactosidase staining, immunofluorescence, and lentivirus were performed to elucidate the underlying mechanism. Results: The results confirmed that IL-37 in synovial cells decreased with aging. Inflammatory stimulus elevated intracellular IL-37 in synoviocytes, while lentiviral knockdown of IL-37 resulted in more inflammatory factor production. Dynamic changes of IL-37 were observed in the nucleus and supernatant. In addition, Caspease-1 inhibitor hindered intracellular IL-37 maturation, and Smad3 inhibitor caused the loss of nuclear translocation of mature IL-37. Transfection of synovial cells with IL-37-expressing lentivirus resulted in relief not only of synovitis but also of the cartilage damage and inflammation caused by synovitis. Conclusion: This study provides new insights into the intracellular antiinflammatory mechanism of IL-37. It also confirms that IL-37 decreases with cellular senescence and that increasing intracellular IL-37 can effectively treat synovitis and synovitis-induced inflammatory damage to cartilage. [ABSTRACT FROM AUTHOR]

Background: Radiofrequency ablation has become a favorable treatment modality for small hepatocellular carcinoma (HCC) recently; however, insufficient radiofrequency ablation (RFA) was shown to lead to enhanced invasiveness and metastasis of HCC in our previous study, while the underlying molecular mechanism has not been understood. Materials and Methods: In order to explore the influence of the hypoxic microenvironment on residual cancer and cancer stem cell (CSC)-like characteristics of HCC cells in this process, an in vitro hypoxic model and an insufficient RFA mouse model were established with HCC cancer cell lines. Immunochemistry staining and western blot were used to examine the expression of hypoxia-inducible factor (HIF)-1α and liver CSC markers. The 3D colon formation assay, tumor cell invasion assay, and gene transfection assays were applied to test the change in liver CSC stemness and HCC cell invasion. Results: After insufficient RFA treatment, the upregulated HIF-1α expression was associated with an increase in the CSC-like population in residual cancer. In vitro, hypoxic tumor cells showed aggressive CSC-like properties and phenotypes. Wnt/β-catenin signaling activation was shown to be necessary for the acquisition of liver CSC-like characteristics under hypoxic conditions. Conclusion: Overall, the aberrantly enhanced HIF-1α expression enhanced the liver CSC-like traits via abnormal Wnt/β-catenin signaling activation after insufficient RFA, and the overexpressed HIF-1α would be a vital factor and useful biomarker during the HCC recurrence and metastasis. [ABSTRACT FROM AUTHOR]

High versus low aerobic capacity significantly impacts the risk for metabolic diseases. Rats selectively bred for high or low intrinsic aerobic capacity differently modify hepatic bile acid metabolism in response to high-fat diets (HFDs). Here we tested if a bile acid sequestrant would alter hepatic and whole body metabolism differently in rats with high and low aerobic capacity fed a 1-wk HFD. Male rats (8 mo of age) that were artificially selected to be high (HCR) and low-capacity runners (LCR) with divergent intrinsic aerobic capacities were transitioned from a low-fat diet (LFD, 10% fat) to an HFD (45% fat) with or without a bile acid sequestrant (BA-Seq, 2% cholestyramine resin) for 7 days while maintained in an indirect calorimetry system. HFD þ BA-Seq increased fecal excretion of lipids and bile acids and prevented weight and fat mass gain in both strains. Interestingly, HCR rats had increased adaptability to enhance fecal bile acid and lipid loss, resulting in more significant energy loss than their LCR counterpart. In addition, BA-Seq induced a greater expression of hepatic CYP7A1 gene expression, the rate-limiting enzyme of bile acid synthesis in HCR rats both on HFD and HFD þ BA-Seq diets. HCR displayed a more significant reduction of RQ in response to HFD than LCR, but HFD þ BA-Seq lowered RQ in both groups compared with HFD alone, demonstrating a pronounced impact on metabolic flexibility. In conclusion, BA-Seq provides uniform metabolic benefits for metabolic flexibility and adiposity, but rats with higher aerobic capacity display adaptability for hepatic bile acid metabolism. [ABSTRACT FROM AUTHOR]

Sleep disorders affect mental and physical health. Infertile women undergoing assisted reproductive technology (ART) treatment are prone to sleep disorders. Sleep condition, its influencing factors, and the association between sleep condition and ART treatment outcomes before treatment have not been explored within a population with a large sample size. Therefore, we investigated the sleep characteristics of 1002 Chinese infertile women before ovulation induction and investigated the influencing factors (negative and positive psychological factors, demographics, and fertility characteristics). We also examined whether sleep conditions before treatment predicted reproductive outcomes. We found that 24.1% of participants reported poor sleep quality. Women with primary infertility reported poorer sleep than women with secondary infertility. Negative psychological factors, including depression, anxiety, and perceived stress were associated with poor sleep, whereas positive affect was linked with good sleep. Adverse sleep characteristics, including poor subjective sleep quality, sleep disturbances, and poor sleep efficiency, decreased the quantity and quality of oocytes retrieved, fertilization rates, and clinical pregnancy rates. This study indicates that before ART treatment, a large number of females with infertility suffer from sleep problems, which are affected by psychological factors and infertility type, and unhealthy sleep characteristics may impair treatment outcomes. Our findings highlight the importance of screening and treatment for sleep disorders before the enrollment of ART treatment in infertile women. [ABSTRACT FROM AUTHOR]

The non-uniform usage of synonymous codons occurs in genomes of all organisms, including DNA and RNA viruses. The preferential selection of a codon at the expense of other synonymous codons within the same group is known as Codon Usage Bias. The understanding of this bias assists in unveiling the factors driving molecular evolution, as defined by the selection-mutationdrift theory. According to this model, molecular evolution is predominantly driven by mutation, natural selection, and genetic drift. Nevertheless, elements like nucleotide composition, gene length, and protein secondary structure also contribute to this process. Comprehensive genomic analyses that highlight the codon usage preference of the African Swine Fever Virus (ASFV) are infrequent. ASFV, a hemorrhagic and highly contagious viral disease, almost invariably results in 100% fatality among infected pigs and wild boars. This study, therefore, embarked on a thorough examination of codon usage patterns in ASFV's complete genomic sequences, an endeavor of great relevance to molecular evolution studies, complex transmission models, and vaccine research. For an exhaustive evaluation of ASFV's whole-genome codon usage, we used parameters like ENC, RSCU, and CAI. A Principal Component Analysis was carried out to reaffirm the interconnected RSCU lineages based on the continent, and their evolutionary relationships were later elucidated through phylogenetic tree construction. ASFV emerged as a low-biased codon user (ENC = 52.8) that is moderately adapted to its host. Its genome has a high AT composition (64.05%), suggesting the impact of mutational pressure on genomic evolution. However, neutrality plot analysis revealed natural selection's slight supremacy over mutational pressure. The low codon bias (>45) implies ASFV's diverse usage of synonymous codons within a given codon family, allowing for effective translation and subsequent successful viral replication cycles. Its moderate. [ABSTRACT FROM AUTHOR]

Aerosol and cloud properties retrieved from the Moderate Resolution Imaging Spectroradiometer (MODIS) on-board the Aqua satellite were used to investigate aerosol-cloud interaction (ACI) over eastern China, using aerosol optical depth (AOD) as a proxy for the aerosol concentration, during a period of 15 years (2008-2022). Two contrasting areas were selected: the heavily polluted Yangtze River Delta (YRD) and a clean area over the East China Sea (ECS). Linear regression analysis shows the opposite behaviour of the cloud droplet effective radius (CER) and AOD relationship in the two different aerosol regimes. CER decreases with the increase of AOD in the moderately polluted atmosphere (0.10.3) over the YRD, CER increases with increasing AOD. Evaluation of the ACI index (here defined as the change in CER as a function of AOD) as function of the cloud liquid water path (LWP) shows that in the moderately polluted atmosphere over the ECS the ACI index is significant and positive in the LWP interval [40 g m-2, 200 g m-2], and increases substantially with increasing LWP. In contrast, in the polluted atmosphere over the YRD the ACI index is significant and negative in the LWP interval [0 g m-2, 120 g m-2] and does not change notably as function of LWP in this interval. To further analyse the influence of AOD and meteorological conditions on cloud parameters, the geographical detector method (GDM) has been used. The results show that all factors have a significant influence on the cloud parameters over the ECS, except for cloud top pressure (CTP), but the influence of AOD is larger than that of any of the meteorological factors. Among the meteorological factors, lower tropospheric stability (LTS) has the largest influence on the cloud parameters and relative humidity (RH) the smallest. Over the YRD, the explanatory power of the effect of AOD and meteorological parameters on cloud parameters is much smaller than over the ECS, except for RH which has a statistically significant influence on CTP and can explain 65% of the variation of CTP. The combined effect of meteorological factors and AOD on cloud parameters enhances the explanatory power over the effect of individual parameters. The study further shows that over the ECS the effect of RH and LTS on the CER/AOD relationship is opposite to that of pressure vertical velocity (PVV). Over the YRD, The CER is larger in unstable atmospheric conditions than in stable conditions, irrespective of the AOD and the CER is much larger in high relative humidity conditions than in low relative humidity conditions. [ABSTRACT FROM AUTHOR]

The objective of this study was to investigate the cellulose degradation rate (CDR) and lignin degradation rate (LDR) of Codonopsis pilosula straw (CPS) and the optimal fermentation parameters for mixed fungal fermentation. Single-factor tests were used to study the effects of the fungal ratio (Trichoderma reesei: Coprinus comatus), fungal inoculum, corn flour content, and fermentation time on the degradation rate of cellulose and lignin. Based on the results of this experiment, the optimal fermentation factors were identified, and the effects of various factors and their interactions on the degradation rates of cellulose and lignin were further evaluated using the response surface method. The quadratic polynomial mathematical model of degradation rates of the cellulose and lignin in CPS by mixed fungus fermentation was established using Design Expert software v8.0.6. Under the optimal parameters for fungal fermentation of CPS straw (fungal ratio 4:6, fungal inoculum 8%, corn flour content 10%, fermentation time of 15 d), the CDR and LDR reached 13.65% and 10.73%, respectively. Collectively, the mixed fungal fermentation of CPS resulted in decreased lignin and cellulose content, better retention of nutrients, and enhanced fermentation quality. The results of this study indicate that fermentation using Trichoderma reesei and Coprinus comatus is a productive method for straw degradation, providing a theoretical basis for the development of CPS as feed. [ABSTRACT FROM AUTHOR]

In this paper, a stable and accurate algorithm to compute all solutions of the inverse kinematics problem of a 6 revolute manipulator chain is presented. A system of equations is constructed based on the fundamental closure conditions, leading to a closed algebraic system of 20 equations involving 16 quantities, composed of trigonometric functions of five among the six unknown joint angles. Two among these five are stably eliminated using singular value decomposition (SVD) avoiding the need to consider special cases. The resulting system of equations involving three unknowns is solved by conversion to a generalized eigenvalue problem. The remaining three unknown angles are obtained using the previously computed pseudoinverse. In this formulation we exploit the inherently complex form of the system reducing it to 10 complex equations in 9 quantities, which substantially accelerates the SVD computation. The method’s robustness is demonstrated through a comparison to current methods and several examples including known problematic cases where some axis or link lengths vanish, or some joint angles are 180 degrees, as well as cases where multiple eigenvalues arise. [ABSTRACT FROM AUTHOR]

Takotsubo cardiomyopathy (TCM) has been reported to occur after subarachnoid hemorrhage, and the involvement of a critical activity of catecholamines has been mentioned, but the details of its onset have not been fully clarified. Recently, proper arterial stiffness could be measured with cardio-ankle vascular index. Therefore, we aimed to clarify the role of arterial stiffness in onset of TCM using rabbits under infusion of noradrenaline and injection of blood into brain ventricle. Rabbits were divided into three groups: infusion of noradrenaline (group A), infusion of noradrenaline + injection of saline into the brain ventricle (group B), infusion of noradrenaline + injection of blood in the brain ventricle (group C). Aortic arterial stiffness beta (Aβ) and femoral arterial stiffness beta (Fβ) were defined according to definition of the cardio-ankle vascular index. Blood pressure (BP), Aβ, Fβ, and femoral vessel resistance (FVR) were measured. Left ventricular movement were monitored with echocardiography. BP increased uniformly in all three groups. Fβ in the group A, B and C increased from 3.6 ± 3.2, 3.6 ± 3.6 and 3.9_ ± 4.2 to 15 ± 2, 17.9 ± 2.4, 34.8 ± 9.1 due to the ICP enhancements in addition to noradrenaline administration, respectively. Fβ in groups B and C was significantly larger than that in group A. On echocardiography, a much higher akinesic area of the apex was observed in group C compared with group A and B. Cardiac movements similar to TCM were observed slightly in group B and definitely in group C. Noradrenaline administration infusion and blood injection into the brain ventricle induced TCM accompanying with enhanced femoral arterial stiffness. These results suggested that elevated arterial stiffness might be involved in the formation of TCM in addition to a critical activity of catecholamines and an increase in intracranial pressure with blood injection. [ABSTRACT FROM AUTHOR]

Oral attenuated rotavirus vaccine is safe and effective in developed countries but, however, it is less effective in low income countries such as African and Asian countries. Low vaccine effectiveness in low-income countries is arising from a variety of sources such as maternal antibodies, chronic enteropathy and other enteric diseases such as cholera, typhoid, and parasitic diseases, as well as the microbiota. There is increasingly evidence related to the risk of intussusception for the oral vaccine. The development of effective and safer rotavirus vaccines, particularly, non-living candidates, is critical. The aim of this review therefore is to explore some of the effective rotavirus vaccine alternatives to live attenuated oral virus vaccines. It primarily reveals non-living candidates such as inactive rotavirus vaccines, rotavirus-like particles, recombinant subunit proteins and non-living mucosal rotavirus vaccines. These approaches have been tested in a variety of animal models with great success in eliciting powerful immune responses. It is high time now for various vaccine manufacturers to look at these tested approaches, as they will provide hope to low-income countries in terms of producing vaccines that are both safe and effective. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to evaluate the predictive value of drug-induced sleep endoscopy (DISE) for the outcomes of velopharyngeal surgery in adult patients with Friedman stage II and III obstructive sleep apnea syndrome (OSAS). Methods: A total of 39 male OSAS patients with Friedman stage II and III were retrospectively analyzed. Subjects with an apnea-hypopnea index (AHI) > 5 events/h indicated by polysomnography (PSG) and typical symptoms, such as snoring, sleep apnea, and daytime sleepiness, were included in this study. All these patients underwent pre-operative DISE examinations and were treated by velopharyngeal surgery and evaluated by velum, oropharynx, tongue base, and epiglottis (VOTE) scoring system. Clinical, polysomnographic parameters (e.g., hypopnea, apnea, AHI, lowest oxygen saturation, etc.), cephalometric variables, and DISE findings were evaluated. The treatment outcomes were assessed by polysomnography at least 6 months after surgery. Results: All 39 patients showed complete velopharyngeal airway collapses during pre-operativeDISE examinations. After surgery, the AHI was significantly improved from 50.2 ± 21.6 to 19.8 ± 19 events/h (P < 0.05). There were 23 responders (59.0%) and 16 non-responders (41.0%). The glossopharyngeal airway collapse degree (GA-CD) was significantly different between responders and non-responders (P < 0.05). The velopharyngeal airway collapse pattern (VA-CP) and GA-CD were independently predictive of treatment outcomes (both P < 0.05). Patients with non-lateral VA-CP and grade II GA-CD (collapse degree > 50%) had a significantly lower surgical success rate than those without (P < 0.05). Conclusion: The VA-CP and GA-CD in DISE examination are valuable for predicting the treatment outcomes of velopharyngeal surgery in patients with Friedman stage II and III OSAS. Patients with lateral VA-CP and grade I GA-CD are appropriate candidates for velopharyngeal surgery. [ABSTRACT FROM AUTHOR]

Introduction: Contrast-enhanced T1WI flow-sensitive black-blood (CE-T1WI FSBB) is a newly developed sequence which had not been widely used for differential diagnosis of brain tumors. Methods: To quantify the pre-operative imaging features of intratumoral microbleeds and intratumoral vessels using CE-T1WI FSBB scan and study the differences in biological behavior of meningiomas and schwannomas underlying the imaging features. Seventy-three cases of meningiomas and 24 cases of schwannomas confirmed by postoperative pathology were included. Two neuroradiologists independently counted intratumoral vessels and intratumoral microbleeds based on CE-T1WI FSBB images. The vessel density index (VDI) and microbleed density index (MDI) were the number of intratumoral vessels and the number of intratumoral microbleeds divided by the tumor volume, respectively. The consistency test of intratumoral vessel count and intratumoral microbleed count based on CE-T1WI FSBB were summarized using 2-way random intraclass correlation coefficients (ICC). Mann-Whitney U-test and chi-square test were used to determine significant differences between meningiomas and schwannomas, and fibrous meningiomas and epithelial meningiomas. P<0.05 was considered statistically significant. Results: The ICC of intratumoral vessels count and intratumoral microbleeds count were 0.89 and 0.99, respectively. There were significant differences in the number of intratumoral microbleeds (P<0.01) and MDI values (P<0.01) between meningiomas and schwannomas. There were no differences in the number of intratumoral vessels (P=0.64), VDI (P=0.17), or tumor volume (P=0.33). There were also differences in the number of intratumoral microbleeds (P<0.01), the MDI value (P<0.01), and the sex of patients (P<0.05) between fibrous meningiomas and epithelial meningiomas. Discussion: CE-T1WI FSBB can be a new technique for differentiating schwannomas from meningiomas, and even different types of meningiomas. Schwannomas have a higher incidence of intratumoral hemorrhage, more intratumoral microbleeds, and higher MDI values than meningiomas, which provides a newbasis for preoperative differential diagnosis and treatment decisions. [ABSTRACT FROM AUTHOR]

Objectives: To identify preoperative prognostic factors for acute ischemic stroke (AIS) patients receiving mechanical thrombectomy (MT) and compare the performance of quantitative collateral score (qCS) and visual collateral score (vCS) in outcome prediction. Methods: Fifty-five patients with AIS receiving MT were retrospectively enrolled. qCS was defined as the percentage of the volume of collaterals of both hemispheres. Based on the dichotomous outcome assessed using a 90- day modified Rankin Scale (mRS), we compared qCS, vCS, age, sex, National Institute of Health stroke scale score, etiological subtype, platelet count, international normalized ratio, glucose levels, and low-density lipoprotein cholesterol (LDL-C) levels between favorable and unfavorable outcome groups. Logistic regression analysis was performed to determine the effect on the clinical outcome. The discriminatory power of qCS, vCS, and their combination with cofounders for determining favorable outcomes was tested with the area under the receiver-operating characteristic curve (AUC). Results: vCS, qCS, LDL-C, and age could all predict clinical outcomes. qCS is superior over vCS in predicting favorable outcomes with a relatively higher AUC value (qCS vs. vCS: 0.81 vs. 0.74) and a higher sensitivity rate (qCS vs. vCS: 72.7% vs. 40.9%). The prediction power of qCS C LDL-C C age was best with an AUC value of 0.91, but the accuracy was just increased slightly compared to that of qCS alone. Conclusion: Collateral scores, LDL-C and age were independent prognostic predictors for patients with AIS receiving MT; qCS was a better predictor than vCS. Furthermore, qCS C + LDL-C + age offers a strong prognostic prediction power and qCS alone was another good choice for predicting clinical outcome. [ABSTRACT FROM AUTHOR]

In this article, we describe the free, open-source Python-based Space Physics Environment Data Analysis System (PySPEDAS), a platform for multi-mission, multi-instrument retrieval, analysis, and visualization of Heliophysics data. PySPEDAS currently contains load routines for data from 23 space missions, as well as a variety of data from ground-based observatories. The load routines are built from a common set of general routines that provide access to datasets in different ways (e.g., downloading and caching CDF files or accessing data hosted on web services), making the process of adding additional datasets simple. In addition to load routines, PySPEDAS contains numerous analysis tools for working with the dataset once it is loaded. We describe how these load routines and analysis tools are built by utilizing other free, open-source Python projects (e.g., PyTplot, cdflib, hapiclient, etc.) to make tools for space and solar physicists that are extremely powerful, yet easy-to-use. After discussing the code in detail, we show numerous examples of code using PySPEDAS, and discuss limitations and future plans. [ABSTRACT FROM AUTHOR]

Multiple factors such as genes, environment, and age are involved in developing Parkinson's disease (PD) pathology. However, how various factors interact to cause PD remains unclear. Here, 3-month and 9-month-old hα-syn+/- mice were treated with low-dose rotenone for 2 months to explore the mechanisms that underline the environment-gene-age interaction in the occurrence of PD. We have examined the behavior of mice and the PD-like pathologies of the brain and gut. The present results showed that impairments of the motor function and olfactory function were more serious in old hα-syn+/- mice with rotenone than that in young mice. The dopaminergic neuron loss in the SNc is more in old hα-syn+/- mice with rotenone than in young mice. Expression of hα-syn+/- is increased in the SNc of ha-syn+/- mice following rotenone treatment for 2 months. Furthermore, the number of activated microglia cells increased in SNc and accompanied the high expression of inflammatory cytokines, namely, TNF-α and IL-18 in the midbrain of old hα-syn+/- mice treated with rotenone. Meanwhile, we found that after treatment with rotenone, hα-syn positive particles deposited in the intestinal wall, intestinal microflora, and T lymphocyte subtypes of Peyer's patches changed, and intestinal mucosal permeability increased. Moreover, these phenomena were age-dependent. These findings suggested that rotenone aggravated the PD-like pathologies and affected the brain and gut of human a-syn+/- transgenic mice in an age-dependent manner. [ABSTRACT FROM AUTHOR]

Several echocardiographic methods to estimate pulmonary vascular resistance (PVR) have been proposed. So far, most studies have focused on relatively low PVR in patients with a nonspecific type of pulmonary hypertension. We aimed to clarify the clinical usefulness of a new echocardiographic index for evaluating markedly elevated PVR in chronic thromboembolic pulmonary hypertension (CTEPH). We studied 127 CTEPH patients. We estimated the systolic and mean pulmonary artery pressure using echocardiography (sPAPEcho, mPAPEcho) and measured the left ventricular internal diameter at end diastole (LVIDd). sPAPEcho/LVIDd and mPAPEcho/LVIDd were then correlated with invasive PVR. Using receiver operating characteristic curve analysis, a cutoff value for the index was generated to identify patients with PVR > 1000 dyn·s·cm−5. We analyzed pre‐ and postoperative hemodynamics and echocardiographic data in 49 patients who underwent pulmonary endarterectomy (PEA). In this study, mPAPEcho/LVIDd moderately correlated with PVR (r = 0.51, p < 0.0001). There was a better correlation between PVR and sPAPEcho/LVIDd (r = 0.61, p < 0.0001). sPAPEcho/LVIDd ≥ 1.94 had an 77.1% sensitivity and 75.4% specificity to determine PVR > 1000 dyn·s·cm−5 (area under curve = 0.804, p < 0.0001, 95% confidence interval [CI], 0.66–0.90). DeLong's method showed there was a statistically significant difference between sPAPEcho/LVIDd with tricuspid regurgitation velocity2/velocity–time integral of the right ventricular outflow tract (difference between areas 0.14, 95% CI, 0.00–0.27). The sPAPEcho/LVIDd and mPAPEcho/LVIDd significantly decreased after PEA (both p < 0.0001). The sPAPEcho/LVIDd and mPAPEcho/LVIDd reduction rate (ΔsPAPEcho/LVIDd and ΔmPAPEcho/LVIDd) was significantly correlated with PVR reduction rate (ΔPVR), respectively (r = 0.58, p < 0.01; r = 0.69, p < 0.05). In conclusion, the index of sPAPEcho/LVIDd could be a simpler and reliable method in estimating CTEPH with markedly elevated PVR and also be a convenient method of estimating PVR both before and after PEA. [ABSTRACT FROM AUTHOR]

Background: Noninvasive assessment of pulmonary artery systolic pressure by Doppler echocardiography (sPAPECHO) has been widely adopted to screen for pulmonary hypertension (PH), but there is still a high proportion of overestimation or underestimation of sPAPECHO. We therefore aimed to explore the accuracy and influencing factors of sPAPECHO with right heart catheterization (RHC) as a reference. Methods: A total of 218 highly suspected PH patients who underwent RHC and echocardiography within 7 days were included. The correlation and consistency between tricuspid regurgitation (TR)-related methods and RHC results were tested by Pearson and Bland–Altman methods. TR-related methods included peak velocity of TR (TR Vmax), TR pressure gradient (TR-PG), TR mean pressure gradient (TR-mPG), estimated mean pulmonary artery pressure (mPAPECHO), and sPAPECHO. With mPAP ≥ 25 mm Hg measured by RHC as the standard diagnostic criterion of PH, the ROC curve was used to compare the diagnostic efficacy of sPAPECHO with other TR-derived parameters. The ratio (sPAPECHO–sPAPRHC)/sPAPRHC was calculated and divided into three groups as follows: patients with an estimation error between − 10% and + 10% were defined as the accurate group; patients with an estimated difference greater than + 10% were classified as the overestimated group; and patients with an estimation error greater than − 10% were classified as the underestimated group. The influencing factors of sPAPECHO were analyzed by ordinal regression analysis. Results: sPAPECHO had the highest correlation coefficient (r = 0.781, P < 0.001), best diagnostic efficiency (AUC = 0.98), and lowest bias (mean bias = 0.07 mm Hg; 95% limits of agreement, − 32.08 to + 32.22 mm Hg) compared with other TR-related methods. Ordinal regression analysis showed that TR signal quality, sPAPRHC level, and pulmonary artery wedge pressure (PAWP) affected the accuracy of sPAPECHO (P < 0.05). Relative to the good signal quality, the OR values of medium and poor signal quality were 0.26 (95% CI: 0.14, 0.48) and 0.23 (95% CI: 0.07, 0.73), respectively. Compared with high sPAPRHC level, the OR values of low and medium sPAPRHC levels were 21.56 (95% CI: 9.57, 48.55) and 5.13 (95% CI: 2.55, 10.32), respectively. The OR value of PAWP was 0.94 (95% CI: 0.89, 0.99). TR severity and right ventricular systolic function had no significant effect on the accuracy of sPAPECHO. Conclusions: In this study, we found that all TR-related methods, including sPAPECHO, had comparable and good efficiency in PH screening. To make the assessment of sPAPECHO more accurate, attention should be paid to TR signal quality, sPAPRHC level, and PAWP. [ABSTRACT FROM AUTHOR]

Extant research on the antecedents of workplace cyberbullying pays little attention to the role of perpetrator traits in influencing workplace cyberbullying, as well as the unique occurrence context that distinguishes workplace cyberbullying with juvenile cyberbullying, workplace bullying, and adult cyberbullying in general. To fill these gaps, we consider the antecedents of workplace cyberbullying under the theoretical lens of the general theory of crime and routine activities theory. We build a model incorporating low self-control, a widely discussed perpetrator trait in criminology theories, with three types of routine activities representing the unique occurrence context for workplace cyberbullying—mWork, boundary-spanning in enterprise social media, and proactive email checking. We tested our model with 2025 employees in the United States. Our findings demonstrate that low self-control and the three routine activities are strong motivators for workplace cyberbullying. Our findings further show that the effect of low self-control on workplace cyberbullying is amplified by the three routine activities. The study contributes to our understanding of why workplace cyberbullying occurs and offers potential implications for managers interested in reducing incidences of workplace cyberbullying in their organization. [ABSTRACT FROM AUTHOR]

A prospective, comparative study of ventilation-perfusion planar imaging and ventilation-perfusion SPECT for chronic thromboembolic pulmonary hypertension. SPECT perfusion imaging was then performed, and three times more radioactivity counts of perfusion imaging than ventilation imaging were acquired. Correlation between perfusion abnormalities extent in ventilation/perfusion SPECT/CT with hemodynamic parameters in patients with chronic thromboembolic pulmonary hypertension. [Extracted from the article]

Background: Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) patients is unknown. Methods: NSCLC patients undergoing radical resection and subsequent adjuvant chemotherapy from 2013 to 2017 at Sun Yat-sen University Cancer Center were retrospectively reviewed. Fasted serum lipid levels were measured before and after chemotherapy. The optimal lipid cut-off values at baseline and fluctuation were determined using X-tile™. The fluctuations in serum lipid levels and disease-free survival (DFS) were assessed. Results: Serum cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglyceride, apolipoprotein (Apo) A-I, and ApoB all significantly increased after adjuvant chemotherapy. X-tile determined 1.52 mmol/L of HDL-C and 0.74 g/L of ApoB as the optimal cut-off values before chemotherapy. Patients with HDL-C ≥ 1.52 mmol/L (median DFS: not reached vs. 26.30 months, P = 0.0005) and a decreased HDL-C level after adjuvant chemotherapy (median DFS: 80.43 vs. 26.12 months, P = 0.0204) had a longer DFS. An HDL-C level that increased by ≥ 0.32 mmol/L after chemotherapy indicated a worse DFS. A high baseline ApoB level were associated with a superior DFS. In the univariate analysis and the multivariate Cox analyses, a high baseline HDL-C level and a HDL-C reduction after adjuvant chemotherapy were independent indicators for superior DFS. High baseline HDL-C was related to N0-1 stage (χ2 = 6.413, P = 0.011), and HDL-C fluctuation was significantly correlated with specific chemotherapy regimens (χ2 = 5.002, P = 0.025). Conclusions: Adjuvant chemotherapy increased various lipid levels in resected NSCLC patients. A higher HDL-C level before chemotherapy and a reduced HDL-C level after adjuvant chemotherapy were independent predictors of longer DFS in patients with curable NSCLC. [ABSTRACT FROM AUTHOR]

In order to meet the load demand of power system, BP based on genetic algorithm is applied to the typical daily load forecasting in summer. The demand change of summer load is analysed. Simulation results show the accuracy of the algorithm. In terms of power supply, the reserves of fossil energy are drying up. According to the prediction of authoritative organizations, the world's coal can be mined for 216 years. As a renewable energy, wind power has no carbon emissions compared with traditional fossil energy. At present, it is generally believed that wind energy and solar energy are green power in the full sense, and they are inexhaustible clean power. The model of wind power solar hydrogen hybrid energy system is established. The control strategy of battery power compensation for delayed power of hydrogen production is adopted, and different operation modes are divided. The simulation results show that the system considering the control strategy can well meet the load demand. Battery energy storage system is difficult to respond to short-term peak power fluctuations. Super capacitor is used to suppress it. This paper studies the battery supercapacitor complementary energy storage system and its control strategy. When the line impedance of each generation unit in power grid is not equal, its output reactive power will be affected by the line impedance and distributed unevenly. A droop coefficient selection method of reactive power sharing is proposed. Energy storage device is needed to balance power and maintain DC voltage stability in the DC side of microgrid. Therefore, a new droop control strategy is proposed. By detecting the DC voltage, dynamically translating the droop characteristic curve, adjusting the output power, maintaining the DC voltage in a reasonable range, reducing the capacity of the DC side energy storage device. Photovoltaic grid connected inverter chooses the new droop control strategy. [ABSTRACT FROM AUTHOR]

The cover glass for thin-film transistor liquid crystal display (TFT-LCD) panel is the high aluminum silicate glass. Compared with the conventional soda lime glass, its higher viscosity of glass liquid brought more difficulties in the melting and fining process of mass production. For better fining performance, some oxides that can reduce the viscosity are necessary. In this paper, the fining properties of high aluminum glass batches with and without B2O3 were investigated by CeO2 agent under reduced atmospheric pressure of 1000 mbar, 500 mbar, and 300 mbar. Area Fraction, mean bubble size, number of bubbles and the ascending velocity of bubbles were analyzed quantitatively by high-temperature observation (HTO) system in the fining process. The results showed that B2O3 could efficiently promote the melting and fining process. [ABSTRACT FROM AUTHOR]

Peste des petits ruminants virus (PPRV) causes an acute and highly contagious disease in domestic and wild small ruminants throughout the world, mainly by invoking immunosuppression in its natural hosts. It has been suggested that the non-structural C protein of PPRV helps in evading host responses but the molecular mechanisms by which it antagonizes the host responses have not been fully characterized. Here, we report the antagonistic effect of PPRV C protein on the expression of interferon-β (IFN-β) through both MAVS and RIG-I mediated pathways in vitro. Dual luciferase reporter assay and direct expression of IFN-β mRNA analysis indicated that PPRV C significantly down regulates IFN-β via its potential interaction with MAVS and RIG-I signaling molecules. Results further indicated that PPRV C protein significantly suppresses endogenous and exogenous IFN-β-induced anti-viral effects in PPRV, EMCV and SVS infections in vitro. Moreover, PPRV C protein not only down regulates IFN-β but also the downstream cytokines of interferon stimulated genes 56 (ISG56), ISG15, C-X-C motif chemokine (CXCL10) and RIG-I mediated activation of IFN promoter elements of ISRE and NF-κB. Further, this study deciphers that PPRV C protein could significantly inhibit the phosphorylation of STAT1 and interferes with the signal transmission in JAK-STAT signaling pathway. Collectively, this study indicates that PPRV C protein is important for innate immune evasion and disease progression. [ABSTRACT FROM AUTHOR]

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in the regulation of coronary microcirculation through activation of adenosine receptors (ARs). Adenosine is regulated by various enzymes and nucleoside transporters for its balance between intra- and extracellular compartments. Adenosine-mediated coronary microvascular tone and reactive hyperemia are through receptors mainly involving A2AR activation on both endothelial and smooth muscle cells, but also involving interaction among other ARs. Activation of ARs further stimulates downstream targets of H2O2, KATP, KV and KCa2+ channels leading to coronary vasodilation. An altered adenosine-ARs signaling in coronary microcirculation has been observed in several cardiovascular diseases including hypertension, diabetes, atherosclerosis and ischemic heart disease. Adenosine as a metabolite and its receptors have been studied for its both therapeutic and diagnostic abilities. The present review summarizes important aspects of adenosine metabolism and AR-mediated actions in the coronary microcirculation. [ABSTRACT FROM AUTHOR]

: Osteosarcoma (OS) is a highly metastatic primary malignant tumor. CircRNA hsa_circ_0028173 (circATP2A2) has been uncovered to be related to the advancement of OS. However, the biological role of circATP2A2 in OS has not been validated. circATP2A2 and MYH9 were upregulated while miR-335-5p was downregulated in OS. OS patients with high circATP2A2 expression displayed a shorter overall survival and the area under curve of circATP2A2 was 0.77, manifesting that circATP2A2 might be a diagnostic and prognostic biomarker. circATP2A2 silencing repressed OS cell proliferation and glycolysis in vivo and constrained OS cell proliferation, glycolysis, migration, and invasion in vitro. circATP2A2 regulated MYH9 expression through sponging miR-335-5p. MiR-335-5p inhibitor reversed the repressive effect of circATP2A2 knock-down on OS cell malignancy and glycolysis. MYH9 over-expression overturned miR-335-5p upregulation-mediated OS cell malignancy and glycolysis. circATP2A2 accelerated OS cell malignancy and glycolysis through upregulating MYH9 via sponging miR-335-5p, offering a promising target for OS treatment. [ABSTRACT FROM AUTHOR]

Objectives: Right ventricular (RV) function is identified as a key determinant of the outcome in patients with pulmonary hypertension (PH). Several studies have assessed the role of peak global longitudinal RV strain in PH patients; however, less emphasis was given to the RV regional longitudinal strain. The aim of this study was to evaluate the regional RV systolic strain in PH patients and investigate the relationship of these parameters with the severity of PH. Methods: RV regional longitudinal peak systolic strain (LPSS) and strain rate (LPSSR) were measured using speckle tracking echocardiography on 100 patients with PH who underwent right heart catheterization, and 29 control subjects. Severe PH was identified by a decreased cardiac index (CI) (<2.0 L/min/m2). Results: LPSS and LPSSR of the RV free wall were significantly lower in PH patients than control subjects, especially when comparing the basal and mid regions (P <.001). When comparing severe PH and nonsevere PH, basal and mid LPSS and LPSSR were significantly lower (P <.001). RV free wall mid LPSSR correlated with CI (r = −.703, P <.001). In the multiple logistic regression analysis, mid LPSSR was identified as an independent predictor of severe PH (odds ratio 1.82; 95% confidential interval 1.39–2.40; P <.001). In the receiver operating characteristics curve analysis, a cutoff value of mid LPSSR of −0.92 s−1 predicted severe PH, with a sensitivity and specificity of 75.0% and 93.7%, respectively (AUC = 0.889, P <.001). Conclusions: RV free wall mid longitudinal peak systolic strain rate may be useful for the detection of severely impaired RV performance in PH. [ABSTRACT FROM AUTHOR]

Pseudo-random sequence plays an important role in the field of the phase noise simulation. This study analyses the pseudo-random sequence generated by the method based on cellular automata (CA). Compared with the method of look-up table and linear feedback neighbourhood registers, the simulation results show that the pseudo-random sequence generated by the CA method has better adaptability in the process of phase noise simulation. [ABSTRACT FROM AUTHOR]

In this paper, an efficient volume surface integral equation (VSIE) method with nonconformal discretization is developed for the analysis of electromagnetic scattering from composite metallic and dielectric (CMD) structures. This VSIE scheme utilizes curved tetrahedral (triangular) elements for volume (surface) modeling and the associated CRWG (CSWG) basis functions for volume current (surface) current modeling. Further, a discontinuous Galerkin (DG) volume integral equation (VIE) method and a DG surface integral equation (SIE) approach are adopted for dielectric and metallic parts, respectively, which allow both conformal and nonconformal volume/surface discretization improving meshing flexibility considerably. Numerical results are provided to demonstrate the accuracy, efficiency, and flexibility of our scheme. [ABSTRACT FROM AUTHOR]