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Simple Summary: Muscle strength increases with age, and the period in which the increase in muscle mass is highest is the growth and development period in adolescents. In this context, the improvement of muscle power and muscle strength in adolescents can be achieved with the development of simple motor skills. Research on the relationship between biological maturation, muscle strength, and muscle power was limited in adolescents, and this research will make an important contribution to the literature. In this research, the relationship between biological maturation and muscle strength and power was investigated. In conclusion, biological maturation was found to be significantly associated with muscle strength and power in adolescents. The purpose of this study was to investigate the relationship between adolescents' biological maturation level and their muscle power, as well as their overall muscle strength. Overall, 691 adolescents (414 boys and 277 girls) aged 12.01–11.96 (measured for body mass, body height as well as vertical jump, muscle power, and muscle strength). There was a statistically significant difference in terms of average right and left grip strength, vertical jump, and power in the late maturation group. For the body height and vertical jump averages in male adolescents, it was observed that the body height and vertical jump averages in the late group were significantly lower than in the early and on-time maturation groups. For female adolescents' chronological age, sitting height, body mass, BMI, left and right grip strength, and power averages were found to be significantly higher compared with the on-time group (p < 0.05). It was established that biological maturation has a substantial link with vertical jump height and power, as well as grip strength on the right and left hands. [ABSTRACT FROM AUTHOR]