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Six new tirucallane-type triterpenoids, named munropenes A–F (1–6), were extracted from the whole plants of Munronia pinnata using a water extraction method. Their chemical structures were determined based on detailed spectroscopic data. The relative configurations of the acyclic structures at C-17 of munropenes A–F (1–6) were established using carbon–proton spin-coupling constants (2,3JC,H) and inter-proton spin-coupling constants (3JH,H). Furthermore, the absolute configurations of munropenes A–F (1–6) were determined through high-performance liquid chromatography (HPLC), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analyses. The antiproliferative effects of munropenes A–F were evaluated in five tumor cell lines: HCT116, A549, HepG2, MCF7, and MDAMB. Munropenes A, B, D, and F (1, 2, 4, and 6) inhibited proliferation in the HCT116 cell line with IC50 values of 40.90, 19.13, 17.66, and 32.62 µM, respectively. [ABSTRACT FROM AUTHOR]

A new tirucallane, 3β-hydroxy-3-decarbonyl-24-epi-piscidinol A (1), and two new pairs of tetranortriterpene 23-epimers, named thaimoluccepimers A (2) and B (3), were isolated from the seeds of a Thai mangrove,Xylocarpus moluccensis. The structures of these compounds were elucidated by HRESIMS and NMR spectroscopic analysis. [ABSTRACT FROM AUTHOR]

Two new tirucallane-type triterpenoids, (24 Z)-tirucalla-7,24-diene-3 β,11 β,26-triol ( 1) and (3 S,24 R)-tirucall-7-ene-3,24,25-triol ( 2), along with the known compound celastrol ( 3), were isolated from the root barks of Celastrus stylosus Wall. The structures of 1- 3 were established by spectroscopic methods, including extensive 2D NMR and MS analyses. It is the first report on tirucallane-type triterpenoids from the genus Celastrus and may be of vital chemotaxonomic significance. [ABSTRACT FROM AUTHOR]

Two new tirucallane-type triterpenoids, 3 α,24 β,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene ( 1) and 3 α-acetoxy-21 β-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone ( 2), were isolated from the stem barks of Aphanamixis grandifolia, and their structures were elucidated on the basis of spectroscopic data analysis including 1D, 2D NMR, IR, and ESI-MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI-H460 and HeLa cell lines. [ABSTRACT FROM AUTHOR]

Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5β-tirucall-9(11),25-dien-3-one ( 1), squalene and a mixture of the phytosterols stigmasterol and β-sitosterol. Microplate Alamar Blue Assay (MABA) showed that 1 inhibited the growth of Mycobacterium tuberculosis H37Rv with a MIC of 64 μg/mL, while squalene and the sterol mixture have MICs of 100 and 128 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A–E (1–5) and agallochols A–D (6–9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and Excoecaria agallocha. The structures of these compounds were established by HR-ESIMS and extensive one-dimensional (1D) and two-dimensional (2D) NMR investigations. The absolute configurations of 1 and 2 were unequivocally determined by single-crystal X-ray diffraction analyses, conducted with Cu Kα radiation; whereas those of 4, 6–8 were assigned by a modified Mosher's method and the comparison of experimental electronic circular dichroism (ECD) spectra. Most notably, 5, 6, 7, and 9 displayed potent activation effects on farnesoid–X–receptor (FXR) at the concentration of 10.0 μM; 10 exhibited very significant agonistic effects on pregnane–X–receptor (PXR) at the concentration of 10.0 nM. [ABSTRACT FROM AUTHOR]