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Abstract Background Bone marrow toxicity in advanced prostate cancer patients who receive [177Lu]Lu-PSMA-617 is a well-known concern. In early stage patients; e.g. low volume metastatic hormone sensitive prostate cancer (mHSPC) patients, prevention of late bone marrow toxicity is even more crucial due to longer life expectancy. To date, bone marrow dosimetry is primarily performed using blood sampling. This method is time consuming and does not account for possible active bone marrow uptake. Therefore other methodologies are investigated. We calculated the bone marrow absorbed dose for [177Lu]Lu-PSMA-617 in mHSPC patients using SPECT/CT imaging and compared it to the blood sampling method as reference. Methods Eight mHSPC patients underwent two cycles (3 and 6 GBq) of [177Lu]Lu-PSMA-617 therapy. After each cycle, five time point (1 h, 1 day, 2 days, 3 days, 7 days) SPECT/CT was performed at kidney level. Bone marrow dosimetry was performed using commercial software by drawing ten 1.5 cm diameter spheres in the lowest ten vertebrae to determine the time-integrated activity. Simplified protocols using only 2 imaging time points and 3 vertebrae were also compared. Blood-based dosimetry was based on the blood sampling method according to the EANM guideline. Results Mean bone marrow absorbed dose was significantly different (p

ObjectiveAutomated speech recognition (ASR) systems have become increasingly sophisticated, accurate, and deployable on many digital devices, including on a smartphone. This pilot study aims to examine the speech recognition performance of ASR apps using audiological speech tests. In addition, we compare ASR speech recognition performance to normal hearing and hearing impaired listeners and evaluate if standard clinical audiological tests are a meaningful and quick measure of the performance of ASR apps.MethodsFour apps have been tested on a smartphone, respectively AVA, Earfy, Live Transcribe, and Speechy. The Dutch audiological speech tests performed were speech audiometry in quiet (Dutch CNC-test), Digits-in-Noise (DIN)-test with steady-state speech-shaped noise, sentences in quiet and in averaged long-term speech-shaped spectrum noise (Plomp-test). For comparison, the app's ability to transcribe a spoken dialogue (Dutch and English) was tested.ResultsAll apps scored at least 50% phonemes correct on the Dutch CNC-test for a conversational speech intensity level (65 dB SPL) and achieved 90–100% phoneme recognition at higher intensity levels. On the DIN-test, AVA and Live Transcribe had the lowest (best) signal-to-noise ratio +8 dB. The lowest signal-to-noise measured with the Plomp-test was +8 to 9 dB for Earfy (Android) and Live Transcribe (Android). Overall, the word error rate for the dialogue in English (19–34%) was lower (better) than for the Dutch dialogue (25–66%).ConclusionThe performance of the apps was limited on audiological tests that provide little linguistic context or use low signal to noise levels. For Dutch audiological speech tests in quiet, ASR apps performed similarly to a person with a moderate hearing loss. In noise, the ASR apps performed more poorly than most profoundly deaf people using a hearing aid or cochlear implant. Adding new performance metrics including the semantic difference as a function of SNR and reverberation time could help to monitor and further improve ASR performance.

Abstract Introduction In health services research, there is a special emphasis on the transition from adolescence into adulthood. During this transition period, adolescents change from pediatric to adult medical care. This process must be carefully structured, particularly when special medical care is required. Challenges and difficulties become apparent particularly in the case of rare diseases. This is increasingly so when the rare disease affects the adolescence-specific development of patients, such as Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), also known as Müllerian agenesis. Methods A systematic literature review identified the care requirements of girls and young women with MRKHS, as well as studies of medical care during the adolescent transition period for various other diseases. This investigation was carried out in the years 2012 and 2013, and was updated in 2014/2015. In addition, the reference lists of the identified studies were reviewed. Results Nine publications on MRKHS and ten publications on the transition from adolescence to adulthood were included. Medical care requirements and measures were identified for the following areas: diagnosis during adolescence and organization of medical care, reactions to the diagnosis, functional infertility, psychological stress and threat to self-image, contact with others, and dealing with MRKHS coping strategies. Discussion There is still a great demand for research in the area of care during the transition period from adolescence into adulthood, particularly for rare diseases. The recommendations for treating MRKHS patients derived from the literature should be implemented and evaluated with regard to their effectiveness.