Search

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPA) is an extremely rare neoplasm that generally originates from the nasopharynx surface epithelium. The case presented herein is of a 70-year-old male patient referred from another centre, who was observed to have this tumour together with squamous cell carcinoma. The clinicopathological findings of this combination are presented, which has very rarely been mentioned in the literature. Although the prognosis of TL-LGNPA is generally excellent, it may sometimes be combined with other tumours, and therefore it must be kept in mind that it could have a clinically more aggressive course.

Abstract Objective Risk analysis models, which are used in the diagnostic algorithm of incidental pulmonary nodules, are based on patient data from developed countries. Mayo Clinic, Brock University and Herder are among the most known models. We aim to compare the reliability of these models in patients with indeterminate solid nodules and to investigate the contribution of the predictors used to the model. Methods We analysed 305 patients who performed transthoracic needle biopsy and positron emission tomography/computed tomography for solid nodules, retrospectively. For all three models, the malignancy risk probabilities of patients were calculated, and patients were classified as low (

Background/Aims: As targeted therapies are promising in the treatment of lung cancer (LC), it is important to identify the genetic variations in tumors. The present research aimed to determine the regional prevalence of alterations in ALK, ROS1, and EGFR genes. Materials and Methods: ALK rearrangement in 1152, ROS1 rearrangement in 390, and EGFR mutations in 1054 cases with LC were evaluated. Results: Alteration rates of ALK, ROS1, and epidermal growth factor receptor (EGFR) genes were 3.5%, 0.4%, and 11.2% in the samples, respectively. ALK rearrangements were mainly detected in young patients (P < 0.01) and in females (P < 0.01). Females were also more often inflicted by EGFR variations, especially from the exon 19 deletion. Exon 21 L858R mutations were more frequently found in men. However, any statistical significance between EGFR alterations and gender or age was not discovered. Conclusion: In this study, molecular changes were less frequent than expected. We thought that this low rate confirmed the aphorism of “smokes like a Turk, ” which could be because almost all patients were active or passive smokers.

Amaç: Bu çalışmada, vestibüler disfonksiyonlu hastaların, psikolojik profil ve kişilik özelliklerini değerlendirmeyi amaçlanmıştır.Gereç ve Yöntem: Vestibüler disfonksiyon şikayeti olan 225 hasta ve vestibüler disfonksiyon şikayeti olmayan 227 kontrol olmak üzere toplam 452 kişi çalışmaya alındı. Otorinolaringolojik muayene ve vestibüler değerlendirme yapıldı. Baş dönmesinin yol açtığı özür ve şiddeti belirlemek için Dizziness Handicap İndeksi (DHI) formu hastalar tarafından dolduruldu. Hasta ve kontrol grubuna, Eysenck Personality Questionnaire-Revised Abbreviated (EPQR-A), Type D personality scale (DS-14) ve Hospital Anxiety Depression Scale (HADS) formları dolduruldu.Bulgular: Hastaların 157’si (%69.8) kadın, 68’i (%30.2) erkek, kontrollerin 133’ü (%58.6) kadın, 94’ü (%41.4) erkek idi. Hasta ve kontrol grubunda ortalama yaş 39.72±14.08 ve 35.02±11.80 idi. Hastaların 81’inin (%36), kontrollerin 42’sinin (%18.4) psikiyatrik tedavi aldığı saptandı. EPQR-A, nevrotizm alt ölçeği, vertigolu hastalarda kontrol grubuna göre istatistiksel olarak anlamlı düzeyde daha yüksek bulundu. HADS’ın anksiyete ve depression alt ölçeği, vertigolu hastalarda kontrol grubuna göre daha yüksek ve istatistiksel olarak anlamlı bulundu. DS 14’ün, negative emotions and social suppression alt ölçekleri, vertigolu hastalarda kontrol grubuna göre daha yüksek ve istatistiksel olarak anlamlı olarak bulundu.Sonuç: Bu çalışma, vestibüler disfonksiyonlu hastalarda "nevrotik" kişilik özelliklerinin ve Tip D kişiliğin daha yüksek oranda olduğunu gösterdi. Sonuç olarak, vestibüler hastalıklardan şikayet eden hastaların psikolojik profil ve kişilik özelliklerinin, tanı ve tedavide önemli olduğunu düşünmekteyiz.

Inflammatory myofibroblastic tumor is composed of myofibroblast and inflammatory cell infiltration of the tissue. Malign transformation and recurrence rate of this tumor is rare and accepted as benign fibroinflammatory disease. The main etiology is unclear, but infection, trauma, and immunologic event are accused. In this study, we presented a 75-year-old man with a mass on his tongue, which was diagnosed as “inflammatory myofibroblastic tumor.” This type of tumor is rarely seen in the tongue and might be difficult to diagnose. Complete mass excision was provided for an adaquete treatment.

Objective:The aim of this study is to investigate the frequency of fractures and related factors in children with spina bifida who were followed up in our hospital.Materials and Methods:By retrospectively examination of the medical records of 450 patients with spina bifida, who were followed up by our clinic between 2000 and 2018, the patients were evaluated in terms of factors such as frequency of fracture, age of the first fracture, lesion level, ambulation capacity, physical therapy initiation age, fracture site and mechanism.Results:In the 450 patients examined, the fracture rate was 5.7%. While there was a relationship between low ambulatory capacity and high-level lesions and fracture risk, the early initiation of physical therapy did not protect against fracture.Conclusion:According to these data, fractures are more common in patients with spina bifida. It was concluded that the quality of mobilisation, not the duration, was the more important risk factor for fracture.