807 results on '"authors"'
Search Results
2. Effect of Socio-Demographic Factors, Health Literacy, and Mothers' Nutritional Literacy on Obesity-Related Behaviors among Female Adolescents; A Cross-Sectional Study.
- Author
-
Authors Rahmani F., Varmazyar A., Aghajari P., and Hosseinzadeh M.
- Published
- 2023
- Full Text
- View/download PDF
3. KMT-2022-BLG-0440Lb: A new q < 10−4 microlensing planet with the central-resonant caustic degeneracy broken.
- Author
-
Zhang, Jiyuan, Zang, Weicheng, Jung, Youn Kil, Yang, Hongjing, Gould, Andrew, Sumi, Takahiro, Mao, Shude, Dong, Subo, Authors), (Leading, Collaboration), (The KMTNet, MAP, (The, and Collaboration), (The MOA
- Subjects
PLANETS ,BAYESIAN analysis ,NATURAL satellites ,GRAVITATIONAL lenses - Abstract
We present the observations and analysis of a high-magnification microlensing planetary event, KMT-2022-BLG-0440, for which the weak and short-lived planetary signal was covered by both the KMTNet survey and follow-up observations. The binary-lens models with a central caustic provide the best fits, with a planet/host mass ratio, q = 0.75–1.00 × 10
−4 at 1σ. The binary-lens models with a resonant caustic and a brown-dwarf mass ratio are both excluded by Δχ2 > 70. The binary-source model can fit the anomaly well but is rejected by the 'colour argument' on the second source. From Bayesian analyses, it is estimated that the host star is likely a K or M dwarf located in the Galactic disc, the planet probably has a Neptune-mass, and the projected planet-host separation is |$1.9^{+0.6}_{-0.7}$| or |$4.6^{+1.4}_{-1.7}$| au, subject to the close/wide degeneracy. This is the third q < 10−4 planet from a high-magnification planetary signal (A ≳ 65). Together with another such planet, KMT-2021-BLG-0171Lb, the ongoing follow-up program for the KMTNet high-magnification events has demonstrated its ability to detect high-magnification planetary signals for q < 10−4 planets, which are challenging for the current microlensing surveys. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
4. Dementia 5: supporting people to live with dementia and comorbidities.
- Author
-
Foster, Authors Debbie and Harrison Dening, Karen
- Published
- 2023
5. Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium.
- Author
-
Maitra, Raka, Horne, Charlotte M, O'Daly, Owen, Papanastasiou, Evangelos, Gaser, Christian, authors, IMAGEN list of, and Consortium, IMAGEN
- Subjects
BRAIN anatomy ,CEREBRAL cortex anatomy ,PARIETAL lobe ,TEMPORAL lobe ,PSYCHOSES ,HUMAN voice ,RISK assessment ,CHILD psychopathology ,QUESTIONNAIRES ,METHICILLIN resistance ,LONGITUDINAL method ,PSYCHOSOCIAL factors ,ADULTS ,ADOLESCENCE - Abstract
Background and Hypothesis Psychotic Like Experiences (PLEs) are widely prevalent in children and adolescents and increase the risk of developing psychosis. Cortical gyrification characterizes brain development from in utero till about the first 2 years of life and can be measured in later years as static gyrification changes demonstrating neurodevelopment and dynamic gyrification changes reflecting brain maturation during adolescence. We hypothesized that PLEs would be associated with static cortical gyrification changes reflecting a neurodevelopmental abnormality. Study Design We studied 1252 adolescents recruited in the IMAGEN consortium. We used a longitudinal study design, with Magnetic Resonance Imaging measurements at age 14 years and age 19 years; measurement of PLEs using the Community Assessment of Psychic Experiences (CAPE) questionnaire at age 19 years; and clinical diagnoses at age 23 years. Study Results Our results show static gyrification changes in adolescents with elevated PLEs on 3 items of the CAPE—voice hearing, unusual experiences of receiving messages, and persecutory ideas—with lower cortical gyrification in fronto-temporal regions in the left hemisphere. This group also demonstrated dynamic gyrification changes with higher cortical gyrification in right parietal cortex in late adolescence; a finding that we replicated in an independent sample of patients with first-episode psychosis. Adolescents with high PLEs were also 5.6 times more likely to transition to psychosis in adulthood by age 23 years. Conclusions This is the largest study in adolescents that demonstrates fronto-temporal abnormality of cortical gyrification as a potential biomarker for vulnerability to PLEs and transition to psychosis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Worth the paper it's written on? A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK.
- Author
-
Rimmer, Michael P, Henderson, Ian, Parry-Smith, William, Raglan, Olivia, Tamblyn, Jennifer, Heazell, Alexander E P, Higgins, Lucy E, and authors, the UKARCOG NESTT working group
- Subjects
STILLBIRTH ,NEONATAL death ,PROOF & certification of death ,CAUSES of death ,CROSS-sectional method - Abstract
Background The Medical Certificate of Stillbirth (MCS) records data about a baby's death after 24 weeks of gestation but before birth. Major errors that could alter interpretation of the MCS were widespread in two UK-based regional studies. Methods A multicentre evaluation was conducted, examining MCS issued 1 January 2018 to 31 December 2018 in 76 UK obstetric units. A systematic case-note review of stillbirths was conducted by Obstetric and Gynaecology trainees, generating individual 'ideal MCSs' and comparing these to the actual MCS issued. Anonymized central data analysis described rates and types of error, agreement and factors associated with major errors. Results There were 1120 MCSs suitable for assessment, with 126 additional submitted data sets unsuitable for accuracy analysis (total 1246 cases). Gestational age demonstrated 'substantial' agreement [K = 0.73 (95% CI 0.70–0.76)]. Primary cause of death (COD) showed 'fair' agreement [K = 0.26 (95% CI 0.24–0.29)]. Major errors [696/1120; 62.1% (95% CI 59.3–64.9%)] included certificates issued for fetal demise at <24 weeks' gestation [23/696; 3.3% (95% CI 2.2–4.9%)] or neonatal death [2/696; 0.3% (95% CI 0.1–1.1%)] or incorrect primary COD [667/696; 95.8% (95% CI 94.1–97.1%)]. Of 540/1246 [43.3% (95% CI 40.6–46.1%)] 'unexplained' stillbirths, only 119/540 [22.0% (95% CI 18.8–25.7%)] remained unexplained; the majority were redesignated as either fetal growth restriction [FGR: 195/540; 36.1% (95% CI 32.2–40.3%)] or placental insufficiency [184/540; 34.1% (95% CI 30.2–38.2)]. Overall, FGR [306/1246; 24.6% (95% CI 22.3–27.0%)] was the leading primary COD after review, yet only 53/306 [17.3% (95% CI 13.5–22.1%)] FGR cases were originally attributed correctly. Conclusion This study demonstrates widespread major errors in MCS completion across the UK. MCS should only be completed following structured case-note review, with particular attention on the fetal growth trajectory. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. KMT-2021-BLG-0171Lb and KMT-2021-BLG-1689Lb: two microlensing planets in the KMTNet high-cadence fields with followup observations.
- Author
-
(杨弘靖), Hongjing Yang, (臧伟呈), Weicheng Zang, Gould, Andrew, Yee, Jennifer C, Hwang, Kyu-Ha, Christie, Grant, Sumi, Takahiro, (张纪元), Jiyuan Zhang, (毛淑德), Shude Mao, Authors), (Leading, Albrow, Michael D, Chung, Sun-Ju, Han, Cheongho, Jung, Youn Kil, Ryu, Yoon-Hyun, Shin, In-Gu, Shvartzvald, Yossi, Cha, Sang-Mok, Kim, Dong-Jin, and Kim, Hyoun-Woo
- Subjects
MICROLENSING (Astrophysics) ,PLANETS ,EXTRASOLAR planets ,VERY large array telescopes ,PHASE space - Abstract
Follow-up observations of high-magnification gravitational microlensing events can fully exploit their intrinsic sensitivity to detect extrasolar planets, especially those with small mass ratios. To make followup observations more uniform and efficient, we develop a system, HighMagFinder, to automatically alert possible ongoing high-magnification events based on the real-time data from the Korea Microlensing Telescope Network (KMTNet). We started a new phase of follow-up observations with the help of HighMagFinder in 2021. Here we report the discovery of two planets in high-magnification microlensing events, KMT-2021-BLG-0171 and KMT-2021-BLG-1689, which were identified by the HighMagFinder. We find that both events suffer the 'central-resonant' caustic degeneracy. The planet-host mass-ratio is q ∼ 4.7 × 10
−5 or q ∼ 2.2 × 10−5 for KMT-2021-BLG-0171, and q ∼ 2.5 × 10−4 or q ∼ 1.8 × 10−4 for KMT-2021-BLG-1689. Together with two other events, four cases that suffer such degeneracy have been discovered in the 2021 season alone, indicating that the degenerate solutions may have been missed in some previous studies. We also propose a quantitative factor to weight the probability of each solution from the phase space. The resonant interpretations for the two events are disfavoured under this consideration. This factor can be included in future statistical studies to weight degenerate solutions. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
8. Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort.
- Author
-
Simuni, Tanya, Merchant, Kalpana, Brumm, Michael C., Cho, Hyunkeun, Caspell-Garcia, Chelsea, Coffey, Christopher S., Chahine, Lana M., Alcalay, Roy N., Nudelman, Kelly, Foroud, Tatiana, Mollenhauer, Brit, Siderowf, Andrew, Tanner, Caroline, Iwaki, Hirotaka, Sherer, Todd, Marek, Kenneth, Parkinson's Progression Marker Initiative Authors, Steering Committee, Seibyl, John, and Coffey, Christopher
- Published
- 2022
- Full Text
- View/download PDF
9. Implementation of Machine Learning algorithms to classify university academic success.
- Author
-
Jiménez Delgado, Efrén, Roldán Morales, Authors Linnette, and Calvo Araya, Yesenia
- Subjects
MACHINE learning ,ACADEMIC achievement ,CURRICULUM ,RANDOM forest algorithms ,DECISION trees - Abstract
Machine learning is a software tool that allows information present in databases to be converted into intelligent decisions based on data and not on experience or feelings. This work presents a review of the algorithms used in the classification of student performance present in the database of the national technical university, specifically in the software engineering career. Information classification analysis using machine learning algorithm has become a modern and powerful instrument, which could help academic institutions improve retention and performance rate of courses by students and with this obtain a more general view of student performance before starting the course based on information from other courses and general student variables in order to reduce the risk of failure. The main objective of this work is to describe the variables used by the National Technical University and the application of different automated learning algorithms in order to obtain the metrics that allow demonstrating the best algorithm among those studied. Finally, the article concludes with a classification algorithm that provides an accuracy of around 80% to 82% that can be replicated in other university institutions. [ABSTRACT FROM AUTHOR]
- Published
- 2022
10. Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial.
- Author
-
Carter, Ben, Zenasni, Zohra, Moat, Stuart J, Hudson, Peter R, Russell, Ian T, McCaddon, Andrew, authors, The FolATED group consists of the following, and FolATED group consists of the following authors
- Subjects
METHYLMALONIC acid ,DIETARY supplements ,FOLIC acid ,OLDER people ,SOCIAL marginality ,ANTIDEPRESSANTS ,VITAMINS ,HOMOCYSTEINE ,RESEARCH ,VITAMIN B12 ,RESEARCH methodology ,EVALUATION research ,COMPARATIVE studies ,RANDOMIZED controlled trials ,RESEARCH funding ,ACYCLIC acids - Abstract
Background: Individuals with low serum vitamin B-12 and high serum folate have higher plasma concentrations of methylmalonic acid (MMA). Whether folic acid (FA) causes an increase in MMA is not known.Objectives: We aimed to determine the impact of FA supplementation on plasma MMA concentration in people with low or marginal serum vitamin B-12.Methods: We conducted a multicenter double-blind placebo-controlled randomized trial of oral FA (5 mg/d for 12 wk) in middle-aged patients treated with antidepressant medication participating in the FoLATED (Folate Augmentation of Treatment-Evaluation for Depression) trial. Participants defined as having "low" serum vitamin B-12 (vitamin B-12 ≥150 and <220 ng/L) or "marginal" serum vitamin B-12 (vitamin B-12 ≥ 220 and <280 ng/L) were included. The primary outcome of this substudy was MMA at week 12. A mixed-effects linear regression was fitted and reported using the adjusted mean difference (aMD).Results: A total of 177 participants were included (85 randomly assigned to placebo and 92 to FA); the mean ± SD age was 46.2 ± 11.8 y, and 112 (63.3%) were female. The MMA analysis included 135 participants and the aMD was -0.01 (95% CI: -0.06, 0.04; P = 0.71). Serum folate was measured on 166 participants and increased in the supplementation group; the aMD was 21.6 μg/L (95% CI: 8.13, 25.02 μg/L; P < 0.001). A total of 117 participants were assessed for RBC folate, which also increased in the supplementation group; the aMD was 461 μg/L (95% CI: 387, 535 μg/L; P < 0.001).Conclusions: Supplementation of FA leads to an increase of serum and RBC folate, but does not change plasma MMA concentration in individuals with serum vitamin B-12 between 150 and 280 ng/L. We cannot exclude effects in older people or those with serum vitamin B-12 <150 ng/L. Previously reported associations may arise from effects of impaired vitamin B-12 status on folate metabolism.This trial was registered at www.isrctn.com as ISRCTN37558856. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
11. Aesculetin Exhibits Strong Fluorescent Photoacid Character.
- Author
-
Knoor, Authors: Leah H., Du Laney, George R., Jonker, Isaac B., Hoogewerf, Liam P., Tu, Yukun, Pham, Hunter T., Yoo, Joy, and Muyskens, Mark A.
- Subjects
TIME-resolved spectroscopy ,FLUORESCENCE yield ,ANIMAL defenses ,FLUORESCENCE spectroscopy ,PLANT defenses ,BORIC acid - Abstract
Coumarins are bioactive molecules that often serve as defenses in plant and animal systems, and understanding their fundamental behavior is essential for understanding their bioactivity. Aesculetin (6,7-dihydroxycoumarin) has recently attracted attention due to its ability to act as an antioxidant, but little is known about its photophysical properties. The fluorescence lifetimes of its neutral and anion form in water are 19 ± 2 ps and 2.3 ± 0.1 ns, respectively. Assuming the short lifetime of the neutral is determined by ESPT, we estimate k
PT ~ 5 × 1010 s–1 . Using steady-state and time-resolved fluorescence spectroscopy, we determine its ground and excited-state p K a 1 to be 7.3 and –1, respectively, making it one of the strongest photoacids of the natural coumarins. Aesculetin exhibits a strong pH dependence of the relative fluorescence quantum yield becoming much more fluorescent above p K a 1 . The aesculetin anion has slightly photobasic character. We also report that aesculetin forms a fluorescent catechol-like complex with boric acid, and this complex has a p K c of 5.6. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
12. Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer.
- Author
-
Besson, Caroline, Moore, Amy, Wu, Wenting, Vajdic, Claire M, Sanjose, Silvia de, Camp, Nicola J, Smedby, Karin E, Shanafelt, Tait D, Morton, Lindsay M, Brewer, Jerry D, Zablotska, Lydia, Engels, Eric A, Cerhan, James R, Slager, Susan L, Han, Jiali, Berndt, Sonja I, manuscript, the InterLymph Consortium. Full authors list is given at the end of the, de Sanjose, Silvia, and InterLymph Consortium. Full authors list is given at the end of the manuscript
- Subjects
LYMPHOCYTIC leukemia ,CHRONIC leukemia ,SKIN cancer ,GENETIC polymorphisms ,BASAL cell carcinoma ,META-analysis ,SQUAMOUS cell carcinoma ,CHRONIC lymphocytic leukemia ,RESEARCH ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,SKIN tumors ,COMPARATIVE studies ,RESEARCH funding - Abstract
Background: Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases.Methods: We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).Results: Higher CLL-PRS was associated with increased BCC risk (OR4th-quartile-vs-1st-quartile = 1.13, 95% CI: 1.02-1.24, Ptrend = 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (Ptrend = 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th-quartile-vs-1st-quartile = 1.22, 95% CI: 1.08-1.38, Ptrend = 1.36 × 10-5), which was driven by shared genetic susceptibility at the 6p25.3 locus.Conclusion: These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
13. Effect of Alkyl Structures on the Anti‐stacking and Anchoring of Pd/Diamine‐Functionalized Graphene Nanoparticles in Application in Suzuki Reaction.
- Author
-
Tian, Yinbing Please verify that the linked ORCID identifiers are correct for each author. The ORCID IDs for 'Yinbing Tian', 'Yuanyuan Wang', and 'Li Yi Dai' seem to be invalid. Please check and supply the correct ORCID IDs for these authors. --> Please confirm, Tang, Zijie, Ru, Yu, Wang, Yuanyuan, and Dai, Liyi
- Subjects
SUZUKI reaction ,NANOPARTICLES ,GRAPHENE ,METAL catalysts ,CHEMICAL yield ,PHENYLENEDIAMINES - Abstract
Main observation and conclusion: Three diamines (1,8‐diaminooctane/p‐phenylenediamine/biphenylenediamine) with different alkyl groups were used to synthesize the functionalized graphene networks. Pd as the common metal catalyst was used to explore the effects of alkyl types of diamines on anti‐stacking, metal anchoring ability of functional graphene and hence the catalytic performance. The results were discussed by characterization of the material and its catalytic properties. All catalysts showed excellent catalytic performance on the Suzuki cross‐coupling reaction with a high yield of up to 100%. The p‐phenylenediamine and biphenylenediamine functionalized graphene with larger specific surface area was beneficial to improve the stability of the graphene catalyst and maintain good catalytic activity after 5 cycles. The Pd nanoparticles in 1,8‐octanediamine materials have smaller size and a smaller loading with the same or even better catalytic performance than p‐phenylenediamine, biphenylenediamine materials, due to the stronger electron donating ability of N of octanediamine than that of p‐phenylenediamine. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
14. Clinimetric Properties of Self-reported Disability Scales for Whiplash: A Systematic Review for the Whiplash Core Outcome Set (CATWAD).
- Author
-
Griffin, Alexandra R., Leaver, Andrew M., Arora, Mohit, Walton, David M., Peek, Aimie, Bandong, Aila N., Sterling, Michele, Rebbeck, Trudy, and CATWAD Co-authors
- Published
- 2021
- Full Text
- View/download PDF
15. Protein diversification: exploring the potential of seaweed for food.
- Author
-
Haines, Authors: Stephen, Ross, Alastair, Thomas, Ancy, Samuelsson, Linda, and Deb-Choudhury, Santanu
- Subjects
MARINE algae as food ,PROTEINS ,RIBULOSE bisphosphate carboxylase ,HEAT shock proteins ,FOOD aroma ,PROTEOMICS - Abstract
The article offers information on the Seaweed is a challenging material for analytical measurements and adjusting proteomic and metabolomic tools to measure the protein and metabolite content of macroalgae. It discusses that it will help to fulfil the potential of an abundant New Zealand marine resource that is still locally underutilised as a domestic and export whole food and ingredient.
- Published
- 2022
16. The use of steroids in cervicofacial infections in UK OMFS departments: a Maxillofacial Surgery Trainees Research Collaborative (MTReC) study.
- Author
-
Kent, Samuel, MTReC Writing group, McDonald, Chris, Hennedige, Anusha, Henry, Alastair, Dawoud, Basim, Kulkarni, Raghav, Logan, Greg, Exley, Rebecca, Kyzas, Panos, Morrison, Roderick, McCaul, James, MTReC Collaborating authors, Brandsma, Dirk Stephanus, Cashman, Helen, Swain, Aoife, Java, Kapil, Vithlani, Gauri, Watson, Melanie, and Christopher, Mark
- Subjects
STEROID drugs ,HEART beat ,MAXILLOFACIAL surgery ,DEGLUTITION disorders ,INFECTION - Abstract
Introduction: Defining current inpatient management of cervicofacial infections is key to identifying strategies to optimise care. Steroid use is beneficial in peritonsillar and orbital abscess, but there are few studies of steroid use in odontogenic cervicofacial infections. Our previous research identified widespread variation in practice, necessitating a national audit to define current practice. Methods: A multicentre, trainee-led snapshot audit was carried out across 25 hospitals in the UK. Information recorded included demographic features, presentation, surgical and medical management, and steroid administration. Results: One thousand two admissions were recorded. Fifty-five percent were male, with mean age 37.3 years (range 0–94 years). Steroids were administered to 357 patients (36%), 159 of whom received steroids on admission, and 254 peri-operatively. Patients who were prescribed steroids had significantly higher white cell count (12.4 vs 11.5), CRP (79.5 vs 57) and heart rate (94 vs 88) on admission. Justifications given for administration included swelling (74), dysphagia (21), and airway compromise (7). Three patients (0.8%) reported steroid-related side effects. Conclusions: This study uses the largest recorded cohort of cervicofacial infections to define current inpatient steroid administration. Our results suggest that steroids are targeted towards the most compromised 1/3 of patients. The incidence of steroid-related side effects was low. Defining the characteristics of patients currently receiving steroids will aid in determining whether steroid administration is an effective adjunct in treating odontogenic cervicofacial infection. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
17. High Tg Polymer Insulator Yields Organic Photovoltaic Blends with Superior Thermal Stability at 150 oC.
- Author
-
Chen, Fei Please verify that the linked ORCID identifiers are correct for each author. The ORCID IDs for 'Miaomiao Li' and 'Long Ye' seem to be invalid. Please check and supply the correct ORCID IDs for these authors. --> Please confirm that given names and sur, Zhang, Ying, Wang, Qi, Gao, Mengyuan, Kirby, Nigel, Peng, Zhongxiang, Deng, Yunfeng, Li, Miaomiao, and Ye, Long
- Subjects
THERMAL stability ,POLYMER blends ,CONJUGATED polymers ,POLYMERS ,SMALL molecules ,SOLAR cells - Abstract
Main observation and conclusion: Record‐breaking organic solar cells (OSCs) based on blends of polymer donors and small molecule acceptors often show undesirable degradation, which severely precludes their practical use. Herein, we demonstrate a facile and cost‐effective approach to construct thermally stable OSCs at 150 oC by incorporating a small amount of a polymer insulator polyacenaphthylene (PAC) with high glass‐transition temperature over 230 oC into polymer:acceptor blends. The model PTB7‐Th:EH‐IDTBR blend with 10 wt% PAC maintained above 85% of its initial efficiency upon continuous heating at 150 oC for over 800 h, while the efficiency of the blend without PAC sharply dropped by 70% after ~300 h. Owing to high miscibility with acceptors, PAC confines the motion of the acceptor molecules and suppresses the acceptor crystallization at elevated temperatures, leading to significantly improved stability. Importantly, the effectiveness of this blending approach was also validated in many other OSC systems, showing great potential for achieving high‐performance thermally stable electronics. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
18. Modelling the small-scale deposition of snow onto structured Arctic sea ice during a MOSAiC storm using snowBedFoam 1.0.
- Author
-
Hames, Océane, JafariCRYOS, School of Architecture, Civil and EnvironmentalEngineering, EPFL, Lausanne, Switzerland;These authors contributed equally to this work;mahdi.jafari@epfl.ch, Mahdi, Wagner, David N., Raphael, Ian, Clemens-Sewall, David, Polashenski, Chris, Shupe, Matthew D., Schneebeli, Martin, and Lehning, Michael
- Subjects
SEA ice ,SURFACE dynamics ,FLUID dynamics ,MEASUREMENT errors ,SURFACE structure ,COMPUTER simulation - Abstract
The remoteness and extreme conditions of the Arctic make it a very difficult environment to investigate. In these regions, the wind has a substantial effect and redistributes a large part of the snow, which complicates precipitation estimates. Moreover, the snow mass balance in the sea ice system is still poorly understood, notably due to the complex structure of its surface. Quantitatively assessing the snow distribution on sea ice and its connection to the sea ice surface features is an important step to remove these uncertainties. In this work we introduce snowBedFoam 1.0., a physics-based snow transport model implemented in the open source fluid dynamics software OpenFOAM. We combine the numerical simulations with terrestrial lidar observations of surface dynamics to simulate snow deposition on a piece of MOSAiC sea ice with a complicated structure typical for pressure ridges. The results demonstrate that a large fraction of snow accumulates in their vicinity, which compares favorably against terrestrial laser scans. However, the approximations imposed by the numerical framework together with potential measurement errors (precipitation) give rise to quantitative inaccuracies. The modelling of snow distribution on sea ice should help to better constrain precipitation estimates and more generally assess and predict snow and ice dynamics in the Arctic. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
19. Resuscitative endovascular balloon occlusion of the aorta in combat casualties: The past, present, and future.
- Author
-
Stokes, Sarah C., Theodorou, Christina M., Zakaluzny, Scott A., DuBose, Joseph J., Russo, Rachel M., and *Both Dr. Stokes and Dr. Theodorou contributed equally to this manuscript and are dual first authors.
- Published
- 2021
- Full Text
- View/download PDF
20. Intensive Care Needs and Short-Term Outcome of Multisystem Inflammatory Syndrome in Children (MIS-C): Experience from North India.
- Author
-
Angurana, Suresh Kumar, Awasthi, Puspraj, Thakur, Ajay, Randhawa, Manjinder Singh, Nallasamy, Karthi, Kumar, Manoj Rohit, Naganur, Sanjeev, Kumar, Mahendra, Goyal, Kapil, Ghosh, Arnab, Bansal, Arun, Jayashree, Muralidharan, Angurana, Authors Suresh Kumar, and Kumar Angurana, Suresh
- Subjects
MULTISYSTEM inflammatory syndrome in children ,SARS-CoV-2 ,COVID-19 ,REVERSE transcriptase polymerase chain reaction ,CRITICAL care medicine ,PEDIATRIC intensive care ,LEUCOCYTES - Abstract
Objectives: To describe the intensive care needs and outcome of multisystem inflammatory syndrome in children (MIS-C).Methodology: This retrospective study was conducted in the pediatric emergency, pediatric intensive care unit (PICUs) and the coronavirus disease 2019 (COVID 19) hospital of a tertiary teaching and referral hospital in North India over a period of 5 months (September 2020 to January 2021). Clinical details, laboratory investigations, intensive care needs, treatment and short-term outcome were recorded.Results: Forty children with median interquartile range age of 7 (5-10) years were enrolled. The common clinical features were fever (97.5%), mucocutaneous involvement (80%), abdominal (72.5%) and respiratory (50%) symptoms. Shock was noted in 80% children. Most cases (85%) required PICU admission where they received nasal prong oxygen (40%), non-invasive (22.5%) and invasive (22.5%) ventilation and vasoactive drug support (72.5%). The confirmation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposure was in the form of positive serology (66.7%), reverse transcriptase polymerase chain reaction (10%), and contact with SARS-CoV-2 positive case (12.5%). The common echocardiographic findings included myocardial dysfunction (ejection fraction <55%; 72.5%), and coronary artery dilatation or aneurysm (22.5%). The immunomodulatory treatment included intravenous immunoglobulin (2 g/kg) (100%) and steroids (methylprednisolone 10-30 mg/kg/day for 3-5 days) (85%). Aspirin was used in 80% and heparin (low molecular weight) in 7.5% cases. Two children died (5%) and median duration of PICU and hospital stay in survivors were 5 (2-8) and 7 (4-9) days, respectively. Children with shock showed higher total leucocyte count and higher rates of myocardial dysfunction.Conclusion: Cardiovascular involvement and shock are predominant features in severe disease. Early diagnosis can be challenging given the overlapping features with other diagnoses. A high index of suspicion is warranted in children with constellation of fever, mucocutaneous, gastrointestinal and cardiovascular involvement alongwith evidence of systemic inflammation and recent or concurrent SARS-CoV-2 infection. The short-term outcome is good with appropriate organ support therapies and immunomodulation. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
21. Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment.
- Author
-
Vaidya, Jayant S., Bulsara, Max, Baum, Michael, Tobias, Jeffrey S., on behalf of the TARGIT-A trial authors, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik L., Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R., Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, and Sperk, Elena
- Subjects
INTRAOPERATIVE care ,CANCER relapse ,LUMPECTOMY ,BREAST tumors - Abstract
In the randomised TARGIT-A trial, risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy was non-inferior to whole-breast external beam radiotherapy, for local recurrence. In the long-term, no difference was found in any breast cancer outcome, whereas there were fewer deaths from non-breast-cancer causes. TARGIT-IORT should be included in pre-operative consultations with eligible patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
22. 41st Annual DavidW. Smith workshop on malformations and morphogenesis: Abstracts of the 2020 annual meeting.
- Author
-
Gripp, Karen W., Jones, Kenneth Lyons, Wenger, Tara L., Abstract Authors, Smith Workshop, and Adam, Margaret P.
- Abstract
The 41st Annual David W. Smith Workshop on Malformation and Morphogenesis was scheduled to take place in Skamania, Washington, on September 11–16, 2020. Due to the COVID‐19 pandemic and the associated recommendations to avoid travel and congregation in large groups, this meeting took place differently from its original plan. Rather than bringing trainees, clinicians and researchers with an interest in congenital malformations and their underlying morphogenesis together for several days in a workshop with submitted presentations and research lectures, this meeting took place virtually. A 1 day online meeting was organized in order to allow trainees to present their work. This Conference Report includes the highest scoring abstracts submitted by trainees and presented at the 2020 virtual David W. Smith Workshop. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
23. Neurological induced incontinence in people with multiple sclerosis.
- Author
-
Hill, Authors Barry
- Abstract
Background: People with multiple sclerosis (MS) are predisposed to neurological induced incontinence due to the pathophysiology of the disease. Aims: This short article aims to discuss the underpinning rationale of neurological induced incontinence in people with MS and explores urinary catheter options. Urinary catheters will be discussed, exploring different types of catheter, catheter sizing, and information on the manufacturers that can support patients and services as well as procurement needs for staff. Findings: Neurogenic bladder occurs when transmissions between the brain and the bladder are delayed or interrupted. While some people are born with neurogenic bladder issues, in the case of MS patients, the disease's effect on the brain through the development of lesions leads to progressively worsening body functions, quite often in the lower extremities. Conclusions: As bladder function degrades due to neurogenic bladder, patients with MS can experience frequent, painful or urgent urination, urinary incontinence, and urinary retention. Urinary catheterisation may be an option they use to manage their symptoms and may enhance their quality of life, enabling them to continue with other activities of daily living. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
24. National survey of radiation oncologists' practice patterns regarding hormone-naïve prostate cancer with bone metastases.
- Author
-
Nakamura, Katsumasa, Ishikawa, Hitoshi, Akimoto, Tetsuo, Aoki, Manabu, Kariya, Shinji, Kawamura, Hidemasa, Kumano, Tomoyasu, Kozuka, Takuyo, Konishi, Kenta, Sakaguchi, Masakuni, Takayama, Kenji, and Appendix, Other authors are shown in
- Published
- 2020
- Full Text
- View/download PDF
25. KMT-2019-BLG-1339L: An M Dwarf with a Giant Planet or a Companion near the Planet/Brown Dwarf Boundary.
- Author
-
Han, Cheongho, Kim, Doeon, Udalski, Andrzej, Gould, Andrew, authors, Leading, Albrow, Michael D., Chung, Sun-Ju, Hwang, Kyu-Ha, Jung, Youn Kil, Lee, Chung-Uk, Ryu, Yoon-Hyun, Shin, In-Gu, Shvartzvald, Yossi, Yee, Jennifer C., Zang, Weicheng, Cha, Sang-Mok, Kim, Dong-Jin, Kim, Hyoun-Woo, Kim, Seung-Lee, and Lee, Dong-Joo
- Published
- 2020
- Full Text
- View/download PDF
26. One Planet or Two Planets? The Ultra-sensitive Extreme-magnification Microlensing Event KMT-2019-BLG-1953.
- Author
-
Han, Cheongho, Kim, Doeon, Jung, Youn Kil, Gould, Andrew, Bond, Ian A., authors, Leading, Albrow, Michael D., Chung, Sun-Ju, Hwang, Kyu-Ha, Lee, Chung-Uk, Ryu, Yoon-Hyun, Shin, In-Gu, Shvartzvald, Yossi, Yee, Jennifer C., Zang, Weicheng, Cha, Sang-Mok, Kim, Dong-Jin, Kim, Hyoun-Woo, Kim, Seung-Lee, and Lee, Dong-Joo
- Published
- 2020
- Full Text
- View/download PDF
27. Endovascular Treatment for Acute Ischemic Stroke in Patients on Oral Anticoagulants: Results From the MR CLEAN Registry.
- Author
-
Goldhoorn, Robert-Jan B., van de Graaf, Rob A., van Rees, Jan M., Lingsma, Hester F., Dippel, Diederik W.J., Hinsenveld, Wouter H., Postma, Alida, van den Wijngaard, Ido, van Zwam, Wim H., van Oostenbrugge, Robert J., Roozenbeek, Bob, and MR CLEAN Registry Investigators—Group Authors
- Published
- 2020
- Full Text
- View/download PDF
28. A Wide-orbit Exoplanet OGLE-2012-BLG-0838Lb.
- Author
-
Poleski, R., Suzuki, Daisuke, Udalski, A., Xie, Xiaojia, Yee, J. C., Koshimoto, Naoki, Gaudi, B. S., Gould, A., authors, leading, Skowron, J., Szymański, M. K., Soszyński, I., Pietrukowicz, P., Kozłowski, S., Wyrzykowski, Ł., Ulaczyk, K., tion, Abe, Fumio, Barry, Richard K., and Bennett, David. P.
- Published
- 2020
- Full Text
- View/download PDF
29. Enhanced lactic acid production by Bacillus coagulans through simultaneous saccharification, biodetoxification, and fermentation.
- Author
-
Liu, Jiantong Author: Please check that all authors and their affiliations are correct. --> Please check if link to ORCID is correct. -->, Cai, Yuyuan, Liu, Ling, Zhan, Rui, Zhao, Shumiao, Liang, Yuxiang, Peng, Nan WILEY, Zhu, Jing, Li, Hong, Xiao, Naidong, Hu, Jinglong, He, Mingxiong, and Hu, Guoquan
- Subjects
LACTIC acid ,FERMENTATION ,TRICHODERMA viride ,CHEMICAL industry ,BACILLUS (Bacteria) ,MASS spectrometry - Abstract
Agricultural straw is abundant worldwide, but efficient production of lactic acid from straw is still challenging. In this paper, Trichoderma viride R16 was cultivated using corncob as the substrate in a fed‐batch process, after which the enzymes from T. viride R16 broth were analyzed through protein mass spectrometry and used for lactic acid production. Dioxygenase activity was found in the T. viride R16 enzymes, and 0.2 g/L phenolics (vanillin, 4‐hydroxybenzaldehyde, syringaldehyde) was degraded during enzyme production. Lactic acid production and yield from NH3‐H2O2 pretreated and washed corncob were increased by more than 24% and total phenolics was significantly lower using T. viride R16 enzymes compared with commercial enzymes in batch and fed‐batch fermentation. These characteristics of T. viride R16 support industrial applications with efficient in situ detoxification of phenolic inhibitors without adding an extra step during lactic acid production from pretreated agricultural straw using simultaneous saccharification and fermentation. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
30. The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia. A Prospective Cohort Study.
- Author
-
Jensen, Andreas Vestergaard, Egelund, Gertrud Baunbæk, Andersen, Stine Bang, Petersen, Pelle Trier, Benfield, Thomas, Witzenrath, Martin, Rohde, Gernot, Ravn, Pernille, Faurholt-Jepsen, Daniel, Baunbæk Egelund, Gertrud, Bang Andersen, Stine, and Members of the CAPNETZ study group except the authors:
- Subjects
HYPERGLYCEMIA ,BIOMARKERS ,PROGNOSIS ,MORTALITY ,BLOOD pressure ,BLOOD sugar analysis ,PNEUMONIA-related mortality ,PNEUMONIA ,RESEARCH ,PREDICTIVE tests ,TIME ,RESEARCH methodology ,EVALUATION research ,MEDICAL cooperation ,HOSPITAL mortality ,SEVERITY of illness index ,COMPARATIVE studies ,COMMUNITY-acquired infections ,COMORBIDITY ,LONGITUDINAL method ,PROPORTIONAL hazards models - Abstract
Rationale: Hyperglycemia is associated with mortality in patients with community-acquired pneumonia (CAP), and hyperglycemia may be a biomarker of severity. However, hyperglycemia has a major disadvantage because the association is diminished in patients with diabetes mellitus (DM). This hampers the use of hyperglycemia as a biomarker. Accounting for habitual glucose levels could overcome this disadvantage.Objectives: We hypothesized that the glycemic gap (the difference between plasma glucose and the estimated average glucose) may be associated with mortality irrespective of DM.Methods: Among 1,933 adults with CAP included in a prospective multicenter cohort, we investigated the association between the glycemic gap and 90-day mortality. Hemoglobin A1c was used to estimate the average glucose. The association was assessed with Cox proportional hazard models after adjustment for age, sex, CURB-65 (Confusion, urea >7 mmol/L, respiratory rate ≥30 breaths/minute, systolic blood pressure <90 mmHg or diastolic blood pressure ≤60 mmHg and age ≥65 years), and comorbidities. In the prespecified analysis the absolute and relative glycemic gaps were used as a continuous variable. In a post hoc analysis, the absolute and relative glycemic gaps were used as a categorical variable grouped according to quartiles.Results: In the post hoc analysis, patients with the lowest (negative) and highest (positive) absolute glycemic gap quartiles had increased risk of 90-day mortality (hazard ratio, 2.6; 95% confidence interval, 1.02-6.65; and hazard ratio, 2.5; 95% confidence interval, 1.01-6.06, respectively). A similar association was found for the relative glycemic gap. The associations were independent of age, CURB-65 score, sex, or number of comorbidities and not modified by DM.Conclusions: Patients with the highest and lowest glycemic gap may have an increased risk of 90-day mortality, and the association was not modified by DM. These associations were found in an exploratory post hoc analysis and should be validated in other populations before further conclusions can be made. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
31. Response to: Consensus and agreements on the classification of fibrotic diseases.
- Author
-
Massen, Georgie M, Stewart, Iain, Quint, Jennifer K, and Authors, All
- Subjects
NOSOLOGY ,MEDICAL personnel - Abstract
We thank the Chiun-Feng Tsai and colleagues for their interest in our Delphi study on the classification of fibrotic disease[1] and are grateful for the opportunity to respond. Nervous and reproductive systems were not sufficiently represented in subsequent rounds for consensus definition, contributing instead to clinical agreement. To minimize fatigue, the design excluded diseases that previously reached consensus definition, reducing the survey burden each round. [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
32. The Prevalence and Management of Dehydration amongst Neonatal Admissions to General Paediatric Wards in Kenya-A Clinical Audit.
- Author
-
Akech, Samuel, Rotich, Beatrice, Chepkirui, Mercy, Ayieko, Philip, Irimu, Grace, English, Mike, authors, Clinical Information Network, and Clinical Information Network authors
- Subjects
DEHYDRATION in children ,WEIGHT loss ,CREATININE ,ELECTROLYTES ,DEXTROSE ,HALOTHERAPY ,COMPARATIVE studies ,DEHYDRATION ,FLUID therapy ,HOSPITAL care ,INTRAVENOUS therapy ,RESEARCH methodology ,MEDICAL cooperation ,PHYSIOLOGIC salines ,RESEARCH ,SALT ,EVALUATION research ,TREATMENT effectiveness ,DISEASE prevalence - Abstract
An audit of randomly selected case records of 810 patients admitted to 13 hospitals between December 2015 and November 2016 was done. Prevalence of dehydration was 19.7% (2293 of 11 636) [95% CI: 17.1-22.6%], range across hospitals was 9.4% to 27.0%. Most cases with dehydration were clinically diagnosed (82 of 153; 53.6%), followed by excessive weight loss (54 of 153; 35.3%) and abnormal urea/electrolytes/creatinine (23 of 153; 15.0%). Documentation of fluids prescribed was poor but, where data were available, Ringers lactate (30 of 153; 19.6%) and 10% dextrose (18 of 153; 11.8%) were mostly used. Only 17 of 153 (11.1%) children had bolus fluid prescription, and Ringer's lactate was most commonly used for bolus at a median volume per kilogram body weight of 20 ml/kg (interquartile range, 12-30 ml/kg). Neonatal dehydration is common, but current documentation may underestimate the burden. Heterogeneity in practice likely reflects the absence of guidelines that in turn reflects a lack of research informing practical treatment guidelines. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
33. Reply to Kuek : Optimism with Caution: Elexacaftor-Tezacaftor-Ivacaftor in Patients with Advanced Pulmonary Disease.
- Author
-
Burgel, Pierre-Régis, Da Silva, Jennifer, Paillasseur, Jean-Louis, Martin, Clémence, and all authors from “Rapid improvement after starting elexacaftor-tezacaftor-ivacaftor in patients with cystic fibrosis and advanced pulmonary disease”.
- Subjects
PATIENTS ,CYSTIC fibrosis ,PYRIDINE ,PHENOLS ,INDOLE compounds ,LUNG diseases ,HETEROCYCLIC compounds ,QUINOLONE antibacterial agents - Abstract
The article presents the reply from the author providing the first data describing the effects of initiating elexacaftor–tezacaftor–ivacaftor in a large cohort of patients with cystic fibrosis.
- Published
- 2021
- Full Text
- View/download PDF
34. MIRACLE2 and SCAI grade identify patients for early wakening after out-of-hospital cardiac arrest: a post hoc analysis of the THAW trial.
- Author
-
Simpson, Rupert, Karamasis, Grigoris V., Davies, John, Pareek, Nilesh, Keeble, Thomas R., Study Group Collaborating Authors, Maccaroni, Maria, Damian, Max, and Watson, Noel
- Published
- 2023
- Full Text
- View/download PDF
35. Clinicopathologic Characteristics of HER2-positive Metastatic Colorectal Cancer and Detection of HER2 in Plasma Circulating Tumor DNA.
- Author
-
Wei, Qing, Zhang, Yinjie, Gao, Jing, Li, Jian, Li, Jie, Li, Yanyan, Zhou, Jun, Lu, Ming, Gong, Jifang, Zhang, Xiaotian, Shen, Lin, Sun, Yu, Chang, Lianpeng, Wang, Xicheng, and Q.W. and Y.Z. contributed equally to this work as first authors.
- Published
- 2019
- Full Text
- View/download PDF
36. Thiolated γ-polyglutamic acid as a bioadhesive hydrogel-forming material: evaluation of gelation, bioadhesive properties and sustained release of KGF in the repair of injured corneas.
- Author
-
Xu, These authors contributed equally.He-Lin, Tong, Meng-Qi, Wang, Li-Fen, Chen, Rui, Li, Xin-Ze, Sohawon, Yasin, Yao, Qing, Xiao, Jian, and Zhao, Ying-Zheng
- Published
- 2019
- Full Text
- View/download PDF
37. Role of late amniocentesis in the era of modern genomic technologies.
- Author
-
collaborating authors, Daum, H., Zenvirt, S., Meiner, V., Frumkin, A., Shkedi Rafid, S., Ben David, A., Nadjari, M., Yanai, N., Yagel, S., Helman, S., Silverstein, Shira, Eilat, Avital, Macarov, Michal, Zvi, Naama, Szmulewicz, Adi, Fahham, Duha, Hacohen, Nuphar, Kimchi, Adva, and Shaag, Avraham
- Subjects
AMNIOCENTESIS ,DNA copy number variations ,FETAL abnormalities ,MICROARRAY technology ,HUMAN abnormalities ,GESTATIONAL age ,THIRD trimester of pregnancy ,RESEARCH evaluation ,TIME ,RETROSPECTIVE studies - Abstract
Objective: Traditionally, amniocentesis is performed between 17 and 23 weeks of gestation. This enables decisions regarding the course of pregnancy to be made before viability. Less frequently, amniocentesis is performed in the third trimester. Advanced genomic technologies such as chromosomal microarray analysis (CMA) provide more detailed information about the fetus compared with traditional G-banded chromosomal analysis. The aim of this study was to assess the indications for and safety of late amniocentesis, genetic-test results (especially in the context of CMA technology) and outcome of pregnancies that underwent the procedure after 24 weeks.Methods: Medical records were analyzed retrospectively of all women in whom amniocentesis was performed at a gestational age of 24 + 0 to 38 + 6 weeks, at Hadassah Medical Center, between June 2013 and March 2017. Parameters investigated included indications for late amniocentesis, complications, CMA results and pregnancy outcome.Results: During the study period, 291 women (303 fetuses, 277 singleton and 14 twin pregnancies; in two twin pairs, one fetus was terminated before amniocentesis) underwent late amniocentesis. CMA was performed in all instances of amniocentesis. The most frequent indication was abnormal sonographic finding(s) (204/303 fetuses, 67%). Preterm delivery occurred in 1.7% and 5.1% of pregnancies within the first week and within 1 month following the procedure, respectively. Aneuploidy was detected in nine (3%) fetuses and nine (3%) others had a pathogenic/likely pathogenic copy number variant, suggesting that CMA doubled the diagnostic yield of traditional karyotyping. Maximal diagnostic yield (17.5%) was achieved for the subgroup of fetuses referred with abnormal sonographic findings in two or more fetal anatomical systems. Variants of uncertain significance or susceptibility loci were found in another nine (3%) fetuses.Conclusions: In pregnancies undergoing late amniocentesis, CMA increased detection rates of fetal abnormalities and had a shorter turnaround time compared with traditional chromosomal analysis; therefore, late amniocentesis may serve as a helpful tool for detecting fetal abnormalities or reassuring parents following late-appearing abnormal sonographic findings. However, CMA may expose findings of uncertain significance, about which the couple should be precounseled. The procedure appears to be safe. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
38. Antibacterial and osteogenic activity of a multifunctional microporous coating codoped with Mg, Cu and F on titanium.
- Author
-
ZhaoCo-first authors., Quanming, Yi, Lei, Hu, Annan, Jiang, Libo, Hong, Lin, and Dong, Jian
- Abstract
As preferred materials for bone tissue repair and replacement, titanium (Ti) and its alloys have been widely applied in clinical practice. However, since these materials are bioinert, synostosis cannot occur between these materials and natural bone. Therefore, modifying the surface of Ti with bioactive elements has been the subject of intense research. In the present study, a magnesium–copper–fluorine (Mg–Cu–F) codoped titanium dioxide microporous coating (MCFMT) was prepared on the surface of Ti by micro-arc oxidation (MAO). The coating had a micro/nanoporous structure and was uniformly doped with Mg, Cu and F. In vitro, the MCFMT could promote the adhesion, proliferation, differentiation, mineralization and apoptosis of MC3T3-E1 osteoblasts. In addition, MCFMT could inhibit the growth of Staphylococcus, providing a good antibacterial effect. Further studies showed that MCFMT promoted MAPK expression and might promote osteogenesis through ERK1/2 signaling. Therefore, establishing an MCFMT coating on the Ti surface is a feasible and effective way to improve the biological activity of Ti. This study provides a new concept and method for improving the biological activity of Ti and thus has important theoretical significance and potential applications. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
39. Improving NanoCluster Beacon performance by blocking the unlabeled NC probes.
- Author
-
ChenThese authors contributed equally., Yu-An, Vu, Huong T., Liu, Yen-Liang, Chen, Yuan-I, Nguyen, Trung Duc, Kuo, Yu-An, Hong, Soonwoo, Chen, Yin-An, Carnahan, Savannah, Petty, Jeffrey T., and Yeh, Hsin-Chih
- Subjects
MOLECULAR probes ,FLUORESCENCE - Abstract
While NanoCluster Beacon (NCB) is a versatile molecular probe, it suffers from a low target-specific signal issue due to impurities. Here we show that adding a “blocker” strand to the reaction can effectively block the nonfunctional probes and enhance the target-specific signal by 14 fold at a 0.1 target/probe ratio. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
40. Key factor governing the physicochemical properties and extent of proton transfer in protic ionic liquids: ΔpKa or chemical structure?
- Author
-
MiranThese two authors equally contributed to this work., Muhammed Shah, Hoque, Mahfuzul, Yasuda, Tomohiro, Tsuzuki, Seiji, Ueno, Kazuhide, and Watanabe, Masayoshi
- Abstract
In order to identify the key factor governing the transport properties and extent of proton transfer in protic ionic liquids (PILs), a series of PILs were prepared by simple neutralisation of a super-strong acid, bis(trifluoromethanesulfonyl)amide acid (H[NTf
2 ]), with a range of amines comprising diverse structures, including secondary and tertiary amines. The bulk physicochemical properties of the resulting PILs with a wide variation in the ΔpKa values of the constituent acid and protonated bases were compared to those of previously reported PILs derived from a super-strong base, 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), and different acids (M. S. Miran, H. Kinoshita, T. Yasuda, M. A. B. H. Susan and M. Watanabe, Phys. Chem. Chem. Phys., 2012, 14, 5178–5186) with emphasis on the thermal stability, vibrational spectroscopy, density, viscosity, conductivity, and ionicity characteristics. The thermal stability of all PILs, as analysed by thermogravimetric analysis (TGA), was found to linearly increase with the ΔpKa values. However, isothermal TGA measurements for an extended duration indicated that [NTf2 ]-based PILs exhibit higher thermal stability than [DBU]-based PILs at low ΔpKa values (<15). PILs with secondary amines showed higher viscosity and lower ionic conductivity than those with tertiary amines because of the formation of multiple hydrogen bonds. The evaluated ionicity suggested that all [NTf2 ]-based PILs are “good PILs”, irrespective of the basicity of the amines, and have higher ionicity than [DBU]-based PILs particularly at low ΔpKa values (<15). [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
41. Magnitude and pattern of improvement in processes of care for hospitalised children with diarrhoea and dehydration in Kenyan hospitals participating in a clinical network.
- Author
-
Akech, Samuel, Ayieko, Phillip, Irimu, Grace, Stepniewska, Kasia, English, Mike, and Clinical Information Network authors
- Subjects
CHILD death ,DIARRHEA ,DEHYDRATION in children ,DEHYDRATION prevention ,DIARRHEA prevention ,CHILD welfare ,HOSPITAL care of children ,COMPARATIVE studies ,DEHYDRATION ,RESEARCH methodology ,MEDICAL quality control ,MEDICAL cooperation ,QUALITY assurance ,RESEARCH ,RESEARCH funding ,DISEASE management ,EVALUATION research - Abstract
Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
42. The sacrificial inactivation of the blue-light photosensor cryptochrome from Drosophila melanogaster.
- Author
-
KuttaThese authors contributed equally., Roger Jan, Archipowa, Nataliya, and Scrutton, Nigel Shaun
- Abstract
Drosophila melanogaster cryptochrome functions as the primary blue-light receptor that mediates circadian photo entrainment. Absorption of a photon leads to reduction of the protein-bound FAD via consecutive electron transfer along a conserved tryptophan tetrad resembling the signalling state required for conformational changes and induction of subsequent signalling cascades. However, how the initial photochemistry and subsequent dark processes leading to downstream signalling are linked to each other at the molecular level is still poorly understood. Here, we investigated in detail the initial photochemical events in DmCRY by time-resolved and stationary absorption spectroscopy combined with quantum chemical and molecular dynamics calculations. We resolved the early events along the conserved tryptophan tetrad and the final deprotonation of the terminal tryptophanyl radical cation. These initial events lead to conformational changes, such as the known C-terminal tail release, Trp decomposition, and finally FAD release providing evidence that DmCRY does not undergo a photocycle. We propose that light is a negative regulator of DmCRY stability even under in vitro conditions where the proteasomal machinery is missing, that is in line with its biological function, i.e. entrainment of the circadian clock. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
43. Approaching quality improvement at scale: a learning health system approach in Kenya.
- Author
-
Irimu, Grace, Ogero, Morris, Mbevi, George, Agweyu, Ambrose, Akech, Samuel, Julius, Thomas, Nyamai, Rachel, Githang'a, David, Ayieko, Philip, English, Mike, and Clinical Information Network Authors Group
- Subjects
INSTRUCTIONAL systems ,HOSPITAL care of children - Published
- 2018
- Full Text
- View/download PDF
44. ERACODA: the European database collecting clinical information of patients on kidney replacement therapy with COVID-19.
- Author
-
Noordzij, Marlies, Duivenvoorden, Raphaël, Pena, Michelle J, Vries, Hanne de, Kieneker, Lyanne M, and authors, for the collaborative ERACODA
- Subjects
COVID-19 treatment ,COVID-19 ,GENERAL Data Protection Regulation, 2016 - Published
- 2020
- Full Text
- View/download PDF
45. Oxidant-free oxidation of C–H bonds by cathodic hydrogen evolution: a phosphonic Kolbe oxidation/cyclization process.
- Author
-
ZhangCo-first authors., Lei, Zhang, Zhenxing, Zhang, Jianning, Li, Kangle, and Mo, Fanyang
- Subjects
OXIDATION ,HYDROGEN evolution reactions ,KOLBE reaction - Abstract
An anodic oxidation/cyclization of 2-(aryl)aryl phosphonic acid monoesters for ethoxy dibenzooxaphosphorin oxide synthesis has been developed. This unprecedented electrochemical oxidation reaction proceeds at room temperature with no oxidant or electrolyte required, and exhibits high atom-economy with H
2 being the only byproduct. A series of ethoxy dibenzooxaphosphorin oxides were obtained in good yields. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
46. Photocrosslinking polymeric ionic liquids via anthracene cycloaddition for organic electronics.
- Author
-
PopereThese authors contributed equally., Bhooshan C., Sanoja, Gabriel E., Thomas, Elayne M., Schauser, Nicole S., Jones, Seamus D., Bartels, Joshua M., Helgeson, Matthew E., Chabinyc, Michael L., and Segalman, Rachel A.
- Abstract
Polymeric ionic liquids (i.e., PILs) are single ion-conducting materials that exhibit the thermal and electrochemical stability of ionic liquids and the mechanical properties of polymers. Although PILs are exciting for a variety of applications in energy conversion and storage, the tradeoff between mechanics and ion transport remains an important limitation in materials design. Herein, a photocrosslinkable PIL based on the cycloaddition reaction of anthracene is converted from a viscous liquid into a soft solid without detrimental effects on the bulk ionic conductivity. The independent control of mechanical- and ion-conducting properties results from negligible changes in polymer segmental dynamics (i.e., glass transition temperature) upon crosslinking. This was demonstrated for both a polymer (i.e., N = 279) and its corresponding oligomer (i.e., N = 10). The ease of processability facilitated by the presented molecular design is illustrated by both patterning the PIL into μm-sized features, and incorporating it as a dielectric in thin-film transistors for low-voltage operation independent of device fabrication geometry. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
47. A generalized approach for NMR studies of lipid–protein interactions based on sparse fluorination of acyl chains.
- Author
-
De BiasioThese authors contributed equally., Alfredo, Ibáñez de Opakua, Alain, Bostock, Mark J., Nietlispach, Daniel, Diercks, Tammo, and Blanco, Francisco J.
- Subjects
PROTEIN-lipid interactions ,FLUORINATION ,NUCLEAR magnetic resonance spectroscopy - Abstract
Sparse lipid fluorination enhances the lipids'
1 H signal dispersion, enables clean molecular distinction by19 F NMR, and evinces micelle insertion of proteins via fluorine-induced signal shifts. We present a minimal fluorination scheme, and illustrate the concept on di-(4-fluoro)-heptanoylphosphatidylcholine micelles and solubilised seven-helix transmembrane pSRII protein. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
48. Monitoring the formation of GaN nanowires in molecular beam epitaxy by polarization-resolved optical reflectometry.
- Author
-
CorfdirEqually contributed authors., Pierre, Calabrese, Gabriele, Laha, Apurba, Auzelle, Thomas, Geelhaar, Lutz, Brandt, Oliver, and Fernández-Garrido, Sergio
- Subjects
NUCLEATION ,NANOWIRES ,THIN films ,MOLECULAR beam epitaxy ,GALLIUM nitride - Abstract
We analyze the temporal variation of the substrate optical reflectance during the formation of GaN nanowires in molecular beam epitaxy using transverse electric and transverse magnetic polarized light. The time dependence of the reflectance signal is simulated using an effective medium approach that takes into account the spatial fluctuations in the length and density of the nanowire ensemble within the area probed by the laser beam. Our study demonstrates that optical reflectometry is a powerful technique to detect the onset of nanowire nucleation, assess the deposition rate, and estimate the fluctuations in the nanowire length and covered area fraction at the μm scale. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
49. A quinoline-based compound for explosive 2,4,6-trinitrophenol sensing: experimental and DFT-D3 studies.
- Author
-
HalderThese authors contributed equally to this work., Shibashis, Ghosh, Pritam, Hazra, Ananta, Banerjee, Priyabrata, and Roy, Partha
- Subjects
QUINOLINE ,PHENOLS ,DENSITY functional theory - Abstract
A quinoline-based Schiff base compound, 2,5-dimethylbis(quinolin-2-ylmethylene)benzene-1,4-diamine (DQB), has been found to be a chemosensor for 2,4,6-trinitrophenol (TNP). DQB has been synthesized by condensation between two equivalents of quinoline-4-carboxaldehyde and one equivalent of 2,5-dimethyl-1,4-diaminobenzene in methanol under ambient reaction conditions and characterized by using standard spectroscopic methods. It shows an emission band at 440 nm with high intensity (λ
ex = 390 nm). The emission intensity is quenched severely in the presence of TNP while other nitroaromatic compounds fail to reduce the intensity, signifying high selectivity towards TNP. The fluorescence quenching mechanism can be explained by theoretical calculations as an RET-ICT based pathway. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
50. Highlights from the Faraday discussion on photoinduced processes in nucleic acids and proteins.
- Author
-
Segarra-MartíThese authors contributed equally to this work., Javier, Ramakrishnan, Remya, Vinals, Javier, and Hughes, Ashley J.
- Subjects
NUCLEIC acids ,TRANSITION metal compounds ,BACTERIORHODOPSIN - Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.