1. A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantation.
- Author
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John D Lang, Alvin B Smith, Angela Brandon, Kelley M Bradley, Yuliang Liu, Wei Li, D Ralph Crowe, Nirag C Jhala, Richard C Cross, Luc Frenette, Kenneth Martay, Youri L Vater, Alexander A Vitin, Gregory A Dembo, Derek A Dubay, J Steven Bynon, Jeff M Szychowski, Jorge D Reyes, Jeffrey B Halldorson, Stephen C Rayhill, Andre A Dick, Ramasamy Bakthavatsalam, Jared Brandenberger, Jo Ann Broeckel-Elrod, Laura Sissons-Ross, Terry Jordan, Lucinda Y Chen, Arunotai Siriussawakul, Devin E Eckhoff, and Rakesh P Patel
- Subjects
Medicine ,Science - Abstract
Decreases in endothelial nitric oxide synthase derived nitric oxide (NO) production during liver transplantation promotes injury. We hypothesized that preemptive inhaled NO (iNO) would improve allograft function (primary) and reduce complications post-transplantation (secondary). Patients at two university centers (Center A and B) were randomized to receive placebo (n = 20/center) or iNO (80 ppm, n = 20/center) during the operative phase of liver transplantation. Data were analyzed at set intervals for up to 9-months post-transplantation and compared between groups. Patient characteristics and outcomes were examined with the Mann-Whitney U test, Student t-test, logistic regression, repeated measures ANOVA, and Cox proportional hazards models. Combined and site stratified analyses were performed. MELD scores were significantly higher at Center B (22.5 vs. 19.5, p
- Published
- 2014
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