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Objective To explore the anti corrosion ability of laser welded composite wire in artificial saliva con⁃ taining salivary amylase and pancreatic amylase, and to compare the effect of two kinds of amylase on corrosion resis⁃ tance of wire and its mechanism. Methods The corrosion resistance of composite wire was evaluated by electrochemi⁃ cal polarization and immersion test. The soluble corrosion products after 28 d immersion in artificial saliva were detect⁃ ed by plasma spectrometer. The surface morphology was analyzed by scanning electron microscope, energy spectrometer and atomic force microscope. Results Salivary amylase and pancreatic amylase could improve the corrosion resistance of the composite arch wire; the same isomerase would have different effects on the same alloy corrosion resistance. Con⁃ clusion When the new metal biological material is applied to the oral cavity, the amylase may have influence on its corrosion resistance.