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Acute kidney injury (AKI) is a common clinical problem, and patients who survive AKI have a high risk of chronic kidney disease (CKD). The acute protective effects of Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors in AKI have been examined, there is still relatively little known regarding the impact of acute CDK4/6 inhibition on the chronic sequence of AKI. Therefore, we utilized the CDK4/6 inhibitor Palbociclib to examine the long-term effects of CDK4/6 inhibition in a rodent model of ischemic AKI. Palbociclib (Palb) was administered during the acute stage or post the acute stage of AKI and mice were sacrificed 21 days post injury. We found that Palb could cause renal senescence and renal fibrosis. Furthermore, dasatinib (D) plus quercetin (Q) were used to eliminate senescent cells in ischemic AKI murine model and Palb was administered post the treatment of D + Q. We found that Palb could reverse the senolytic and antifibrotic effects induced by D + Q, which indicates that the profibrotic effect of Palb could be ascribed to its pro-senescent effects. Our results demonstrate that CDK4/6 inhibitors treatment might be deleterious on the chronic sequence of AKI. [ABSTRACT FROM AUTHOR]

Background: The clinical value of myocardial torsion quantification in prognostic assessment and risk stratification of various cardiovascular diseases is gradually being recognized. However, normal values of left and right ventricular (LV and RV) torsion and torsion rates (TRs) have not been fully determined, and their correlation with age and gender has not been well studied. Purpose: To establish normal ranges of biventricular torsion, peak systolic and diastolic TRs using magnetic resonance feature tracking (MR‐FT) technique based on a large sample of healthy adults, and further investigate their relationship with age and gender. Study Type: Retrospective. Population: 566 Healthy adults (312 males, aged 43 ± 10 years; 254 females, aged 43 ± 11 years). Field Strength/Sequence: 1.5T/gradient echo. Assessment: Biventricular torsion, peak systolic, and diastolic TRs. Statistical Tests: Shapiro–Wilk test, Student's t‐test, Mann–Whitney‐U test, linear regression, intraclass correlation coefficient, Bland–Altman analysis. Differences were regarded as statistically significant at P < 0.05. Results: Women demonstrated greater magnitudes of left ventricle (LV) torsion (1.23 ± 0.44 vs. 1.00 ± 0.42°/cm), peak systolic TR (9.69 ± 3.70 vs. 8.27 ± 3.73°/cm*sec), peak diastolic TR (−7.78 ± 2.82 vs. −6.06 ± 2.44°/cm*sec), and RV torsion (2.20 ± 1.23 vs. 1.65 ± 1.11°/cm*sec), peak systolic TR (16.07 ± 8.18 vs. 12.62 ± 7.08°/cm*sec), peak diastolic TR (−15.39 ± 6.53 vs. −11.70 ± 6.03°/cm*sec). For both genders, the magnitudes of LV and RV torsion, peak systolic, and diastolic TRs increased linearly with age. All the measurements of biventricular torsion, peak systolic and diastolic TRs achieved good to excellent intraobserver and interobserver reproducibility, with all intraclass correlation coefficients >0.70. Data Conclusion: The present study systematically provided age‐ and sex‐stratified reference values for LV and RV torsion and TRs using MR‐FT technique. Women and aging are associated with greater magnitudes of biventricular torsion, peak systolic, and diastolic TRs. Level of Evidence: 3 Technical Efficacy: Stage 2 [ABSTRACT FROM AUTHOR]

When a transformer is in a long-term heavy load operation state, the oil temperature reaches the alarm temperature; if a slight fault occurs inside the transformer, traditional inverse time current protection and other protections that react to phase current may not operate due to insufficient sensitivity or they may operate for too long. Based on this, this article proposes a new principle of accelerating inverse time overcurrent protection based on transformer oil temperature. The proposed method uses transformer oil temperature to accelerate the action time of traditional inverse-time overcurrent protection, then introduces the transformer oil temperature factor and acceleration index to optimize the inverse time characteristic curve, and establishes a mathematical model to optimize the adjustment for the complexity of adjustment of the protection action equation and the risk of mismatch of the protection after the acceleration of oil temperature. The existing theoretical analysis and simulation verification results show that the proposed new overcurrent protection scheme based on the transformer oil temperature acceleration inverse time can effectively improve the protection of the rapidity and sensitivity, providing a new research idea for the combination of non-electrical and electrical quantity protection. [ABSTRACT FROM AUTHOR]

Electroencephalography (EEG) microstates are used to study cognitive processes and brain disease-related changes. However, dysfunctional patterns of microstate dynamics in Alzheimer's disease (AD) remain uncertain. To investigate microstate changes in AD using EEG and assess their association with cognitive function and pathological changes in cerebrospinal fluid (CSF). We enrolled 56 patients with AD and 38 age- and sex-matched healthy controls (HC). All participants underwent various neuropsychological assessments and resting-state EEG recordings. Patients with AD also underwent CSF examinations to assess biomarkers related to the disease. Stepwise regression was used to analyze the relationship between changes in microstate patterns and CSF biomarkers. Receiver operating characteristics analysis was used to assess the potential of these microstate patterns as diagnostic predictors for AD. Compared with HC, patients with AD exhibited longer durations of microstates C and D, along with a decreased occurrence of microstate B. These microstate pattern changes were associated with Stroop Color Word Test and Activities of Daily Living scale scores (all P < 0.05). Mean duration, occurrences of microstate B, and mean occurrence were correlated with CSF Aβ 1–42 levels, while duration of microstate C was correlated with CSF Aβ 1–40 levels in AD (all P < 0.05). EEG microstates are used to predict AD classification with moderate accuracy. Changes in EEG microstate patterns in patients with AD correlate with cognition and disease severity, relate to Aβ deposition, and may be useful predictors for disease classification. [ABSTRACT FROM AUTHOR]

BACKGROUND: Okra contains flavonoids and vitamin C as antioxidants and it contains polysaccharides as immunomodulators. Flavonoids regulate the inflammatory response in mice and may be related to gut microbiota. This study therefore aimed to investigate the impact of okra extract (OE) on inflammation in mice and to elucidate its underlying mechanism. METHOD: Forty male Kunming (KM) mice were categorized into four groups: the control (CON) group, the lipopolysaccharide stimulation (LPS) group, the 5 mg mL−1 OE intervention (LPS + OE) group, and the 5 mg mL−1 OE supplementation plus mixed antibiotics (LPS + OE + ABX) group. RESULTS: The results showed that, compared with the OE group, the expression of inflammatory signaling pathway genes was upregulated and gut barrier genes were inhibited in the OE + ABX group. The Fxr receptor was activated and the abundance of Akkermansia was increased after OE supplementation, whereas the effect was reversed in the OE + ABX group. Meanwhile, Fxr was correlated positively with Akkermansia. CONCLUSION: The OE supplementation alleviated the inflammatory response in mice under LPS stimulation, accompanied by changes in gut microbiota and bile acid receptors, whereas the addition of antibiotics caused a disturbance to the gut microbiota in the OE group, thus reducing the effect of OE in alleviating the inflammatory response. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Background/Objectives: Agriophyllum squarrosum (L.) Moq. (A. squarrosum), also known as sandrice, is an important medicinal plant widely distributed in dunes across all the deserts of China. Common garden trials have shown content variations in flavonoids among the ecotypes of sandrice, which correlated with temperature heterogeneity in situ. However, there have not been any environmental control experiments to further elucidate whether the accumulation of flavonoids was triggered by cold stress; Methods: This study conducted a four-day ambient 4 °C low-temperature treatment on three ecotypes along with an in situ annual mean temperature gradient (Dulan (DL), Aerxiang (AEX), and Dengkou (DK)); Results: Target metabolomics showed that 12 out of 14 flavonoids in sandrice were driven by cold stress. Among them, several flavonoids were significantly up-regulated, such as naringenin and naringenin chalcone in all three ecotypes; isorhamnetin, quercetin, dihydroquercetin, and kaempferol in DL and AEX; and astragalin in DK. They were accompanied by 19 structural genes of flavonoid synthesis and 33 transcription factors were markedly triggered by cold stress in sandrice. The upstream genes, AsqAEX006535−CHS, AsqAEX016074−C4H, and AsqAEX004011−4CL, were highly correlated with the enrichment of naringenin, which could be fine-tuned by AsqAEX015868−bHLH62, AsqAEX001711−MYB12, and AsqAEX002220−MYB1R1; Conclusions: This study sheds light on how desert plants like sandrice adapt to cold stress by relying on a unique flavonoid biosynthesis mechanism that regulating the accumulation of naringenin. It also supports the precise development of sandrice for the medicinal industry. Specifically, quercetin and isorhamnetin should be targeted for development in DL and AEX, while astragalin should be precisely developed in DK. [ABSTRACT FROM AUTHOR]

The northern South China Sea, including the Zhujiangkou Basin and the Beibuwan Basin, developed high-quality lacustrine source rocks during the Eocene rifting period. These source rocks are vital for hydrocarbon generation in the northern South China Sea. The Zhu I depression in the Zhujiangkou Basin and the Beibuwan Basin typically exhibit high abundance of C30 4-methyl steranes. However, shales in the Eocene Wenchang Formation in the Zhu III depression of the Zhujiangkou Basin contains lower quantities of high-quality lacustrine source rocks with 4-methyl steranes, which often co-elute with some pentacyclic triterpanes in gas chromatography-mass spectrometry (GC-MS). Therefore, the single 4-methylsterane parameter based on GC-MS cannot accurately distinguish organic source in the deep to semi-deep water lacustrine source rocks of the Wenchang Formation from other source rocks, thus impeding the recognition of their contributions to petroleum reservoirs. In this study, GC-MS of aliphatic hydrocarbons, palynofacies and algal identification, as well as stable carbon isotope data of organic matter were used to identify the algal species and construct the paleoclimate during deposition of the Wenchang Formation source rocks in the Zhu III depression of the Zhujiangkou Basin. It is suggested that during the Wenchang Formation period, freshwater green algae prevailed in the lake, which is likely account for the relatively low content of 4-methyl steranes in the high-quality lacustrine source rocks. Controlled by the algal species, it is proposed that the content of C30 tetracyclic polyprenoids (TPP) can better indicate the quality of the Wenchang source rocks than C30 4-methyl steranes. Consequently, a relationship between the TPP index and the quality of the lacustrine source rocks in the Wenchang Formation of the Zhu III depression was established. A higher TPP index indicates higher organic matter abundance and hydrogen index of the lacustrine source rocks. When applied to the origin analysis of oils in the Zhu III depression, it is believed that the organic-rich deep lacustrine source rocks in the Wenchang Formation made great contribution to the transitional zone crude oils in the Wenchang A and Wenchang B depressions. [ABSTRACT FROM AUTHOR]

Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by brain network dysfunction. Few studies have investigated whether the functional connections between executive control networks (ECN) and other brain regions can predict the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS). Objective: The purpose of this study is to examine the relationship between the functional connectivity (FC) within ECN networks and the efficacy of rTMS. Methods: We recruited AD patients for rTMS treatment. We established an ECN using baseline period fMRI data and conducted an analysis of the ECN's FC throughout the brain. Concurrently, the support vector regression (SVR) method was employed to project post-rTMS cognitive scores, utilizing the connectional attributes of the ECN as predictive markers. Results: The average age of the patients was 66.86±8.44 years, with 8 males and 13 females. Significant improvement on most cognitive measures. We use ECN connectivity and brain region functions in baseline patients as features for SVR model training and fitting. The SVR model could demonstrate significant predictability for changes in Montreal Cognitive Assessment scores among AD patients after rTMS treatment. The brain regions that contributed most to the prediction of the model (the top 10% of weights) were located in the medial temporal lobe, middle temporal gyrus, frontal lobe, parietal lobe and occipital lobe. Conclusions: The stronger the antagonism between ECN and parieto-occipital lobe function, the better the prediction of cognitive improvement; the stronger the synergy between ECN and fronto-temporal lobe function, the better the prediction of cognitive improvement. [ABSTRACT FROM AUTHOR]

With the booming development of communication technology and electronic devices, increasingly complex real-world scenarios propose higher demands on electromagnetic interference (EMI) shielding materials. Wearable EMI shielding materials with Joule heating capability and human motion detection can effectively promote benign functioning of the human body and protect sensitive electronic devices in cold and harsh environments. In this paper, silver nanowires (AgNWs)/polyurethane (PU) composite foams with multicellular structures were prepared by a simple dip-drying method. Benefiting from the high conductivity (10,417 S m–1) of the ultralong AgNW network and the interfacial polarization between the silver nanoparticles and the AgNWs, the composite foams have a high EMI shielding performance dominated by microwave absorption. The EMI shielding effectiveness (SE) and specific EMI shielding effectiveness (SSE/t) of the composite foam in the X-band (8.2–12.4 GHz) reached 94.96 dB and 9,169.8 dB cm2 g–1, respectively. The electromagnetic shielding effectiveness is up to 99.99999997%. Meanwhile, at an external voltage of 0.75 V, the surface saturation temperature of the IAgNWs–5/PU composite foam rapidly increased from room temperature to 125.6 °C and remained steady. Furthermore, the IAgNWs–5/PU composite foam can be used as a multifunctional sensing device for monitoring human motion signals based on the good resilience of the PU foam and the stability of the AgNW conductive network. These superior properties make the AgNWs/PU composite foam have great potential applications in military equipment, aerospace, and wearable electronic devices. [ABSTRACT FROM AUTHOR]

Cruciferae brassica oilseed rape is the third largest oilseed crop in the world and the first in China, as well as a fertilizer-dependent crop. With the increased application of organic fertilizers from livestock manure in agricultural production in recent years, the resulting antibiotic pollution and its ecological health effects have attracted widespread attention. In this study, typical tetracycline and sulfonamide antibiotics tetracycline (TC) and sulfamethoxazole (SMZ) were used to investigate the effects of antibiotics on rapeseed quality and oxidative stress at the level of secondary metabolism on the basis of examining the effects of the two drugs on the growth of soil-cultivated rapeseed seedlings. The results showed that both plant height and biomass of rapeseed seedlings were significantly suppressed and ROS were significantly induced in rapeseed by exposure to high concentrations (2.5 mg/kg) of TC and SMZ. Carotenoids, tocopherols, and SOD enzymes were involved in the oxidative stress response to scavenge free radicals in rapeseed, but phenolic acids and flavonoids contents were decreased, which reduced the quality of the seeds to some extent. [ABSTRACT FROM AUTHOR]

Environmental enrichment has the potential to improve the welfare and post‐release survival of hatchery fish stocked for conservation purposes. However, the effectiveness of environmental enrichment is partly dependent on the fish species, life stage, and specific enrichment structure used. To enhance the effectiveness of environmental enrichment, it is crucial to focus on characteristic differences in enrichment structures, such as type and level. This study investigated how differences in enrichment type and level affected physiological and behavioral aspects of the welfare of pre‐release juvenile rock bream Oplegnathus fasciatus by evaluating growth performance, basal and stressed cortisol levels, antioxidant enzyme activities, and exploratory behaviors regarding anxiety and flexibility. Fish were reared for 4 weeks in different enrichment treatments: barren, low‐level cover structure, high‐level cover structure, low‐level interference structure (LI), and high‐level interference structure (HI). The results revealed that fish reared with the LI treatment showed less anxiety and greater flexibility with respect to exploratory behaviors, without oxidative damage being detected. Despite exhibiting less anxiety as well, fish reared in the HI treatment had oxidative damage, indicated by lower superoxide dismutase activity, compared to those in the barren treatment. In addition, none of these enrichment structures enhanced growth performance or mitigate chronic and acute stress responses. Overall, the low‐level interference structure may be more favorable in promoting the behavioral welfare of the fish. Application of this type and level of enrichment may increase the survival of the hatchery fish after release, which is critical to stocking success. [ABSTRACT FROM AUTHOR]

Decolorization is a necessary step before the extraction of okra pectin, and the reapplication of removed pigment will benefit hierarchical utilization of resources. Based on sweeping-frequency ultrasonic preprocessing (SFUP), effects of drying methods (hot air drying (HD), freeze-drying (FD)), sieves (of 60, 80, and 120 mesh) on removal rate and stability of okra pigment (OPI) were investigated. Color deepening caused by the formation of enzymatic products within 1 h of OPI degradation was explained. The extracted OPI was finally applied to noodles to check its stability further. Results showed that compared with non-ultrasonic treatment, SFUP increased removal rate of OPI with the maximum value of 49.32%, and further enhanced the stability of OPI when applied to noodles. OPI through sieves of 80 mesh owned brighter color and more excellent stability, and colored noodles with OPI through SFUP and FD had a small total color difference and strong stability. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the baseline levels of serotype-specific IgG antibodies to Streptococcus pneumoniae (S. pneumoniae) and assess their impact on the assessment of vaccine immunogenicity. Methods: We used a subset of serum samples from a randomized controlled trial. The blood of 584 healthy participants was collected on day 0 before and day 28 after the 23-valent pneumococcal polysaccharide vaccine (PPSV23) vaccination. Serotype-specific IgG against PPSV23-covered serotypes were measured by the World Health Organization (WHO) reference enzyme-linked immunosorbent assay (ELISA). Vaccine immunogenicity was compared using conversion rates (proportion of participants with IgG levels following immunization that are 2-fold greater than the baseline) and geometric mean fold rises (GMFRs) between the two groups, which were grouped according to pre-vaccination (baseline) IgG antibody levels. Results: Our data showed that over half of individuals have baseline IgG levels for 15 out of 23 serotypes above 1.3 µg/mL, and geometric mean concentrations (GMCs) were generally higher in the elderly group and the female group; significant differences were found in 15 serotypes for vaccine immunogenicity based on the seroconversion rate or GMFRs between individuals with baseline IgG ≥ 1.3 µg/mL and individuals with baseline IgG < 1.3 µg/mL. The seroconversion rate decreased with the increase of baseline IgG levels according to a linear regression model. Conclusions: The assessment of vaccine immunogenicity could be impacted by the fact that many adults had high baseline antibody levels. This study is registered in the Chinese Clinical Trial Registry, number NCT05298800. [ABSTRACT FROM AUTHOR]

Oil well cement is prone to corrosion and damage in carbon dioxide (CO2) acidic gas wells. In order to improve the anti-corrosion ability of oil well cement, polymer resin was used as the anti-corrosion material. The effect of polymer resin on the mechanical and corrosion properties of oil well cement was studied. The corrosion law of polymer anti-corrosion cement in an acidic gas environment was studied. The long-term corrosion degree of polymer anti-corrosion cement was evaluated using an improved neural network model. The cluster particle algorithm (PSO) was used to improve the accuracy of the neural network model. The results indicate that in acidic gas environments, the compressive strength of polymer anti-corrosion cement was reduced under the effect of CO2, and the corrosion depth was increased. The R2 of the prediction model PSO-BPNN3 is 0.9970, and the test error is 0.0136. When corroded for 365 days at 50 °C and 25 MPa pressure of CO2, the corrosion degree of the polymer anti-corrosion cement was 43.6%. The corrosion depth of uncorroded cement stone is 76.69%, which is relatively reduced by 33.09%. The corrosion resistance of cement can be effectively improved by using polymer resin. Using the PSO-BP neural network to evaluate the long-term corrosion changes of polymer anti-corrosion cement under complex acidic gas conditions guides the evaluation of its corrosion resistance. [ABSTRACT FROM AUTHOR]

Heterostructured oxides with versatile active sites, as a class of efficient catalysts for CO2 electrochemical reduction (CO2ER), are prone to undergo structure reconstruction under working conditions, thus bringing challenges to understanding the reaction mechanism and rationally designing catalysts. Herein, we for the first time elucidate the structural reconstruction of CuO/SnO2 under electrochemical potentials and reveal the intrinsic relationship between CO2ER product selectivity and the in situ evolved heterostructures. At −0.85 VRHE, the CuO/SnO2 evolves to Cu2O/SnO2 with high selectivity to HCOOH (Faradaic efficiency of 54.81 %). Mostly interestingly, it is reconstructed to Cu/SnO2‐x at −1.05 VRHE with significantly improved Faradaic efficiency to ethanol of 39.8 %. In situ Raman spectra and density functional theory (DFT) calculations reveal that the synergetic absorption of *COOH and *CHOCO intermediates at the interface of Cu/SnO2‐x favors the formation of *CO and decreases the energy barrier of C−C coupling, leading to high selectivity to ethanol. [ABSTRACT FROM AUTHOR]

Heterostructured oxides with versatile active sites, as a class of efficient catalysts for CO2 electrochemical reduction (CO2ER), are prone to undergo structure reconstruction under working conditions, thus bringing challenges to understanding the reaction mechanism and rationally designing catalysts. Herein, we for the first time elucidate the structural reconstruction of CuO/SnO2 under electrochemical potentials and reveal the intrinsic relationship between CO2ER product selectivity and the in situ evolved heterostructures. At −0.85 VRHE, the CuO/SnO2 evolves to Cu2O/SnO2 with high selectivity to HCOOH (Faradaic efficiency of 54.81 %). Mostly interestingly, it is reconstructed to Cu/SnO2‐x at −1.05 VRHE with significantly improved Faradaic efficiency to ethanol of 39.8 %. In situ Raman spectra and density functional theory (DFT) calculations reveal that the synergetic absorption of *COOH and *CHOCO intermediates at the interface of Cu/SnO2‐x favors the formation of *CO and decreases the energy barrier of C−C coupling, leading to high selectivity to ethanol. [ABSTRACT FROM AUTHOR]

The widespread contamination of the environment by polyhalogenated carbazoles (PHCZs) has been increasingly observed during the past decade. Among numerous PHCZ congeners, 3,6-dichlorocarbazole (36-CCZ) is often among the most frequently detected at higher concentrations. Although the environmental level of the legacy pesticide p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT) has been declining, it continues to be ubiquitously detected. These two compounds were found to interfere with each other during analyses using gas chromatography (GC) coupled with single- or triple-quadrupole low-resolution mass spectrometry (MS or MS/MS). The base peak in the mass spectra was that of m/z 235 for both compounds. In MS/MS with multiple reaction monitoring (MRM), the same transitions (235 → 200 and 235 → 165) were often used. Under the same GC operating conditions, the SH-I-5MS capillary column used in this work did not resolve the two compounds at baseline. Pre-treatment using cleanup column chromatography can fractionate the sample extract, with the two compounds separated in different fractions before instrumental analyses. Reversed-phase HPLC columns also work for resolving 36-CCZ and p,p′-DDT. Possible overlaps in GC retention and similarity in MS spectra might have caused data inaccuracy for 36-CCZ as well as p,p′-DDT in some studies published to date, and steps to avoid the interference should be taken into quality control protocols in future research and environmental monitoring. [ABSTRACT FROM AUTHOR]

A precise analytical method based on QuEChERS has been proposed for the concurrent determination of 11 polyhalogenated carbazoles (PHCZs), benzocarbazole (BZCZ), and 9H-carbazoles (CZ). The quantification was confirmed by gas chromatography using triple quadrupole tandem mass spectrometry (Shimadzu GC–MS/MS-TQ8040) and gas chromatography coupled mass spectrometry (Agilent 7890A-5973 GC–MS). The developed method was validated by testing the following parameters: linearity, instrument limit of detection (LOD), instrument limit of quantification (LOQ), method limit of detection (MLD), method limit of quantification (MLQ), matrix effect (ME), accuracy, and precision. All compounds showed good linearity in the range of 0.005–0.2 μg/mL with correlation coefficients higher than 0.992. The method demonstrated satisfactory recoveries (ranging from 71.21 to 105.04%) for most of the compounds with relative standard deviation precision (RSD) < 10.46%, except 3-BCZ (Recovery = 67.53%, RSD = 2.83%). The values of LOD and LOQ varied from 0.05 to 0.24 ng and 0.14 to 0.92 ng, respectively, while those of MLD and MLQ ranged from 0.02 to 0.12 ng/g wet weight (ww) and 0.07 to 0.45 ng/g ww, respectively. The developed method represents a reliable tool for the routine analysis of PHCZ congeners in invertebrate animals. [ABSTRACT FROM AUTHOR]

Background: The purpose of this study was to demonstrate the in vitro anti-nephritis activity of Rostellularia procumbens (L.) Nees (R. procumbens) extract and to make a preliminary investigation of its anti-nephritis mechanism. Methods: A prediction network was built that describes the relationship between R. procumbens and CGN. Then, the potential targets for R. procumbens against CGN were imported into the DAVID database for Gene Ontology (GO) biological annotation analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. A lipopolysaccharide (LPS)-stimulated rat mesangial cell HBZY-1 model in vitro was used to examine the anti-inflammatory activity of R. procumbens extract. RNA-seq was utilized to investigate differentially expressed genes (DEGs) and enriched signaling pathways between groups. Finally, qPCR was used for the validation analysis of the experimental results. Results: The results of network pharmacology showed that R. procumbens exerts its therapeutic effect on CGN through the AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt, IL-17 signaling pathway, and so on. R. procumbens n-butanol extract (J-NE) can effectively relieve inflammation in HBZY-1. The results of KEGG pathway enrichment suggest that J-NE attenuated CGN was associated with the IL-17 signaling pathway, and the results of RNA-seq were consistent with network pharmacology. Targets enriched in the IL-17 signaling pathway, including Chemokine (C-C motif) ligand 7 (CCL7), Lipocalin 2 (LCN2), Chemokine (C-C motif) ligand 2 (CCL2), and Chemokine (C-X-C motif) ligand 1 (CXCL1), have been identified as crucial targets attenuating CGN by J-NE. Conclusion: R. procumbens is a promising pharmacological candidate for the treatment of CGN in the present era. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to develop a low-radiation dose, one-step integrated coronary–carotid–cerebral computed tomography angiography (ICCC-CTA) technique to analyze the relationship between cardiovascular and cerebrovascular atherosclerosis and evaluate the risk factors of plaque to provide an early-stage treatment to patients and reduce vascular events. Methods: A total of 300 consecutive asymptomatic patients with cardiovascular risk factors who underwent ICCC-CTA were enrolled in this prospective study. The association between coronary and carotid-cerebrovascular atherosclerosis was assessed. The primary cardiovascular risk factors for various plaque types in cardiovascular or cerebrovascular disease were evaluated using multivariate analysis. Results: Among 300 patients, 189 (63%) had plaques in their coronary and cerebral arteries. The presence of calcified and mixed plaques in the carotid-cerebral and coronary arteries was strongly correlated (χ2 = 20.71, P = 0.001; χ2 = 8.96, P = 0.003, respectively). Multivariate logistic regression analysis revealed that abnormal blood glucose [OR = 1.44, 95% CI 0.12–0.62, P = 0.01] and abnormal total cholesterol [OR = 1.28, 95% CI 0.07–0.46, P = 0.01] are risk factors in all the models in the coronary artery, non-calcified plaque group. Abnormal blood glucose [OR = 1.43, 95% CI 0.11–0.61, P = 0.01] and abnormal systolic blood pressure [OR = 1.02, 95% CI 0.01–0.04, P = 0.02] are risk factors in all the models in the coronary artery calcified plaque group. Abnormal blood glucose level [OR = 1.44, 95% CI = 0.12–0.62, P = 0.01] was only a risk factor in the non-calcified plaque carotid–cerebral artery group. Conclusions: We confirm that elevated blood glucose and total cholesterol levels are associated with coronary and carotid-cerebrovascular plaques using the novel one-step low dose cerebral-carotid-cardiac CTA technique. These findings will provide insights for further studies focusing on developing low-radiation dose one-step ICCC-CTA to screen cardiovascular/cerebrovascular plaques in general population with cardiovascular risk factors. Advances in knowledge: We developed a low–radiation dose, one-step ICCC-CTA technique to detect cardiovascular and cerebrovascular atherosclerosis. We evaluated the risk factors for plaque burden for the early treatment and reduction of vascular events. These findings supported the development of low–radiation dose one-step ICCC-CTA to screen for cardiovascular/cerebrovascular disease in general population with cardiovascular risk factors. [ABSTRACT FROM AUTHOR]

BACKGROUND: Blueberry extract (BE) is rich in phenols, especially anthocyanins. Anthocyanins regulate the inflammatory response in mice and may be related to gut microbiota and bile acid receptors. The aim of the present study was to explore the effects of BE on the inflammatory response by regulating gut microbiota and bile acid receptors in mice administered Escherichia coli lipopolysaccharide (LPS). METHOD: Thirty male KM mice were randomly divided into three groups: CON (control diet) group; LPS (LPS stimulation) group; and LPS + BE (LPS stimulation, 5% BE intervention) group. RESULTS: our results showed that, compared with the LPS group, the addition of BE decreased the level of inflammatory factors in serum and tissues, inhibited the TLR4/MyD88 signaling pathway, protected the intestinal barrier and activated FXR/TGR5, which was related to gut microbiota (especially Akkermansia). The active component (e.g., cyanidin 3‐O‐glucoside, C3G) in BE may be an important factor in regulating gut microbiota. CONCLUSION: BE alleviated the inflammatory response mainly by activating bile acid receptor expression and regulating the gut microbiota; this effect may be related to the composition of bioactive substances in BE. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Objective: Formal education and other cognitive challenges influence brain structure and improve function. It is believed that cognitive activities create a cognitive reserve (CR) that can slow the decline due to aging and neurodegenerative diseases. This study investigated alterations of regional cerebral blood flow (rCBF) associated with high and low CR in different stages of Alzheimer's disease (AD) and examined whether rCBF alteration mediates the relationship between education and cognitive performance. Methods: Patients with AD or amnestic mild cognitive impairment (aMCI) and healthy controls were divided into low cognitive reserve (LCR) and high cognitive reserve (HCR) subgroups according to median of education years (≤ 9 vs. > 9 years). The final study population included 89 AD patients (67 LCR, 22 HCR), 74 aMCI patients (44 LCR, 30 HCR), and 66 healthy controls (29 LCR, 37 HCR). All subjects were examined by arterial spin labeling magnetic resonance imaging and a neurocognitive test battery. rCBF was compared among groups by two-way analysis of variance. Mediation analyses were used to explore the relationships among education, rCBF, and cognitive test scores. Results: There were significant interaction effects of disease state (AD, aMCI, HC) and education level (LCR, HCR) on CBF in right hippocampus, posterior cingulate cortex, and right inferior parietal cortex (R_IPC). Education regulated episodic memory score by influencing right hippocampal CBF in HC_HCR and aMCI_HCR subgroups. Conclusion: Our results indicate that the protective effect of education against cognitive dysfunction in early-stage AD is mediated at least partially by altered CBF in right hippocampus. [ABSTRACT FROM AUTHOR]

Sensing, Computing and Communication Integration (SC2) is widely believed as a new enabling technology. A non‐negative tensor sparse factorisation (NTSF) algorithm based on tensor analysis is proposed for sensing and classification of Small Geological Structure in coal mines. Utilising this method, advanced detection of geological anomalies hidden in coal seams was achieved. The morphological properties of geological anomalies in coal seams and the propagation characteristics of guided waves were first thoroughly studied. A three‐dimensional (3D) medium geometry model was developed for a complicated coal seam with Goaf, collapse column, scouring zone, and tiny fault based on COMSOL Multiphysics. On this model, the third‐order tensors data was constructed. Then, the TUCKER‐based NTSF algorithm was employed for feature extraction and classification. To achieve multi‐dimensional feature, the two‐dimensional data in the form of a matrix is collected, and a multiplicative update method is introduced to update the algorithm iteratively. Finally, the Support Vector Machine (SVM) multi‐classifier with Gaussian radial basis kernel function is selected for classification of Small Geological Structure. The experimental results show that the classification accuracy based on the NTSF and SVM is as high as 97.33%, which demonstrates that the proposed algorithm is suitable for Sensing and Classification of Small Geological Structure in coal mines. [ABSTRACT FROM AUTHOR]

Background: Abnormalities in white matter (WM) may be a crucial physiologic feature of Alzheimer's disease (AD). However, neuroimaging's ability to visualize the underlying functional degradation of the WM region in AD is unclear. Objective: This study aimed to explore the differences in amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) in the WM region of patients with AD and healthy controls (HC) and to investigate further whether these values can provide supplementary information for diagnosing AD. Methods: Forty-eight patients with AD and 46 age-matched HC were enrolled and underwent resting-state functional magnetic resonance imaging and a neuropsychological battery assessment. We analyzed the differences in WM activity between the two groups and further explored the correlation between WM activity in the different regions and cognitive function in the AD group. Finally, a machine learning algorithm was adopted to construct a classifier in detecting the clinical classification ability of the values of ALFF/ALFF in the WM. Results: Compared with HCs, patients with AD had lower WM activity in the right anterior thalamic radiation, left frontal aslant tract, and left forceps minor, which are all positively related to global cognitive function, memory, and attention function (all p < 0.05). Based on the combined WM ALFF and fALFF characteristics in the different regions, individuals not previously assessed were classified with moderate accuracy (75%), sensitivity (71%), specificity (79%), and area under the receiver operating characteristic curve (85%). Conclusion: Our results suggest that WM activity is reduced in AD and can be used for disease classification. [ABSTRACT FROM AUTHOR]

Fertility is a major component of fitness but its genetic architecture remains poorly understood. Using a full diallel cross of 50 Drosophila Genetic Reference Panel inbred lines with whole genome sequences, we found substantial genetic variation in fertility largely attributable to females. We mapped genes associated with variation in female fertility by genome-wide association analysis of common variants in the fly genome. Validation of candidate genes by RNAi knockdown confirmed the role of the dopamine 2-like receptor (Dop2R) in promoting egg laying. We replicated the Dop2R effect in an independently collected productivity dataset and showed that the effect of the Dop2R variant was mediated in part by regulatory gene expression variation. This study demonstrates the strong potential of genome-wide association analysis in this diverse panel of inbred strains and subsequent functional analyses for understanding the genetic architecture of fitness traits. [ABSTRACT FROM AUTHOR]

Purpose: Sex differences in Alzheimer's disease (AD) progression provide clues to pathogenesis and better patient management. We examined sex differences in emotional memory among AD patients, amnestic mild cognitive impairment (aMCI) patients, and healthy controls (HCs) as well as potential associations with altered regional cerebral blood flow (rCBF). Methods: The recognition memory task with emotional pictures was applied to evaluate enhancement of emotional memory (EEM) and 3D pseudo-continuous arterial spin labeling MRI was performed to measure the rCBF in 74 AD patients (41 females), 74 aMCI patients (45 females), and 74 HCs (43 females). Group differences in EEM were tested by two-way analysis of covariance (ANCOVA) with repeated measures. The main effects of clinical group and sex as well as group × sex interactions on rCBF were assessed by two-way ANCOVA. Correlation analyses were conducted to investigate associations between EEM and rCBF. Results: With disease progression, EEM gradually disappeared. Among aMCI patients, females exhibited a greater index of recollection (Pr) for positive/high-arousal and negative/low-arousal pictures versus neutral pictures (P = 0.005, P = 0.003), while males exhibited a greater Pr for negative/high-arousal versus neutral pictures (P = 0.001). There were significant sex × group effects on rCBF in left inferior parietal, supramarginal, superior temporal and middle temporal gyri, and rCBF of left inferior parietal gyrus was correlated with Pr for positive/high-arousal pictures among female aMCI patients (r = 0.584, q = 0.005). Conclusion: Males and females exhibit distinct changes in EEM associated with altered rCBF, which should be considered in future neuroimaging studies. [ABSTRACT FROM AUTHOR]

The terrigenously-dominated marine shales which were deposited in the lower Eocene Pinghu Formation were thought to be a potential source rock in the Xihu Depression of the East China Sea Shelf Basin. However, the exceptionally high total organic carbon content (TOC, >6% on average) of the tidal sand ridge samples was not compatible with their sedimentary environment, indicating coal-bearing sedimentary debris may have been transferred from the coast to the ocean. In this study, new sights into the origins and supply of organic materials in the coastal environment were proposed in the neritic organic matter of the Eocene Pinghu Formation. A discriminant model was developed using plynofacies analysis data to pinpoint the source of organic materials in marine source rocks. The discrimination results suggested that marine mudstones were associated with tidal flat mudstones rather than deltaic ones. The biomarker characteristics of mudstones deposited in various environments support this assertion, indicating that the supply of plant materials in tidal flats is the primary organic matter source for the marine environment. The organic matter abundance was elevated in tidal flats due to their superior preservation conditions. Additionally, the lithological assemblage of tidal flats suggests that tidal currents can scour marshes and then transport dispersed terrigenous organic materials to neritic areas. These findings indicate that coal-bearing sedimentary debris was likely transferred from the coast to the ocean, and tidal currents are thought to be the dominant mechanism driving organic matter from the tidal to the marine environment. [ABSTRACT FROM AUTHOR]

Non-cooperative spacecraft pose acquisition is a challenge in on-orbit service (OOS), especially for targets with unknown structures. A method for the pose measurement of non-cooperative spacecrafts based on the collaboration of binocular and time-of-flight (TOF) cameras is proposed in this study. The joint calibration is carried out to obtain the transformation matrix from the left camera coordinate system to the TOF camera system. The initial pose acquisition is mainly divided into feature point association and relative motion estimation. The initial value and key point information generated in stereo vision are yielded to refine iterative closest point (ICP) frame-to-frame registration. The final pose of the non-cooperative spacecraft is determined through eliminating the cumulative error based on the keyframes in the point cloud process. The experimental results demonstrate that the proposed method is able to track the target spacecraft during aerospace missions, which may provide a certain reference value for navigation systems. [ABSTRACT FROM AUTHOR]

Objective: Septate uterus is the most common structural uterine anomaly, which is related to the adverse pregnancy outcomes in women of childbearing age. This article provides a retrospective review of hysteroscopic uterine septum resection performed in our hospital during recent years, focusing on the patients with recurrent miscarriage and primary infertility, and also to identify which patients are more likely to benefit from the surgery. Methods: This is a single-center retrospective study. Cases of women who underwent hysteroscopic septum resection at West China Second Hospital of Sichuan University from January 2014 to December 2019, retrieved through the medical record system, were divided into three groups: Group A was the recurrent miscarriage group, Group B had a history of pregnancy with spontaneous abortion once at most, and Group C was the primary infertility group. Each patient was followed up by telephone about further pregnancy, miscarriage and live birth for at least 1 year. Results: A total of 176 surgical patients were included in this study. Group A, B, and C include 42, 74, and 60 cases, respectively. The postoperative pregnancy rates of the three groups were 71.4, 82.4, and 75.0%; live births rates were 50.0, 74.3, and 71.7%; and spontaneous abortion rates were 21.4, 17.6, and 13.3%. 62 patients had a complete uterine septum and 114 had a partial uterine septum. For patients with complete septate uterus, the preoperative pregnancy rate was 54.84% and the pregnancy rate increased to 85.48% after surgery; and yet the preoperative and postoperative pregnancy rates in patients with partial septate uterus were close (from 71.9 to 72.8%). Conclusions: After uterine septum resection, the pregnancy rate and spontaneous abortion rate in RSA patients were not significantly different from the other two groups, but the live birth rate was still significantly lower. Patients with complete uterine septum may benefit more from surgery. The surgical indications should be carefully and strictly evaluated. [ABSTRACT FROM AUTHOR]

Background: Fruit flesh colour is not only an important commodity attribute of eggplant but is also closely related to maturity. However, very little is known about its formation mechanism in eggplant. Results: Two inbred lines of eggplant, green 'NC7' and white 'BL', were used in this study to explain the differences in flesh colour. Transcriptome sequencing results revealed a total of 3304 differentially expressed genes (DEGs) in NC7 vs. BL. Of the DEGs obtained, 2050 were higher and 1254 were lower in BL. These DEGs were annotated to 126 pathways, where porphyrin and chlorophyll metabolism, flavonoid biosynthesis, and photosynthesis-antenna proteins play vital roles in the colour formation of eggplant flesh. At the same time, Gene Ontology (GO) enrichment significance analysis showed that a large number of unigenes involved in the formation of chloroplast structure were lower in BL, which indicated that the formation of chloroplasts in white-fleshed eggplant was blocked. This was confirmed by transmission electron microscopy (TEM), which found only leucoplasts but no chloroplasts in the flesh cells of white-fleshed eggplant. Several genes encoding ERF and bHLH transcription factors were predicted to participate in the regulation of chlorophyll biosynthetic genes. Conclusions: The results of this study indicated that differences in the gene expression of the chlorophyll metabolic pathway were the main cause of the different flesh colour formations. These findings will increase our understanding of the genetic basis in eggplant flesh colors formation mechanism. [ABSTRACT FROM AUTHOR]

A new organic-inorganic hybrid coated titanium fibre was developed via self-assembled modification for rapid and efficient solid-phase microextraction (SPME). Oriented titania nanorods (TiO2NRs) were in situ grown on the Ti wire as a fibre substrate through direct electrochemical anodisation. Subsequently, dodecyl groups were chemically bonded to the surface of TiO2NRs via self-assembly of n-dodecyltrimethoxysilane. The dodecyl-functionalised TiO2NRs coated Ti fibre was used to extract representative aromatic compounds coupled to high-performance liquid chromatography with UV detection. The new fibre exhibited excellent extraction efficiency and selectivity for the studied polycyclic aromatic hydrocarbons (PAHs) compared to commercial polydimethylsiloxane and polyacrylate fibres. The influential factors affecting the SPME process of PAHs were investigated and optimised. Under the optimised conditions, the developed method presented dynamic linear ranges from 0.03 to 500 μg·L−1 with correlation coefficients higher than 0.999 and limits of detection from 0.006 to 0.57 μg·L−1. Relative standard deviations (RSDs) varied between 3.51% and 4.93% and between 4.17% and 5.23% for intra-day and inter-day measurements with one single fibre, respectively. RSDs for the fibre-to-fibre reproducibility from 4.26% to 8.65% were achieved. The developed method was successfully applied to the selective preconcentration and determination of target PAHs in different environmental water samples. The relative recoveries from 89.62% to 113.1% were obtained with RSDs below 8.53%. Moreover, this fibre can be used over 200 times and fabricated in a precisely controllable manner. [ABSTRACT FROM AUTHOR]

Simple Summary: Agriophyllum squarrosum (sand rice) is an annual psammophyte that has been used in traditional Chinese medicine for many years. Its medicinal properties have been studied in mice and human, but the nutritional value and metabolic function of the above-ground parts as a ruminant feed ingredient have not been reported. Here, we find that supplementing lamb diets with A. squarrosum reduced blood lipids, enhanced immunity and anti-inflammatory capacities, and mediated lipid metabolism in adipose tissue and adipocytes of Tan lambs. These findings have provided strong evidence that A. squarrosum has the potential to be used as a beneficial dietary supplement for ruminants. Agriophyllum squarrosum (sand rice), a widespread desert plant, possesses anti-hyperglycemic and anti-inflammatory properties, and has been used in traditional Chinese medicine for many years. However, its effects on ruminants are unknown. To fill this gap, we examined the effects of A. squarrosum on the immune and anti-inflammatory responses of lambs. A total of 23, 6-month-old Tan ewe-lambs (27.6 ± 0.47 kg) were divided into four groups and offered a basic diet (C—control), or a diet that contained 10%, 20%, or 30% A. squarrosum, on a dry matter basis, for 128 days. Serum concentrations of total cholesterol were lower (p = 0.004) in the 30% supplemented lambs than controls, while concentrations of high-density lipoprotein cholesterol were lower (p = 0.006) in the 10% and 20%, but not in 30% supplemented lambs than controls. Serum-cortisol concentrations were lower (p = 0.012) in the 30% supplemented lambs and free fatty acid concentrations were higher in the 10% and 20% supplemented lambs than in control lambs (p < 0.001). Supplementation with A. squarrosum decreased (p < 0.05) the area of adipocytes in subcutaneous adipose tissue, but there was no difference between the 20% and 30% diets. Conversely, the area in visceral adipose tissue (VAT) increased (p < 0.05), especially for the 10% and 20% supplemented diets. Supplementation with A. squarrosum also enriched immune and anti-inflammatory related and lipid and glucose-metabolic pathways and associated differentially expressed gene expressions in adipose tissue. A total of 10 differential triacylglycerol, 34 differential phosphatidylcholines and seven differential phosphatidylethanolamines decreased in the diet with 30% supplementation, when compared to the other diets. Finally, adipocyte-differentiation genes, and immune and inflammatory response-related gene expression levels decreased in lamb adipocytes cultured with an aqueous A. squarrosum extract. In conclusion, supplementing lamb diets with A. squarrosum reduced blood lipids, enhanced immunity and anti-inflammatory capacities, and mediated lipid metabolism in adipose tissue and adipocytes of Tan lambs. A level of approximately 10% is recommended, but further research is required to determine the precise optimal level. [ABSTRACT FROM AUTHOR]

Secondary metabolism, which helps a plant cope with external stress, is sensitive to environmental changes and plays a prominent role in maintaining plant health. However, few studies of the effects of tetracycline on the relationships between secondary metabolism and plant stress responses have been performed. Here, secondary metabolism, nutritional value, and oxidative stress responses in oilseed rape (Brassica napus L.) exposed to tetracycline for 14 days were investigated. Tetracycline inhibited growth and biomass accumulation and decreased the chlorophyll content. The sinapine, phenol, and flavonoid contents were 118.46%, 99.67%, and 93.07% higher, respectively, but the carotenoid content was 76.47% lower in plants exposed to 8 mg/L tetracycline than the control plants. Tetracycline affected the nutritional value of oilseed rape. Tetracycline decreased the dietary fiber, soluble sugar contents, and microelement (Fe, Mn, and Zn) contents. The antioxidant system also responded strongly to tetracycline. The catalase and peroxidase activities were increased and the superoxide dismutase activity was decreased by tetracycline. Tetracycline caused oxidative damage and secondary metabolite disturbances and adversely affected oilseed rape growth and quality. The results provide a new perspective on the effects of tetracycline on plants in relation to secondary metabolites and improve our understanding involved in the toxicity of tetracycline. [ABSTRACT FROM AUTHOR]

Background: As a noninvasive tool, myocardial deformation imaging may facilitate the early detection of cardiac dysfunction. However, normal reference ranges of myocardial strain and strain rate (SR) based on large-scale East Asian populations are still lacking. This study aimed to provide reference values of left ventricular (LV) and right ventricular (RV) strain and SR based on a large cohort of healthy Chinese adults using cardiovascular magnetic resonance (CMR) feature tracking (FT). Methods: Five hundred and sixty-six healthy Chinese adults (55.1% men) free of hypertension, diabetes, and obesity were included. On cine CMR, biventricular global radial, circumferential, and longitudinal strain (GRS, GCS, and GLS), and the peak radial, circumferential, and longitudinal systolic, and diastolic SRs (PSSRR, PSSRC, PSSRL, PDSRR, PDSRC, and PDSRL), and regional radial and circumferential strain at the basal, mid-cavity, and apical levels were measured. Associations of global and regional biventricular deformation indices with age and sex were investigated. Results: Women demonstrated greater magnitudes of LV GRS (37.6 ± 6.1% vs. 32.1 ± 5.3%), GCS (− 20.7 ± 1.9% vs. − 18.8 ± 1.9%), GLS (− 17.8 ± 1.8% vs. − 15.6 ± 1.8%), RV GRS (25.1 ± 7.8% vs. 22.1 ± 6.7%), GCS (− 14.4 ± 3.6% vs. − 13.2 ± 3.2%), GLS (− 22.4 ± 5.2% vs. − 20.2 ± 4.6%), and biventricular peak systolic and diastolic SR in all three coordinate directions (all P < 0.05). For the LV, aging was associated with increasing amplitudes of GRS, GCS, and decreasing amplitudes of PDSRR, PDSRC, PDSRL (all P < 0.05). For the RV, aging was associated with an increase in the magnitudes of GRS, GCS, GLS, PSSRR, PSSRC, PSSRL, and a decrease in the magnitude of PDSRR, PDSRC (all P < 0.05). Biventricular radial and circumferential strain measurements at the basal, mid-cavity, and apical levels were all significantly related to age and sex in both sexes (all P < 0.05). Conclusions: We provide age- and sex-specific normal values of biventricular strain and SR based on a large sample of healthy Chinese adults with a broad age range. These results may be served as a reference standard for cardiac function assessment, especially for the Chinese population. [ABSTRACT FROM AUTHOR]

Aims: To determine if there is a moderating effect of cultural intelligence between the conflict of nursing relationships and teamwork. Background: Relationship conflicts that exist in the nursing teamwork cannot be ignored. It would lead to poor teamwork and impact on patients' poor outcomes. In the meantime, cultural intelligence has been proven that people who have a higher cultural intelligence can do better at the work. Methods: The sample included 550 clinic nurses from five different hospitals in Shanghai. The Cultural Intelligence Scale, the Relationship Conflict Scale, and the Nursing Teamwork Survey Scale were used to investigate. Through the Johnson–Neyman method and SPSS Process Macro, the moderating effect of cultural intelligence was analysed. Results: The findings showed that cultural intelligence was founded to be significant (b = 2.03, p < 0.01). When the cultural intelligence score is greater than or equal to 90.8, the relationship conflict between nurses will not affect teamwork. Conclusions: The findings of this study may provide data to improve nurses' performance in team cooperation. Implication for nursing management: Nursing managers should pay attention to the construction of the nurse's cultural intelligence. Nursing managers should guide nurses in daily work to continuously develop their own cultural intelligence. Enable nurses to effectively transfer social skills from one culture to another, and improve teamwork skills. [ABSTRACT FROM AUTHOR]

With the development of science and technology, people's demand for display products has increased, and slim border display will become one of the most important directions in the future. In this paper, we analyze the influence of the metal wire pattern of the bending part of AMOLED panel on the reduction of the bottom frame of the module. We analyze the influence by finite element analysis method. Here we simulate and analyze the width, pitch, thickness and pattern of metal wiresres, and summarizes the method and law of reducing the bottom frame of the module. Meanwhile the bending radius of the bottom frame is reduced to R0.2mm, and the bottom frame of the module is reduced effectively. [ABSTRACT FROM AUTHOR]

Oil-well cement-based materials have inherent brittleness; therefore, they cannot be directly used to seal oil and gas wells for a long time. To improve the elasticity of oil-well cement-based composites, a flexible epoxy resin system was developed. The flexibility, TG, and SEM of the cured resin system were evaluated. At the same time, the resin was added to oil-well cement-based materials to improve its elasticity. The compressive strength and elastic modulus of resin cement stone were tested, and the microstructure was analyzed by XRD, TG, and SEM/EDS. The results showed that the structure of the cured resin is compact, the thermal decomposition temperature is 243.9 °C, and it can recover its original shape after compression. At the curing age of 28 days, the compressive strength of cement-based composites containing 30% resin decreased by 26.7%, while the elastic modulus significantly decreased by 63.2%, and the elasticity of cement-based composites was significantly improved. The formation of hydration products (e.g., calcium silicate hydrate, and calcium hydroxide) in the resin cement slurry is obviously lower than that of pure cement, which is the reason for the decrease in compressive strength. The flexible structure of polymer particles and polymer film formed by epoxy resin is distributed inside the cement stone, which significantly improves the elasticity of oil-well cement-based composites. The results of this paper are helpful for the design of elastic cement slurry systems. [ABSTRACT FROM AUTHOR]

Disulfidptosis is a prevalent apoptotic mechanism, intrinsically linked to cancer prognosis. However, the specific involvement of disulfidptosis-related long non-coding RNA (DRLncRNAs) in Kidney renal clear cell carcinoma (KIRC) remains incompletely understood. This study aims to elucidate the potential prognostic significance of disulfidptosis-related LncRNAs in KIRC. Expression profiles and clinical data of KIRC patients were retrieved from the TCGA database to discern differentially expressed DRLncRNAs correlated with overall survival. Cox univariate analysis, Lasso Regression, and Cox multivariate analysis were used to construct a clinical prediction model. Six signatures, namely FAM83C.AS1, AC136475.2, AC121338.2, AC026401.3, AC254562.3, and AC000050.2, were established to evaluate overall survival (OS) in the context of Kidney renal clear cell carcinoma (KIRC) in this study. Survival analysis and ROC curves demonstrated the strong predictive performance of the associated signature. The nomogram exhibited accurate prognostic predictions for overall patient survival, offering substantial clinical utility. Gene set enrichment analysis revealed that risk signals were enriched in various immune-related pathways. Furthermore, the risk features exhibited significant correlations with immune cells, immune function, immune cell infiltration, and immune checkpoints. This study has unveiled, for the first time, six disulfdptosis-related LncRNA signatures, laying a solid foundation for enhanced and precise prognostic predictions in KIRC. The purpose of this study is to clarify the potential prognostic significance of disulfidptosis-related LncRNAs(DRlncRNAs) in renal carcinoma is kidney renal clear cell carcinoma (KIRC). We used cox regression and Lasso regression to analyze KIRC data in TCGA. This study created a risk score model composed of six DRlncRNAs, which laid a solid foundation for accurate prediction of KIRC. [ABSTRACT FROM AUTHOR]

Bridging plugging is the most used method of plugging in unconventional oil reservoirs, and many factors affect the effect of bridging and plugging. Since the laboratory cannot simulate the actual leakage size of the lost formation and the corresponding leakage plugging process at the drilling site, the laboratory experiment results cannot reflect the actual leakage plugging construction effect. Aiming at the problem of frequent fracture leakage during drilling in Chepaizi block, Xinjiang, China, this paper proposes a set of machine learning methods based on a neural network. Three types of factors and 14 parameters with a strong correlation with the leakage control effect were screened out. Three categories of factors include construction parameters, choice of plugging material, and fluid properties of the carrier fluid. The training was carried out based on the collected field data, the appropriate activation function was set, and the deep well network structure was optimized. By improving the field plugging measures in the later period, the model was verified by these actual cases, and the results showed that the established model produced the highest R 2 of 0.974, has a good fit, and predicts well. [ABSTRACT FROM AUTHOR]

A new type of magnetic hydrogel (Fe3O4/CMC‐co‐p[AA‐IA]) adsorbent was synthesized using magnetic carboxymethyl chitosan (CMC) matrix with acrylic acid and itaconic acid monomers by radical graft copolymerization and it was applied to the adsorption of malachite green (MG) aqueous solution. The chemical structural characteristics of hydrogel adsorbent were characterized by Fourier transform infrared spectra (FT‐IR), scanning electrons microscope (SEM), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), and X‐ray diffraction (XRD). These characteristics revealed that acrylic acid and itaconic acid monomers were successfully grafted onto the CMC backbone. Hydrogel adsorbent in deionized water has an excellent swelling ratio. To optimize the effect of various factors including pH, adsorbent dosage, ionic strengthen, initial concentration, contact time, and temperature on the adsorption capacity of MG dye were investigated in a batch. The adsorption equilibrium in the adsorption process follows the Langmuir isotherm adsorption and belongs to the monolayer adsorption. For describing the adsorption kinetics of MG dye, the pseudo‐second‐order kinetic model is more suitable appropriately than the pseudo‐first kinetic model. The thermodynamics model shows that the adsorption process is endothermic and spontaneous. After five cycles of adsorption and desorption, the hydrogel adsorbent also has better adsorption efficiency. These results show that the adsorbent has a better swelling capacity and a better adsorption performance. [ABSTRACT FROM AUTHOR]

Aims: The aim of this study was to evaluate alterations in left ventricular (LV) systolic and diastolic function in subjects with prediabetes and diabetes using cardiovascular magnetic resonance-feature tracking (CMR- FT). Methods: We included 35 subjects with prediabetes, 30 subjects with diabetes, and 33 healthy controls of similar age and sex distributions who underwent CMR examination. LV global radial, circumferential, and longitudinal strain (GRS, GCS, and GLS), peak systolic strain rate (PSSR), and peak diastolic strain rate (PDSR) were measured and compared among the three groups. Pearson's correlation and linear regression analyses were applied for statistical analyses. Results: Subjects with prediabetes and diabetes had a significantly lower GLS than healthy controls, but there were no significant differences in ejection fraction (EF), GRS, GCS, or global radial, circumferential and longitudinal PSSR among the three groups. Global radial, circumferential, and longitudinal PDSR in patients with diabetes were all significantly lower than those in the healthy controls. Compared to subjects with prediabetes, patients with diabetes had a significantly lower global circumferential PDSR. Global longitudinal PDSR in subjects with prediabetes was significantly lower than that in healthy controls. Multivariable linear regression analyses demonstrated that elevated HbA1c levels were independently associated with decreased global circumferential and longitudinal PDSR (β = −0.203, p = 0.023; β = −0.207, p = 0.040, respectively). Conclusions: CMR-FT has potential value to evaluate early alterations in LV systolic and diastolic function in subjects with prediabetes and diabetes. Elevated HbA1c levels were independently associated with impaired LV diastolic function in the general population free of overt cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a severe neurodegenerative disease, which mainly manifests as memory and progressive cognitive impairment. At present, there is no method to prevent the progression of AD or cure it, and effective intervention methods are urgently needed. Network-targeted intermittent theta burst stimulation (iTBS) may be effective in alleviating the cognitive symptoms of patients with mild AD. The abnormal function of the dorsolateral prefrontal cortex (DLPFC) within executive control network (ECN) may be the pathogenesis of AD. Here, we verify the abnormality of the ECN in the native AD data set, and build the relevant brain network. In addition, we also recruited AD patients to verify the clinical effects of DLPFC-targeted intervention, and explor the neuro-mechanism. Sixty clinically diagnosed AD patients and 62 normal controls were recruited to explore the ECN abnormalities. In addition, the researchers recruited 20 AD patients to explore the efficacy of 14-session iTBS treatments for targeted DLPFC interventions. Functional magnetic resonance imaging and neuropsychological assessment of resting state were performed before and after the intervention. Calculate the changes in the functional connectivity of related brain regions in the ECN, as well as the correlation between the baseline functional connectivity and the clinical scoring scale, to clarify the mechanism of the response of iTBS treatment to treatment. Our results showed that compared with normal control samples, the brain function connection between the left DLPFC and the left IPL within the ECN of AD patients was significantly enhanced (t = 2.687, p = 0.008, FDR-corrected p = 0.045). And we found that iTBS stimulation significantly reduced the functional magnetic resonance imaging signal between the left DLPFC and the left IPL in the ECN (t = 4.271, p < 0.001, FDR-corrected p = 0.006), and it was related to the improvement of the patient's clinical symptoms (r = −0.470, p = 0.042). This work provides new insights for targeted brain area interventions. By targeted adjusting the functional connection of ECN to improve the clinical symptoms and cognitive function of AD patients. [ABSTRACT FROM AUTHOR]

The semiarid regions are one of the core areas in the construction of ecological civilization in China. Previous studies have shown that afforestation was an effective way for the ecological restoration to prevent soil degradation in the semiarid regions of North China. Unfortunately, little is known about the genetic information of these afforested plant populations, resulting in the defective assessment of the population stability and conservation in the process of ecological restoration under climate change. In this study, using maternally and bi-parentally inherited markers, genetic diversity was estimated in 5 artificial and 12 natural populations of Caragana korshinskii. The significant genetic differentiation was found among the artificial populations, and it could not support their population persistence in the restoration ecosystems. Compared to the natural populations, the artificial populations harbored much lower genetic diversity in both nrITS and cpDNA, which indicated that mating might be greatly limited and unbalanced among the germplasms. Based on the ecological niche modeling analysis, we proposed that both the natural and artificial populations were at a great risk of facing the impact of climate change, although the artificial populations were afforested in the optimum areas. These results suggested that it was necessary to assess the genetic diversity of founder populations before afforestation, and to conduct genetic rejuvenation for the defective artificial forest. This study proposed a pragmatic approach to guide the sustainable afforestation and provided the molecular evaluation on the ecological restoration in the desert areas of North China. [ABSTRACT FROM AUTHOR]

Purpose: Phthalic acid esters (PAEs) and polycyclic aromatic hydrocarbons (PAHs) are of global concern because of their serious environmental impacts. The identification of zones contaminated with PAEs and PAHs in the soil is urgently needed to provide a basis for land use and remediation. Materials and methods: Zhejiang Province was used as a typical example to identify contaminated zones by measuring the concentrations of PAEs and PAHs in gridded soil with a 1/6° latitude by 1/4° longitude resolution. Based on the concentrations and spatial distributions of PAEs and PAHs in superficial soil in Zhejiang, the estimation of inventory, and the assessment of ecological risk, the contaminated zones and possible sources of these two groups of pollutants were identified. Results and discussion: High spatial variability of PAE concentrations in the surface soils was observed in Zhejiang Province. The areas with high PAE concentrations were in the middle region of Zhejiang where highly urbanized and industrialized. The spatial distribution of PAH in the surface soil of Zhejiang appeared to be uneven. High PAH concentrations in the soil of Zhejiang were mainly measured in plains areas and can be linked to the development of industry and multiple emission sources. Conclusions: PAE pollution mainly originated from centralized plastic manufacturing, plastic product use, and plastic waste recycling. PAH contamination was linked to the combustion of fuels in vehicle engines and industrial discharge from a cluster of low-capacity boilers. These results can provide a database and reliable reference information for land use and remediation in other agroindustrial ecotone areas. [ABSTRACT FROM AUTHOR]

Background: While reference values of left atrial (LA) deformation parameters in Western populations have been established, reference data in healthy Asian populations are limited. Purpose: To establish age‐ and sex‐specific reference values for LA strain and strain rate (SR) based on a large sample of healthy Chinese adults using magnetic resonance‐feature tracking (MR‐FT). Study Type: Retrospective. Population: Four hundred and eight healthy Chinese adults (220 males, aged 43.5 ± 11.5 years; 188 females, aged 45.3 ± 12.8 years). Field Strength/Sequence: 1.5 T/balanced steady‐state free precession. Assessment: Reservoir strain (εs), conduit strain (εe), booster strain (εa), peak positive SR (SRs), peak early negative SR (SRe), and peak late negative SR (SRa) were obtained by MR‐FT. Statistical Tests: We used Shapiro–Wilk test, Student's t‐test, Mann–Whitney U‐test, linear regression, and coefficient of determination (r2). Results: Women demonstrated significantly greater LA strain (εs [%]: 44.0 ± 9.9 vs. 38.3 ± 8.7; εe [%]: 26.7 ± 8.0 vs. 22.3 ± 6.8; εa [%]: 17.3 ± 4.4 vs. 16.0 ± 3.8) and SR (SRs [/second]: 1.8 ± 0.5 vs. 1.6 ± 0.4; SRe [/second]: −2.5 ± 0.9 vs. −2.1 ± 0.7; SRa [/second]: −1.9 ± 0.6 vs. −1.8 ± 0.5) than men. For both sexes, aging was significantly associated with decreased εs, SRs, εe, and SRe (r2 = 0.07, r2 = 0.05, r2 = 0.19, and r2 = 0.24 for men; r2 = 0.13, r2 = 0.11, r2 = 0.31, and r2 = 0.46 for women), and significantly increased εa (r2 = 0.03 and r2 = 0.05 for men and women). There was no significant correlation between age and SRa in both sexes (P = 0.057 and P = 0.377 for men and women, respectively). Data Conclusion: We provide age‐ and sex‐specific reference values for LA strain and SR based on a large sample of healthy Chinese adults using MR‐FT. Level of Evidence: 3 Technical Efficacy Stage: 5 [ABSTRACT FROM AUTHOR]