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Fabry disease (FD) is a rare X chromosome‐linked disorder and can be easily misdiagnosed. Here, we report the case of a 69‐year‐old male patient with FD who developed heart failure and showed extremely high pulmonary artery pressure. His initial symptom was recurrent atrial fibrillation. The left and right atrial inner diameters were large, and the ventricular wall was thick. Gene analysis which showed GLA c.215T>C p.Met72Thr mutation and single photon emission computed tomography indicated the diagnosis of FD with coronary microvascular dysfunction. The patient was prescribed anti‐heart failure drugs, including vericiguat. Following the treatment, his heart function and microvascular perfusion significantly improved, which might be due to the beneficial effects of vericiguat. [ABSTRACT FROM AUTHOR]

Aims: A high red blood cell distribution width (RDW) at admission or discharge is associated with a worse prognosis in hospitalized patients with heart failure (HF), and the prognostic value of the in‐hospital change in RDW (∆RDW) remains debatable. Methods and results: We included 5514 patients with critical illness and HF from the MIMIC‐IV database. The ΔRDW was calculated by the RDW at discharge minus that at admission. Clinical outcomes included all‐cause mortality at 90 day, 180 day, and 1 year after discharge. The median age of the patients was 73.91 years, and 46.37% were women. Kaplan–Meier curve and Cox regression analyses were used to examine the association between the ΔRDW and all‐cause mortality at different time points. A multivariable Cox proportional hazard model showed that the ΔRDW (per 1% increase) was independently associated with all‐cause mortality at 90 day, 180 day, and 1 year after adjusting for confounding factors (hazard ratio [HR] = 1.17, 95% confidence interval [CI] = 1.13–1.21, P < 0.001; HR = 1.17, 95% CI = 1.14–1.20, P < 0.001; and HR = 1.18, 95% CI = 1.15–1.20, P < 0.001, respectively). Restricted cubic splines showed a non‐linear relationship between the ΔRDW and the risk of clinical outcomes. High ΔRDW was associated with a high risk of mortality at different time points. A subgroup analysis showed that this positive association remained consistent in pre‐specified subgroups. Conclusions: Our study suggests that an increased RDW during hospitalization is independently associated with short‐ or long‐term all‐cause mortality in critical‐ill patients with HF. [ABSTRACT FROM AUTHOR]

With the rapid development of social networks, academic social networks have attracted increasing attention. In particular, providing personalized recommendations for learners considering data sparseness and cold-start scenarios is a challenging task. An important research topic is to accurately discover potential friends of learners to build implicit learning groups and obtain personalized collaborative recommendations of similar learners according to the learning content. This paper proposes a personalized explainable learner implicit friend recommendation method (PELIRM). Methodologically, PELIRM utilizes the learner's multidimensional interaction behavior in social networks to calculate the degrees of trust between learners and applies the three-degree influence theory to mine the implicit friends of learners. The similarity of research interests between learners is calculated by cosine and term frequency–inverse document frequency. To solve the recommendation problem for cold-start learners, the learner's common check-in IP is used to obtain the learner's location information. Finally, the degree of trust, similarity of research interests, and geographic distance between learners are combined as ranking indicators to recommend potential friends for learners and give multiple interpretations of the recommendation results. By verifying and evaluating the proposed method on real data from Scholar.com, the experimental results show that the proposed method is reliable and effective in terms of personalized recommendation and explainability. [ABSTRACT FROM AUTHOR]

This paper investigates the seismic behavior of a seismic-damaged double-deck viaduct frame pier (DVFP) strengthened with CFRP and enveloped steel, four strengthened DVFP specimens with different degrees of initial damage were tested under quasi-static cyclic loading. Based on the test results, the hysteretic behavior, the stiffness and strength degradation, crack propagation, and failure mechanism were firstly analyzed. Then, the damage indexes of the tested specimens were calculated with different models to evaluate the seismic strengthening performance. Results of this study show that CFRP and enveloped steel strengthening could effectively improve the strength and ductility of pre-damaged DVFPs. The ultimate load, the failure displacement and the displacement ductility of the moderately damaged specimen after being strengthened were found to increase by 120.74%, 35% and 32.33%, respectively. For the severely damaged specimens with CFRP and enveloped steel strengthening, the figures were 105.36%, 25.98% and 31.41%, respectively. The research results can provide reference for the hybrid strengthening application of seismic-damaged DVFP. [ABSTRACT FROM AUTHOR]

We analyzed the differences in knowledge spillover effect between industries by constructing an econometric model. In the model, we measured the relation degree and validity between influencing factors and their influence on knowledge spillover. The result indicates that there is a convergent pattern in the steady state of enterprise knowledge spillover and imitation structure, which formed the screw type advancement of innovation and imitation. Knowledge spillover is influenced by such factors as R&D, trade and traffic condition, labor force mobility, enterprise knowledge absorbency, market mechanism flexibility, time lag of knowledge spillover, and changes of factory site besides trade cost and space-time span. Enterprise knowledge absorbency is proportionate to knowledge spillover. When enterprise knowledge storage quantity disparity is equal to enterprise knowledge absorbency, the knowledge spillover effect is greatest. The time lag of knowledge spillover and the knowledge degeneration rate display inverse ratio with knowledge spillover effect. [ABSTRACT FROM AUTHOR]

Background: Few studies had examined the role of ABO blood groups on CAD in hypertensive patients with different blood pressure (BP) controls. Methods: A total of 2708 patients with primary hypertension (HTN) were consecutively enrolled and underwent coronary angiography (CAG) due to angina-like chest pain. The severity of coronary artery stenosis was assessed by Gensini score (GS). Patients were divided into two groups due to results of CAG: HTN with CAD (n = 2185) and HTN without CAD (n = 523). Poor BP control was defined as systolic BP (SBP) ≥ mean in the study. Multivariable regression analysis was used to determine the potential impact of ABO blood groups on risk of the presence and severity of CAD. Results: Compared to HTN without CAD group, the percentage of A blood group was statistically higher and O blood group was significantly lower in HTN with CAD group. Moreover, percentage of the angiography-proven CAD was higher in A blood group than that in non-A blood group (p < 0.05). After adjusting for confounding factors, A blood group was independently associated with CAD (odds ratio (OR): 1.422; 95% confidence interval (CI): 1.017–1.987; p = 0.039) and GS (β = 0.055, p = 0.046) in patients with poor BP control. Conclusions: A blood group was an independent risk factor for the presence and severity of CAD in hypertensive patients with poor BP control. [ABSTRACT FROM AUTHOR]