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Abstract Long COVID is a multi-systemic disease characterized by the persistence or occurrence of many symptoms that in many cases affect the pulmonary system. These, in turn, may deteriorate the patient’s quality of life making it easier to develop severe complications. Being able to predict this syndrome is therefore important as this enables early treatment. In this work, we investigated three machine learning approaches that use clinical data collected at the time of hospitalization to this goal. The first works with all the descriptors feeding a traditional shallow learner, the second exploits the benefits of an ensemble of classifiers, and the third is driven by the intrinsic multimodality of the data so that different models learn complementary information. The experiments on a new cohort of data from 152 patients show that it is possible to predict pulmonary Long Covid sequelae with an accuracy of up to $$94\%$$ 94 % . As a further contribution, this work also publicly discloses the related data repository to foster research in this field.

Current practice in cancer treatment collects multimodal data, such as radiology images, histopathology slides, genomics and clinical data. The importance of these data sources taken individually has fostered the recent rise of radiomics and pathomics, i.e., the extraction of quantitative features from radiology and histopathology images collected to predict clinical outcomes or guide clinical decisions using artificial intelligence algorithms. Nevertheless, how to combine them into a single multimodal framework is still an open issue. In this work, we develop a multimodal late fusion approach that combines hand-crafted features computed from radiomics, pathomics and clinical data to predict radiotherapy treatment outcomes for non-small-cell lung cancer patients. Within this context, we investigate eight different late fusion rules and two patient-wise aggregation rules leveraging the richness of information given by CT images, whole-slide scans and clinical data. The experiments in leave-one-patient-out cross-validation on an in-house cohort of 33 patients show that the proposed fusion-based multimodal paradigm, with an AUC equal to 90.9%, outperforms each unimodal approach, suggesting that data integration can advance precision medicine. The results also show that late fusion favourably compares against early fusion, another commonly used multimodal approach. As a further contribution, we explore the chance to use a deep learning framework against hand-crafted features. In our scenario characterised by different modalities and a limited amount of data, as it may happen in different areas of cancer research, the results show that the latter is still a viable and effective option for extracting relevant information with respect to the former.

The exponential growth of IoT devices, smartphones, smartwatches, and vehicles equipped with positioning technology, such as Global Positioning System (GPS) modules, has boosted the development of location-based services for several applications in Intelligent Transportation Systems. However, the inherent error of location-based technologies makes it necessary to align the positioning trajectories to the actual underlying road network, a process known as map-matching. To the best of our knowledge, there are no comprehensive tools that allow us to model street networks, conduct topological and spatial analyses of the underlying street graph, perform map-matching processes on GPS point trajectories, and deeply analyse and elaborate these reconstructed trajectories. To address this issue, we present PyTrack, an open-source map-matching-based Python toolbox designed for academics, researchers and practitioners that integrate the recorded GPS coordinates with data provided by the OpenStreetMap, an open-source geographic information system. This manuscript overviews the architecture of the library offering a detailed description of its capabilities and modules. Besides, we provide an introductory guide to getting started with PyTrack covering the most fundamental steps of our framework. For more information on PyTrack, users are encouraged to visit the official repository at https://github.com/cosbidev/PyTrack or the official documentation at https://pytrack-lib.readthedocs.io.