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Abstract Background Cancer burden from the elderly has been rising largely due to the aging population. However, research on the long‐term epidemiological trends in cancer of the elderly is lacking. Methods Registry data of this population‐based cross‐sectional study were from the Surveillance, Epidemiology, and End Results (SEER) database. The study population aged 65 years or more, from geographically distinct regions. Joinpoint regression and JP Surv method were used to analyze cancer trends and survival. Results Mortality rate during 1975–2020 decreased from 995.20 to 824.99 per 100,000 elderly persons, with an average annual decrease of 0.421% (95% CI, 0.378–0.464). While overall incidence increased with no significance. Prostate (29%) and breast (26%) cancer were the most common malignancies, respectively, in elderly males and females, and the mortality for both of the two (prostate 15%, breast 14%) ranked just behind lung and bronchus cancer, which had the highest mortality rates in males (29%) and females (23%). Many cancers showed adverse trends in the latest follow‐up periods (the last period calculated by the Joinpoint method). For intrahepatic cholangiocarcinoma, incidence (male Annual Percentage Change [APC] = 7.4*; female APC = 6.7*) and mortality (male APC = 3.0*; female APC = 3.3*) increased relatively fast, and its survival was also terrible (3‐year survival only 10%). Other cancers with recent increasing mortality included cancer of anus, anal canal and anorectum, retroperitoneum, pleura, peritoneum, etc. Most cancers had favorable trends of survival during the nearest follow‐up period. Conclusion Against the background of overall improvement, many cancers showed adverse trends. Further research for the underlying mechanisms and targeted implements towards adverse trends is also urgent.

Biogenic amines (BA) are the general term for a class of bioactive low-molecular mass organic compounds containing amino groups. Excessive intake of BA will cause adverse physiological reactions and even endanger life. This article presents a systematic review of the sources, biosynthetic mechanism, microbial traceability, detection technologies, and influential factors of BA in wine, as well as the strategies used to control BA during winemaking. This article will provide theoretical guidance for efficient analysis and control of BA in wine, which will in turn promote the healthy and green development of the Chinese wine industry.

WO3-ZrO2 solid acid catalysts were prepared by the impregnation method and characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), Brunauer-Emmett-Teller (BET), and pyridine adsorbed IR spectroscopy (Py-IR). The catalysts were used for catalytic deoxygenation of Jatropha curcas oil. The optimal conditions for the deoxygenation of the generated oil were obtained by response surface methodology based on Box-Behnken four-factor experiments. Response surface methodology (RSM) was applied while determining the optimal conditions for the Jatropha oil deoxygenation percentage. The rate was calculated based on Box-Behnken four-factor experiments, with reaction temperature, catalyst amount, reaction time, and reaction pressure as independent variables and the deoxygenation of Jatropha curcas oil as response values. The optimal reaction conditions obtained were a temperature of 370 °C, pressure of 2 MPa, time of 7 h, and catalyst amount of 0.22 g. The deoxygenation percentage of the generated oil under the optimal conditions was 95.1%, which was close to the theoretical value, indicating that the model was reliable. The generated oil contained more jet fuel components, with 68.1% C8-C16, 12.0% isoalkanes, 14.2% cycloalkanes, and 8.9% aromatic compounds under the optimum conditions. This study provides an effective and simple method for preparation of bio-aviation fuel.

WO3-ZrO2 solid acid catalysts were prepared by the impregnation method and characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), Brunauer-Emmett-Teller (BET), and pyridine adsorbed IR spectroscopy (Py-IR). The catalysts were used for catalytic deoxygenation of Jatropha curcas oil. The optimal conditions for the deoxygenation of the generated oil were obtained by response surface methodology based on Box-Behnken four-factor experiments. Response surface methodology (RSM) was applied while determining the optimal conditions for the Jatropha oil deoxygenation percentage. The rate was calculated based on Box-Behnken four-factor experiments, with reaction temperature, catalyst amount, reaction time, and reaction pressure as independent variables and the deoxygenation of Jatropha curcas oil as response values. The optimal reaction conditions obtained were a temperature of 370 °C, pressure of 2 MPa, time of 7 h, and catalyst amount of 0.22 g. The deoxygenation percentage of the generated oil under the optimal conditions was 95.1%, which was close to the theoretical value, indicating that the model was reliable. The generated oil contained more jet fuel components, with 68.1% C8-C16, 12.0% isoalkanes, 14.2% cycloalkanes, and 8.9% aromatic compounds under the optimum conditions. This study provides an effective and simple method for preparation of bio-aviation fuel.

Cholangiocarcinoma (CCA), which is highly malignant, shows a relatively poor prognosis, due to the insensitivity of the tumour to chemotherapy and radiotherapy. Photodynamic therapy (PDT) has become a promising palliative therapeutic option for patients with unresectable cholangiocarcinoma (CCA), while the functional amount of ROS is limited by intracellular redox systemen. Sulfasalazine (SASP), a well-known anti-inflammatory agent, which also acts as an inhibitor of the amino acid transport system xc (xCT), decreases the intracellular glutathione (GSH) level, thus weakening the antioxidant defence of the cell by inhibition of the antiporter. However, the combination of SASP and PDT remains unexplored. We have reported that polyhematoporphyrin (PHP)-mediated PDT inhibits the cell viability of CCA cells and organoids. Furthermore, in PHP-enriched HCCC-9810 and TFK-1CCA cells, SASP enhances the sensitivity to PHP-mediated PDT through a GSH-dependent mechanism. We found that PHP-PDT can up-regulate xCT expression to promote cells against overloaded ROS, while SASP reduces GSH levels. After the combination of SASP and PHP-PDT, cell viability and GSH levels were significantly inhibited. xCT was also observed to be inhibited by SASP in human organoid samples. Our findings suggest that, in combination with PDT, SASP has potential as a promising approach against CCA.

Abstract Background Underlying liver function is a major concern when applying surgical resection for hepatocellular carcinoma (HCC). We aimed to explore the capability of the albumin-bilirubin (ALBI) grade to predict post-hepatectomy liver failure (PHLF) and long-term survival after hepatectomy for HCC patients with different Barcelona Clinic Liver Cancer (BCLC) stages. Methods Between January 2010 and December 2014, 338 HCC patients who were treated with liver resection were enrolled. The predictive accuracy of ALBI grade system for PHLF and long-term survival across different BCLC stages was examined. Results A total of 26 (7.7%) patients developed PHLF. Patients were divided into BCLC 0/A and BCLC B/C categories. ALBI score was found to be a strong independent predictor of PHLF across different BCLC stages by multivariate analysis. In terms of overall survival (OS), it exhibited high discriminative power in the total cohort and in BCLC 0/A subgroup. However, differences in OS between ALBI grade 1 and 2 patients in BCLC B/C subgroup were not significant (P = 0.222). Conclusion The ALBI grade showed good predictive ability for PHLF in HCC patients across different BCLC stages. However, the ALBI grade was only a significant predictor of OS in BCLC stage 0/A patients and failed to predict OS in BCLC stage B/C patients.

This study aims to explore the relationship between the basic characteristics of college students’ social anxiety and the perceived social support and sense of coherence, and further explore the mediating role of the sense of coherence between perceived social support and social anxiety. A questionnaire survey of 420 college students was conducted using the Interaction Anxiousness Scale (IAS), the Perceived Social Support Scale (PSSS) and the Sense of Coherence-13(SOC-13). The results showed that: (1) The social anxiety in contemporary college students was very high, and the phenomenon of social anxiety of female is significantly higher than male. (2) College students’ social anxiety were significantly negatively correlated with both perceived social support and sense of coherence, and perceived social support was significantly related to sense of coherence. (3) Sense of coherence plays a partial mediation between perceived social support and social anxiety. This study provides theoretical support for revealing the mechanism between perceived social support and social anxiety.

Animal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought to elucidate the mechanism of T(reg-)cell defects in CHF patients.We performed flow cytometry analysis and demonstrated reduced numbers of peripheral blood CD4(+)CD25(+)FOXP3(+)CD45RO(-)CD45RA(+) naïve T(reg) (nT(reg)) cells and CD4(+)CD25(+)FOXP3(+)CD45RO(+)CD45RA(-) memory T(reg) (mT(reg)) cells in CHF patients as compared with non-CHF controls. Moreover, the nT(reg)/mT(reg) ratio (p