Search

Abstract Background Follicular dendritic cell sarcoma is a rare stromal tumor with no standard treatment. However, some reports have revealed that follicular dendritic cell sarcoma has an inflammatory pseudotumor variant associated with Epstein–Barr virus infection that has a relatively good prognosis. In this report, we present a case of a resected inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver, and have reviewed the literature on the clinicopathological, molecular, and genomic features of this tumor. Case presentation The inflammatory pseudotumor variant of follicular dendritic cell sarcoma originates only in the liver or spleen, causes no symptoms, and is more common in middle-aged Asian women. It has no characteristic imaging features, which partially explains why the inflammatory pseudotumor variant of follicular dendritic cell sarcoma is difficult to diagnose. Pathologically, the inflammatory pseudotumor variant of follicular dendritic cell sarcoma has spindle cells mixed with inflammatory cells and is variably positive for follicular dendritic cell markers (CD21, CD23, and CD35) and Epstein–Barr virus-encoded RNA. On genetic analysis, patients with this tumor high levels of latent membrane protein 1 gene expression and extremely low levels of host C–X–C Chemokine Receptor type 7 gene expression, indicating that the inflammatory pseudotumor variant of follicular dendritic cell sarcoma has a latent Epstein–Barr virus type 2 infection. Conclusions The inflammatory pseudotumor variant of follicular dendritic cell sarcoma is an Epstein–Barr virus-associated tumor and a favorable prognosis by surgical resection, similar to Epstein–Barr virus-associated gastric cancer. more...

Coseismic avalanches and rockfalls, as well as their simultaneous air blast and muddy flow, which were induced by the 2015 Gorkha earthquake in Nepal, destroyed the village of Langtang. In order to reveal volume and structure of the deposit covering the village, as well as sequence of the multiple events, we conducted an intensive in situ observation in October 2015. Multitemporal digital elevation models created from photographs taken by helicopter and unmanned aerial vehicles reveal that the deposit volumes of the primary and succeeding events were 6.81 ± 1.54 × 106 and 0.84 ± 0.92 × 106 m3, respectively. Visual investigations of the deposit and witness statements of villagers suggest that the primary event was an avalanche composed mostly of snow, while the collapsed glacier ice could not be dominant source for the total mass. Succeeding events were multiple rockfalls which may have been triggered by aftershocks. From the initial deposit volume and the area of the upper catchment, we estimate an average snow depth of 1.82 ± 0.46 m in the source area. This is consistent with anomalously large snow depths (1.28–1.52 m) observed at a neighboring glacier (4800–5100 m a.s.l.), which accumulated over the course of four major snowfall events between October 2014 and the earthquake on 25 April 2015. Considering long-term observational data, probability density functions, and elevation gradients of precipitation, we conclude that this anomalous winter snow was an extreme event with a return interval of at least 100 years. The anomalous winter snowfall may have amplified the disastrous effects induced by the 2015 Gorkha earthquake in Nepal. more...