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The three-dimensional, finite-difference model of R.L. Street (Stanford University) has been adapted at the simulation of wind-induced currents in the northern basin of the Lake of Lugano. The model makes use of complete Navier-Stokes equations and a dynamical algorithm to calculate the eddy viscosity. The model predictions are compared with data collected in the measure campaign of 1979. A further application of the model is the cold inflow simulation in a stratified basin with inclusion of turbulent vertical exchange processes. A two-dimensional version of the model, which assumes an hydrostatic pressure distribution, is utilized to simulate the thermal sommer development of the Lake of Lugano, during 40 days. The model includes the thermical interactions and the wind influence. The results obtained show the possible application of the three-dimensional model to the currents simulation in lake basins. The two-dimensional model may be utilized to predict the development of a basin subject to a thermal load. [ABSTRACT FROM AUTHOR]

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A new one-dimensional numerical model that includes physical and biochemical processes has been developed. The biochemical processes, influenced by the lake dynamics, are required for forecasting water quality. The model is used to investigate the effects of different internal restoration measures, such as artificial mixing, input of oxygen and drainage of deep water. The model is applied to the Northern Basin of Lake Lugano, a Swiss-Italian border lake. The lake is highly eutrophic and chemically stratified throughout the year. The model was calibrated over one year and validated over a period of several years. The results agree well with the measured data. The coupled model reproduces the observed depth dependency of conductivity even during long simulation times. Due to the predominant mixing, decoupled physical models cannot maintain such gradients. The forecasting capabilities of the model are demonstrated for different case studies. The impact of restoration measures on water quality is rather small. Best results are achieved by reducing the external nutrient loading. Caution is recommended for internal measures as these have to be studied in greater detail. [ABSTRACT FROM AUTHOR]

The hydrodynamic processes in the Lake of Lugano (Lago di Lugano) have been the object of three major measuring campaigns. The first during summer 1979 in the North Basin, the second in the autumn of 1984 in the South Basin and the last in 1989 again in the North Basin. It is expected that analysis of the collected data in conjunction with theoretical concepts will yield conclusive findings on the driving forces and hydrodynamics of the lake. Numerical models have been applied to the lake and the results have been compared to the measurements. Some models calculate the periods and distributions of amplitude, as well as surface velocities and internal seiches. Other models calculate wind-induced water circulation. Evidence is given to the peculiarities of the North Basin and the difficulties related with the depth-width ratio and with its deep chemical stratification. [ABSTRACT FROM AUTHOR]

The dynamic model Seemod developed at the EAWAG (Imboden and Gächter, 1978) and modified by Bührer (Ambühl and Bührer, 1984), was adapted to the South Basin of the Lake of Lugano (Lago di Lugano). The model can predict the evolution of the state of the lake, described by the concentrations of dissolved phosphorus, dissolved oxygen particulate phosphorus and organic particulate carbon, in function of phosphorus load and taking into account physical and biochemical initial- and boundary conditions. The model parameters were chosen through measurements and calibrations by short runs. A 10-year-long simulation was done, starting from the data of 1980, and its results agree quite well with the measurements. Then some 15-year-long simulations were done, which corresponded to different scenarios related to a progressive linking up of sewage systems to water treatment plants. The model predicts that a satisfactory water quality level can only be reached by reducing the total phosphorus input to less than 25 t/a. [ABSTRACT FROM AUTHOR]

By large scale circulation in lakes one means motions whose characteristic length scales extend over most parts or all of the water masses in a lake or the ocean. We present the governing equations and motivate, by means of a scale analysis, the various simplified versions of model equations that are in use in computational lake dynamics. This scale analysis not only permits rational deduction of the reduced equations, it equally provides a means of estimating their limitations. These are discussed as are the difficulties and the peculiarities inherent in the proposed equation sets. Special features of external and internal wave motions are studied. For barotropic oscillations of a lake system (Lake of Lugano) it is shown that substantial water masses are exchanged between the individual basins at the resonating periods. Baroclinic seiches of a three layer model in which each layer is effective within its own domain show (for the North basin of the Lake of Lugano) that mode structures may differ from layer to layer pointing at important modifications of classical interpretations of higher baroclinic wave dynamics. And in large lakes in the equatorial belt the β-effect forces modifications of the classical understanding of seiche behavior. Long periodic oscillating features may be attributed to topographic Rossby waves or higher baroclinic internal gravity waves; the observational identification is, however, difficult because lack of spatial resolution of the data makes this identification non-unique. We, finally present results of a full nonlinear numerical baroclinic circulation model and demonstrate that it is able to reproduce the gross features of the immediate response to strong storms during a few days. [ABSTRACT FROM AUTHOR]

Examines the effect of liver transplantation for patients with multifocal hepatocellular carcinoma (HCC). Absolute contraindications for transplantations; Prognosis of patients with liver transplants with multifocal HCC; Growth pattern of HCC.

Bio-electrospraying (BES) is a technique used for the processing of cells and can be applied to tissue engineering. The association of BES with scaffold production techniques has been shown to be an interesting strategy for the production of biomaterials with cells homogeneously distributed in the entire structure. Various studies have evaluated the effects of BES on different cell types. However, until the present moment, no studies have evaluated the impact of BES time on mesenchymal stem cells (MSC). Therefore, the aim of this work was to standardise the different parameters of BES (voltage, flow rate, and distance of the needle from the collecting plate) in relation to cell viability and then to evaluate the impact of BES time in relation to viability, proliferation, DNA damage, maintenance of plasticity and the immunophenotypic profile of MSC. Using 15 kV voltage, 0.46 ml/h flow rate and 4 cm distance, it was possible to form a stable and continuous jet of BES without causing a significant reduction in cell viability. Time periods between 15 and 60 min of BES did not cause alterations of viability, proliferation, plasticity, and immunophenotypic profile of the MSC. Time periods above 30 min of BES resulted in DNA damage; however, the DNA was able to repair itself within five hours. These results indicate that bio-electrospraying is an adequate technique for processing MSC which can be safely applied to tissue engineering and regenerative medicine. [ABSTRACT FROM AUTHOR]