1. Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial
- Author
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Mohsen Adib, Mohammad Hossein Jarrahzadeh, Tayebeh Toliyat, Laila Shirbeigi, Nafiseh Khosravi Dehaghi, and Seyede Nargess Sadati Lamardi
- Subjects
ajuga ,ecdysterone ,persian medicine ,pressure ulcer ,randomized controlled trial ,Pharmacy and materia medica ,RS1-441 - Abstract
Background and objectives: Ajuga genus is used as wound healing in traditional Persian medicine. This study aimed to evaluate the effectiveness of Ajuga chamaecistus ssp. tomentella ointment on healing pressure ulcers in patients admitted to the intensive care unit. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 131 patients with grade 1 or 2 pressure ulcers were randomly assigned into one of two groups through simple randomization. The study group received 3% Ajuga ointment, containing 17.26 µg/mL of 20-hydroxyecdysone (ecdysterone) as the main compound, while the control group received placebo twice a day for 14 days in addition to the standard care for pressure ulcers Changes in the degree and size of wounds were considered as the primary outcomes of the study based on the 2-digit Stirling scale. Results: Forty patients in each group completed the research. Mean (95% confidence interval) difference values, for wound degree, between two groups on day 7 vs. day 0 was -0.88 (-1.01 to -0.76, p more...
- Published
- 2024
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