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The assessment of colleges’ effectiveness heavily relies on the employment status of graduates. Government-industry-university-research (GIUR) collaboration in cultivation talent is the key to improving the employment rate of college graduates. Based on the theoretical framework of the triple helix, this study develops a tripartite evolutionary game model that encompasses government, enterprises, and university research institutions. The research findings indicate (1) the evolutionary convergence of strategies among the subjects of the three-party game. (2) The attainment of a stable ideal evolution state for (1,1,1) is possible when the requisite conditions are met. This suggests that the cultivation of aligned talent in GIUR collaborations should coordinate the interests of various stakeholders. (3) Drawing inspiration from parameter-sensitive simulation, the problem of mismatch between talent cultivation and social demand can be effectively addressed through measures such as reducing the cost of cooperation, balancing the distribution of benefits, and implementing appropriate reward and punishment mechanisms. In response to these implications, we put forward some management insights and suggestions.

Abstract When the proliferation of residual hepatocytes is prohibited, biliary epithelial cells (BECs) transdifferentiate into nascent hepatocytes to accomplish liver regeneration. Despite significant interest in transdifferentiation, little is known about the maintenance of nascent hepatocytes in post-injured environments. Here, we perform an N-ethyl-N-nitrosourea (ENU) forward genetic screen and identify a mutant containing a nonsense mutation in the gene nibrin (nbn), which encodes a component of the Mre11-Rad50-Nbn (MRN) complex that activates DNA damage response (DDR). The regenerated hepatocytes cannot be maintained and exhibit apoptosis in the mutant. Mechanistically, the nbn mutation results in the abrogation of ATR-Chk1 signaling and accumulations of DNA damage in nascent hepatocytes, which eventually induces p53-mediated apoptosis. Furthermore, loss of rad50 or mre11a shows similar phenotypes. This study reveals that the activation of DDR by the MRN complex is essential for the survival of BEC-derived hepatocytes, addressing how to maintain nascent hepatocytes in the post-injured environments.

Due to the similar chemical structures and physicochemical properties, it is challenging to distinguish dextran, maltodextrin, and soluble starch from the polysaccharide products of plant origin, such as Lycium barbarum polysaccharides (LBPs). Using the first-order derivatives of Fourier-transformed infrared spectroscopy (FTIR, wave range 1800–400 cm−1), this study proposed a two-step pipeline to identify dextran, maltodextrin, and soluble starch from adulterated LBPs samples qualitatively and quantitatively. We applied principal component analysis (PCA) to reduce the dimensionality of FTIR features. For the qualitative step, a set of machine learning models, including logistic regression, support vector machine (SVM), Naïve Bayes, and partial least squares (PLS), were used to classify the adulterants. For the quantitative step, linear regression, LASSO, random forest, and PLS were used to predict the concentration of LBPs adulterants. The results showed that logistic regression and SVM are suitable for classifying adulterants, and random forests is superior for predicting adulterant concentrations. This would be the first attempt to discriminate the adulterants from the polysaccharide's product of plant origin. The proposed two-step methods can be easily extended to other applications for the quantitative and qualitative detection of samples from adulterants with similar chemical structures.

The implementation of the upgrading of the national coal electric power unit has provided a clear proposal to promote the clean and low-carbon transformation of the power industry. With the power of large-scale intermittent renewable energy and power generation, the electric crew should be flexible enough to adjust resources to achieve a depth of 35% THA. This article aims to propose a heat extracting and heat storage system for fire power plants, to realize the coordinated control strategy of the deep peak, and to explore the coordinated control strategy of the steam–molten salt heat exchanger, molten salt and water exchanger, and the turbine’s main control. The simulation results reveal that the coordinated control of the steam–molten salt heat exchanger, molten salt and water heat exchanger, and steam turbine control could reduce the depth of the fire power unit by 10% THA. The output power response speed of the thermal power unit is enhanced by utilizing the heat turbine, which could effectively enhance the output power response speed of the thermal power unit and increase the output power response speed pertinent to 302.55 s by 75.60%.

Summary: Upon extensive hepatocyte loss or impaired hepatocyte proliferation, liver regeneration occurs via biliary epithelial cell (BEC) transdifferentiation, which includes dedifferentiation of BECs into bipotential progenitor cells (BP-PCs) and then redifferentiation of BP-PCs to nascent hepatocytes and BECs. This BEC-driven liver regeneration involves reactivation of hepatoblast markers, but the underpinning mechanisms and their effects on liver regeneration remain largely unknown. Using a zebrafish extensive hepatocyte ablation model, we perform an N-ethyl-N-nitrosourea (ENU) forward genetic screen and identify a liver regeneration mutant, liver logan (lvl), in which the telomere maintenance 2 (tel2) gene is mutated. During liver regeneration, the tel2 mutation specifically inhibits transcriptional activation of a hepatoblast marker, hematopoietically expressed homeobox (hhex), in BEC-derived cells, which blocks BP-PC redifferentiation. Mechanistic studies show that Tel2 associates with the hhex promoter region and promotes hhex transcription. Our results reveal roles of Tel2 in the BP-PC redifferentiation process of liver regeneration by activating hhex.

Multistep wind speed forecasting is of great significance for wind energy utilization. To further improve the performance of multistep wind speed forecasting, a new multistep forecasting strategy is proposed based on the basic wind speed multistep forecasting strategy and the corresponding forecasting system is established. The system consists of three parts, including a wavelet decomposition preprocessing module, nonlinear autoregressive artificial neural network and nonlinear autoregressive exogenous artificial neural network composite prediction module, and support vector machine classifier postprocessing module. The system analyzes historical wind speed data from two different angles to obtain dual time series features. Then, the double time series feature is used to improve the accuracy and stability of the multipart forecast. The predictive performance of the system is verified through two experiments. Experiment I tests the prediction accuracy and computing resource consumption of the system. Experiment II tests the stability of the system prediction under different wind conditions. The results show that, compared with the traditional multistep prediction strategy system, the new system has a better prediction accuracy and more stable prediction performance.

The molecular weight, the triple-helix conformation, the monosaccharide content, the manner of glycosidic linkages, and the polysaccharide conjugates of polysaccharides all affect bioactivity. The purpose of this study was to determine how different molecular weights affected the bioactivity of the Lycium barbarum polysaccharides (LBPs). By ethanol-graded precipitation and ultrafiltration membrane separation, one oligosaccharide (LBPs-1, 1.912 kDa) and two polysaccharides (LBPs-2, 7.481 kDa; LBPs-3, 46.239 kDa) were obtained from Lycium barbarum. While the major component of LBPs-1 and LBPs-2 was glucose, the main constituents of LBPs-3 were arabinose, galactose, and glucose. LBPs-2 and LBPs-3 exhibited triple-helix conformations, as evidenced by the Congo red experiment and AFM data. Sugar residues of LBPs-2 and LBPs-3 were elucidated by NMR spectra. The polysaccharides (LBPs-2 and LBPs-3) exhibited much higher antioxidant capacities than oligosaccharide (LBPs-1). LBPs-3 showed higher oxygen radical absorbance capacity (ORAC) and superoxide dismutase (SOD) activity than LBPs-2, but a lower capability for scavenging ABTS+ radicals. In zebrafish, LBPs-2 and LBPs-3 boosted the growth of T-lymphocytes and macrophages, enhanced the immunological response, and mitigated the immune damage generated by VTI. In addition to the molecular weight, the results indicated that the biological activities would be the consequence of various aspects, such as the monosaccharide composition ratio, the chemical composition, and the chemical reaction mechanism.

This paper explores the effects of wearable medical devices (WMDs) in vital sign monitoring, which is the key to telemedicine rehabilitation. First, 60 young patients were selected from the department of oral and maxillofacial surgery in a Chinese hospital. The vital signs of the patients, namely, ear temperature, pulse, blood oxygen saturation, and blood pressure, were measured by both the WMDs and the traditional devices. The measurements were carried out at 6:00, 10:00, 14:00, and 18:00 on the first day of each month in 2018. The comparison between the measured results shows that the WMDs and the traditional devices have no difference in the measured data and measurement time of any vital sign (P > 0.05), but the WMDs consumed much less time in data transcription and the entire measurement process. This means the WMDs are suitable for vital sign measurement in telemedicine rehabilitation.

Liver cancer is one of the most prevalent cancers in humans. Hepatocytes normally undergo dedifferentiation after the onset of hepatocellular carcinoma, which in turn facilitates the progression of cancer. Although the process of hepatocellular carcinoma dedifferentiation is of significant research and clinical value, the cellular and molecular mechanisms underlying it are still not fully characterized. We constructed a zebrafish liver cancer model based on overexpression of the oncogene krasG12V to investigate the hepatocyte dedifferentiation in hepatocellular carcinoma. We found that, after hepatocarcinogenesis, hepatocytes dedifferentiated and the Notch signaling pathway was upregulated in this progress. Furthermore, we found that inhibition of the Notch signaling pathway or deficiency of sox9b both prevented hepatocyte dedifferentiation following hepatocellular carcinoma induction, reducing cancer metastasis and improving survival. In conclusion, we found that hepatocytes undergo dedifferentiation after hepatocarcinogenesis, a process that requires Notch signaling and likewise the activation of Sox9.

Although the optimization of wind turbine blade aerodynamic performance has achieved fruitful results, whether airfoil concavity, an important method for preventing flow separation, is also feasible for improving the aerodynamic performance has not been confirmed scientifically. Thus, we selected the blade of a small horizontal-axis wind turbine as a research model and proposed an optimization method based on airfoil concavity near the trailing edge of the blade suction surface. The experimental results showed that airfoil concavity improved blade aerodynamic performance by 3–15%. Subsequently, its effects on the sound pressure level within the wake flow field were investigated using an acoustic array, and the results suggested that the sound pressure level was reduced by 9.6–15.8%. Lastly, a modal test of the rotor blade was conducted. Although the natural frequencies of the 1st and 2nd order vibrations had hardly changed, their vibrational stiffness were increased by 7 and 4.9%, respectively, which indicated that airfoil concavity significantly improved structural robustness.