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1. Inhibitory Effect of Eriodictyol on IgE/Ag-Induced Type I Hypersensitivity.

Author

Jung-Min Yoo, Ji-Hee KIM, Sae-Jin PARK, Yeo-Jin KANG, and Tack-Joong KIM

Subjects
MAST cells, ALLERGIES, PHYSIOLOGICAL effects of cytokines, SPHINGOLIPIDS, GRANULATION, CALCIUM-dependent protein kinase
Abstract

The article examines the effect of eriodictyol, derived from the painted maple and yerba santa, on mast cell degranulation and on an allergic response in an animal model. It further investigates its effect on the expression of the ceramide kinase (CERK) involved in calcium-dependent degranulation, and on ceramide activation by multiple cytokines. It reports that eriodictyol appeared to inhibit mast-cell degranulation by inhibiting sphingolipid metabolism.

Published
2012
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