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Relevance: It was noted that after conducting еndonasal surgical interventions in the nasal cavity and paranasal sinuses, prolonged functional disorders were observed, accompanied by reactive edema, leading to sinus congestion, crusting and respiratory failure. Purpose: the aim of the study was to increase the effectiveness of treatment of patients with chronic rhinosinusitis by improving the technique of early postoperative rehabilitation. Materials and methods: the results were obtained from a comprehensive examination and treatment of 110 patients with chronic purulent and polypous sinusitis, aged 21 to 60 years, who were divided into two similar groups. Patients of the first group and second group received basic postoperative therapy, including systemic antibiotics. In addition, patients of the first group (main) instilled Sinuforte 1 time per day in both halves of the nose. Sinuforte began to be administered from the second day a fter surgery or the day after removal of tampons. Patients of the second group (control) washing the nose with saline 4-5 times a day and instilled Pinosol oil in the nose. Patients were evaluated for ten days after surgery. The subjective state of patients (complaints) was assessed, the clinical endoscopic picture, olfactometry were evaluated, rhinocytograms were performed. Results: a good clinical result was obtained, comparable or greater than the effect of treating patients without the inclusion of Sinuforte in complex therapy. In this case, the drug is administered once a day, while washing the nose and regular cleaning of the nasal cavity by a doctor is not required. [ABSTRACT FROM AUTHOR]