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Background and aim: The effects of tamoxifen on the serum levels of hormones and acute phase reactants have been studied previously, but study results have been inconsistent, especially in women with breast cancer. Hence, we conducted this meta-analysis of randomized controlled trials (RCTs) to try to clarify the effects of tamoxifen on estradiol, insulin-like growth factor 1 (IGF-1), sex hormone binding globulin (SHBG), and C-reactive protein (CRP) serum levels in women with breast cancer or at risk of developing breast cancer. Methods: Databases were systematically searched up to December 2023. The meta-analysis was generated through a random-effects model and is presented as the weighted mean difference (WMD) and 95 % confidence intervals (CI). Results: Nine publications were included in the present meta-analysis. The comprehensive findings from the random-effects model revealed an elevation in estradiol (WMD: 13.04 pg/mL, 95 % CI: 0.79, 25.30, p = 0.037) and SHBG levels (WMD: 21.26 nmol/l, 95 % CI: 14.85, 27.68, p = 0.000), as well as a reduction in IGF-1 (WMD: −14.41 μg/L, 95 % CI: −24.23, −4.60, p = 0.004) and CRP concentrations (WMD: −1.17 mg/dL, 95 % CI: −2.29, −0.05, p = 0.039) following treatment with tamoxifen in women with breast cancer or at risk of developing breast cancer, with no impact on IGFBP-3 levels (WMD: 0.11 μg/mL, 95 % CI: −0.07, 0.30, p = 0.240). Conclusion: Tamoxifen administration seems to increase estradiol and SHBG levels and reduce CRP and IGF-1 levels in women with breast cancer or at risk of developing breast cancer. Further studies are needed to determine whether these changes have any clinical relevance.

Inconsistencies are evident within the literature regarding the effect of cocoa consumption on anthropometric outcomes. To address the influence of cocoa consumption on weight, body mass index (BMI), and waist circumference (WC) in overweight and obese subjects we conducted a time and dose–response meta-analysis of randomized controlled trials (RCTs). Scopus, Web of Science, Embase, and PubMed/Medline were searched for relevant articles from inception until July 11, 2023. The random effects method meta-analysis compared changes in anthropometric outcomes in participants Results are displayed as weighted mean difference (WMD) with 95 % confidence interval (CI). 19 RCTs were included in the present meta-analysis. Cocoa consumption significantly decreased body weight (WMD: −0.26 kg, 95 % CI: −0.49 to −0.02, P = 0.028), BMI (WMD: −0.16 kg/m2, 95 % CI: −0.30 to −0.02, P = 0.021), and WC (WMD: −0.69 cm, 95 % CI: −1.35 to −0.03, p = 0.038). In subgroup analyses, cocoa consumption resulted in lowered body weight in dosages ≤20 g/day (WMD: −0.33 kg), and treatment duration ˃4 weeks (WMD: −0.35 kg). In the non-linear dose–response assessment, a negative correlation was found between cocoa consumption dose (up to 50 g/day) and changes in WC (P = 0.001) and body weight (P = 0.0007). Cocoa consumption is associated with a reduction in BMI, weight, and WC in overweight and obese subjects; however, statistically significant effects were only detected in doses less than 20 g/day and interventions longer than 4 weeks.

BackgroundMore than half of patients with irritable bowel syndrome (IBS) report aggravating their symptoms with certain foods. Currently, Low fermentable oligo-, di-, and monosaccharides and polyols diet (LFD) is the most accepted dietary intervention for IBS. Recent randomized controlled trials (RCTs) have been suggested that gluten restriction may reduce the symptoms of patients with IBS. However, the results from these studies are conflicting. This study filled this knowledge gap by evaluating the impact of the gluten-free diet (GFD) on IBS symptoms.MethodsA systematic search was carried out in Pubmed/Medline, Cochrane CENTRAL, Scopus, and Web of Science up to April 2023. A random-effect model was applied to estimate the standardized mean difference (SMD) and 95% confidence interval (95% CI) for each outcome.ResultsA total of nine controlled trials were included in the meta-analysis. In contrast to gluten-containing diet, GFD was unable to reduce overall symptoms (SMD − 0.31; 95% CI −0.92, 0.31), bloating (SMD −0.37; 95% CI −1.03, 0.30), and quality of life (SMD −0.12, 95% CI −0.64, 0.39); but had a slight trend to reduce abdominal pain (SMD –0.68; 95% CI −1.36, −0.00). Also, LFD significantly reduced the IBS-Severity score system (SMD 0.66, 95% CI 0.31, 1.01) and improved quality of life (SMD −0.36, 95% CI −0.70, −0.01), compared to GFD.ConclusionA GFD is not robust enough to be routinely recommended for IBS patients, and its efficacy is significantly lower than that of an LFD. Only a certain subgroup of IBS patients may benefit from GFD; further studies are needed to target this subgroup.

ObjectiveManaging dietary glycemic index (GI) deserves further attention in the interplay between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). This study aimed to evaluate the relationship between dietary GI and the odds of NAFLD in patients with T2DM.MethodsA cross-sectional study was carried out between April 2021 and February 2022, including 200 participants with T2DM aged 18-70 years, of which 133 had NAFLD and 67 were in the non-NAFLD group. Cardiometabolic parameters were analyzed using standard biochemical kits and dietary intake was assessed using a validated food frequency questionnaire. Binary logistic regression was applied to explore odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD according to tertiles of dietary GI.ResultsHighest vs. lowest tertile (< 57 vs. > 60.89) of energy-adjusted GI was not associated with the odds of having NAFLD (OR 1.25, 95% CI = 0.6-2.57; P-trend = 0.54) in the crude model. However, there was an OR of 3.24 (95% CI = 1.03-10.15) accompanied by a significant trend (P-trend = 0.04) after full control for potential confounders (age, gender, smoking status, duration of diabetes, physical activity, waist circumference, HbA1c, triglycerides, total cholesterol, dietary intake of total carbohydrates, simple carbohydrates, fat, and protein).ConclusionHigh dietary GI is associated with increased odds of NAFLD in subjects with T2DM. However, interventional and longitudinal cohort studies are required to confirm these findings.

Up to the present date, according to the official reports of the World Health Organization (WHO), 205,338,159 patients have been confirmed with the coronavirus disease (COVID-19) and 4,333,094 have died as a consequence of this infectious disorder. The majority of COVID-19 patients will develop hematological, biochemical, immunological, hormonal and other complex alterations of their laboratory data which may be diagnosed using different biomarkers. In this paper, we review the alterations of the hematology, immunology, biochemistry, hormonal and other laboratory panels discovered in the subjects diagnosed with SARS-CoV-2 infection, based on the available data in the literature.

Abstract The ESR1 rs9340799 polymorphism has been frequently investigated with regard to its association with breast cancer (BC) susceptibility, but the findings have been inconclusive. In this work, we aimed to address the inconsistencies in study findings by performing a systematic review and meta-analysis. Eligible studies were identified from the Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, VIP and Wanfang databases based on the predefined inclusion and exclusion criteria. The pooled odds ratio (OR) was then calculated under five genetic models: homozygous (GG vs. AA), heterozygous (AG vs. AA), dominant (AG + GG vs. AA), recessive (GG vs. AA + AG) and allele (G vs. A). Combined results from 23 studies involving 34,721 subjects indicated a lack of significant association between the polymorphism and BC susceptibility (homozygous model, OR = 1.045, 95% CI 0.887–1.231, P = 0.601; heterozygous model, OR = 0.941, 95% CI 0.861–1.030, P = 0.186; dominant model, OR = 0.957, 95% CI 0.875–1.045, P = 0.327; recessive model, OR = 1.053, 95% CI 0.908–1.222, P = 0.495; allele model, OR = 0.987, 95% CI 0.919–1.059, P = 0.709). Subgroup analyses by ethnicity, menopausal status and study quality also revealed no statistically significant association (P > 0.05). In conclusion, our results showed that the ESR1 rs9340799 polymorphism was not associated with BC susceptibility, suggesting its limited potential as a genetic marker for BC.

The effect of supplementation with zinc on levels of IGF-1 remains relatively unexplored, and many of previous studies have reported equivocal findings. Thus, the aim of this study was to elucidate the influence of zinc on IGF-1. A complete systematic search was executed in Scopus, Web of Science, Embase, and PubMed/MEDLINE, by reviewers, from database inception until June 2019. Weighted mean difference (WMD) with the 95% CI was used for assessing the effects of zinc on IGF-1. We evaluated between study heterogeneity using the I-squared and the Q-test statistic. Ten studies reported changes in plasma levels of IGF-1. Combined results ascertained an increase in IGF-1 levels following zinc administration (WMD: 8.620 ng/ml, 95% CI: 1.126, 16.113, I2 = 97.3%). Subgroup analyses demonstrated that zinc intake dosage ≤10 mg/day (WMD: 9.50 ng/ml, 95% CI: 1.47, 17.53) and intervention length ˃8 weeks (WMD: 10.08 ng/ml, 95% CI: 0.67, 19.48) significantly greater increased IGF-1 levels. The present study demonstrated that zinc supplementation can elicit significant increases in IGF-1 in humans. In addition, greater increments were observed when zinc intake dosage was ≤10 mg/day and intervention duration ˃8 weeks. Keywords: Zinc, IGF-1, Humans, Meta-analysis

Background The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P0.05). Conclusion We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

BackgroundThe XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency.MethodsStudies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704).ResultsOverall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081-1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140-1.493, P0.05).ConclusionWe demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

Background. An unanswered question in the field of nutrition is whether there is an association between vitamin D intake and the lipid profile in adults. We conducted this cross-sectional study in order to investigate the impact of vitamin D intake on the lipid profile of adults in the context of the 2017–2018 National Health and Nutrition Examination Survey (NHANES). Methods. Serum lipids and high-sensitivity C-reactive protein (hs-CRP) concentrations and the Vitamin D intake in 2588 people aged 19 to 70 years was collected using laboratory analysis and 24-h recall, respectively. The one-way ANOVA test was used to compare quantitative variables and the chi-squared test was used to compare qualitative ones. Multivariate logistic regression for three models was performed to assess the odds ratio (OR) of high total cholesterol (TC) (>200 mg/dL), triglycerides (TG) (>150 mg/dL), low-density lipoprotein cholesterol (LDL-C) (>115 mg/dL), high-density lipoprotein cholesterol (HDL-C) (1 mg/l) based on the tertiles of dietary vitamin D (D2 + D3) intake. Results. After adjusting for age, sex, race, body mass index, serum 25-hydroxyvitamin D2, alcohol intake, energy intake, protein intake, carbohydrate intake, fiber intake and fat intake, individuals in the tertile with the highest versus lowest vitamin D intake (>1 mcg/day vs. Conclusions. Our cross-sectional study indicates that higher dietary vitamin D (D2 + D3) intake is associated with lower TC, LDL-C and hs-CRP levels. No relationship between dietary vitamin D intake and TG or HDL-C values was detected. Further large-scale randomized trials are needed to evaluate the actual association between dietary vitamin D intake and the lipid profile.

Introduction: Risk of diabetes mellitus type 2 (T2DM) is variable between individuals due to different metabolic phenotypes. In present network meta-analysis, we aimed to evaluate the risk of T2DM related with current definitions of metabolic health in different body mass index (BMI) categories. Methods: Relevant articles were collected by systematically searching PubMed and Scopus databases up to 20 March 2018 and for analyses we used a random-effects model. Nineteen prospective cohort studies were included in the analyses and metabolically healthy normal weight (MHNW) was considered as the reference group in direct comparison for calculating indirect comparisons in difference type of BMI categories. Results: Total of 199403 participants and 10388 cases from 19 cohort studies, were included in our network meta-analysis. Metabolically unhealthy obesity (MUHO) group poses highest risk for T2DM development with 10 times higher risk when is compared with MHNW (10.46 95% CI; 8.30, 13.18) and after that Metabolically unhealthy overweight (MUOW) individuals were at highest risk of T2DM with 7 times higher risk comparing with MHNW (7.25, 95% CI; 5.49, 9.57). Metabolically healthy overweight and obese (MHOW/MHO) individuals have (1.77, 95% CI; 1.33, 2.35) and (3.00, 95% CI; 2.33, 3.85) risk ratio for T2DM development in comparison with MHNW respectively. Conclusion: In conclusion we found that being classified as overweight and obese increased the risk of T2DM in comparison with normal weight. In addition, metabolically unhealthy (MUH) individuals are at higher risk of T2DM in all categories of BMI compared with metabolically healthy individuals.

High-fructose corn syrup (HFCS) has been speculated to have stronger negative metabolic effects than sucrose. However, given the current equivocality in the field, the aim of the present study was to determine the impact of HFCS use compared to sucrose on anthropometric and metabolic parameters. We searched PubMed, Scopus, Cochrane Central and web of sciences, from database inception to May 2022. A random effects model and the generic inverse variance method were applied to assess the overall effect size. Heterogeneity analysis was performed using the Cochran Q test and the I2 index. Four articles, with 9 arms, containing 767 participants were included in this meta-analysis. Average HFCS and sucrose usage equated to 19% of daily caloric intake. Combined data from three studies indicated that HFCS intake does not significantly change the weight (weighted mean difference (WMD): −0.29 kg, 95% CI: −1.34, 0.77, I2 = 0%) when compared to the sucrose group. Concordant results were found for waist circumstance, body mass index, fat mass, total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Moreover, overall results from three studies indicated a significant increase in CRP levels (WMD: 0.27 mg/l, 95% CI: 0.02, 0.52, I2 = 23%) in the HFCS group compared to sucrose. In conclusion, analysis of data from the literature suggests that HFCS consumption was associated with a higher level of CRP compared to sucrose, whilst no significant changes between the two sweeteners were evident in other anthropometric and metabolic parameters.

Although there is a consensus on beneficial effects of a low calorie diet in management of non-alcoholic fatty liver disease, the optimal composition of diet has not yet been elucidated. The aim of this review is to summarize the results of current randomized controlled trials evaluating the effects of low fat diet (LFD) vs. low carbohydrate diet (LCD) on NAFLD. This is a systematic review of all the available data reported in published clinical trials up to February 2022. The methodological quality of eligible studies was assessed, and data were presented aiming specific standard measurements. A total of 15 clinical trial studies were included in this systematic review. There is an overall lack of consensus on which dietary intervention is the most beneficial for NAFLD patients. There is also an overall lack of consensus on the definition of the different restrictive diets and the percentage of macronutrient restriction recommended. It seems that low calorie diets, regardless of their fat and carbohydrate composition, are efficient for liver enzyme reduction. Both LCD and LFD have similar effects on liver enzymes change; however, this improvement tends to be more marked in LFD. All calorie restrictive dietary interventions are beneficial for reducing weight, liver fat content and liver enzymes in individuals with NAFLD. Low fat diets seem to be markedly successful in reducing transaminase levels. Further research is needed to explore diet intensity, duration and long-term outcome.

Background and aimsDietary regimens are crucial in the management of non-alcoholic fatty liver disease (NAFLD). The effects of intermittent fasting (IF) have gained attention in this regard, but further research is warranted. Thus, we aimed to ascertain the overall effects of the 5:2 IF diet (5 days a week of normal food intake and 2 consecutive fasting days) in patients with NAFLD compared to a control group (usual diet).Methods and resultsA 12-week randomized controlled trial was performed to evaluate the effects of the 5:2 IF diet on anthropometric indices, body composition, liver indices, serum lipids, glucose metabolism, and inflammatory markers in patients with NAFLD. The IF group (n = 21) decreased body weight (86.65 ± 12.57–82.94 ± 11.60 kg), body mass index (30.42 ± 2.27–29.13 ± 1.95 kg/m2), waist circumference (103.52 ± 6.42–100.52 ± 5.64 cm), fat mass (26.64 ± 5.43–23.85 ± 5.85 kg), fibrosis (6.97 ± 1.94–5.58 ± 1.07 kPa), steatosis scores/CAP (313.09 ± 25.45–289.95 ± 22.36 dB/m), alanine aminotransferase (41.42 ± 20.98–28.38 ± 15.21 U/L), aspartate aminotransferase (34.19 ± 10.88–25.95 ± 7.26 U/L), triglycerides (171.23 ± 39.88–128.04 ± 34.88 mg/dl), high-sensitivity C-reactive protein (2.95 ± 0.62 −2.40 ± 0.64 mg/L), and cytokeratin-18 (1.32 ± 0.06–1.19 ± 0.05 ng/ml) values compared to the baseline and the end of the control group (n = 23)—p ≤ 0.05 were considered as significant. However, the intervention did not change the levels of high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, insulin, HOMA-IR, and total antioxidant capacity.ConclusionAdhering to the 5:2 IF diet can reduce weight loss and related parameters (fat mass and anthropometric indicators of obesity), as well as hepatic steatosis, liver enzymes, triglycerides, and inflammatory biomarkers in patients with NAFLD.

Objectives: Cherries are rich in polyphenols and anthocyanins and are believed to possess strong anti-inflammatory activity and cardio-protective effects. This study aim was to summarize the overall effect of sour cherry consumption on blood pressure and biomarkers associated with the inflammation. Methods: MEDLINE/PubMed, Cochrane, and Scopus were searched to find relevant papers up to April 2019. There were no time and language restrictions. This systematic review and meta-analysis was performed in accordance with the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Eleven studies with 275 participants were included in this meta-analysis. Mean dose of the sour cherry was 170 mL/day, whilst mean duration of interventions was six weeks. Combined the results using random-effects model showed significant reductions in diastolic blood pressure levels following sour cherry consumption (WMD: −2.32 mmHg, 95% CI: −4.45, −0.19, I2 = 39%), but there were no significant changes in systolic blood pressure (WMD: −2.64 mmHg, 95% CI: −5.84, 0.56, I2 = 33%), IL-6 levels (WMD: 0.12 pg/mL, 95% CI: −0.13, 0.36, I2 = 49%), hs-CRP (WMD: −0.13 mg/mL, 95% CI: −0.47, 0.22, I2 = 49%) or TNF-α (WMD: −0.07 pg/mL, 95% CI: −0.18, 0.05, I2 = 00%). Conclusion: Sour cherry supplementation results a decrease in diastolic blood pressure, but elicits no significant effect on systolic blood pressure, IL-6 levels, CRP levels and TNF-α. Keywords: Sour cherry, Blood pressure, Inflammation

Background and Objectives: Today, the criteria of social acceptance and success, have changed, which affect psychological health, including self-esteem. On the other hand, obesity and overweight have increased in recent decades, which have many effects on the incidence of physical and psychological diseases. This study was carried out with the aim of investigating the relationship between obesity, waist circumference, and body fat with self-esteem in young men. Methods: In this analytical cross-sectional study, 246 young men were randomly selected according to the inclusion criteria of the study. Demographic indicators were evaluated by a questionnaire, anthropometric measurements by introduced standards, and self-esteem by validated Rosenberg’s questionnaire with Cronbach's coefficient of 0.84. Data were analyzed by one-way analysis of variance, Chi-Square and multivariable logistic regression at a significance level of 0.05. Results: In this study, 47% of the subjects had moderate self-esteem. In the modified model, the relationship between waist circumference and self-esteem was inverse. The rate of low self-esteem in body mass index groups was significant after adjustment of known confounding factors, and subjects with higher body mass index were more at risk. Conclusion: Overall, according to the results of this study, the waist circumference, and body mass index have an inverse relationship with self-esteem. Therefore, prospective studies can further help to understand the physiological and psychological relationships of this phenomenon.

Background & Objective: There are few studies that have been examined the association between dietary acid load and healthy diet patterns. The purpose of this study was to evaluate the association between dietary acid load with alternative Mediterranean diet score (aMED) and dietary approaches to stop hypertension (DASH). Matrrials & Methodes: This cross-sectional study was conducted among 270 women with age range 20-50 years in Tehran, Iran. Usual dietary intakes were assessed by a semi-quantitative food frequency questionnaire, which contains 168 food items. Potential renal acid load (PRAL) and Net Endogenous Acid Production (NEAP) and Dietary acid load (DAL) was calculated for each person. The scores of aMED and DASH were estimated for participants. Results: The mean ± SD of age was 32.64 ±8.44 years. AMED scores were significant difference among the PRAL, NEAP and DAL tertiles (P

Background: Trying to find a drug with more clinical efficacy in treating obesity is one of the priorities. The aim of this study was to evaluate the efficacy of orlistat, sibutramine, lorcaserin and metformin on weight loss in obese people. Methods: The databases of PubMed, Scopus, Google Scholar and Cochran Library were searched up to November 2016. In present study search strategy was performed by using selected keywords. Two independent investigators scanned and extracted the relevant data. The pairwise method was used to compare the difference between the mean difference weight loss for orlistat, sibutramine, lorcaserin and metformin in two direct methods (comparison of orlistat, sibutramine, lorcaserin and metformin with the control group) and non-direct (Compare orlistat, sibutramine, lorcaserin and metformin together). We assessed the quality of included trials using the quantitative 5-point Jadad scale. The heterogeneity across studies was assessed by using Cochrane’s Q and I2 tests. Publication bias was reported by means of funnel plots and Egger’s tests. Results: The present study performed on 36 clinical studies with a population of 3672. Our study results did show that sibutramine (mean difference -4.97 kg, 95% confidence interval -6.70 to -3.23), metformin (mean difference -4.45 kg, 95% confidence interval -9.27 to 0.38), orlistat (mean difference -2.37 kg, 95% confidence interval -3.45 to -1.30), lorcaserin (mean difference -2.36 kg, 95% confidence interval -4.58 to -0.15), respectively, had the most effect on weight loss compared with the placebo group. In addition, orlistat compared to lorcaserin (mean difference -0.01 kg, 95% confidence interval -2.47 to 2.45) resulted in more weight loss, but compared to metformin (mean difference 2.07 kg, 95% confidence interval -2.78 to 7.02) and sibutramine (mean difference 0.52 kg, 95% confidence interval -4.46 to 5.50) lead to less weight loss. Conclusion: The present study indicated that orlistat had a greater effect on weight loss compared with lorcaserin, and had lower effect on weight loss compared with sibutramine and metformin in apparently healthy obese individuals.

Background and Objectives: Increased dietary acid load lead to increase in risk of diabetes. The aim of this study was to investigate the association between dietary acid load with body composition and inflammatory biomarkers in patients with type 2 diabetes. Methods: In this descriptive cross-sectional study, the study population composed of 185 type 2 diabetic patients (with mean age of 51.62 years). The food frequency questionnaire (containing 147 food items), was completed to assess dietary intake. Then, acid load indices of potential renal acid load (PRAL) and Net Endogenous Acid Production (NEAP), was calculated for each person. Inflammatory factors (C-reactive protein, interleukin-6, and TNF-α), and anthropometric factors (weight, height, waist circumference, and body fat percentage), were measured. Data were analyzed by linear regression, Pearson, and covariance tests. Results: Among the variables, the total body fat percentage (β=0.190, p=0.042) and inflammatory factor TNF-α (β=0.167, p=0.031) had a positive and significant correlation with PRAL acid load index. Among tertiles of dietary acid load, only total body fat and TNF-a, were significantly different among the PRAL tertiles, so that the total body fat percentage and TNF-a inflammatory factor, were higher in 2nd and 3rd tertile, respectively, and this relationship remained significant after adjusting for the confounders (p=0.038, p=0.032, respectively). Conclusion: The findings of the present study showed that the PRAL index has a positive correlation with increased body fat and TNF-α.

Background and Objectives: Obesity is a worrying problem in the present age and is the cause of many chronic non-communicable diseases. Several nutritional and non-nutritional factors are involved in the emergence of this health crisis. One of the important nutritional factors is the quality of nutrition. In this study, the relationship of the Alternative Healthy Eating Index (AHEI-2010) in relation to obesity, vitamin D3, and CRP, was investigated in the elderly. Methods: This descriptive-analytic (cross-sectional) study, was performed on 190 older adults referred to health centers of Tehran University of Medical Sciences using cluster sampling. Food intake was measured by Food Frequency Questionnaire. The level of vitamin D and hs-CRP were calculated in fasting blood, and variables of weight, height, and waist circumference, were measured .In the final analysis with logistic regression, confounding factors, were adjusted and p

Background: Anxiety is a common psychological disorder that impacts on the quality of life. In recent decades, anxiety has increased, as well as obesity especially among young people. The aim of this study is to investigate the relationship between general and central obesity with anxiety among Iranian young men. Methods: This cross-sectional study was conducted in 2016 on 246 men who were selected through cluster sampling according to the inclusion criteria. Anthropometric measurements were performed according to the standard procedure. Anxiety was assessed by DASS questionnaires with Cronbach's coefficient 0.78. In the final analysis, confounding factors were controlled and P < 0.05 was considered statistically significant. Results: In this study, 27% of the population had extreme anxiety and 29% had moderate anxiety. In the adjusted model, there was an inverse relationship between anxiety and central obesity (OR = 0.25, 95% CI: 0.07-0.85, P-trend < 0.01), as well as total body fat. The odds ratio of anxiety based on body mass index groups was not significant. Conclusions: Overall central obesity and total body fat have an inverse relationship with anxiety. Prospective studies are required to confirm these associations in young populations.