1. Effects of levothyroxine substitution therapy on hunger and food intake in individuals with hypothyroidism
- Author
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Bjarke R Medici, Birte Nygaard, Jeppe L la Cour, Martin Krakauer, Andreas Brønden, Mette P Sonne, Jens J Holst, Jens F Rehfeld, Tina Vilsbøll, Jens Faber, and Filip K Knop
- Subjects
levothyroxine ,hunger ,food intake ,hypothyroidism ,body composition ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Context: In individuals with hypothyroidism and overweight, levothyroxine substitution therapy is often expected to cause weight loss due to its effect on resting energy expenditure. However, despite levothyroxine-induced enhancement of resting energy expenditure, fat mass loss is rarely seen after levothyroxine substitution therapy. The mechanism behind this conundrum is unknown. Aim: The aim of the study was to assess the effect of levothyroxine t herapy on hunger sensations and ad libitum food intake in individuals with hypothyroidism. Design and setting: Prospective cohort study of 18 newly diagnosed hypothyroid women (thyroid-stimulating hormone (TSH) >10 mU/L). Participants were investigated at diagnosis, after normalization of TSH (
- Published
- 2023
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