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Edentulism is a prevalent oral health issue that has a detrimental social and psychological impact on patients ‘quality of life. The treatment option adopted has a significant impact on the level of quality with the goal can be achieved. For edentulous patients, implant-supported fixed restorations are a well-established treatment modality. Implant dentistry philosophies and procedures have evolved and changed over the time to give esthetics and functional outcomes. Immediate loading has various advantages over traditional loading without sacrificing the quality of the output. An immediate fixed provisional promotes a high level of patient satisfaction with respect to esthetics, phonetics, mastication and psychological comfort, enabling patients to return to their normal routine and maintain quality of life within a short period of time. Without question, the optimal solution for any edentulous patient from whom it is still clinically viable to place implants is all-on-X dental implant solution. Whether All-on-four All-on-five, All-on-six or any variation of a full implant supported design, there is a best option for quality of life, long term durability, bone maintenance, health improvement and frankly happiness.

Although dental implants are most common prosthetic treatment used to replace missing tooth, it gained considerable importance over a decade owing to the availability of advanced techniques that can help in achieving a greater success rate and much better osseointegration. The chances that the implanted tooth can be rejected due to inflammation caused by oral microflora still persist. The term peri-implantitis is used to describe a destructive inflammatory process affecting the soft and hard tissues around osseo integrated implants, leads to the formation of a peri-implant pocket and loss of supporting bone. Predisposing factors are poor plaque control, inflammation, infection, smoking, diabetes and occlusal overload. It is diagnosed on the basis of clinical and radiographic interpretation and still no definitive criteria have been proposed for the diagnosis and treatment of peri-implantitis. However treatment can be both conservative and surgical. The cumulative interceptive supportive therapy protocol serves as good guide for the treatment of the peri-implantitis. Radiological examination it is very important pre- and post-operative assessment of implant surgery. Among all radiological methods, periapical radiography (PA) and cone beam computer tomography (CBCT) are common to asses post-operative peri-implant bone defects.

Missing teeth may result in a functional and cosmetic deficit and have traditionally been replaced with dentures or bridges. Dental implants rely on the maintenance of a direct structural and functional connection between living bone and the implant surface, this is termed osseointegration. Osseointegration has undoubtedly been one of the most significant scientific breakthroughs in dentistry over the past 40 years. Insufficient bone volume is a common problem encounter in the rehabilitation of the edentulous posterior maxilla with implant-supported prostheses. The bone available for implant placement may be limited by the presence of the maxillary sinus together with loss of alveolar bone height. Bone volume may be increased by augmentation, commonly the sinus cavity is augmented with autogenous bone or biomaterials or both. Procedures are variously described in the literature as sinus lift, sinus augmentation, sinus floor elevation or augmentation of atrophic maxillary sinus. Implant placement may be combined with sinus augmentation as one-stage technique. Alternatively sinus augmentation may be carried out as some time prior to implant placement as a two-stage technique.

Basal cell carcinoma (BCC) has a slow evolution and possible massive tissue destruction when neglected and reaches large dimensions. BCC involves various histological subtypes, the nodular form being the most common. Frequent localization on the face confirms that ultraviolet radiation is an important risk factor for this type of skin cancer. Basal cell carcinoma is most frequently on the cutaneous lips. It is reported that BCC is more frequent in the upper lip in women, while squamous cell carcinoma (SCC) seems to be more frequent in men, in the lower lip. Smoking and alcohol are reported as predisposing factors. The study purpose was to evidence the high incidence of BCC of the perioral and lips regions. 2) Methods: Retrospective descriptive study on a group of 55 patients diagnosed with BCCof the face, in whom surgical excision (in oncologic limits) treatment was performed, and postoperative follow-up was applied. 3) Results: The predominance of the ulcerated-infiltrative form was highlighted, predominantly in the age group between 60 and 80 years. 4) Conclusions: The increased number of BCC as well as the growing number of large and neglected tumors, evidenced the need of including BCC in a cancer registry and the implementation of a screening program, as well as a better information of the population regarding this type of skin cancer.

Immediate function has become an accepted treatment modality for fixed restorations in completely edentulous jaws. Guided implant surgery is considered as a safe and minimally invasive flapless procedures. A total of 26 patients (10 males and 16 females, mean age 50.0+/- 15.5 years) were enrolled in the present retrospective clinical study, 265 implants post-extractive were installed, immediately loaded by means of a provisional fixed full arch. In our present study, a total of 265 SKY classic fast @ fix implants from Bredent were used for the reconstruction in 3 cases of both jaws, for the reconstruction of a single jaw in 5 cases, for the reconstruction of the maxilla in 6 cases and for the reconstruction of the mandible in 5 cases. Within the limits of this study, complete-arch fixed reconstruction by means of guided surgery and immediate loading of implant placed in fresh extraction sockets appears to be a reliable and successful procedure. Further long-term prospective studies on a larger sample of patients are needed to confirm these positive outcomes.

Cystic fibrosis (CF) is primarily known for its pulmonary consequences, which are extensively explored in the existing literature. However, it is noteworthy that individuals with CF commonly display gastrointestinal (G-I) manifestations due to the substantial presence of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in the intestinal tract. Recognized as pivotal nonpulmonary aspects of CF, G-I manifestations exhibit a diverse spectrum. Identifying and effectively managing these manifestations are crucial for sustaining health and influencing the overall quality of life for CF patients. This review aims to synthesize existing knowledge, providing a comprehensive overview of the G-I manifestations associated with CF. Each specific G-I manifestation, along with the diagnostic methodologies and therapeutic approaches, is delineated, encompassing the impact of innovative treatments targeting the fundamental effects of CF on the G-I tract. The findings underscore the imperative for prompt diagnosis and meticulous management of G-I manifestations, necessitating a multidisciplinary team approach for optimal care and enhancement of the quality of life for affected individuals. In conclusion, the authors emphasize the urgency for further clinical studies to establish a more robust evidence base for managing G-I symptoms within the context of this chronic disease. Such endeavors are deemed essential for advancing understanding and refining the clinical care of CF patients with G-I manifestations.

Sistemul imunitar joacă un rol complex în apărarea organismului ca răspuns la „non-self“, răspunde anormal la antigenii alergeni (hipersensibilitate şi autoimunitate) şi este caracterizat prin toleranţă imună cu lipsa de reactivitate la propriile structuri (auto). Scop. Scopul acestui studiu este de a demonstra că, în dermatita atopică, deficitul imun influenţează dezvoltarea atopiei, severitatea bolii şi dezvoltarea de comorbidităţi. Material şi metode. În urma analizei foilor de observaţie, 135 de cazuri diagnosticate cu AD au fost incluse în studiu. Analiza statistică a fost realizată cu ajutorul SPSS V20 pentru determinarea frecvenţei şi testarea ipotezelor, pentru p

The immune system shows a complex role to defend the body in response to “non-self” antigens, respond abnormally to antigens allergens (hypersensitivity and autoimmunity) and shows immune tolerance by lack of reactivity to its own structures (self). Aim. The aim of this study is to demonstrate that in atopic dermatitis immune deficiency influences the development of atopy, disease severity and comorbidities. Material and methods. Following medical record review, 135 cases diagnosed with AD were included in the study. Statistical analysis was performed using SPSS v20 for determining the frequency and testing the hypotheses, for p < 0.05, by t tests and One-Way ANOVA. Results. Of the 135 cases, 51.9% were male children and 48.1% female children aged 1 month to 127 months with a mean of 26.21. According to total serum IgE level, 64.4% of patients had elevated IgE levels, 35.6% normal levels. According to the SCORAD, children had mild AD in 20.7% of cases, moderate in 70.4%, and severe in 8.9%. IgA deficiency was found for 48.1% of cases, and for 51.9% normal. IgG deficiency was found in 38.5% of cases. The independent samples t tests showed statistical significant demonstrating correlations between IgE level and IgA immune deficiency, between SCORAD and IgG and IgA immune deficiency. Atopic march is influenced by elevated IgE, IgA and IgG immune deficiency, p

Aim of the study The aim of this study is to emphasize the principles of face burn management based on our personal experience correlated with published literature data. We aim to illustrate different possible approaches of treatment in order to obtain good functional and aesthetic outcomes. Material and methods The study group included 342 patients (144 females and 198 males), with ages ranging between 18 and 92 years old, hospitalized and treated in the Burn Unit from the “Sf. Spiridon” Emergency County Hospital from Iași, Romania, during december 2020 – october 2023. The inclusion criteria for the study were: patients over 18 years old, isolated burn lesions only of the face or in association with burn lesions distributed on various anatomical regions, burns of all degrees. Results The group included 144 females (42,1%) and 198 males (57,89%). The etiologies of the burns were represented by flame (123 cases) – 35,96%, scald (103 cases) – 30,11%, contact (52) – 15,20%, electrocutions (31) – 9,06% or ultraviolet exposure (33) – 9,64%. 134 patients (39,18%) had isolated lesions of the face and 208 patients (60,81%) associated other localisations as well. Out of the total number of cases, the majority (276 cases) – 69% were treated conservatory, while 31% required different forms of surgical interventions. Conclusions The management of facial burns must be multidisciplinary and early in the face of serious complications that may endanger the vital, functional and aesthetic prognosis. Periodic evaluations must be constant and involve the physical and mental status of the patient. Social, family and professional integration takes a significant place in the overall management of facial burns to limit the difficulty of reintegration of a person affected by burns.