Search

The wake of an Ahmed body may be divided into high- and low-drag regimes where the rear slant angle (φ) is in the ranges of 12.5°–30° and larger than 30°, respectively. This work aims to gain a relatively thorough understanding of unsteady predominant coherent structures around an Ahmed body of φ = 35° in the low-drag regime. Extensive hot-wire, wall pressure, flow visualization and particle image velocimetry measurements have been conducted at Reynolds number $Re \in [0.3,2.7] \times {10^5}$ , based on the square root of the model's frontal area. A total of five distinct Strouhal numbers have been identified in the wake. One of them, Stw ≈ 0.30, is captured behind the vertical base, which is associated with the structures that emanate from the upper recirculation bubble and pinch off from the lower bubble, respectively. It is found that Stw scales with a characteristic length αS, which reflects physically the bubble size, and the Strouhal number $St_w^ + $ based on αS is a constant 0.20, irrespective of the value of φ. A corner vortex rolling upstream is observed near the lower end of the slanted surface, whose formation mechanism and dynamical role are discussed. The Reynolds-number effect on the flow is also documented. Based on the present and previously reported data, a conceptual flow structure model is proposed for a low-drag Ahmed body, including both steady and unsteady coherent structures around the body. [ABSTRACT FROM AUTHOR]

The noncollinear interactions between the guided optical wave (GOW) and magnetostatic backward volume wave (MSBVW) in a double-layered magnetic film structure are investigated theoretically. The explicit expressions for the rf magnetization of the MSBVW and the mode conversion efficiency (MCE) of GOW were presented in terms of various geometrical parameters and the rf input power in the case that the insertion loss of the MSBVW is taken into consideration. The effects of the thicknesses of two magnetic layers and a separation layer on the MCE of GOW and magneto-optic (MO) coupling bandwidth are calculated in detail. The MCE of the GOW and the MO bandwidth can be increased significantly in a double-layered magnetic film structure by properly choosing the thicknesses of two magnetic layers and a separation layer. © 2004 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Examines the attainment of time-dependent quantum dynamics calculation for the title reaction in full mathematical dimensions on a potential energy surface. Behavior of cyanide (CN) in the vibrational ground state of potential average 5D and 6D; Impact of CN vibrational excitation on reaction probability; Structure of the potential saddle point.

Objective: In view of the poor prognosis of most peripheral T cell lymphoma (PTCL) subtypes treated with conventional chemotherapy such as CHOP/CHOP-like regimens, high-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) seems a reasonable option in eligible patients. Nevertheless, owing to the small size of the study and the heterogeneity of most published series, a consensus on the role of ASCT as the first-line consolidation therapy for high-risk PTCL patients has not been reached so far. Study Design: We searched MEDLINE, EMBASE, EBSCO, Web of Science, clinicaltrials.gov and the Cochrane Library. Hazard ratio (HR) and 95% confidence intervals (CIs) were calculated by a fixed/random effect model. Results: Twenty-one studies were eligible. Although no statistical significance was observed in these studies, there was a trend toward survival advantage for the HDT/ASCT group as compared to the historical control group (HR 0.81, 95% CI 0.31-2.13). Statistical differences were confirmed in terms of overall survival (OS) between complete remission (CR) and non-CR patients (HR 3.17, 95% CI 0.92-5.42), patients with good and poor risk according to the International Prognostic Index (IPI; HR 0.36, 95% CI 0.22-0.60, I2 49%) and Prognostic Index for PTCL (PIT; HR 0.31, 95% CI 0.17-0.58; HR 0.31, 95% CI 0.18-0.54). Conclusion: The clear and convincing proof of the effects of up-front HDT/ASCT still depends on sufficient large PTCL-restricted randomized trials in the future. Patients who failed to attain CR before transplant exhibited a worse prognosis; patients with good risk of IPI or PIT had a substantially better OS after ASCT. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Adeno-associated virus (AAV) is widely considered a promising vector for therapeutic gene delivery. This promise is based on previous studies assessing AAVs safety and toxicity, ability to infect nondividing cells, elicit a limited immune response and provide long-term gene expression. However, we now find that earlier studies underappreciated the degree of AAV immunogenicity as well as the extent to which genetic background, through regulation of immune responsiveness, influences the duration of gene expression and thereby the effectiveness of AAV-mediated gene therapy. We evaluated antibody responses in 12 mouse strains to AAV serotype 2 (AAV2) and AAV2-expressed transgene products including green fluorescent protein (GFP), human a1-antitrypsin and murine interleukin-10. As expected, all immunocompetent mice administered AAV2 developed serologic evidence of immune responsiveness to the virus. However, a previously unidentified serologic prozone effect was observed suggesting that the concentrations of anti-AAV2 antibodies may have historically been subject to marked underestimation. Furthermore, strains with genetic predisposition to autoimmunity (eg, NOD, NZW, MRL-lpr) specifically imparted a functionally deleterious immune response to AAV-delivered transgene products. These findings suggest that more thorough studies of anti-AAV immunity should be performed, and that genetic predisposition to autoimmunity should be considered when assessing AAV efficacy and safety in humans.Gene Therapy (2004) 11, 233-240. doi:10.1038/sj.gt.3302144 [ABSTRACT FROM AUTHOR]

In this paper transient waves caused by a line heat source moving with a uniform velocity inside isotropic homogeneous thermoelastic half-space are studied under the GL model of generalized thermoelasticity. The problem is reduced to the solution of three differential equations by introducing the elastic vector potential and the thermoelastic scalar potential. Using Laplace and Fourier transforms solutions are obtained in transforms domain. Applying inverse transforms approximate solutions of the displacement at the boundary valid in the small time range are given. Also the approximate region valid for the solutions is given and two special cases, (i) the source is motionless and (ii) the relaxation times vanish, are studied. Numerical evaluations are presented for the medium of copper. [ABSTRACT FROM AUTHOR]

Presents information on a study which determined the ileal apparent of amino acids in corn, soybean meal, feather meal, and dried whey in young pigs. Materials and methodology of the study; Results and discussion of the study.

Copyright of Canadian Journal of Zoology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)