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Marta Imamura,1 Rosa Alves Targino,1 Wu Tu Hsing,2,3 Satiko Imamura,1 Raymundo Soares Azevedo,3 Lucy Santos Villas Boas,4 Tania Regina Tozetto-Mendoza,5 Fábio Marcon Alfieri,1,6 Thais Raquel Filippo,1 Linamara Rizzo Battistella1,71Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo Medical School, São Paulo, 2Division of Physical Medicine, Center for Acupuncture, Institute of Orthopedics and Traumatology, University of São Paulo, São Paulo, 3Department of Pathology, University of São Paulo, São Paulo, 4Laboratory of Medical Investigation LIM-52-HCFMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo, 5Tropical Laboratory of Hematology/Medical Research Laboratory-LIM 52, Institute of Tropical Medicine, University of São Paulo, São Paulo, 6Program of Master in Health Promotion, São Paulo Adventist University Center, São Paulo, 7Department of Legal Medicine, Medical Ethics, Social and Labor Medicine – Medicine School, University of São Paulo, São Paulo, BrazilIntroduction: Fibromyalgia and osteoarthritis may present a relationship with the concentration of cytokines. The aim of this study was to compare the serum concentrations of IL-12p70, tumor necrosis factor, IL-10, IL-6, IL-1ß, and IL-8 in patients with knee osteoarthritis and fibromyalgia.Materials and methods: The study included 53 women (71.2±7.6 years old) diagnosed with knee osteoarthritis with moderate-to-severe pain (visual analog scale >4) for at least 3 months. Sixty women (54.1±8.1 years old) diagnosed with fibromyalgia according to the American College of Rheumatology criteria and with moderate-to-severe pain (visual analog scale >4) also participated in this study. For the dosage of cytokines, blood was collected in the morning: 5 mL from the cubital vein. The material was centrifuged at 4°C, separated into 100 µL aliquots and stored at -80°C until processing. Serum concentrations of the studied cytokines were assessed using the BD Cytometric Bead Array method. Data were analyzed with Student’s t-test and the Mann–Whitney U test.Results: We found higher levels of IL-6, IL-10, and IL-1ß in fibromyalgia patients. After adjustment of age as a covariate, there was no statistically significant difference in the concentration of any cytokine between fibromyalgia and knee osteoarthritis patients.Conclusion: Patients with knee osteoarthritis and fibromyalgia with the same duration and intensity of pain demonstrate similar concentrations of cytokines. Aging may play a role in cytokine profile, a finding not so extensively addressed in the literature and one that should be further investigated.Keywords: cytokines, osteoarthritis, fibromyalgia, aging

Fábio Marcon Alfieri,1,2 Marcelo Riberto,3 Àngels Abril-Carreres,4 Maria Boldó-Alcaine,4 Elisabet Rusca-Castellet,4 Roser Garreta-Figuera,4 Linamara Rizzo Battistella51São Paulo Adventist University Center, São Paulo, Brazil; 2Institute of Physical and Rehabilitation Medicine Hospital of Clinics, University of São Paulo, Brazil; 3School of Medicine in Ribeirão Preto, University of São Paulo, Brazil; 4University Hospital Mútua Terrassa Department of Rehabilitation, University of Barcelona, Barcelona, Spain; 5School of Medicine, Institute of Physical Medicine and Rehabilitation, Clinics Hospital of University of São Paulo, São Paulo, BrazilBackground: Exercise programs have proved to be helpful for frail older adults. This study aimed to investigate the effects of an exercise program with a focus on postural control exercises in frail older adults.Method: Twenty-six older adults (76.7 ± 4.9 years) deemed clinically stable, chosen from the Falls Unit, University Hospital Mútua Terrassa, Barcelona, Spain, participated in this single-group study. Volunteers' postural control was evaluated using the Timed Up and Go test (TUG) and the Guralnik test battery, and their static and dynamic posturography were evaluated using the Synapsys Posturography System®. These evaluations were performed before and after the intervention program, which included an educational session and two weekly 1-hour sessions over an 8-week period of stretching exercises, proprioception, balance, and motor coordination. Data were analyzed using the Student's t-test or the Wilcoxon test, with a significance level of 5%.Results: The TUG and Guralnik tests did not show significant differences. Concerning static posturography, there was improvement in the base of support (P = 0.006), anteroposterior displacement with eyes open (P = 0.02) and closed (P = 0.03), and the total amplitude of the center of pressure with eyes closed (P = 0.02). Regarding dynamic posturography, a decrease of the oscillation speed in the anteroposterior direction (P = 0.01) was observed in individuals with their eyes open.Conclusion: The program used in this study was safe and was able to promote some improvement in postural control, especially in the anteroposterior direction and in the base of support. However, it is noteworthy that further improvements could be obtained from a program of longer duration and greater frequency.Keywords: balance, aging, intervention, falls

Fábio Marcon Alfieri,1 Marcelo Riberto,2 Lucila Silveira Gatz,3 Carla Paschoal Corsi Ribeiro,4 José Augusto Fernandes Lopes,4 Linamara Rizzo Battistella41São Paulo Adventist University Center, São Paulo, 2Faculty of Medicine in Ribeirão Preto, University of São Paulo, 3Physical Educator, São Paulo, 4School of Medicine, Institute of Physical Medicine and Rehabilitation, Clinics Hospital of University of São Paulo, São Paulo, BrazilObjective: The objective of this study was to analyze the efficacy of multisensory versus muscle strengthening to improve postural control in healthy community-dwelling elderly.Participants: We performed a single-blinded study with 46 community-dwelling elderly allocated to strength (GS, n = 23; 70.18 ± 4.8 years 22 women and 1 man) and multisensory exercises groups (GM, n = 23; 68.8 ± 5.9 years; 22 women and 1 man) for 12 weeks.Methods: We performed isokinetic evaluations of muscle groups in the ankle and foot including dorsiflexors, plantar flexors, inversion, and eversion. The oscillation of the center of pressure was assessed with a force platform.Results: The GM group presented a reduction in the oscillation (66.8 ± 273.4 cm2 to 11.1 ± 11.6 cm2; P = 0.02), which was not observed in the GS group. The GM group showed better results for the peak torque and work than the GS group, but without statistical significance.Conclusion: Although the GM group presented better results, it is not possible to state that one exercise regimen proved more efficacious than the other in improving balance control.Keywords: postural control, aging, exercise, multisensory, strengthening