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Naeem Mubarak,1 Sarwat Ali Raja,1 Asma Sarwar Khan,1,2 Sabba Kanwal,1 Nasira Saif-ur-Rehman,1 Muhammad Majid Aziz,1 Irshad Hussain,3 Ernieda Hatah,4 Che Suraya Zin5 1Department of Pharmacy Practice, Lahore Medical & Dental College, University of Health Sciences, Lahore, Punjab, Pakistan; 2Department of Pharmacy Practice, University of Health Sciences, Lahore, Punjab, Pakistan; 3Department of Pharmacy, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Sindh, Pakistan; 4Department of Pharmacy, The National University of Malaysia, Bangi, Malaysia; 5Kulliyyah of Pharmacy, International Islamic University, Kuantan, MalaysiaCorrespondence: Naeem MubarakLahore Medical & Dental College, University of Health Sciences, Tulspura, North Canal Bank, Lahore, 53400, PakistanTel +92 42-37392208Email naeem.mubarak@lmdc.edu.pkChe Suraya ZinUniversiti Islam Antarabangsa, Malaysia Kampus Kuantan, Pahang Darul Makmur, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, Kuantan, Pahang, 25200, MalaysiaTel +60 11-14881605Email chesuraya@iium.edu.myBackground: There is a growing global interest in formulating such policies and strategic plans that help devise collaborative working models for community pharmacists (CPs) and general practitioners (GPs) in primary care settings.Objective: To conceptualize a stakeholder-driven framework to improve collaboration between CPs and GPs in Malaysian primary care to effectively manage medicines in chronic diseases.Design and Setting: A qualitative study that involved individual semi-structured interviews of the leadership of various associations, guilds, and societies representing CPs, GPs, and Nurses in Malaysia.Methods: This study collected and reported data in accordance with the guidelines of the Consolidated Criteria for Reporting of Qualitative Studies. Key informants were recruited based on purposive (expert) sampling. Interviews were transcribed verbatim and data were coded based on the principles of thematic analysis in NVivo.Results: A total of 12 interviews (5 CPs, 5 GPs, and 2 nurses) were conducted. Five themes emerged: Theme 1 highlighted a comparison of community pharmacy practice in Malaysia and developed countries; Theme 2 involved current practices in Malaysian primary care; Theme 3 encompassed the advantages of CP–GP collaboration in chronic diseases; Theme 4 highlighted the barriers which impede collaboration in Malaysian primary care; and Theme 5 delineated the way forward for CP–GP collaboration in Malaysia.Conclusion: The actionable insights obtained from the Malaysian stakeholders offered an outline of a framework to enhance collaboration between CPs and GPs in primary care. Generally, stakeholders were interested in CP–GP collaboration in primary care and identified many positive roles performed by CPs, including prescription review, adherence support, and patient education. The framework of the way forward includes: separation of CP and GP roles through a holistic revision of relevant legislation to grant an active role to CPs in chronic care; definition of protocols for collaborative practices; incentivization of both stakeholders (CPs and GPs); and design and implementation of an effective regulatory mechanism whereby the Malaysian Ministry of Health may take a leading role.Keywords: community pharmacist, general practitioner, chronic disease, collaborative care, Malaysia, qualitative research medicine management