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Heavy metals (HMs) pollution in the environment is a persistent issue and draws public attention constantly. However, there is little research assessing the pollution level of HMs in the Henan section of the Yellow River although the river is one of the most important water supply rivers in Henan province. In this research, the fraction contents of six HMs in the Henan section of the Yellow River were investigated by adopting the European Community Bureau of Reference (BCR) sequential extraction procedure. Moreover, the potential health risk caused by HMs was evaluated by adopting both the geo-accumulation index (Igeo) and ecological hazard index method. The results indicate the presence of a light HM pollution level in the Yellow River generally. However, the health risk caused by Cd cannot be neglected. Fraction analysis indicates that the content of the B2 fraction is high, which needs more attention. Overall, branch afflux might be one of the important pathways through which anthropogenic activities influence the Yellow River. The results of both the Igeo and ecological hazard index indicate that the potential health risk caused by HMs is low in the Yellow River, and the Yellow River protection policies implemented by Henan province may be the underlying reason. HIGHLIGHTS In this study, the content of six heavy metals in the Yellow River of the Henan section was investigated by adopting the BCR method.; The concentration of Cd was significantly higher than the background value.; The B1 fraction of Mn and B2 fraction of Pb were high, and the potential health risk should receive more attention.;

Garden-cultivated Ginseng (GG) and mountain-cultivated Ginseng (MG) both belong to Panax Ginseng C. A. Meyer. However, the effective substances which can be used to distinguish GG from MG remain obscure. Therefore, the purpose of this study was to screen for discriminating markers that can assist in the correct identification of GG and MG. HPLC Q-TOF/MS and various chemometrics methods were used to analyze the chemical profiles of 13 batches of Ginseng and to explore the characteristic constituents of both GG and MG. The hepatocyte-protecting effects of GG and MG were investigated through a paclitaxel-induced liver injury model. Through a combination of correlation analysis and bioinformatic techniques, markers for differentiation between GG and MG were ascertained. A total of 40 and 41 compounds were identified in GG and MG, respectively, and 15 characteristic ingredients contributed significantly to the discrimination of GG from MG. Correlation analysis and network pharmacology were applied and ginsenosides Rg1, Re, Rb1, Rc, Rb2, and Rg3 were found to be discriminating markers of GG and MG. Six markers for the identification of GG and MG were screened out by a step-wise mutually oriented “chemical profiling–pharmaceutical effect” correlation strategy, which is of great significance for future quality assessment of Ginseng products.