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Thematic learning is an integrated learning that focuses on student involvement in the learning of each sub-theme. The research in this paper is to uncover and explain the teacher's skills in managing the class for the fifth-grade students' thematic learning at SD Khatolik St. Vincentius Noongan. The researchers used qualitative research methods with data collection methods in the form of observation, interviews, and documentation. Data analyses were data reduction, data presentation, and conclusion drawing. The research result indicates that there are two types of class management in theme learning, non-physical and physical class management. Caring, firmness, change, and high standards comprise non-physical classroom management. Meanwhile, physical classroom management entails rearranging the blackboard's position, seating adjustment, bulletin boards, and window rearrangement in the classroom. Thematic learning is unusual in that it takes a teacher's inventiveness to manage the class. Of course, this management is dependent on the qualities and requirements of the pupils. Because each student's demands are unique, we must make the class as appealing as feasible while managing it.

Alzheimer’s disease (AD) has traditionally been discussed as a disease where serious cognitive decline is a result of Aβ-plaque accumulation, tau tangle formation, and neurodegeneration. Recently, it has been shown that metabolic dysregulation observed with insulin resistance and type-2 diabetes actively contributes to the progression of AD. One of the pathologies linking metabolic disease to AD is the release of inflammatory cytokines that contribute to the development of brain neuroinflammation and mitochondrial dysfunction, ultimately resulting in amyloid-beta peptide production and accumulation. Improving these metabolic impairments has been shown to be effective at reducing AD progression and improving cognitive function. The polyphenol resveratrol (RSV) improves peripheral metabolic disorders and may provide similar benefits centrally in the brain. RSV reduces inflammatory cytokine release, improves mitochondrial energetic function, and improves Aβ-peptide clearance by activating SIRT1 and AMPK. RSV has also been linked to improved cognitive function; however, the mechanisms of action are less defined. However, there is evidence to suggest that chronic RSV-driven AMPK activation may be detrimental to synaptic function and growth, which would directly impact cognition. This review will discuss the benefits and adverse effects of RSV on the brain, highlighting the major signaling pathways and some of the gaps surrounding the use of RSV as a treatment for AD.