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Abstract Background Natalizumab and fingolimod are used as high-efficacy treatments in relapsing–remitting multiple sclerosis. Several observational studies comparing these two drugs have shown variable results, using different methods to control treatment indication bias and manage censoring. The objective of this empirical study was to elucidate the impact of methods of causal inference on the results of comparative effectiveness studies. Methods Data from three observational multiple sclerosis registries (MSBase, the Danish MS Registry and French OFSEP registry) were combined. Four clinical outcomes were studied. Propensity scores were used to match or weigh the compared groups, allowing for estimating average treatment effect for treated or average treatment effect for the entire population. Analyses were conducted both in intention-to-treat and per-protocol frameworks. The impact of the positivity assumption was also assessed. Results Overall, 5,148 relapsing–remitting multiple sclerosis patients were included. In this well-powered sample, the 95% confidence intervals of the estimates overlapped widely. Propensity scores weighting and propensity scores matching procedures led to consistent results. Some differences were observed between average treatment effect for the entire population and average treatment effect for treated estimates. Intention-to-treat analyses were more conservative than per-protocol analyses. The most pronounced irregularities in outcomes and propensity scores were introduced by violation of the positivity assumption. Conclusions This applied study elucidates the influence of methodological decisions on the results of comparative effectiveness studies of treatments for multiple sclerosis. According to our results, there are no material differences between conclusions obtained with propensity scores matching or propensity scores weighting given that a study is sufficiently powered, models are correctly specified and positivity assumption is fulfilled.

The development of a sustainable wood energy chain is an essential part of ecological and energy transition in Reunion Island (Indian Ocean), where Acacia mearnsii is the main potential wood energy resource identified to date. In order to assess future wood biomass supply chain strategies, a major first issue is to gain knowledge of the spatial distribution of this species forest stands.In this study, we assessed the potential of very high spatial resolution multispectral imagery for mapping the main forest stands in a study area located the Western Highlands region, where Acacia mearnsii expands alongside Acacia heterophylla, an endemic forest species and Cryptomeria japonica, an exotic forest stand. A reference database including 150 samples of seven classes (Acacia mearnsii (mature and non-mature), Acacia heterophylla (mature and non-mature), Cryptomeria japonica, ‘herbaceous areas’, and ‘bare soils’) was used to classify a Pleiades image acquired in May 2020. Spectral and textural indices were used in an incremental classification procedure using a random classifier.The best results (Kappa = 0.84, global accuracy = 84%) were obtained for the classification using all spectral and textural bands. The resulting map enables analyzing the spatial distribution of the different forest stands.

As some of the most threatened ecosystems in the world, the declining condition and coverage of coastal habitats results in the loss of the myriad ecosystem services they provide. Due to the variability in physical and biological characteristics across sites, it is imperative to increase location-based information to inform local management projects, which will potentially help to reestablish functions of coastal habitats. Since oysters are often used in restoration projects, this study quantified spatial and temporal patterns in eastern oyster spat settlement in a bar-built estuary in northeast Florida, USA that is host to a robust population of intertidal oyster reefs. Spat settlement was found to occur from April to October with small peaks in the spring and large ones around September. Inter-annual differences in spat settlement were likely influenced by existing environmental conditions and heavily affected by large-scale events such as tropical cyclones. Variations in regional spat settlements are possibly driven by the residence times of the watersheds, the density of adult populations, and the location of the spat collectors. The results of this study illustrate place-based variability in oyster settlement patterns and underscore the importance of local monitoring for oyster resource management, restoration, and research.

Deep learning image processing models have had remarkable success in recent years in generating high quality images. Particularly, the Improved Denoising Diffusion Probabilistic Models (DDPM) have shown superiority in image quality to the state-of-the-art generative models, which motivated us to investigate their capability in the generation of the synthetic electrocardiogram (ECG) signals. In this work, synthetic ECG signals are generated by the Improved DDPM and by the Wasserstein GAN with Gradient Penalty (WGAN-GP) models and then compared. To this end, we devise a pipeline to utilize DDPM in its original $2D$ form. First, the $1D$ ECG time series data are embedded into the $2D$ space, for which we employed the Gramian Angular Summation/Difference Fields (GASF/GADF) as well as Markov Transition Fields (MTF) to generate three $2D$ matrices from each ECG time series, which when put together, form a 3-channel $2D$ datum. Then $2D$ DDPM is used to generate $2D~3$ -channel synthetic ECG images. The $1D$ ECG signals are created by de-embedding the $2D$ generated image files back into the $1D$ space. This work focuses on unconditional models and the generation of Normal Sinus Beat ECG signals exclusively, where the Normal Sinus Beat class from the MIT-BIH Arrhythmia dataset is used in the training phase. The quality, distribution, and the authenticity of the generated ECG signals by each model are quantitatively evaluated and compared. Our results show that in the proposed pipeline and in the particular setting of this paper, the WGAN-GP model is consistently superior to DDPM in all the considered metrics.

A great number of computer vision publications have focused on distinguishing between human action recognition and classification rather than the intensity of actions performed. Indexing the intensity which determines the performance of human actions is a challenging task due to the uncertainty and information deficiency that exists in the video inputs. To remedy this uncertainty, in this paper we coupled fuzzy logic rules with the neural-based action recognition model to rate the intensity of a human action as intense or mild. In our approach, we used a Spatio-Temporal LSTM to generate the weights of the fuzzy-logic model, and then demonstrate through experiments that indexing of the action intensity is possible. We analyzed the integrated model by applying it to videos of human actions with different action intensities and were able to achieve an accuracy of 89.16% on our intensity indexing generated dataset. The integrated model demonstrates the ability of a neuro-fuzzy inference module to effectively estimate the intensity index of human actions.