Search

Cél: Szekunder elemzés révén a szervezett bűnözés 21. századi formájának megismerése és az ellene irányuló fellépés lehetséges eszközeinek a feltérképezése. Vajon elégségesnek bizonyul-e a (büntető)jogi szabályozás és a bűnüldözés eszköztára, vagy más módszerek és lehetőségek irányába kell haladnunk és bővítenünk. Módszertan: A tanulmányban az analízis és szintézis duális egységének, valamint a forráskritikának az alkalmazása valósul meg. Mindezt kiegészíti a felhasznált jelentésekben szereplő adatok további elemzése és értékelése, amely szekunder kutatásnak felel meg. Megállapítások: A 21. században a szervezett bűnözés jellege, csoportdinamizmusa és a hozzá kapcsolódó jellegzetességek megváltoztak. A szerző álláspontja szerint egy eszközzel – mint például a (büntető)jogi szabályozással, vagy például hatékonyabb bűnüldöző technikákkal stb. – nem lehet ellene fellépni. Megoldási alternatívaként a teljes ellehetetlenítés stratégiája szolgálhat, amelynek részleteiről a tanulmányban levont következtetések alapján olvashatunk. Érték: A dolgozat értéke kimutatható a szervezett bűnözés jelenségének feltérképezésére irányuló kutatómunkából, a primer és szekunder adatok elemzéséből és értékeléséből, a következtetések levonásából, valamint a javaslatok megfogalmazásából.

Background: Identification of predictors for atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) can lead to better long-term results. Our aim was to investigate the association between novel CT imaging markers reflecting the severity of coronary atherosclerosis and the risk of recurrence following PVI. Methods: This study included 80 patients with paroxysmal/persistent AF who underwent PVI. The patients were divided into two groups: Group 1–23 patients with recurrence and Group 2–57 patients without recurrence. Results: Patients with recurrence presented with a more enlarged left atrial diameter and reduced left ventricle EF, as assessed by echocardiography. Elevated calcium scores and right coronary artery (RCA) stenosis were correlated with a higher risk of AF recurrence (25.38 ± 4.1% vs. 9.76 ± 2.32%, p = 0.001). Patients with AF recurrence presented a higher left atrial volume index (LAVI) (61.38 ± 11.12 mm3/m2 vs. 46.34 ± 12.27 mm3/m2, p < 0.0001). The bi-atrial volume index (BAVI) was similarly higher in the AF recurrence group (98.23 ± 14.44 mm3/m2 vs. 76.48 ± 17.61 mm3/m2, p < 0.0001). Increased EAT volumes located around the LA (EAT-LA) were correlated with recurrence (25.55 ± 6.37 vs. 15.54 ± 8.44, p < 0.0001). Conclusions: RCA stenosis, together with atrial volumes and EAT-AS evaluated by CCTA, is associated with the risk of AF recurrence following PVI.

Inflammation is a key factor in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. COVID-19 infection is known to cause systemic inflammation, but its impact on local plaque vulnerability is unclear. Our study aimed to investigate the impact of COVID-19 infection on coronary artery disease (CAD) in patients who underwent computed tomography angiography (CCTA) for chest pain in the early stages after infection, using an AI-powered solution called CaRi-Heart®. The study included 158 patients (mean age was 61.63 ± 10.14 years) with angina and low to intermediate clinical likelihood of CAD, with 75 having a previous COVID-19 infection and 83 without infection. The results showed that patients who had a previous COVID-19 infection had higher levels of pericoronary inflammation than those who did not have a COVID-19 infection, suggesting that COVID-19 may increase the risk of coronary plaque destabilization. This study highlights the potential long-term impact of COVID-19 on cardiovascular health, and the importance of monitoring and managing cardiovascular risk factors in patients recovering from COVID-19 infection. The AI-powered CaRi-Heart® technology may offer a non-invasive way to detect coronary artery inflammation and plaque instability in patients with COVID-19.

Cél: A Lewin és kutatótársai által alkotott vezetési stílusok rendészeti szervekben gyakorolt hatásának vizsgálata, amit a szervezetben szolgálatot ellátó, élettapasztalattal és szakmai életúttal rendelkező, kiforrott személyiségek véleménye is formálhat, új megvilágításban tüntethet fel. Módszertan: A kutatást kvantitatív metódus felhasználásával hajtottuk végre, a résztvevők online elérhető kérdőíveket töltöttek ki, amelyeket matematikai statisztikai próbáknak vetettünk alá. Megállapítások: A vezetési stílusokról, a vezető személyéről, az azokhoz köthető attribútumokról reális képet sikerült felállítanunk, egy olyan torzításmentes kép tárult elénk, amely új tudományos eredmények létrejöttét generálta a vezetéstudomány területén. Érték: A rendészettudomány tudásbázisának bővítése, a vezetés- és szervezéstudomány új kutatási eredményeinek szervezeti szinten történő hasznosítása a rendvédelemben. Lewin az elméletét 1938-ban a iowai Gyermekjóléti Kutatási Központban tízéves gyermekek körében végzett kísérlet eredményeképpen fogalmazta meg. Közel 80 év elteltével ennek aktualitását mind az egyén és mind a szervezetek vonatkozásában a társadalmi átalakulási folyamatok jelentős mértékben befolyásolták. Minderre figyelemmel az elmélet újragondolását a horizontálisan és vertikálisan felépülő (szervezeti és szakmai) rendészeti szervek vezetése vonatkozásában is indokolt megvizsgálni, amit a szervezetben szolgálatot ellátó, élettapasztalattal és szakmai életúttal rendelkező, kiforrott személyiségek véleménye is formálhat, új megvilágításban tüntethet fel.

Because it is impossible to comprehensively characterize biodiversity at all levels of organization, conservation prioritization efforts need to rely on surrogates. As species distribution maps of relished groups as well as high-resolution remotely sensed data increasingly become available, both types of surrogates are commonly used. A good surrogate should represent as much of biodiversity as possible, but it often remains unclear to what extent this is the case. Here, we aimed to address this question by assessing how well bird species and habitat diversity represent one another. We conducted our study in Romania, a species-rich country with high landscape heterogeneity where bird species distribution data have only recently started to become available. First, we prioritized areas for conservation based on either 137 breeding bird species or 36 habitat classes, and then evaluated their reciprocal surrogacy performance. Second, we examined how well these features are represented in already existing protected areas. Finally, we identified target regions of high conservation value for the potential expansion of the current network of reserves (as planned under the new EU Biodiversity Strategy for 2030). We found a limited reciprocal surrogacy performance, with bird species performing slightly better as a conservation surrogate for habitat diversity than vice versa. We could also show that areas with a high conservation value based on habitat diversity were represented better in already existing protected areas than areas based on bird species, which varied considerably between species. Our results highlight that taxonomic and environmental (i.e., habitat types) data may perform rather poorly as reciprocal surrogates, and multiple sources of data are required for a full evaluation of protected areas expansion.

Abstract Although many different mechanisms for subduction initiation have been proposed, only few of them are viable in terms of consistency with observations and reproducibility in numerical experiments. In particular, it has recently been demonstrated that intra‐oceanic subduction triggered by an upwelling mantle plume could greatly contribute to the onset and operation of plate tectonics in the early and, to a lesser degree, modern Earth. On the contrary, the initiation of intra‐continental subduction still remains underappreciated. Here we provide an overview of 1) observational evidence for upwelling of hot mantle material flanked by downgoing proto‐slabs of sinking continental mantle lithosphere, and 2) previously published and new numerical models of plume‐induced subduction initiation. Numerical modeling shows that under the condition of a sufficiently thick (>100 km) continental plate, incipient downthrusting at the level of the lowermost lithospheric mantle can be triggered by plume anomalies of moderate temperatures and without significant strain‐ and/or melt‐related weakening of overlying rocks. This finding is in contrast with the requirements for plume‐induced subduction initiation within oceanic or thinner continental lithosphere. As a result, plume‐lithosphere interactions within continental interiors of Paleozoic‐Proterozoic‐(Archean) platforms are the least demanding (and thus potentially very common) mechanism for initiation of subduction‐like foundering in the Phanerozoic Earth. Our findings are supported by a growing body of new geophysical data collected in various intra‐continental areas. A better understanding of the role of intra‐continental mantle downthrusting and foundering in global plate tectonics and, particularly, in the initiation of “classic” ocean‐continent subduction will benefit from more detailed follow‐up investigations.

Introduction: Autologous native arteriovenous fistula (AVF) created in the non-dominant arm is the gold standard vascular access for dialysis in end-stage renal disease, but the post-surgical vascular access dysfunction causes a reduction in the patient’s quality of life. Creating a functional upper extremity permanent arteriovenous access is limited by the upper limb’s vascular resources, so good management of a complicated arteriovenous fistula may improve patient outcomes. This article highlights the importance of new surgical options in treating complicated AVFs. Case report: We present the case of a patient with a 17-year-old complex radio-cephalic arterio-venous fistula and a series of surgical interventions performed for life salvage in the first place and functional vascular access in the second place. Furthermore, we describe a successfully created uncommon type of fistula in the lower extremity between the great saphenous vein and the anterior tibial artery as the last possible access for hemodialysis in this patient. Results: The patient underwent the first successful dialysis using the newly created lower limb fistula 1 month after the surgery. Conclusion: Applying new surgical techniques to manage AVFs gives a unique chance to improve the quality of life and reduce morbidity and mortality in these patients.

A dolgozat a magyar mobilszolgáltatások áraival kapcsolatos kérdéseket vizsgálja. Számba veszi a mérést akadályozó legfontosabb nehézségeket, melyek lényeges dilemma elé állítják a kutatót. Vagy megpróbálunk egy aggregált mutatót konstruálni, amely a korábbi adatokra épül és inkább a múltbeli, illetve jelenbeli helyzetet jellemzi – feláldozva ezzel az előrejelzés lehetőségét –, vagy megkerülendő a nehézségeket elméleti modellt alkalmazunk az árak jövőbeni felvázolására. E probléma érzékeltetésére két, a gyakorlatban alkalmazott mutatót és azok hiányosságait ismerteti a szerző, majd a jól ismert Bertrand-modell helytállóságát igazolja. A modell eredménye az árverseny, melynek alátámasztására empirikus tényeket sorakoztat fel a szerző. Journal of Economic Literature (JEL) kód: D21, D43, L13

Pharmaceutical compounding enables the preparation of unlicensed medicine to meet specific patient needs that do not have a licensed medicine available on the market. It must be performed in the best possible circumstance by certified pharmacists using validated standard operating procedures to obtain the highest quality medicinal product. The various spinning techniques provide drug delivery systems easily adapted to individual patient’s needs among the emerging technologies. The primary purpose of the present work was to introduce the prototype of a contact drawing device for the compounding of drug delivery systems for individual in-patient needs. The preliminary experiments resulted in oriented fibers of micrometer diameter range. The device can be placed in controlled conditions and could provide drug-loaded fibrous sheets for further treatments assuring the individual patient’s medicine need of the required quality.

A tanulmány a prostituáltak egészségügyi szűréséről szóló rendeleteket, valamint kiskönyveket vizsgálja egy olyan összehasonlító elemzés vonatkozásában, amely az 1853-as győri, valamint a hatályos igazolásra terjed ki.

A dolgozatunk során egy gyártócella megvalósításával foglalkoztunk. Ehhez a FESTO MPS moduljait használtuk fel. A gyártócella vezérlése PLC-vel történik. Nem csak az egyedi elrendezést és munkafolyamatot valósítottunk meg, hanem új funkciókkal is bővítettük a rendszert. Ez két vezérlő egység használatát jelenti, amelyből egy a folyamat irányításáért felel, míg a másik egy webes felületet kezel. A webes felületen láthatjuk az elkészült munkadarabokat tartalmazó raktárt, és különböző munkadarabokból összeállított palettákat rendelhetünk onnan, vagy a raktározásra kerülő munkadarabok típusát és mennyiségét is beállíthatjuk a raktárban.

A szerző egy esettanulmány alapján áttekintést nyújt a hatékony bűnüldözési irányítási stratégiák követelményeiről.

This paper discusses how sectoral characteristics are reflected in the operation of Hungarian accredited innovation clusters. The purpose of this paper is to analyse how sectoral bonding affects the mission of the clusters as well as their innovation and market goals, the membership criteria of the management and the motivation of the members and their cooperation.The study uses a literature review and in-depth interviews to identify the interrelations and the differences between networks and clusters, and to observe several sectoral features in the Hungarian accredited innovation clusters.

Introduction: Premature ventricular complex (PVC) is the most common cardiac arrhythmia, which in some circumstances can lead to syncope, arrhythmia-induced cardiomyopathy and sudden death. In idiopathic PVCs, the first choice of treatment is radio-frequency ablation. Identification of the substrate location makes it possible to determine the ablation site, leading to an increased success rate. Complications are related mainly to the ablation technique, peri-procedural anticoagulation therapy, and the access site. Pericardial tamponade is a rare complication. A case in which the ablation procedure of idiopathic PVCs, complicated by cardiac tamponade, is presented in this paper.

A szerző áttekintést nyújt a személyforgalom visszaszorításáról szóló New York-i egyezmény végrehajtásáról, valamint a mások prostitúciójának kiaknázásáról Magyarországon.

This paper discusses how sectoral characteristics are reflected in the operation of Hungarian accredited innovation clusters. The purpose of this paper is to analyse how sectoral bonding affects the mission of the clusters as well as their innovation and market goals, the membership criteria of the management and the motivation of the members and their cooperation.The study uses a literature review and in-depth interviews to identify the interrelations and the differences between networks and clusters, and to observe several sectoral features in the Hungarian accredited innovation clusters.

A szerző áttekintést nyújt a Magyar Alkotmánybíróság 2011-es reglementációs prostitúcióval kapcsolatos döntéséről és annak tágabb vonatkozásairól.

A szerző áttekintést nyújt a prostitúcióval összefüggésben a rendőri korrupcióval kapcsolatos etikai és gyakorlati kérdésekről.

Understanding why host species differ so much in symbiont loads and how this depends on ecological host and symbiont traits is a major issue in the ecology of symbiosis. A first step in this inquiry is to know whether observed differences among host species are species-specific traits or more related with host-symbiont environmental conditions. Here we analysed the repeatability (R) of the intensity and the prevalence of feather mites to partition within- and among-host species variance components. We compiled the largest dataset so far available: 119 Paleartic passerine bird species, 75,944 individual birds, ca. 1.8 million mites, seven countries, 23 study years. Several analyses and approaches were made to estimate R and adjusted repeatability (R(adj)) after controlling for potential confounding factors (breeding period, weather, habitat, spatial autocorrelation and researcher identity). The prevalence of feather mites was moderately repeatable (R = 0.26-0.53; R(adj) = 0.32-0.57); smaller values were found for intensity (R = 0.19-0.30; R(adj )= 0.18-0.30). These moderate repeatabilities show that prevalence and intensity of feather mites differ among species, but also that the high variation within species leads to considerable overlap among bird species. Differences in the prevalence and intensity of feather mites within bird species were small among habitats, suggesting that local factors are playing a secondary role. However, effects of local climatic conditions were partially observed for intensity.

A tranzakciós költségek már korábban is felbukkantak a szabványosítással foglalkozó írásokban, ám ezek azt vizsgálták, hogy a szabványok alkalmazásával a tranzakciós költségek miként csökkenthetők. Jelen tanulmányban ezzel szemben arra világítok rá, hogy a tranzakciós költségek a szabványosítás során is megjelennek. Ha a szabvány megalkotását egy olyan tranzakcióként értelmezzük, amelynek során a résztvevő felek átadják egymásnak explicit és hallgatólagos tudásukat, akkor a tranzakciós költségek elméletének kereteiben elemezhetővé válik a szabványosítás folyamata. Mivel az egyének tudása specifikus eszköz – aminek az átadása is komoly tranzakciós költségekkel jár –, a szabványosítás során többféleképpen is megjelenhet az opportunizmus. A cikkben amellett érvelek, hogy a mobilpiaci szabványosítás elemezhető a Teece (1986) által felvázolt keretben, ami segít rámutatni, hogy a különböző esetekben milyen megoldással lehet a tranzakciós költségeket mérsékelni. Mindehhez a japán másodikgenerációs szabványosítás tapasztalatait hozom példaként, s ezen keresztül illusztrálom az elméleti rész megállapításait. Journal of Economic Literature (JEL) kód: D23, O31, L96

Voltage-gated proton current (I(Hv)) has been characterized in several cell types, but the majority of the data was collected in phagocytes, especially in human granulocytes. The prevailing view about the role of I(Hv) in phagocytes is that it is an essential supporter of the intense and sustained activity of Nox2 (the core enzyme of the phagocyte NADPH oxidase complex) during respiratory burst. Recently H(v)1, a voltage-gated proton channel, was cloned, and leukocytes from H(v)1 knockout mice display impaired respiratory burst. On the other hand, hardly anything is known about H(v)1 in human granulocytes. Using qPCR and a self made antibody, we detected a significant amount of H(v)1 in human eosinophil and neutrophil granulocytes and in PLB-985 leukemia cells. Using different crosslinking agents and detergents in reducing and non-reducing PAGE, significant expression of H(v)1 homodimers, but not that of higher-order multimers, could be detected in granulocytes. Results of subcellular fractionation and confocal imaging indicate that H(v)1 is resident in both plasmalemmal and granular membrane compartments of resting neutrophils. Furthermore, it is also demonstrated that H(v)1 accumulates in phagosome wall during zymosan engulfment together with, but independently of Nox2. During granulocytic differentiation early and parallel upregulation of H(v)1 and Nox2 expression was observed in PLB-985 cells. The upregulation of H(v)1 or Nox2 expression did not require the normal expression of the other molecule. Using RNA interference, we obtained strong correlation between H(v)1 expression and I(Hv) density in PLB-985 cells. It is also demonstrated that a massive reduction in H(v)1 expression can limit the Nox2 mediated superoxide production of PLB-985 granulocytes. In summary, beside monomers native H(v)1 forms stable proton channel dimer in resting and activated human granulocytes. The expression pattern of H(v)1 in granulocytes is optimized to support intense NADPH oxidase activity.

This paper presents a solution for full integration of a Type-II compensation circuit for DC-DC buck converters. It employs a novel active circuit based on capacitor multiplier, able to emulate the R-series-C ensemble within the conventional Gm-RC compensation network. The proposed solution was used to design a current-mode DC-DC buck converter for automotive applications. The implementation of key circuits in a 180 nm CMOS process is presented in some detail. Simulation results demonstrate that the converter meets all design requirements: it provides a 5 V output voltage over wide ranges of the input voltage, 6 V to 45 V, and load current, between 10 mA and 300 mA. Its frequency and transient responses compare well against the performance of a similar converter that employs a conventional Gm-RC compensation circuit. It consumes 20 $\mu \text{A}$ more, but requires significantly less die area, than its counterpart. Furthermore, the tuning required to compensate for process and temperature variations is realized by programming the multiplication factor of the capacitor multiplier.

Abstract Aim Migration is a constantly changing adaptation due to the climate condition evolution. The struggle for surviving during harsh winter season is different across Europe, being more complex toward the inner parts of the continent. The current approach explores the Common Buzzard number variation during the cold season and the climatic predictors of birds of prey wintering movements in relation to the possible influences of the Carpathian Mountains, which may act as a geographical barrier providing shelter from cold air outbreak from north and northeast of the continent. Location Romania (45°N25°E). Taxon Birds of Prey. Methods We applied a GLMM to investigate the relation between continental and local climatic factors with the number of Common Buzzard observations in two regions. The first region is located inside the Carpathian Arch and the other one outside, east of this large mountains chain. Results The Common Buzzard numbers wintering Eastern from the Carpathian Mountains are highly influenced by AO (Z = 2.87, p

‎‎Given a finite group $G$ and a subset $Ssubseteq G,$ the bi-Cayley graph $bcay(G,S)$ is the graph whose vertex‎ ‎set is $G times {0,1}$ and edge set is‎ ‎${ {(x,0),(s x,1)}‎ : ‎x in G‎, ‎sin S }$‎. ‎A bi-Cayley graph $bcay(G,S)$ is called a BCI-graph if for any bi-Cayley graph‎ ‎$bcay(G,T),$ $bcay(G,S) cong bcay(G,T)$ implies that $T = g S^alpha$ for some $g in G$ and $alpha in aut(G)$‎. ‎A group $G$ is called an $m$-BCI-group if all bi-Cayley graphs of $G$ of valency at most $m$ are BCI-graphs‎. ‎It was proved by Jin and Liu that‎, ‎if $G$ is a $3$-BCI-group‎, ‎then its Sylow $2$-subgroup is cyclic‎, ‎or elementary abelian‎, ‎or $Q$ [European J‎. ‎Combin‎. ‎31 (2010)‎ ‎1257--1264]‎, ‎and that a Sylow $p$-subgroup‎, ‎$p$ is an odd prime‎, ‎is homocyclic [Util‎. ‎Math‎. ‎86 (2011) 313--320]‎. ‎In this paper we show that the converse also holds in the‎ ‎case when $G$ is nilpotent‎, ‎and hence complete the classification of‎ ‎nilpotent $3$-BCI-groups‎.

The COVID-19 pandemic has had a major impact on cardiovascular emergencies. The aim of this study was to investigate the impact of the COVID-19 pandemic on a regional network for management of ST-segment elevation acute myocardial infarction (STEMI). Methods: We report a single center’s experience of patients hospitalized for ACS in a high-volume hub of a STEMI network during the lockdown (in the first pandemic trimester), compared with the same time interval of the previous year and including all consecutive patients referred for an AMI during the second trimester of 2020 (from April to June) or during the same time interval of the previous year, 2019. Results: The absolute number of hospital admissions for AMI decreased by 22.3%, while the non-AMI hospitalizations decreased by 77.14% in Q2-2020 compared to Q2-2019 (210 vs. 48, p < 0.0001). As a consequence, the percentage of AMI cases from the total number of hospital admission increased from 38% to 68% (p < 0.0001), AMI becoming the dominant pathology. In the STEMI group there was a significant reduction of 55% in the absolute number of late STEMI presentations. Functionality of the STEMI network at the hub level did not present a significant alteration with only a minor increase in the door-to-balloon time, from 34 min to 41 min. However, at the level of the network we recorded a lower number of critical cases transferred to the interventional center, with a dramatic reduction of 56.1% in the number of critical STEMI cases arriving in the acute cardiac care unit (17.0% vs. 7.3%, p-0.04 for KILLIP class III, and 21.17% vs. 11.11%, p = 0.08 for resuscitated out of hospital cardiac arrest). Conclusions: The COVID-19 outbreak did not have a major impact on the interventional center’s functionality, but it limited the capacity of the regional STEMI network to bring the critical patient with complicated STEMI to the cathlab in time during the first months of the lockdown. Even a very well-functioning STEMI network like the one in Central Romania had difficulties bringing the most critical STEMI cases to the cathlab in time.

The aim of the study was to develop a semi-automated, computer-aided imaging technique to quantify the amount and distribution of perivascular fat at the level of the iliac arteries (periiliac adipose tissue—PIAT), and to investigate the association of this new computer-aided imaging biomarker with other biomedical imaging biomarkers, which characterize the pelvic adipose tissue (SAT—subcutaneous adipose tissue; VAT—visceral adipose tissue). We included 34 patients with peripheral arterial disease, in whom the volumes of PIAT, SAT and VAT were quantified using a dedicated software, at the level of right and left iliac arteries. Median value of PIAT was five milliliters. Patients with PIAT > five milliliters were in more advanced Fontaine classes, with more complex arterial lesions, compared to those with low PIAT (p < 0.0001). PIAT volumes presented a gradual increase with the Trans-Atlantic Inter-Society Consensus (TASC) class (2.57 +/− 1.98 in TASC A, 4.65 +/− 1.63 in TASC B, 8.79 +/− 1.99 in TASC C and 13.77 +/− 2.74 in TASC D). The distribution of PIAT between the left and right iliac axis was quasi-uniform (correlation between right and left PIAT: r = 0.46, p = 0.005). Linear regression analysis showed that the mean PIAT volume was correlated with VAT (r = 0.38, p = 0.02), but not with the SAT at the level of iliac artery origin (r = 0.16, p = 0.34). PIAT may represent a novel biomedical imaging derived biomarker, which characterizes the distribution of adipose tissue in the pelvic area and may serve as an indicator of the severity and complexity of lower limb ischemia.

In 1996, Harris and Kadison posed the following problem: show that a linear bijection between C∗-algebras that preserves the identity and the set of invertible elements is a Jordan isomorphism. In this paper, we show that if A and B are semisimple Banach algebras and Φ:A→B is a linear map onto B that preserves the spectrum of elements, then Φ is a Jordan isomorphism if either A or B is a C∗-algebra of real rank zero. We also generalize a theorem of Russo.

β2-microglobulin (β2m), the light chain of the MHC-I complex, is associated with dialysis-related amyloidosis (DRA). Recently, a hereditary systemic amyloidosis was discovered, caused by a naturally occurring D76N β2m variant, which showed a structure remarkably similar to the wild-type (WT) protein, albeit with decreased thermodynamic stability and increased amyloidogenicity. Here, we investigated the role of the D76N mutation in the amyloid formation of β2m by point mutations affecting the Asp76-Lys41 ion-pair of WT β2m and the charge cluster on Asp38. Using a variety of biophysical techniques, we investigated the conformational stability and partial unfolding of the native state of the variants, as well as their amyloidogenic propensity and the stability of amyloid fibrils under various conditions. Furthermore, we studied the intermolecular interactions of WT and mutant proteins with various binding partners that might have in vivo relevance. We found that, relative to WT β2m, the exceptional amyloidogenicity of the pathogenic D76N β2m variant is realized by the deleterious synergy of diverse effects of destabilized native structure, higher sensitivity to negatively charged amphiphilic molecules (e.g., lipids) and polyphosphate, more effective fibril nucleation, higher conformational stability of fibrils, and elevated affinity for extracellular components, including extracellular matrix proteins.