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Simple Summary: Actinobacillus (A.) pleuropneumoniae is a major agent of the porcine respiratory diseases complex (PRDC), together with several bacterium and virus species. A. pleuropneumoniae strains are diverse regarding virulence and antigen structure; they have different virulence variants, and the strains can be assigned into 19 serovars. Serovar 16 was described in Hungary for the first time, and it is relatively frequent in pig herds. The aim of the present work was examination of the virulence of the A. pleuropneumoniae A-85/14 strain, the type strain of serovar 16, by infecting piglets. The results prove that the A. pleuropneumoniae A-85/14 strain is a virulent one. Different virulence variants of A. pleuropneumoniae are involved in the etiology of porcine pleuropneumonia. The purpose of the present trial was examination of the virulence of the Actinobacillus pleuropneumoniae A-85/14 strain, the type strain of serovar 16, in an animal challenge experiment. Thirty 12-week-old piglets seronegative for A. pleuropneumoniae were allocated into three trial groups each of 10 animals, and they were infected intranasally with 106, 107, or 108 colony forming units (cfu) of the strain, respectively. Clinical signs were recorded twice a day, and the animals were euthanized 6 days after the infection. Typical clinical signs and postmortem lesions of porcine pleuropneumonia were seen in the animals of each trial group; however, they were generally mild, and no significant differences could be seen between the three groups. Even 106 colony forming units of A. pleuropneumoniae A-85/14 strain could induce clinical signs and lesions. Based on these results, the type strain of serovar 16 of A. pleuropneumoniae must be regarded as a typical pathogenic strain of the species. [ABSTRACT FROM AUTHOR]