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As a remote and non‐contact stimulus, light offers the potential for manipulating the polarization of ferroelectric materials without physical contact. However, in current research, the non‐contact write‐read (erase) process lacks direct observation through the stable current as output signal. To address this limitation, we investigated the photoinduced polarization switching capabilities of the cyanide‐bridged compound [Fe2Co] using visible light, leading to the achievement of rewritable polarization. By subjecting [Fe2Co] crystals to alternating irradiation with 785 nm and 532 nm light, the polarization changes exhibited a distinct square wave pattern, confirming the reliability of the writing and erasing processes. Initialization involved exposing specific crystal units to 532 nm light for storing "1" or "0" information, while reading was accomplished by scanning the units with 785 nm light, resulting in brief current pulses for "1" states and no current signal for "0" states. This research unveils new possibilities for optical storage systems, paving the way for efficient and rewritable data storage and retrieval technologies, such as the next‐generation memories. [ABSTRACT FROM AUTHOR]

As a remote and non‐contact stimulus, light offers the potential for manipulating the polarization of ferroelectric materials without physical contact. However, in current research, the non‐contact write‐read (erase) process lacks direct observation through the stable current as output signal. To address this limitation, we investigated the photoinduced polarization switching capabilities of the cyanide‐bridged compound [Fe2Co] using visible light, leading to the achievement of rewritable polarization. By subjecting [Fe2Co] crystals to alternating irradiation with 785 nm and 532 nm light, the polarization changes exhibited a distinct square wave pattern, confirming the reliability of the writing and erasing processes. Initialization involved exposing specific crystal units to 532 nm light for storing "1" or "0" information, while reading was accomplished by scanning the units with 785 nm light, resulting in brief current pulses for "1" states and no current signal for "0" states. This research unveils new possibilities for optical storage systems, paving the way for efficient and rewritable data storage and retrieval technologies, such as the next‐generation memories. [ABSTRACT FROM AUTHOR]

Four couples of 5,6-membered bis(metallacyclic) Pt(II) complexes with acetylide and isocyanide auxiliary ligands have been prepared and characterized. The structures of (−)-2 and (−)-3 are confirmed by single-crystal X-ray diffraction, showing a distorted square-planar coordination environment around the Pt(II) nucleus. Both solutions and solid samples of all complexes are emissive at RT. Acetylide-coordinated Pt(II) complexes have a lower energy emission than those isocyanide-coordinated ones. The emission spectra of N^N′*C-coordinated Pt(II) derivatives show a lower energy emission maximum relative to N^C*N′-coordinated complexes with the same auxiliary ligand. Moreover, the difference between cyclometalated N^N′*C and N^C*N′ ligands exerts a more remarkable effect on the emission than the auxiliary ligands acetylide and isocyanide. Cytotoxicity and cell imaging of luminescent 5,6-membered bis(metallacyclic) Pt(II) complexes have been evaluated. [ABSTRACT FROM AUTHOR]

We address the 3D shape assembly of multiple geometric pieces without overlaps, a scenario often encountered in 3D shape design, field archeology, and robotics. Existing methods depend on strong assumptions on the number of shape pieces and coherent geometry or semantics of shape pieces. Despite raising attention to 3D registration with complex or low overlapping patterns, few methods consider shape assembly with rare overlaps. To address this problem, we present a novel framework inspired by solving puzzles, named PuzzleNet, which conducts multi-task learning by leveraging both 3D alignment and boundary information. Specifically, we design an end-to-end neural network based on a point cloud transformer with two-way branches for estimating rigid transformation and predicting boundaries simultaneously. The framework is then naturally extended to reassemble multiple pieces into a full shape by using an iterative greedy approach based on the distance between each pair of candidate-matched pieces. To train and evaluate PuzzleNet, we construct two datasets, named DublinPuzzle and ModelPuzzle, based on a real-world urban scan dataset (DublinCity) and a synthetic CAD dataset (ModelNet40) respectively. Experiments demonstrate our effectiveness in solving 3D shape assembly for multiple pieces with arbitrary geometry and inconsistent semantics. Our method surpasses state-of-the-art algorithms by more than 10 times in rotation metrics and four times in translation metrics. [ABSTRACT FROM AUTHOR]

The popularity of online home design and floor plan customization has been steadily increasing. However, the manual conversion of floor plan images from books or paper materials into electronic resources can be a challenging task due to the vast amount of historical data available. By leveraging neural networks to identify and parse floor plans, the process of converting these images into electronic materials can be significantly streamlined. In this paper, we present a novel learning framework for automatically parsing floor plan images. Our key insight is that the room type text is very common and crucial in floor plan images as it identifies the important semantic information of the corresponding room. However, this clue is rarely considered in previous learning-based methods. In contrast, we propose the Row and Column network (RC-Net) for recognizing floor plan elements by integrating the text feature. Specifically, we add the text feature branch in the network to extract text features corresponding to the room type for the guidance of room type predictions. More importantly, we formulate the Row and Column constraint module (RC constraint module) to share and constrain features across the entire row and column of the feature maps to ensure that only one type is predicted in each room as much as possible, making the segmentation boundaries between different rooms more regular and cleaner. Extensive experiments on three benchmark datasets validate that our framework substantially outperforms other state-of-the-art approaches in terms of the metrics of FWIoU, mACC and mIoU. [ABSTRACT FROM AUTHOR]

As one of the most important applications of digitalization, intelligence, and service, the digital twin (DT) breaks through the constraints of time, space, cost, and security on physical entities, expands and optimizes the relevant functions of physical entities, and enhances their application value. This phenomenon has been widely studied in academia and industry. In this study, the concept and definition of DT, as utilized by scholars and researchers in various fields of industry, are summarized. The internal association between DT and related technologies is explained. The four stages of DT development history are identified. The fundamentals of the technology, evaluation indexes, and model frameworks are reviewed. Subsequently, a conceptual ternary model of DT based on time, space, and logic is proposed. The technology and application status of typical DT systems are described. Finally, the current technical challenges of DT technology are analyzed, and directions for future development are discussed. [ABSTRACT FROM AUTHOR]

A novel fluorescent probe SHK for Zn2+ detection was designed based on the hydrazone Schiff base, successfully synthesized by Suzuki coupling and condensation reactions. The probe SHK in DMSO/H2O showed extremely weak fluorescence. However, the solution exhibited an intensive yellow-green emission with the introduction of Zn2+. In contrast, negligible fluorescence change was observed when other metal ions were added, suggesting a high selectivity of SHK for Zn2+ detection. The Job's Plot analysis revealed that a 1:1 stoichiometric adduct SHK-Zn2+ formed during the Zn2+ sensing. The binding constant of the complex was determined to be 184 M− 1, and the detection limit for Zn2+ was calculated to be 112 µM. Moreover, the probe SHK achieved selective fluorescence sensing for Zn2+ on test strips, which guaranteed its practical application prospect. [ABSTRACT FROM AUTHOR]

In the cellular response to stresses, the tumor suppressor p53 is activated to maintain genomic integrity and fidelity. As a transcription factor, p53 exhibits rich dynamics to allow for discrimination of the type and intensity of stresses and to direct the selective activation of target genes involved in different processes including cell cycle arrest and apoptosis. In this review, we focused on how stresses are encoded into p53 dynamics and how the dynamics are decoded into cellular outcomes. Theoretical modeling may provide a global view of signaling in the p53 network by coupling the encoding and decoding processes. We discussed the significance of modeling in revealing the mechanisms of the transition between p53 dynamic modes. Moreover, we shed light on the crosstalk between the p53 network and other signaling networks. This review may advance the understanding of operating principles of the p53 signaling network comprehensively and provide insights into p53 dynamics-based cancer therapy. [ABSTRACT FROM AUTHOR]

Over the years, scientists have been focused on the development of microneedle coating process to coat a broad range of therapeutic agents onto the surface of the solid microneedles for effective drug delivery. The precise dose control, content uniformity as well as large-scale production of coated microneedles are still the core issues that have been the interest of researchers in this topic. To this end, a repeatable method that involved a micro-molding process was demonstrated for mass fabrication of coated microneedles with homogeneous and controllable drug loading under mild conditions. In this system, the dissolvable drug carriers with precise dosage were first mounted onto the solid microneedles and then exposed to the high moisture condition to finally obtain the coated microneedle with uniform and precise drug loading. Using the microneedle molds with the volume of 4.71 nL, 8.24 nL, 10.47 nL, and 12.56 nL per cavity, the drug loadings were precisely controlled at 4.8 ng, 6.4 ng, 9.3 ng, and 13.5 ng per needle, with the standard deviation of 0.09, 0.01, 0.07, and 0.53%, respectively. Mechanical property tests showed that the coated microneedles are strong enough for reliable skin insertion, and with in vivo trials in diabetic mice, we further confirmed the similar hypoglycaemic effect of insulin-coated microneedles to subcutaneous injection. Taken together, the micro-molding-based fabrication process has practical merits in the mass production of coated microneedles with homogeneous and controllable drug loading, facilitating the clinical translation of the microneedle technique. [ABSTRACT FROM AUTHOR]

Diabetes is one of the most serious chronic diseases today. Patients with diabetes need frequent insulin injections or blood sampling to monitor blood glucose levels. The microneedles are a painless transdermal drug delivery system, which has great advantages in achieving self-management. There have been a lot of researches on microneedles used in diabetes treatment. Microneedle-based treatment of diabetes has also changed from a simple and reliable system to a complex and efficient system. This review introduces microfluidic, glucose response, and other contents based on microneedles, and some challenges in the development of microneedles. [ABSTRACT FROM AUTHOR]

Glacier-related mass flows (GMFs) in the high-mountain cryosphere have become more frequent in the last decade, e.g., the 2018 Sedongpu (SDP) GMFs in the Himalayas. Seismic forcing, thermal perturbation and heavy rainfall are common triggers of the GMFs. But the exact role of seimic forcing in the GMF formation is poorly known due to scarity of observational data of real cases. Here the evolution processes of the GMFs and the detachment of the trunk glacier in SDP are reconstructed by using remote sensing techniques, including feature-tracking of multi-source optical satellite imagery and visual interpretation. The reconstruction demonstrates that the high frequency of GMF events in SDP after the Milin earthquake on 18 November 2017 was mainly attributed to the earthquake-induced glacial stress changes and destablisation. The post-earthquake velocity of the trunk glacier is about three times of that in December 2016 and December 2017. The median glacier-surface velocity raised to 0.32 m d−1 between November 2017 and June 2018, being 14%–77% higher than that of pre-earthquake, which is initiated by the seismic forcing and then aggravated by additional loading of ice/rock avalanches, infiltration of liquid water, progressively crevassed glacier, and local compressional deformation. Ensuing surge motion of the trunk glacier resulted from high temperature and heavy precipitation between July and September 2018. We infer that the trunk glacier is more sensitive to the thermal perturbation after the Milin earthquake, which is the predominant cause in sudden surge movement. These findings reveal comprehensive mechanisms of quake-induced, low-angle, glacial detachment and multisource-driven GMF in the Himalayas. [ABSTRACT FROM AUTHOR]

Microneedles (MNs) have been developed for various applications such as drug delivery, cosmetics, diagnosis, and biosensing. To meet the requirements of MNs used in these areas, numerous materials have been used for the fabrication of MNs. However, MNs will be exposed to skin tissues after piercing the stratum corneum barrier. Thus, it is necessary to ensure that the matrix materials of MNs have the characteristics of low toxicity, good biocompatibility, biodegradability, and sufficient mechanical properties for clinical application. In this review, the matrix materials currently used for preparing MNs are summarized and reviewed in terms of these factors. In addition, MN products used on the market and their applications are summarized in the end. This work may provide some basic information to researchers in the selection of MN matrix materials and in developing new materials. [ABSTRACT FROM AUTHOR]

Tuberculosis, caused by mycobacteria, continues to pose a substantial public health threat. Mycobacteria typically use cholesterol from the membranes of host macrophages as a carbon and energy source. Most genes that control cholesterol degradation are regulated by KstR, which is highly conserved in Mycobacterium tuberculosis and Mycobacterium smegmatis. Through bioinformatic analysis, we found a typical global nitrogen regulator (GlnR)‐binding motif (CCGAC‐AACAGT‐GACAC) in the promoter region of kstR of M. smegmatis, and we determined its binding activity in vitro using electrophoretic mobility shift assays. Using RT‐qPCR, we found that nine genes involved in side‐chain or sterol‐ring oxidation were upregulated in a ΔglnR M. smegmatis strain compared to the WT strain and glnR‐complemented strains under nitrogen limitation. ATP assays in macrophages revealed that coordinated GlnR–KstR regulation significantly reduced the viability of M. smegmatis in macrophages. Thus, we found that various genes involved in cholesterol catabolism are regulated by GlnR via KstR in response to environmental nitrogen, and that they further affect the invasive ability of M. smegmatis. These findings revealed a novel regulatory mechanism of cholesterol catabolism, which may be useful in the development of new strategies for controlling tuberculosis. [ABSTRACT FROM AUTHOR]

Dissolving microneedle patch (DMNP) is a minimally invasive and painless self-administration device. However, due to skin deformation, it is difficult to apply it on the large areas of skin or curved skin as the patch size increased for DMNP. Here, we propose a polyvinyl alcohol (PVA)–based dissolving microneedle roller (DMNR) device that can be used for delivering drugs rapidly on the large surface areas or curved skin and does not need to be attached on the skin all the time during drug delivery. The hypoglycemic effect of insulin-loaded DMNRs for transdermal delivery of insulin was studied on the type 1 diabetic rat models. It was found that the insulin-loaded DMNR has an immediate and effective hypoglycemic effect that the blood glucose level reduced below to 50% of original blood glucose at 1 h after DMNRs administrated. [ABSTRACT FROM AUTHOR]

The structure–mechanochromism relationship is explored with respect to packing patterns and corresponding intermolecular interactions that are affected by the number and location of –F. The distinct and reversible mechanochormic luminescence (Δλem up to ca. 90 nm) of yellow solids (−)-1-Yg, (−)-2-Yg, and (−)-3-Yg was displayed with a simultaneous crystal-to-amorphous transformation. The change of multiple triplet excited states accounted for the mechanochormic luminescence, and a switch from the 3π,π* monomer to the excimer/3MMLCT occurred in the grinding process. The mechanical force led to perturbation in the molecular packing, and aggregates with effective Pt⋯Pt and π–π interactions were formed in the amorphous phase, leading to the variation of excited states. The mechanochromic luminescence could be reverted by dropping in CH2Cl2 and could be cycled multiple times without perceivable performance degradation. This work gives a reference for designing mechanochromic luminescent materials toward multicolor and multicomponent responses. [ABSTRACT FROM AUTHOR]

Mitochondrial uncoupling protein 2 (UCP2) deficiency exacerbates brain damage following cerebral ischemia/reperfusion (I/R). The Nod-like receptor protein-3 (NLRP3) inflammasome also plays a vital role in cerebral I/R damage. However, the effect of UCP2 on NLRP3 inflammasome-mediated hyperglycemia and I/R damage is not clear. In the present study, UCP2-knockout (UCP2−/−) and wild-type (WT) mice were used to establish a model of middle cerebral artery occlusion (MCAO) and reperfusion under normo- and hyperglycemic conditions. HT22 cells were established as a model of oxygen–glucose deprivation and reoxygenation (OGD/R) with high glucose to mimic hyperglycemia and I/R in vitro. HT22 cells were treated with/without different concentrations of the UCP2-specific inhibitor genipin for different periods of time. The results showed that UCP2 deficiency significantly increased histopathological changes and apoptosis after cerebral I/R damage in hyperglycemic mice. Moreover, UCP2 deficiency enhanced NLRP3 inflammasome activation in neurons when cerebral I/R damage was exacerbated by hyperglycemia. Furthermore, UCP2 deficiency enhanced NLRP3 inflammasome activation and reactive oxygen species (ROS) production in HT22 cells under OGD/R and high-glucose conditions. UCP2 deficiency aggravated hyperglycemia-induced exacerbation of cerebral I/R damage. UCP2 deficiency also enhanced NLRP3 inflammasome activation and ROS production in neurons in vitro and in vivo. These findings suggest that UCP2 deficiency enhances NLRP3 inflammasome activation following hyperglycemia-induced exacerbation of cerebral I/R damage in vitro and in vivo. UCP2 may be a potential therapeutic target for hyperglycemia-induced exacerbation of cerebral I/R damage. [ABSTRACT FROM AUTHOR]

Copper is essential for many metabolic processes but must be sequestrated by copper chaperones. It is well known that plant copper chaperones regulate various physiological processes. However, the functions of copper chaperones in the plant nucleus remain largely unknown. Here, we identified a putative copper chaperone induced by pathogens (CCP) in Arabidopsis thaliana. CCP harbors a classical MXCXXC copper-binding site (CBS) at its N-terminus and a nuclear localization signal (NLS) at its C-terminus. CCP mainly formed nuclear speckles in the plant nucleus, which requires the NLS and CBS domains. Overexpression of CCP induced PR1 expression and enhanced resistance against Pseudomonas syringae pv. tomato DC3000 compared with Col-0 plants. Conversely, two CRISPR/Cas9-mediated ccp mutants were impaired in plant immunity. Further biochemical analyses revealed that CCP interacted with the transcription factor TGA2 in vivo and in vitro. Moreover, CCP recruits TGA2 to the PR1 promoter sequences in vivo , which induces defense gene expression and plant immunity. Collectively, our results have identified a putative nuclear copper chaperone required for plant immunity and provided evidence for a potential function of copper in the salicylic pathway. [ABSTRACT FROM AUTHOR]

Hypoxia-inducible factor-1 (HIF-1) is the key regulator of cellular adaptive response to hypoxia. Accumulating evidence shows that HIF-1 induces some non-coding RNAs (ncRNAs) including lncRNAs and miRNAs to modulate its own activity, enclosing several feedback loops. How the two classes of ncRNAs are orchestrated in the HIF-1-dependent adaptive response to hypoxia is poorly understood. By selecting lincRNA-p21 and miR-155 as the representatives, we develop an integrated model of the HIF-1 network comprising interlinked positive and negative feedback loops to clarify the interplay between the two ncRNAs in the hypoxic response. By numerical simulations, we find that coordination of lincRNA-p21 and miR-155 shapes the adaptive dynamics of HIF-1α: lincRNA-p21 induction in the early phase stimulates the upregulation of HIF-1α via stabilizing it, while miR-155 induction in the late phase promotes the recovery of HIF-1α via enhancing the degradation of its mRNA. Moreover, HIF-1α-induced PHD2 plays an auxiliary role in the decline of HIF-1α. In addition, lincRNA-p21 and miR-155 modulate each other via regulating HIF-1α activity. Together, lincRNA-p21 and miR-155 coordinate in modulating HIF-1α dynamics, and our work may shed light on the role for ncRNAs in the cellular adaptation to hypoxia. [ABSTRACT FROM AUTHOR]

Solid microneedles (MNs) represent a useful tool for enhancing skin permeability by creating microchannels that provide a drug delivery route. To achieve the solid polymer MNs to become a clinical reality and to be commercialised, it is much essential to understand the skin penetration process. In this work, the effect of polymer MN height and density, drug molecular weight, as well as drug diffusion time on the drug permeability distribution was systemically investigated in vivo. MN with a height of 800 µm was most conductive to enhance the vertical distribution of drug permeation into the skin, while 11 × 11 MN array was most beneficial to promote the horizontal distribution of drug permeation into the skin. In addition, the increasing of drug molecular weight could reduce the drug permeability distribution and Fluorescein isothiocyanate most likely to penetrate into the skin after MNs pre-treatment. With the increase of drug diffusion time, the drug distribution in the subcutaneous gradually weakened until the drug was absorbed by the subcutaneous tissue at 8 h. These results suggest that the solid polymer MNs can penetrate the stratum corneum of the skin for enhancing drug delivery, especially small molecule drugs. [ABSTRACT FROM AUTHOR]

Two new phase of diammonium 5,5′‐bistetrazole‐1,1′‐diolate (α‐ and β‐ABTOX) were prepared, and its structure were characterized by FT‐IR spectroscopy and single X‐ray diffraction. The thermal decomposition processes of α‐ and β‐ABTOX were studies by means of the DTA‐TG and TG‐MS technologies, the crystal morphology of α‐ and β‐ABTOX were studied by SEM technology. The results show thermal stability of α‐ABTOX is better than β‐ABTOX, the crystal morphology of α‐ and β‐ABTOX are rhombus and square. Finally, front orbital energies and the molecular electronic potential (MEP) of α‐ and β‐ABTOX were studied using density functional theory (DFT) B3LYP/6‐311G(d, p) basis set level. [ABSTRACT FROM AUTHOR]

Background: Circulating tumor cells (CTCs) have become potential diagnostic biomarker for several types of cancer, including lung cancer. In this study, we aim to determine whether CTCs detected by CellCollector can be used for early-stage diagnosis of lung cancer. Methods: In this study, we recruited 64 volunteers, among whom 44 were suspected lung cancer patients requiring surgical treatment and 20 were healthy volunteers. We simultaneously analyzed PD-L1 expression in CTCs isolated using the GILUPI CellCollector and copy number variation by next-generation sequencing (NGS). Results: We enrolled a total of 44 patients with suspected lung cancer who required surgery and 20 healthy volunteers. The patients were classified into 4 groups based on their pathological results: benign disease, in situ cancer, microinvasive, and invasive. The CTCs detection rate for each group was 10.00% (1/10), 45% (5/11), 50% (7/14), and 67% (6/9), respectively. Among the patients with lung cancer, the CTCs detection rate increased with disease progression. The rate of CTCs positivity was 52.94% (18/34) in patients who were diagnosed with lung cancer by pathology and 10% (1/10) in patients with benign disease. CTCs were not detected in the control group. The area under the receiver operating characteristic (ROC) curve, a measure for distinguishing patients with primary lung cancer, was 0.715 (95% CI 0.549– 0.880, P=0.041). The sensitivity and specificity of the in vivo CTCs detection strategy for the diagnosis of early-stage lung cancer were 52.94% and 90%, respectively. CTCs were associated with clinical pathology but not with the size and location of the nodules. Conclusion: CTCs isolation using the CellCollector in vivo detection method might be effective for distinguishing between benign and malignant nodules and may be used for early-stage diagnosis of lung cancer. [ABSTRACT FROM AUTHOR]

There is an increasing concern on the drug loading capacity of microneedles (MNs) to meet higher drug dosage requirement. The present study describes the fabrication of modified rapidly separating polyvinyl alcohol (PVA)-based MNs (RS-P-MNs) with high drug loading using a mechanical agitation process. The drugs encapsulated within the PVA polymer gel by mechanical agitation served as an encapsulating agent for drugs that provide a high drug loading capacity and also release of drugs in a controlled manner. The various parameters such as microscopic analysis, atomic force microscopy (AFM), drug loading, drug delivery efficiency, mechanical test, skin penetration ability, and in vitro and in vivo analyses indicate the great potential of the RS-P-MNs. The maximum drug loading capacity of RS-P-MNs was measured to be approximately 900 ng per microneedle, which was almost a hundred times than the traditional drug encapsulating mode. The in vitro and in vivo results suggested that the controlled release of drugs is due to the encapsulating mode (mechanical agitation) of drugs. The prepared RS-P-MNs with high drug loading in this study provided a gentle and controlled release of drugs instead of the robust release of drugs from traditional MNs. [ABSTRACT FROM AUTHOR]

As a famous tumor suppressor, p53 is also activated under hypoxic conditions. Hypoxia‐inducuble factor 1, HIF‐1, is involved in the activation of p53 upon hypoxia. However, how p53 is modulated by the HIF‐1 pathway to decide cell fate is less understood. In this work, we developed a network model including p53 and HIF‐1 pathways to clarify the mechanism of cell fate decision in response to hypoxia. We found that HIF‐1α and p53 are activated under different conditions. Under moderate hypoxia, HIF‐1α is activated to induce glycolysis or angiogenesis, and promotes partial accumulation of p53 by inducing PNUTS. Under severe hypoxia, p53 rises to high levels due to ATR‐dependent stabilization and promotes Mdm2‐dependent HIF‐1α degradation. As a result, fully activated p53 triggers apoptosis. Of note, competition for p300 between HIF‐1α and p53 plays a key role in regulating their transcriptional activities. This work may advance the understanding of the mechanism for p53 regulation by HIF‐1 in the hypoxic response. [ABSTRACT FROM AUTHOR]

The traditional space-invariant isotropic kernel utilized by a bilateral filter (BF) frequently leads to blurry edges and gradient reversal artifacts due to the existence of a large amount of outliers in the local averaging window. However, the efficient and accurate estimation of space-variant kernels which adapt to image structures, and the fast realization of the corresponding space-variant bilateral filtering are challenging problems. To address these problems, we present a space-variant BF (SVBF), and its linear time and error-bounded acceleration method. First, we accurately estimate spacevariant anisotropic kernels that vary with image structures in linear time through structure tensor and minimum spanning tree. Second, we perform SVBF in linear time using two error-bounded approximation methods, namely, low-rank tensor approximation via higher-order singular value decomposition and exponential sum approximation. Therefore, the proposed SVBF can efficiently achieve good edge-preserving results. We validate the advantages of the proposed filter in applications including: image denoising, image enhancement, and image focus editing. Experimental results demonstrate that our fast and error-bounded SVBF is superior to state-of-the-art methods. [ABSTRACT FROM AUTHOR]

Objective: The objective of the study was to evaluate the usefulness of large-section cytokeratin 20 (CK20) staining technique in the detection of infiltration on the distal wall and mesangial metastasis in patients with middle and lower rectal cancer.Materials and Methods: A total of 62 patients with rectal cancer in the middle and lower segment were studied on large slices stained with CK20. Logistic regression was used to analyze the clinicopathologic factors related to distal low and middle rectal cancer metastasis to the mesorectum and rectal wall.Results: Two types of distal metastasis of the tumor were observed in the rectal wall in 18% (11/62) of the patients: submucosal invasion and muscularis propria invasion. The extent of distal metastasis to the rectal wall was around 0.5-1.0 cm. Four types of distal metastasis occurred in the mesorectum: lymph node invasion, blood and lymphatic vessel invasion, perineural invasion, and isolated neoplastic microfoci. Distal metastasis to the mesorectum was observed in 24% (15/62) of the patients. The extent of metastasis to the mesorectum was around 0.5-4.0 cm. Another three patients with microcapillary invasion in the distal mesorectum were observed by immunohistochemistry, as it was difficult to determine the spread by conventional hematoxylin and eosin staining.Conclusion: The large-section CK20 staining technique is useful for the detection of infiltration on the distal wall and mesangial metastasis in patients with middle and lower rectal cancer. [ABSTRACT FROM AUTHOR]

Many natural landscapes that lie in high mountain regions are highly susceptible to geological hazards, and their values and integrity are strongly threatened by the hazards. A preliminary framework was proposed to undertake a quantitative assessment of the impact of earthquake-induced geological hazards on the natural landscapes. Four factors reflecting the aesthetic value, ecological value, integrity of landscapes were selected to assess their vulnerability. The impact of earthquake-induced geological hazards on the landscapes is quantitatively expressed as the product of their vulnerability and resilience. The assessment framework was applied to Jiuzhaigou Valley which was severely struck by the Ms 7.0 earthquake on August 8, 2017. Field survey, satellite image interpretation, high-resolution DEM and unmanned aerial vehicle (UAV) reconnaissance were used to retrieve the values of the assessment factors. Twenty seven World Heritage Sites in the valley strongly influenced by the earthquakeinduced geohazards were evaluated. The impact values of two sites of them (Sparking Lake and Nuorilang Waterfall) are up to 8.24 and 4.65, respectively, and their natural landscapes were greatly damaged. The assessment results show a good agreement with the actual damages of the heritage sites. [ABSTRACT FROM AUTHOR]

The acetylation of p53 plays an essential role in regulating its transcriptional activity. Nevertheless, how p53 acetylation is modulated in cell fate decision is less understood. We developed a network model to reveal how Tip60‐dependent p53 acetylation is regulated to modulate cellular outcome. We proposed that p53 is progressively activated and exhibits distinct dynamics depending on the severity of DNA damage. For mild damage, p53 is primarily activated to trigger cell cycle arrest by transactivating p21, with its concentration showing pulses. For severe damage, p53 is acetylated at Lysine 120 (K120) by Tip60 to trigger apoptosis by inducing PUMA, and its concentration increases to high levels. Several p53‐centered feedback loops coordinate to regulate its acetylation status, ensuring a robust decision on cell fate. [ABSTRACT FROM AUTHOR]

The formation of segregated conductive networks is significantly important for achieving excellent electromagnetic interference (EMI) shielding performance in a conductive polymer composite. Nevertheless, the low melt viscosity of poly(phenylene sulfide) (PPS) would lead to intense diffusion between the conductive filler and PPS molecular chains, which disturbs the selective distribution of the conductive filler to form a segregated structure. Herein, sinter molding was first utilized to control the selective distribution of carbon nanotubes (CNTs) among the interfaces of PPS domains and facilely construct a segregated structure in the resultant CNT/PPS composite. The segregated CNT/PPS composite with only 5.0 wt% CNTs exhibits a very high electrical conductivity of 72.0 S m−1 and EMI shielding effectiveness (EMI SE) of 49.6 dB. Our work provides insight into the development of highly efficient and heat resistant EMI shielding materials via a novel processing method. [ABSTRACT FROM AUTHOR]

Hydrologiska Byrans Vattenbalansavdeling (HBV) Light model was used to evaluate the performance of the model in response to climate change in the snowy and glaciated catchment area of Hunza River Basin. The study aimed to understand the temporal variation of streamflow of Hunza River and its contribution to Indus River System (IRS). HBV model performed fairly well both during calibration (R2=0.87, Reff=0.85, PBIAS=−0.36) and validation (R2=0.86, Reff=0.83, PBIAS=−13.58) periods on daily time scale in the Hunza River Basin. Model performed better on monthly time scale with slightly underestimated low flows period during both calibration (R2=0.94, Reff=0.88, PBIAS=0.47) and validation (R2=0.92, Reff=0.85, PBIAS=15.83) periods. Simulated streamflow analysis from 1995-2010 unveiled that the average percentage contribution of snow, rain and glacier melt to the streamflow of Hunza River is about 16.5%, 19.4% and 64% respectively. In addition, the HBV-Light model performance was also evaluated for prediction of future streamflow in the Hunza River using future projected data of three General Circulation Model (GCMs) i.e. BCC-CSM1.1, CanESM2, and MIROCESM under RCP2.6, 4.5 and 8.5 and predictions were made over three time periods, 2010-2039, 2040-2069 and 2070-2099, using 1980-2010 as the control period. Overall projected climate results reveal that temperature and precipitation are the most sensitive parameters to the streamflow of Hunza River. MIROC-ESM predicted the highest increase in the future streamflow of the Hunza River due to increase in temperature and precipitation under RCP4.5 and 8.5 scenarios from 2010-2099 while predicted slight increase in the streamflow under RCP2.6 during the start and end of the 21th century. However, BCCCSM1.1 predicted decrease in the streamflow under RCP8.5 due to decrease in temperature and precipitation from 2010-2099. However, CanESM2 predicted 22%-88% increase in the streamflow under RCP4.5 from 2010-2099. The results of this study could be useful for decision making and effective future strategic plans for water management and their sustainability in the region. [ABSTRACT FROM AUTHOR]

The aim of investigation is to explore the relationship between demands for lung cancer screening (LCS) and the constructs derived from the health belief model (HBM) in Hefei. The study collected data about socio-demographics, health beliefs in and demands for LCS during early June to later July 2015. By constructing a LCS demands HBM constructs, it calculated indices of demands for LCS (DSI) and HBM constructs, which include perceived risk (PR) and seriousness (PS) of the cancers; and perceived effectiveness (PE), benefits (PB) and difficulties (PD) of the screening. It also performed descriptive and multivariate regression analysis of the demands and the HBM constructs. The amount of 823 respondents participated and completed the survey. 6.4% of them had ever undertaken LCS, whereas 60.1% of them expressed willingness to accept the service of LCS if it is free. In multiple regression analysis which used weights in calculating the HBM construct indices, education displayed significant positive associations with DSI (p = .044), and most of HBM constructs indices (PSI, PRI, PBI, and PDI) were statistically significant with DSI (p < .05). HBM-based constructs regarding LCS have important effects on demands for the service, and may provide effective paths to cancer screening promotion. [ABSTRACT FROM AUTHOR]

Microneedles (MNs) system for transdermal drug delivery has the potential to improve therapeutic efficacy, proving an approach that is more convenient and acceptable than traditional medication systems. This study systematically researched dissolving polymer MNs fabricated from various common FDA-approved biocompatible materials, including gelatine, chitosan, hyaluronic acid (HA) and polyvinyl alcohol (PVA). Upon application of MN patches to the porcine cadaver skin, the MNs effectively perforated the skin and delivered drugs to subcutaneous tissue on contact with the interstitial fluid. Both the in vitro and in vivo drug release tests showed the similar trends but different release rates among the prepared MNs. Interestingly, the drug-release kinetics of PVA MNs were able to be altered by changing the molecular weight. To evaluate the feasibility using the proposed MNs for treating diabetes, an in vivo insulin absorption study in diabetic mice was performed. The results showed different insulin release properties of MNs fabricated from various kinds of polymer, leading to different decrease in blood glucose levels. We made a systematic and comprehensive study of some drug-loaded polymer MNs, and anticipated that dissolving polymer MNs have potential to improve therapeutic efficacy through controlled drug release. [ABSTRACT FROM AUTHOR]

Circularly polarized luminescence (CPL) activity switched by Pt…Pt interaction is disclosed in two couples of dinuclear Pt(ii) complex enantiomers. Upon varying the length of the bridging ligand, intramolecular metal–metal interaction manipulation is achieved as evidenced from crystal structures. Complex (−)-1 exhibiting strong Pt…Pt interaction displays red phosphorescence with a maximum peak at 638 nm, while complex (−)-2 exhibiting weak Pt…Pt interaction displays green phosphorescence with a maximum peak at 530 nm. The observed CPL was opposite in sign for the two complexes. TD-DFT simulations further confirmed the influence of the Pt…Pt distance on the difference in the electronic optical activities. [ABSTRACT FROM AUTHOR]

Surface plasmons supported by various metallic nanostructures have given rise to several significant breakthroughs in the field of integrated photonic devices due to its ability to effectively confine and enhance optical field in subwavelength volume. In particular, the demand to actively control optical responses of plasmonic systems becomes urgent for the miniaturization of signal processing devices, surface-enhanced Raman scattering (SERS) substrates and biochemical sensors. In this paper, we systematically investigate the plasmon modes as well as their interaction in a layered nanostructure composed of a periodically-arranged radiative nanoring and a metallic ground plane, as well as a thin insulating spacer. A tunable transparent peak on the background of the broadband plasmon resonance emerges in the reflection spectrum as changing the periodicity of nanoparticle array, a plasmonic analogue of electromagnetically induced transparency (EIT). Owing to the structural symmetry of the rings, we demonstrate a new scheme of controlling the interference between localized and delocalized plasmons by means of incident polarization and believe that the proposed metasurface may find applications in optical switching if the polarization-controlled components are introduced. [ABSTRACT FROM AUTHOR]

Plasmon-induced transparency (PIT), an analog of electromagnetically induced transparency, originates from destructive interference of plasmonic resonators with different quality factors and brings about the extreme dispersion within the narrow transparency window, promising remarkable potential for slow light, nonlinear optics and biochemical sensors. However, sometimes a broad transmission frequency band is more desirable for other applications such as bandpass filters. In general, strong coupling between bright and dark plasmon modes in coupled resonant systems leads to wide transparency bandwidth at the PIT resonance. Based on multi-oscillator coupling theory, a metasurface structure consisting of three perpendicularly connected metallic nanobars is purposefully designed and numerically demonstrated to support broadband PIT spectral response. The near-field patterns indicate that the broadening of the transparent band results from the constructive interference of dual excitations of the single non-radiative (dark) resonator by the two radiative (bright) antennas. These results show that this scheme of bright-dark-bright mode coupling is significantly beneficial for designing filters operating over a broad frequency range. [ABSTRACT FROM AUTHOR]

Shoot apical meristems (SAM) are resistant to most plant viruses due to RNA silencing, which is restrained by viral suppressors of RNA silencing (VSRs) to facilitate transient viral invasion of the SAM. In many cases chronic symptoms and long-term virus recovery occur, but the underlying mechanisms are poorly understood. Here, we found that wild-type Cucumber mosaic virus (CMVWT) invaded the SAM transiently, but was subsequently eliminated from the meristems. Unexpectedly, a CMV mutant, designated CMVRA that harbors an alanine substitution in the N-terminal arginine-rich region of the coat protein (CP) persistently invaded the SAM and resulted in visible reductions in apical dominance. Notably, the CMVWT virus elicited more potent antiviral silencing than CMVRA in newly emerging leaves of infected plants. However, both viruses caused severe symptoms with minimal antiviral silencing effects in the Arabidopsis mutants lacking host RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) or SUPPRESSOR OF GENE SILENCING 3 (SGS3), indicating that CMVWT induced host RDR6/SGS3-dependent antiviral silencing. We also showed that reduced accumulation of the 2b protein is elicited in the CMVWT infection and consequently rescues potent antiviral RNA silencing. Indeed, co-infiltration assays showed that the suppression of posttranscriptional gene silencing mediated by 2b is more severely compromised by co-expression of CPWT than by CPRA. We further demonstrated that CPWT had high RNA binding activity leading to translation inhibition in wheat germ systems, and CPWT was associated with SGS3 into punctate granules in vivo. Thus, we propose that the RNAs bound and protected by CPWT possibly serve as templates of RDR6/SGS3 complexes for siRNA amplification. Together, these findings suggest that the CMV CP acts as a central hub that modulates antiviral silencing and VSRs activity, and mediates viral self-attenuation and long-term symptom recovery. [ABSTRACT FROM AUTHOR]

Platelet to lymphocyte ratio (PLR) was recently reported as a useful index in predicting the prognosis of lung cancer. However, the prognostic role of PLR in lung cancer remains controversial. The aim of this study was to evaluate the association between PLR and clinical outcome of lung cancer patients through a meta-analysis. Relevant literatures were retrieved from PubMed, Ovid, the Cochrane Library and Web of Science databases. Meta-analysis was performed using hazard ratio (HR) and 95% confidence intervals (CIs) as effect measures. A total of 5,314 patients from 13 studies were finally enrolled in the meta-analysis. The summary results showed that elevated PLR predicted poorer overall survival (OS) (HR: 1.526, 95%CI: 1.268-1.836, p < 0.001) in patients with lung cancer and OS (HR: 1.631, 95%CI: 1.447-1.837, p < 0.001) in patients with nonsmall cell lung cancer (NSCLC). Subgroup analysis revealed that increased PLR was also associated with poor OS in NSCLC treated by surgical resection (HR: 1.884, 95%CI: 1.308-2.714, P < 0.001) and non-surgery (HR: 1.570, 95%CI: 1.323-1.863, P < 0.001). In addition, PLR Cut-off value ≤ 160 (HR: 1.506, 95%CI: 1.292-1.756, P < 0.001) and PLR Cut-off value>160 (HR: 1.842, 95%CI: 1.523-2.228, P < 0.001). In contrast, elevated PLR was not associated with OS (HR: 1.117, 95%CI: 0.796-1.569, P > 0.05) in patients with small cell lung cancer (SCLC).This meta-analysis result suggested that elevated PLR might be a predicative factor of poor prognosis for NSCLC patients. [ABSTRACT FROM AUTHOR]

By oxidation of a couple of chiral cyclometalated platinum(ii) complexes, Pt(La)(C≡C–Ph) (1a) and Pt(Lb)(C≡C–Ph) (1b) (La = (−)-4,5-pinene-6′-phenyl-2,2′-bipyridine and Lb = (+)-4,5-pinene-6'-phenyl-2,2’-bipyridine), a novel pair of platinum(iv) enantiomers, Pt(La)(C≡C–Ph)3 (2a) and Pt(Lb)(C≡C–Ph)3 (2b), were obtained. According to the single crystal X-ray diffraction studies of 2a and 2b, the central platinum atom is wrapped by a C^N^N ligand and three phenylacetylene groups and exhibits a distorted octahedral geometry. Due to the different coordination configurations and electronic structures, complexes 2a and 2b are distinct from 1a and 1b not only in absorption and emission spectra, but also in their chiroptical properties. The oxidation reaction of 1a and 1b is a kinetically controllable process. Given different oxidants to complete the Pt(ii)-to-Pt(iv) process, various oxidation rates were presented. The difference between the ECD spectra of complexes 1a and 2a has been confirmed through TD-DFT calculation and can be useful for designing new redox-responsive materials. [ABSTRACT FROM AUTHOR]

Purpose: Abdominal adipose distribution may be associated with tumor growth, but its impact on gastric carcinoma survival after neo-adjuvant therapies is uncertain. This retrospective study was to determine the association linking BMI and CT-measured fat parameters to the survival in advanced gastric cancer patients who underwent preoperative chemotherapy. Methods: Eighty-four consecutive patients with locally advanced gastric cancer who received neo-adjuvant chemotherapy and following gastrectomy were identified between January 2005 and June 2008. CT parameters were measured retrospectively on the CT images obtained before chemotherapy initiation. Subcutaneous fat thicknesses of the anterior, lateral, and posterior abdominal wall (ASFT, LSFT, and PSFT) represented subcutaneous fat. Intraperitoneal fat thickness (IFT) and retro-renal fat thickness represented visceral fat. Association linking BMI and CT factors to overall survival was evaluated with survival analysis. Results: ASFT and PSFT above the median value (i.e., high ASFT and PSFT) were associated with longer OS ( P = 0.001; 0.003). Conversely, high IFT and high IFT/PSFT were associated with shorter OS ( P = 0.003; 0.003) and DFS ( P < 0.001; 0.004). By multivariate analysis, high IFT and PSFT were independently associated with OS (HR 2.94, 95 % CI 1.54-5.60; 0.38, 95 % CI 0.21-0.71) and DFS (HR 3.28, 95 % CI 1.55-6.93; 0.42, 95 % CI 0.21-0.82). BMI was not significant for OS and DFS. Conclusions: This study provided the first evidence that IFT, ASFT, and PSFT measured before neo-adjuvant chemotherapy were likely to be useful predictive biomarkers for survival of advanced gastric cancer patients. [ABSTRACT FROM AUTHOR]

In this paper, we survey recent approaches to blue-noise sampling and discuss their beneficial applications. We discuss the sampling algorithms that use points as sampling primitives and classify the sampling algorithms based on various aspects, e.g., the sampling domain and the type of algorithm. We demonstrate several well-known applications that can be improved by recent blue-noise sampling techniques, as well as some new applications such as dynamic sampling and blue-noise remeshing. [ABSTRACT FROM AUTHOR]